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Mycobacterium Avium-intracellulare Infection
''Mycobacterium avium-intracellulare'' infection (MAI) is an atypical mycobacterial infection, i.e. one with nontuberculous mycobacteria or NTM, caused by ''Mycobacterium avium'' complex (MAC), which is made of two '' Mycobacterium'' species, ''M. avium'' and ''M. intracellulare''. This infection causes respiratory illness in birds, pigs, and humans, especially in immunocompromised people. In the later stages of AIDS, it can be very severe. It usually first presents as a persistent cough. It is typically treated with a series of three antibiotics for a period of at least six months. ''M. avium'', ''M. intracellulare'', and ''M. chimaera'' are each saprotrophic organisms present in soil and water; entry into hosts is usually via the gastrointestinal tract, but also can be via the lungs. MAC infections can cause fevers, diarrhea, malabsorption, as well as loss of appetite and weight loss, and can disseminate to the bone marrow. MAI is typically resistant to standard mycobacteria ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mycobacterium Avium
''Mycobacterium avium ''complex is a group of mycobacteria comprising ''Mycobacterium intracellulare'' and ''Mycobacterium avium'' that are commonly grouped because they infect humans together; this group, in turn, is part of the group of nontuberculous mycobacteria. These bacteria cause Mycobacterium avium-intracellulare infection, ''Mycobacterium avium-intracellulare'' infections or ''Mycobacterium avium'' complex infections in humans. These bacteria are common and are found in fresh and salt water, in household dust and in soil. MAC bacteria usually cause infection in those who are immunocompromised or those with severe lung disease. Description In the Runyon classification, both bacteria are nonchromogens. They can be differentiated from ''M. tuberculosis'' and each other by commercially available DNA probes. They are characterized as Gram-positive, nonmotile, acid-fast, short to long rods. Colony characteristics * Usually, colonies are smooth, rarely rough, and not pigme ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mycobacterium Haemophilum
''Mycobacterium haemophilum'' is a species of the phylum Actinomycetota (Gram-positive bacteria with high guanine and cytosine content, one of the dominant phyla of all bacteria), belonging to the genus ''Mycobacterium''. Description Short, occasionally curved, gram-positive, nonmotile and strongly acid-fast rods. Colony characteristics *Nonpigmented and rough to smooth colonies. Physiology *Media have to be supplemented with 0.4% haemoglobin or 60 μM hemin (factor X) or 15 mg/ml ferric ammonium citrate respectively, but not with FeCl3 or catalase. *Slow growth on Löwenstein–Jensen medium or Middlebrook 7H10 agar at 32 °C within 2 to 4 weeks. *Growth slower at 25 °C and 35 °C and absent at 37 °C. *Strictly intracellular growth in tissue cultures of fibroblasts. Differential characteristics *Unique among mycobacteria in its requirement for hemin or ferric ammonium citrate for growth. Distribution. Pathogenesis *Infects patients with su ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cough
A cough is a sudden expulsion of air through the large breathing passages that can help clear them of fluids, irritants, foreign particles and microbes. As a protective reflex, coughing can be repetitive with the cough reflex following three phases: an inhalation, a forced exhalation against a closed glottis, and a violent release of air from the lungs following opening of the glottis, usually accompanied by a distinctive sound. Frequent coughing usually indicates the presence of a disease. Many viruses and bacteria benefit, from an evolutionary perspective, by causing the host to cough, which helps to spread the disease to new hosts. Most of the time, irregular coughing is caused by a respiratory tract infection but can also be triggered by choking, smoking, air pollution, asthma, gastroesophageal reflux disease, post-nasal drip, chronic bronchitis, lung tumors, heart failure and medications such as angiotensin-converting-enzyme inhibitors (ACE inhibitors). Treatment should t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lobe (anatomy)
In anatomy, a lobe is a clear anatomical division or extension of an organ (as seen for example in the brain, lung, liver, or kidney) that can be determined without the use of a microscope at the gross anatomy level. This is in contrast to the much smaller lobule, which is a clear division only visible under the microscope. Interlobar ducts connect lobes and interlobular ducts connect lobules. Examples of lobes *The four main lobes of the brain **the frontal lobe **the parietal lobe **the occipital lobe **the temporal lobe *The three lobes of the human cerebellum **the flocculonodular lobe **the anterior lobe **the posterior lobe *The two lobes of the thymus *The two and three lobes of the lungs **Left lung: superior and inferior **Right lung: superior, middle, and inferior *The four lobes of the liver **Left lobe of liver **Right lobe of liver **Quadrate lobe of liver **Caudate lobe of liver *The renal lobes of the kidney *Earlobes Examples of lobules *the cortical lobules o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bronchi
A bronchus is a passage or airway in the lower respiratory tract that conducts air into the lungs. The first or primary bronchi pronounced (BRAN-KAI) to branch from the trachea at the carina are the right main bronchus and the left main bronchus. These are the widest bronchi, and enter the right lung, and the left lung at each hilum. The main bronchi branch into narrower secondary bronchi or lobar bronchi, and these branch into narrower tertiary bronchi or segmental bronchi. Further divisions of the segmental bronchi are known as 4th order, 5th order, and 6th order segmental bronchi, or grouped together as subsegmental bronchi. The bronchi, when too narrow to be supported by cartilage, are known as bronchioles. No gas exchange takes place in the bronchi. Structure The trachea (windpipe) divides at the carina into two main or primary bronchi, the left bronchus and the right bronchus. The carina of the trachea is located at the level of the sternal angle and the fifth thoracic verte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CD4 Cell
