Monogenic Obesity
Monogenic obesity is excess weight caused by a mutation in a single gene, as opposed to syndromic obesity not tied to a single gene variation and most obesity, which is caused by multiple genetic and environmental risk factors. Monogenetic obesity mostly affects the hypothalamus and leptin–melanocortin system (see hypothalamic obesity). However, it accounts for less than 5 percent of severe obesity cases. Known mutations leading to monogenetic obesity include: *Leptin deficiency *Leptin receptor deficiency * Melanocortin-4 receptor (MC4R) *Proopiomelanocortin (POMC *Prohormone convertase 1/3 (PC1/3) *SIM1 Single-minded homolog 1, also known as class E basic helix-loop-helix protein 14 (bHLHe14), is a protein that in humans is encoded by the ''SIM1'' gene. Function SIM1 and SIM2 genes are homologs of ''Drosophila melanogaster'' single-minded (sim), ... * BDNF * NTRK2 References {{Obesity Classification of obesity ...
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Syndromic Obesity
Syndromic obesity (SO) refers to obesity when it occurs as part of a syndrome, often along with intellectual disability. Often syndromic obesity is mediated by abnormal development of the hypothalamus (see hypothalamic obesity). Known types of syndromic obesity include some types of monogenic obesity and: *Prader Willi syndrome *Bardet-Biedl syndrome *Alstrom syndrome *16p11.2 deletion syndrome References

{{reflist Syndromes with obesity ...
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