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Michael R. Rose
Michael R. Rose (born 25 July 1955) is a Professor in the Department of Ecology and Evolutionary Biology at the University of California, Irvine. Michael Roberson Rose was born on July 25, 1955. He obtained his B.S. in 1975 from Queen's University, Kingston, Ontario, Canada. In 1976 he obtained his M.S.. In 1978 he obtained his Ph.D from the University of Sussex. His Ph.D. advisor was Brian Charlesworth. His main area of work has been the evolution of aging, approached both theoretically and empirically via the technique of experimental evolution. In 1991, he published ''Evolutionary Biology of Aging'' exploring a view of the subject based on antagonistic pleiotropy, the hypothesis that aging is caused by genes that have two effects, one acting early in life and the other much later. The genes are favored by natural selection as a result of their early-life benefits, and the costs that accrue much later appear as incidental side-effects that we identify as aging. Dr. Rose has al ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of California, Irvine
The University of California, Irvine (UCI or UC Irvine) is a public land-grant research university in Irvine, California. One of the ten campuses of the University of California system, UCI offers 87 undergraduate degrees and 129 graduate and professional degrees, and roughly 30,000 undergraduates and 6,000 graduate students are enrolled at UCI as of Fall 2019. The university is classified among " R1: Doctoral Universities – Very high research activity", and had $436.6 million in research and development expenditures in 2018. UCI became a member of the Association of American Universities in 1996. The university was rated as one of the "Public Ivies” in 1985 and 2001 surveys comparing publicly funded universities the authors claimed provide an education comparable to the Ivy League. The university also administers the UC Irvine Medical Center, a large teaching hospital in Orange, and its affiliated health sciences system; the University of California, Irvine, Arboretum; and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brian Charlesworth
Brian Charlesworth (born 29 April 1945) is a British evolutionary biologist at the University of Edinburgh, and editor of ''Biology Letters''. Since 1997, he has been Royal Society Research Professor at the Institute of Evolutionary Biology (IEB) in Edinburgh. He has been married since 1967 to the British evolutionary biologist Deborah Charlesworth. Education Charlesworth gained a Bachelor of Arts degree in Natural Sciences (Cambridge), Natural Sciences from Queens' College, Cambridge, followed by a PhD in genetics in 1969 for research into genetic variation in Genetic viability, viability in the fruit fly ''Drosophila melanogaster''. Career Following his PhD, Charlesworth did postdoctoral research at the University of Chicago, University of Liverpool 1971–1974 and the University of Sussex under John Maynard Smith 1974–82. He returned to Chicago, to be professor of ecology and evolution from 1985 to 1997 after which he moved to Edinburgh. Research Charlesworth has worked ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Evolution Of Ageing
Enquiry into the evolution of ageing, or aging, aims to explain why a detrimental process such as ageing would evolve, and why there is so much variability in the lifespans of organisms. The classical theories of evolution (mutation accumulation, antagonistic pleiotropy, and disposable soma) suggest that environmental factors, such as predation, accidents, disease, starvation, ensure that most organisms living in natural settings will not live until old age, and so there will be very little pressure to conserve genetic changes that increase longevity. Natural selection will instead strongly favor genes which ensure early maturation and rapid reproduction, and the selection for genetic traits which promote molecular and cellular self-maintenance will decline with age for most organisms. Theories and hypotheses The beginning August Weismann was responsible for interpreting and formalizing the mechanisms of Darwinian evolution in a modern theoretical framework. In 1889, he theor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Experimental Evolution
Experimental evolution is the use of laboratory experiments or controlled field manipulations to explore evolutionary dynamics. Evolution may be observed in the laboratory as individuals/populations adapt to new environmental conditions by natural selection. There are two different ways in which adaptation can arise in experimental evolution. One is via an individual organism gaining a novel beneficial mutation. The other is from allele frequency change in standing genetic variation already present in a population of organisms. Other evolutionary forces outside of mutation and natural selection can also play a role or be incorporated into experimental evolution studies, such as genetic drift and gene flow. The organism used is decided by the experimenter, based on the hypothesis to be tested. Many generations are required for adaptive mutation to occur, and experimental evolution via mutation is carried out in viruses or unicellular organisms with rapid generation times, such ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antagonistic Pleiotropy
The antagonistic pleiotropy hypothesis was first proposed by George C. Williams in 1957 as an evolutionary explanation for senescence. Pleiotropy is the phenomenon where one gene controls for more than one phenotypic trait in an organism. Antagonistic pleiotropy is when one gene controls for more than one trait, where at least one of these traits is beneficial to the organism's fitness early on in life and at least one is detrimental to the organism's fitness later on due to a decline in the force of natural selection. The theme of G.C. William's idea about antagonistic pleiotropy was that if a gene caused both increased reproduction in early life and aging in later life, then senescence would be adaptive in evolution. For example, one study suggests that since follicular depletion in human females causes both more regular cycles in early life and loss of fertility later in life through menopause, it can be selected for by having its early benefits outweigh its late costs.Wood, J ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