The T helper cells (Th cells), also known as CD4+ cells or CD4-positive cells, are a type of T cell that play an important role in the adaptive immune system. They aid the activity of other immune cells by releasing cytokines. They are considered essential in B cell antibody class switching, breaking cross-tolerance in dendritic cells, in the activation and growth of cytotoxic T cells, and in maximizing bactericidal activity of phagocytes such as macrophages and neutrophils. CD4+ cells are mature Th cells that express the surface protein CD4. Genetic variation in regulatory elements expressed by CD4+ cells determines susceptibility to a broad class of autoimmune diseases. Structure and function Th cells contain and release cytokines to aid other immune cells. Cytokines are small protein mediators that alter the behavior of target cells that express receptors for those cytokines. These cells help polarize the immune response depending on the nature of the immunological insult ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bronchiectasis
Bronchiectasis is a disease in which there is permanent enlargement of parts of the bronchi, airways of the lung. Symptoms typically include a chronic cough with sputum, mucus production. Other symptoms include shortness of breath, hemoptysis, coughing up blood, and chest pain. Wheezing and nail clubbing may also occur. Those with the disease often get lung infections. Bronchiectasis may result from a number of infection, infectious and acquired causes, including measles, pneumonia, tuberculosis, immune system problems, as well as the genetic disorder cystic fibrosis. Cystic fibrosis eventually results in severe bronchiectasis in nearly all cases. The cause in 10–50% of those without cystic fibrosis is unknown. The mechanism of disease is breakdown of the airways due to an excessive inflammatory response. Involved airways (bronchi) become enlarged and thus less able to clear secretions. These secretions increase the amount of bacteria in the lungs, resulting in airway blockage ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cystic Fibrosis
Cystic fibrosis (CF) is a rare genetic disorder that affects mostly the lungs, but also the pancreas, liver, kidneys, and intestine. Long-term issues include difficulty breathing and coughing up mucus as a result of frequent lung infections. Other signs and symptoms may include sinus infections, poor growth, fatty stool, clubbing of the fingers and toes, and infertility in most males. Different people may have different degrees of symptoms. Cystic fibrosis is inherited in an autosomal recessive manner. It is caused by the presence of mutations in both copies of the gene for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Those with a single working copy are carriers and otherwise mostly healthy. CFTR is involved in the production of sweat, digestive fluids, and mucus. When the CFTR is not functional, secretions which are usually thin instead become thick. The condition is diagnosed by a sweat test and genetic testing. Screening of infants at bi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Senior Citizens
Old age refers to ages nearing or surpassing the life expectancy of human beings, and is thus the end of the human biological life cycle, life cycle. Terms and euphemisms for people at this age include old people, the elderly (worldwide usage), OAPs (British usage which stands for Pensioner, Old Age Pensioner), seniors, senior citizens (American usage), older adults (in the social sciences), and the elders (in many cultures). Elderly people often have limited regenerative abilities and are more susceptible to AIDS, herpes, hemorrhoids, and other illnesses than younger adults. A number of other disciplines and domains concern the aging and the aged, such as organic processes of aging (senescence), medical studies of the aging process (gerontology), diseases that afflict older adults (geriatrics), technology to support the aging society (gerontechnology), or leisure and sport activities adapted to older people, such as senior sport. The elderly face various social issues concern ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunodeficiency
Immunodeficiency, also known as immunocompromisation, is a state in which the immune system's ability to fight infectious diseases and cancer is compromised or entirely absent. Most cases are acquired ("secondary") due to extrinsic factors that affect the patient's immune system. Examples of these extrinsic factors include HIV infection and environmental factors, such as nutrition. Immunocompromisation may also be due to genetic diseases/flaws such as SCID. In clinical settings, immunosuppression by some drugs, such as steroids, can either be an adverse effect or the intended purpose of the treatment. Examples of such use is in organ transplant surgery as an anti- rejection measure and in patients with an overactive immune system, as in autoimmune diseases. Some people are born with intrinsic defects in their immune system, or primary immunodeficiency. A person who has an immunodeficiency of any kind is said to be immunocompromised. An immunocompromised individual may particular ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mycobacterium Avium Subspecies Paratuberculosis
''Mycobacterium avium'' subspecies ''paratuberculosis'' (MAP) is an obligate pathogenic bacterium in the genus ''Mycobacterium''. It is often abbreviated ''M. paratuberculosis'' or ''M. avium'' ssp. ''paratuberculosis''. It is the causative agent of Johne's disease, which affects ruminants such as cattle, and suspected causative agent in human Crohn's disease and rheumatoid arthritis. The type strain is ATCC 19698 (equivalent to CIP 103963 or DSM 44133). Pathophysiology MAP causes Johne's disease in cattle and other ruminants. It has long been suspected as a causative agent in Crohn's disease in humans,. but studies have been unable to show definite correlation. One study has argued that the presence of antibodies against ''Mycobacterium avium'' subspecies ''paratuberculosis'' is associated with increased propensity of patients with Crohn's disease to receive biological therapy. Recent studies have shown that MAP present in milk can survive pasteurization, which has raised h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Microbial Cooperation
Microorganisms engage in a wide variety of social interactions, including cooperation. A cooperative behavior is one that benefits an individual (the recipient) other than the one performing the behavior (the actor).West SA, Griffin AS, Gardner A. 2007. Social semantics: altruism, cooperation, mutualism, strong reciprocity and group selection. Eur. Soc. for Evol. Biol. 20:415–432. This article outlines the various forms of cooperative interactions ( mutualism and altruism) seen in microbial systems, as well as the benefits that might have driven the evolution of these complex behaviors. Introduction Microorganisms, or microbes, span all three domains of life – bacteria, archaea, and many unicellular eukaryotes including some fungi and protists. Typically defined as unicellular life forms that can only be observed with a microscope, microorganisms were the first cellular life forms, and were critical for creating the conditions for the evolution of more complex multicellular fo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
