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Michael Sela
Michael Sela ( he, מיכאל סלע; Mieczysław Salomonowicz; 2 March 1924 – 27 May 2022) was an Israeli immunologist of Polish Jewish origin. He was the W. Garfield Weston Professor of Immunology at the Weizmann Institute of Science in Rehovot. He was a president of the Weizmann Institute of Science. Early life and academic career Michael Sela was born as Mieczysław Salomonowicz in Tomaszów Mazowiecki, Poland, on 2 March 1924. In 1935 when he was 11 years old he and his family moved to Romania. In 1941 when he was 17 years old he and his family immigrated to Mandatory Palestine. He studied at the Hebrew University of Jerusalem (M.Sc., Chemistry, 1946; Ph.D., 1954). Sela was professor in the Weizmann Institute's Immunology Department. He was also a president of the Weizmann Institute of Science, from 1975 to 1985. Research Sela is known for his research in immunology, particularly for research on synthetic antigens, molecules that trigger the immune system to atta ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tomaszów Mazowiecki
Tomaszów Mazowiecki (, yi, טאָמעשעוו or ''Tomashuv'') is a city in central Poland with 60,529 inhabitants (2021). The fourth most populous city in the Łódź Voivodeship and the second with free public transport. In Tomaszów Mazowiecki there is the first (and the only) all-year speed skating track in Poland - Ice Arena Tomaszów Mazowiecki, which has been hosting the World Championships. In autumn, the city hosts the international Love Polish Jazz festival, organized by the Polish Ministry of Culture and National Heritage. Location Tomaszów is situated in the Łódź Voivodeship (since 1999); previously, it was part of Piotrków Voivodeship (1975–1998). Prior to World War One it was part of the Piotrków Gubernia (province) of the Russian Empire. Tomaszów occupies an area of as of 2002. The town is situated on the banks of three rivers, the Pilica, Wolbórka, and Czarna Bielina, and is near the Sulejow Reservoir and the edge of the Puszcza Spalska wildernes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antigen
In immunology, an antigen (Ag) is a molecule or molecular structure or any foreign particulate matter or a pollen grain that can bind to a specific antibody or T-cell receptor. The presence of antigens in the body may trigger an immune response. The term ''antigen'' originally referred to a substance that is an antibody generator. Antigens can be proteins, peptides (amino acid chains), polysaccharides (chains of monosaccharides/simple sugars), lipids, or nucleic acids. Antigens are recognized by antigen receptors, including antibodies and T-cell receptors. Diverse antigen receptors are made by cells of the immune system so that each cell has a specificity for a single antigen. Upon exposure to an antigen, only the lymphocytes that recognize that antigen are activated and expanded, a process known as clonal selection. In most cases, an antibody can only react to and bind one specific antigen; in some instances, however, antibodies may cross-react and bind more than one antigen. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Academy Of Sciences
The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the National Academy of Medicine (NAM). As a national academy, new members of the organization are elected annually by current members, based on their distinguished and continuing achievements in original research. Election to the National Academy is one of the highest honors in the scientific field. Members of the National Academy of Sciences serve '' pro bono'' as "advisers to the nation" on science, engineering, and medicine. The group holds a congressional charter under Title 36 of the United States Code. Founded in 1863 as a result of an Act of Congress that was approved by Abraham Lincoln, the NAS is charged with "providing independent, objective advice to the nation on matters related to science and technology. ... to provide scien ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Emil Von Behring
Emil von Behring (; Emil Adolf von Behring), born Emil Adolf Behring (15 March 1854 – 31 March 1917), was a German physiologist who received the 1901 Nobel Prize in Physiology or Medicine, the first one awarded in that field, for his discovery of a diphtheria antitoxin. He was widely known as a "saviour of children," as diphtheria used to be a major cause of child death. His work with the disease, as well as tetanus, has come to bring him most of his fame and acknowledgment. He was honored with Prussian nobility in 1901, henceforth being known by the surname "von Behring." Biography Behring was born in Hansdorf, Kreis Rosenberg, Province of Prussia (now Ławice, Iława County, Poland). His father was a schoolmaster; the family had 13 children. Between 1874 and 1878, he studied medicine at the Kaiser-Wilhelm-Akademie in Berlin, an academy for military doctors, since his family could not afford the university. As a military doctor, he studied the action of iodoform. Due to his w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Academy Of Arts And Sciences
The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and other Founding Fathers of the United States. It is headquartered in Cambridge, Massachusetts. Membership in the academy is achieved through a thorough petition, review, and election process. The academy's quarterly journal, ''Dædalus'', is published by MIT Press on behalf of the academy. The academy also conducts multidisciplinary public policy research. History The Academy was established by the Massachusetts legislature on May 4, 1780, charted in order "to cultivate every art and science which may tend to advance the interest, honor, dignity, and happiness of a free, independent, and virtuous people." The sixty-two incorporating fellows represented varying interests and high standing in the political, professional, and commercial secto ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Copaxone
Glatiramer acetate (also known as Copolymer 1, Cop-1), sold under the brand name Copaxone among others, is an immunomodulator medication used to treat multiple sclerosis. Glatiramer acetate is approved in the United States to reduce the frequency of relapses, but not for reducing the progression of disability. Observational studies, but not randomized controlled trials, suggest that it may reduce progression of disability. While a conclusive diagnosis of multiple sclerosis requires a history of two or more episodes of symptoms and signs, glatiramer acetate is approved to treat a first episode anticipating a diagnosis. It is also used to treat relapsing-remitting multiple sclerosis. It is administered by subcutaneous injection. It is a mixture of random-sized peptides that are composed of the four amino acids found in myelin basic protein, namely glutamic acid, lysine, alanine, and tyrosine. Myelin basic protein is the antigen in the myelin sheaths of the neurons that stimulates a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Multiple Sclerosis
