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Myogel
Myogel is a trade name for a human-based extracellular matrix used in cancer research to provide a 3D cell culture environment for cancer cells. Unlike other synthesized matrices such as matrigel which originated from mice sarcoma, myogel is extracted from a human benign tumor tissue called leiomyoma. Myogel was developed in Tuula Salo's lab at the University of Oulu The University of Oulu ( fi, Oulun yliopisto) is one of the largest universities in Finland, located in the city of Oulu. It was founded on July 8, 1958. The university has around 13,000 students and 2,900 staff. 21 International Master's P .... The idea started in 2009 by culturing cancer cells on myoma discs. Later in 2015, these myoma tissues were processed following matrigel receipt, to extract a gel form called Myogel. Myogel was compared with matrigel and found to be superior in term of enhancing cancer cells proliferation, migration and invasion. References {{oncology-stub Extracellular matrix Cance ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Matrigel
Matrigel is the trade name for the solubilized basement membrane matrix secreted by Engelbreth-Holm-Swarm (EHS) mouse sarcoma cells produced by Corning Life Sciences. Matrigel resembles the laminin/collagen IV-rich basement membrane extracellular environment found in many tissues and is used by cell biologists as a substrate (basement membrane matrix) for culturing cells. Cell culture A common laboratory procedure is to dispense small volumes of chilled (4 °C) liquid Matrigel onto plastic tissue culture labware. When incubated at 37 °C (body temperature) the Matrigel proteins polymerize (solidify) producing a recombinant basement membrane that covers the labware's surface. Cells cultured on Matrigel demonstrate complex cellular behavior that is otherwise difficult to observe under laboratory conditions. For example, endothelial cells create intricate spiderweb-like networks on Matrigel-coated surfaces but not on plastic surfaces. Such networks are highly suggestive of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trade Name
A trade name, trading name, or business name, is a pseudonym used by companies that do not operate under their registered company name. The term for this type of alternative name is a "fictitious" business name. Registering the fictitious name with a relevant government body is often required. In a number of countries, the phrase "trading as" (abbreviated to t/a) is used to designate a trade name. In the United States, the phrase "doing business as" (abbreviated to DBA, dba, d.b.a., or d/b/a) is used, among others, such as assumed business name or fictitious business name. In Canada, "operating as" (abbreviated to o/a) and "trading as" are used, although "doing business as" is also sometimes used. A company typically uses a trade name to conduct business using a simpler name rather than using their formal and often lengthier name. Trade names are also used when a preferred name cannot be registered, often because it may already be registered or is too similar to a name that is a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Extracellular Matrix
In biology, the extracellular matrix (ECM), also called intercellular matrix, is a three-dimensional network consisting of extracellular macromolecules and minerals, such as collagen, enzymes, glycoproteins and hydroxyapatite that provide structural and biochemical support to surrounding cells. Because multicellularity evolved independently in different multicellular lineages, the composition of ECM varies between multicellular structures; however, cell adhesion, cell-to-cell communication and differentiation are common functions of the ECM. The animal extracellular matrix includes the interstitial matrix and the basement membrane. Interstitial matrix is present between various animal cells (i.e., in the intercellular spaces). Gels of polysaccharides and fibrous proteins fill the Interstitial fluid, interstitial space and act as a compression buffer against the stress placed on the ECM. Basement membranes are sheet-like depositions of ECM on which various epithelial cells rest ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cancer Research
Cancer research is research into cancer to identify causes and develop strategies for prevention, diagnosis, treatment, and cure. Cancer research ranges from epidemiology, molecular bioscience to the performance of clinical trials to evaluate and compare applications of the various cancer treatments. These applications include surgery, radiation therapy, chemotherapy, hormone therapy, immunotherapy and combined treatment modalities such as chemo-radiotherapy. Starting in the mid-1990s, the emphasis in clinical cancer research shifted towards therapies derived from biotechnology research, such as cancer immunotherapy and gene therapy. Cancer research is done in academia, research institutes, and corporate environments, and is largely government funded. History Cancer research has been ongoing for centuries. Early research focused on the causes of cancer. Percivall Pott identified the first environmental trigger (chimney soot) for cancer in 1775 and cigarette smoking was identif ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cancer Cell
Cancer cells are cells that divide continually, forming solid tumors or flooding the blood with abnormal cells. Cell division is a normal process used by the body for growth and repair. A parent cell divides to form two daughter cells, and these daughter cells are used to build new tissue or to replace cells that have died because of aging or damage. Healthy cells stop dividing when there is no longer a need for more daughter cells, but cancer cells continue to produce copies. They are also able to spread from one part of the body to another in a process known as metastasis. Classification There are different categories of cancer cell, defined according to the cell type from which they originate. * Carcinoma, the majority of cancer cells are epithelial in origin, beginning in a tissue that lines the inner or outer surfaces of the body. * Leukaemia, originate in the tissues responsible for producing new blood cells, most commonly in the bone marrow. * Lymphoma and myeloma, deriv ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mice