George C
George may refer to: People * George (given name) * George (surname) * George (singer), American-Canadian singer George Nozuka, known by the mononym George * George Washington, First President of the United States * George W. Bush, 43rd President of the United States * George H. W. Bush, 41st President of the United States * George V, King of Great Britain, Ireland, the British Dominions and Emperor of India from 1910-1936 * George VI, King of Great Britain, Ireland, the British Dominions and Emperor of India from 1936-1952 * Prince George of Wales * George Papagheorghe also known as Jorge / GEØRGE * George, stage name of Giorgio Moroder * George Harrison, an English musician and singer-songwriter Places South Africa * George, Western Cape ** George Airport United States * George, Iowa * George, Missouri * George, Washington * George County, Mississippi * George Air Force Base, a former U.S. Air Force base located in California Characters * George (Peppa Pig), a 2-year-old pig ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drosophila Melanogaster
''Drosophila melanogaster'' is a species of fly (the taxonomic order Diptera) in the family Drosophilidae. The species is often referred to as the fruit fly or lesser fruit fly, or less commonly the "vinegar fly" or "pomace fly". Starting with Charles W. Woodworth's 1901 proposal of the use of this species as a model organism, ''D. melanogaster'' continues to be widely used for biological research in genetics, physiology, microbial pathogenesis, and life history evolution. As of 2017, five Nobel Prizes have been awarded to drosophilists for their work using the insect. ''D. melanogaster'' is typically used in research owing to its rapid life cycle, relatively simple genetics with only four pairs of chromosomes, and large number of offspring per generation. It was originally an African species, with all non-African lineages having a common origin. Its geographic range includes all continents, including islands. ''D. melanogaster'' is a common pest in homes, restaurants, and othe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Death By Design/The Life And Times Of Life And Times
''Death by Design'' is a 1995 science documentary directed by Peter Friedman and Jean-François Brunet of the Ecole Normale Supérieure in Paris which focuses on cell biology, with an emphasis on programmed cell death and why our lives depend on it. Cast Featured are prominent biologists such as Nobel prize laureate Rita Levi-Montalcini (along with her artist twin sister Paola Levi-Montalcini), Martin Raff, Polly Matzinger, Pierre Goldstein, and Nobel laureate Robert Horvitz. Notable elements The documentary is notable for its combination of a whimsical use of metaphors with scientific rigor, and incorporates animation, micro-cinematography, and scenes from old Hollywood films and stock footage, including Busby Berkeley-choreographed dance routines. The opening scene features the trailer from the 1950s science fiction film ''It Came From Outer Space ''It Came from Outer Space'' is a 1953 American science fiction horror film, the first in the 3D process from Universal-Int ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Natural Selection
Natural selection is the differential survival and reproduction of individuals due to differences in phenotype. It is a key mechanism of evolution, the change in the heritable traits characteristic of a population over generations. Charles Darwin popularised the term "natural selection", contrasting it with selective breeding, artificial selection, which in his view is intentional, whereas natural selection is not. Genetic diversity, Variation exists within all populations of organisms. This occurs partly because random mutations arise in the genome of an individual organism, and their offspring can inherit such mutations. Throughout the lives of the individuals, their genomes interact with their environments to cause variations in traits. The environment of a genome includes the molecular biology in the Cell (biology), cell, other cells, other individuals, populations, species, as well as the abiotic environment. Because individuals with certain variants of the trait tend ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drosophila
''Drosophila'' () is a genus of flies, belonging to the family Drosophilidae, whose members are often called "small fruit flies" or (less frequently) pomace flies, vinegar flies, or wine flies, a reference to the characteristic of many species to linger around overripe or rotting fruit. They should not be confused with the Tephritidae, a related family, which are also called fruit flies (sometimes referred to as "true fruit flies"); tephritids feed primarily on unripe or ripe fruit, with many species being regarded as destructive agricultural pests, especially the Mediterranean fruit fly. One species of ''Drosophila'' in particular, ''D. melanogaster'', has been heavily used in research in genetics and is a common model organism in developmental biology. The terms "fruit fly" and "''Drosophila''" are often used synonymously with ''D. melanogaster'' in modern biological literature. The entire genus, however, contains more than 1,500 species and is very diverse in appearance, be ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Theodore Garland, Jr
Theodore may refer to: Places * Theodore, Alabama, United States * Theodore, Australian Capital Territory * Theodore, Queensland, a town in the Shire of Banana, Australia * Theodore, Saskatchewan, Canada * Theodore Reservoir, a lake in Saskatchewan People * Theodore (given name), includes the etymology of the given name and a list of people * Theodore (surname), a list of people Fictional characters * Theodore "T-Bag" Bagwell, on the television series ''Prison Break'' * Theodore Huxtable, on the television series ''The Cosby Show'' Other uses * Theodore (horse), a British Thoroughbred racehorse * Theodore Racing, a Formula One racing team See also * Principality of Theodoro, a principality in the south-west Crimea from the 13th to 15th centuries * Thoros (other), Armenian for Theodore * James Bass Mullinger James Bass Mullinger (1834 or 1843 – 22 November 1917), sometimes known by his pen name Theodorus, was a British author, historian, lecturer and scholar. A l ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