Multiple (cerebral) sclerosis (MS), also known as encephalomyelitis disseminata or disseminated sclerosis, is the most common demyelinating disease, in which the insulating covers of nerve cells in the brain and spinal cord are damaged. This damage disrupts the ability of parts of the nervous system to transmit signals, resulting in a range of signs and symptoms, including physical, mental, and sometimes psychiatric problems. Specific symptoms can include double vision, blindness in one eye, muscle weakness, and trouble with sensation or coordination. MS takes several forms, with new symptoms either occurring in isolated attacks (relapsing forms) or building up over time (progressive forms). In the relapsing forms of MS, between attacks, symptoms may disappear completely, although some permanent neurological problems often remain, especially as the disease advances. While the cause is unclear, the underlying mechanism is thought to be either destruction by the immune system ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dvora Teitelbaum
According to the Book of Judges, Deborah ( he, דְּבוֹרָה, ''Dəḇōrā'', "bee") was a prophetess of the God of the Israelites, the fourth Judge of pre-monarchic Israel and the only female judge mentioned in the Bible. Many scholars contend that the phrase, "a woman of Lappidot", as translated from biblical Hebrew in Judges 4:4 denotes her marital status as the wife of Lappidot.Van Wijk-Bos, Johanna WH. ''The End of the Beginning: Joshua and Judges''. Wm. B. Eerdmans Publishing, 2019. Alternatively, "lappid" translates as "torch" or "lightning", therefore the phrase, "woman of Lappidot" could be referencing Deborah as a "fiery woman." Deborah told Barak, an Israelite general from Kedesh in Naphtali, that God commanded him to lead an attack against the forces of Jabin king of Canaan and his military commander Sisera (Judges 4:6–7); the entire narrative is recounted in chapter 4. Judges chapter 5 gives the same story in poetic form. This passage, often called ''The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ruth Arnon
Ruth Arnon (Hebrew: רות ארנון ut aʁ'non born in Tel Aviv on June 1, 1933) is an Israeli biochemist and codeveloper of the multiple sclerosis drug Copaxone. She is currently the Paul Ehrlich Professor of Immunology at the Weizmann Institute of Science, where she is researching anti-cancer and influenza vaccinations. Biography Ruth Rosenberg (later Arnon) was born in Tel Aviv, the youngest of three children. Her father, Alexander Rosenberg, moved with the family to Toulouse to pursue degrees in electrical engineering and mathematics. Upon their return to Israel, he worked for the Israel Electric Corporation. Arnon says her interest in science was inspired by her father. She attended Herzliya Hebrew Gymnasium and knew she wanted to be a medical researcher by the age of 15. She studied chemistry at the Hebrew University of Jerusalem before joining the Israel Defense Forces's Atuda academic study program. Arnon earned her M.Sc. degree in 1955 and served for two years as an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Myelin Sheath
Myelin is a lipid-rich material that surrounds nerve cell axons (the nervous system's "wires") to insulate them and increase the rate at which electrical impulses (called action potentials) are passed along the axon. The myelinated axon can be likened to an electrical wire (the axon) with insulating material (myelin) around it. However, unlike the plastic covering on an electrical wire, myelin does not form a single long sheath over the entire length of the axon. Rather, myelin sheaths the nerve in segments: in general, each axon is encased with multiple long myelinated sections with short gaps in between called nodes of Ranvier. Myelin is formed in the central nervous system (CNS; brain, spinal cord and optic nerve) by glial cells called oligodendrocytes and in the peripheral nervous system (PNS) by glial cells called Schwann cells. In the CNS, axons carry electrical signals from one nerve cell body to another. In the PNS, axons carry signals to muscles and glands or from sensor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Encephalomyelitis
Encephalomyelitis is inflammation of the brain and spinal cord. Various types of encephalomyelitis include: * ''Acute disseminated encephalomyelitis'' or ''postinfectious encephalomyelitis'', a demyelinating disease of the brain and spinal cord, possibly triggered by viral infection. * ''Encephalomyelitis disseminata'', a synonym for multiple sclerosis. * ''AntiMOG associated encephalomyelitis'', one of the underlying conditions for the phenotype neuromyelitis optica and in general all the spectrum of MOG autoantibody-associated demyelinating diseases. * '' Eastern equine encephalitis'', ''Japanese encephalitis'', ''Venezuelan equine encephalitis'', and ''Western equine encephalitis'': a group of viral illnesses that can affect horses and humans; collectively termed ''Equine encephalitis''. * ''Experimental autoimmune encephalomyelitis'' (EAE), an animal model of brain inflammation. * Progressive encephalomyelitis with rigidity and myoclonus (PERM) – A kind of stiff person synd ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polypeptide
Peptides (, ) are short chains of amino acids linked by peptide bonds. Long chains of amino acids are called proteins. Chains of fewer than twenty amino acids are called oligopeptides, and include dipeptides, tripeptides, and tetrapeptides. A polypeptide is a longer, continuous, unbranched peptide chain. Hence, peptides fall under the broad chemical classes of biological polymers and oligomers, alongside nucleic acids, oligosaccharides, polysaccharides, and others. A polypeptide that contains more than approximately 50 amino acids is known as a protein. Proteins consist of one or more polypeptides arranged in a biologically functional way, often bound to ligands such as coenzymes and cofactors, or to another protein or other macromolecule such as DNA or RNA, or to complex macromolecular assemblies. Amino acids that have been incorporated into peptides are termed residues. A water molecule is released during formation of each amide bond.. All peptides except cyclic peptides ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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