A mouse ( : mice) is a small rodent. Characteristically, mice are known to have a pointed snout, small rounded ears, a body-length scaly tail, and a high breeding rate. The best known mouse species is the common house mouse (''Mus musculus''). Mice are also popular as pets. In some places, certain kinds of field mice are locally common. They are known to invade homes for food and shelter. Mice are typically distinguished from rats by their size. Generally, when a muroid rodent is discovered, its common name includes the term ''mouse'' if it is smaller, or ''rat'' if it is larger. The common terms ''rat'' and ''mouse'' are not taxonomically specific. Typical mice are classified in the genus '' Mus'', but the term ''mouse'' is not confined to members of ''Mus'' and can also apply to species from other genera such as the deer mouse, ''Peromyscus''. Domestic mice sold as pets often differ substantially in size from the common house mouse. This is attributable to breeding a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sarcoma
A sarcoma is a malignant tumor, a type of cancer that arises from transformed cells of mesenchymal (connective tissue) origin. Connective tissue is a broad term that includes bone, cartilage, fat, vascular, or hematopoietic tissues, and sarcomas can arise in any of these types of tissues. As a result, there are many subtypes of sarcoma, which are classified based on the specific tissue and type of cell from which the tumor originates. Sarcomas are ''primary'' connective tissue tumors, meaning that they arise in connective tissues. This is in contrast to ''secondary'' (or "metastatic") connective tissue tumors, which occur when a cancer from elsewhere in the body (such as the lungs, breast tissue or prostate) spreads to the connective tissue. The word ''sarcoma'' is derived from the Greek σάρκωμα ''sarkōma'' "fleshy excrescence or substance", itself from σάρξ ''sarx'' meaning "flesh". Classification Sarcomas are typically divided into two major groups: bone sarcom ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Benign Tumor
A benign tumor is a mass of cells (tumor) that does not invade neighboring tissue or metastasize (spread throughout the body). Compared to malignant (cancerous) tumors, benign tumors generally have a slower growth rate. Benign tumors have relatively well differentiated cells. They are often surrounded by an outer surface (fibrous sheath of connective tissue) or stay contained within the epithelium. Common examples of benign tumors include moles and uterine fibroids. Some forms of benign tumors may be harmful to health. Benign tumor growth causes a mass effect that can compress neighboring tissues. This can lead to nerve damage, blood flow reduction ( ischemia), tissue death (necrosis), or organ damage. The health effects of benign tumor growth may be more prominent if the tumor is contained within an enclosed space such as the cranium, respiratory tract, sinus, or bones. For example, unlike most benign tumors elsewhere in the body, benign brain tumors can be life-threateni ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leiomyoma
A leiomyoma, also known as a fibroid, is a benign smooth muscle tumor that very rarely becomes cancer (0.1%). They can occur in any organ, but the most common forms occur in the uterus, small bowel, and the esophagus. Polycythemia may occur due to increased erythropoietin production as part of a paraneoplastic syndrome. The word is from '' leio-'' + '' myo-'' + '' -oma'', "smooth-muscle tumor". The plural form can be either the English leiomyomas or the classical leiomyomata. Uterus Uterine fibroids are leiomyomata of the uterine smooth muscle. As other leiomyomata, they are benign, but may lead to excessive menstrual bleeding (menorrhagia), often cause anemia and may lead to infertility. A rare form of these tumors is uterine lipoleiomyoma—benign tumors consisting of a mixture of adipocytes and smooth muscle cells. Uterine lipoleiomyomata have been observed together with ovarian and other pathologies and some of them may develop into liposarcoma. These tumors are monoclona ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tuula Salo
Tuula may refer to: People * Tuula Haatainen (born 1960), Finnish politician * Tuula Hovi (born 1939), Finnish orienteering competitor * Tuula Kallioniemi (born 1951), Finnish author * Tuula Laaksalo (born 1953), Finnish javelin thrower * Tuula Puputti (born 1977), Finnish ice hockey player * Tuula Rautanen (born 1942), Finnish sprinter * Tuula Teeri (born 1957), Finnish molecular geneticist * Tuula Tenkanen (born 1990), Finnish sailor * Tuula Vilkas (born 1950), Finnish speed skater * Tuula Väätäinen Tuula Anneli Väätäinen (née ''Häkkinen''; born October 2, 1955 in Maaninka) is a Finnish politician. She has been elected as a member of parliament for the Social Democratic Party of Finland in the 2003, 2007, 2011 and 2019 elections. She cur ... (born 1955), Finnish politician * Tuula Yrjölä, Finnish diplomat Places * Tuula, Estonia Other * Tuula (comic) {{disambiguation Finnish feminine given names ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Oulu
The University of Oulu ( fi, Oulun yliopisto) is one of the largest universities in Finland, located in the city of Oulu. It was founded on July 8, 1958. The university has around 13,000 students and 2,900 staff. 21 International Master's Programmes are offered at the university. The university is often ranked as one of the better universities in Finland and in the top-400 worldwide. History * 1919 Oulu College Association was founded to manage the establishment of a university in the town * 1958 Oulu University Act * 1959 Activities begin. Faculty of Philosophy (programs in biology and mathematics), Faculty of Technology (architecture, civil and industrial engineering) and Oulu Teaching School * 1960 Faculty of Medicine * 1965 Teaching begins in humanities * 1965 Departments of Electrical Engineering and Machine Engineering added to the Faculty of Technology * 1972 The Faculty of Humanities and the Faculty of Natural Sciences founded with the division of the Faculty of Ph ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Extracellular Matrix
In biology, the extracellular matrix (ECM), also called intercellular matrix, is a three-dimensional network consisting of extracellular macromolecules and minerals, such as collagen, enzymes, glycoproteins and hydroxyapatite that provide structural and biochemical support to surrounding cells. Because multicellularity evolved independently in different multicellular lineages, the composition of ECM varies between multicellular structures; however, cell adhesion, cell-to-cell communication and differentiation are common functions of the ECM. The animal extracellular matrix includes the interstitial matrix and the basement membrane. Interstitial matrix is present between various animal cells (i.e., in the intercellular spaces). Gels of polysaccharides and fibrous proteins fill the Interstitial fluid, interstitial space and act as a compression buffer against the stress placed on the ECM. Basement membranes are sheet-like depositions of ECM on which various epithelial cells rest ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
