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Michael Creeth
James Michael Creeth (3 October 1924 – 15 January 2010) was an English biochemist whose experiments on DNA viscosity confirming the existence of hydrogen bonds between the purine and pyrimidine bases of DNA were crucial to Watson and Crick's discovery of the double helix structure of DNA. Early life Creeth was educated at Northampton Town and County Grammar School, and went on to read Chemistry at University College Nottingham, first as a war-time undergraduate (1942–44) and then as a postgraduate PhD student (1944-7) under the supervision of D. O. Jordan and John Masson Gulland. Creeth and the decoding of DNA The research conducted by Creeth for his PhD and more especially an associated paper in 1947 was one key element amongst others which paved the way to the decoding of the complexities of DNA in 1953. Put simply, Creeth and his Nottingham colleagues conducted chemical experiments which demonstrated the hydrogen pair bonding in the molecule. In his PhD thesi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Northampton
Northampton () is a market town and civil parish in the East Midlands of England, on the River Nene, north-west of London and south-east of Birmingham. The county town of Northamptonshire, Northampton is one of the largest towns in England; it had a population of 212,100 in its previous local authority in the United Kingdom Census 2011, 2011 census (225,100 as of 2018 estimates). In its urban area, which includes Boughton, Northamptonshire, Boughton and Moulton, Northamptonshire, Moulton, it had a population of 215,963 as of 2011. Archaeological evidence of settlement in the area dates to the Bronze Age Britain, Bronze Age, Roman conquest of Britain, Romans and Anglo-Saxons, Anglo-Saxons. In the Middle Ages, the town rose to national significance with the establishment of Northampton Castle, an occasional royal residence which regularly hosted the Parliament of England. Medieval Northampton had many churches, monasteries and the University of Northampton (thirteenth century), ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Base Pair
A base pair (bp) is a fundamental unit of double-stranded nucleic acids consisting of two nucleobases bound to each other by hydrogen bonds. They form the building blocks of the DNA double helix and contribute to the folded structure of both DNA and RNA. Dictated by specific hydrogen bonding patterns, "Watson–Crick" (or "Watson–Crick–Franklin") base pairs (guanine–cytosine and adenine–thymine) allow the DNA helix to maintain a regular helical structure that is subtly dependent on its nucleotide sequence. The Complementarity (molecular biology), complementary nature of this based-paired structure provides a redundant copy of the genetic information encoded within each strand of DNA. The regular structure and data redundancy provided by the DNA double helix make DNA well suited to the storage of genetic information, while base-pairing between DNA and incoming nucleotides provides the mechanism through which DNA polymerase replicates DNA and RNA polymerase transcribes DNA in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mucus
Mucus ( ) is a slippery aqueous secretion produced by, and covering, mucous membranes. It is typically produced from cells found in mucous glands, although it may also originate from mixed glands, which contain both serous and mucous cells. It is a viscous colloid containing inorganic salts, antimicrobial enzymes (such as lysozymes), immunoglobulins (especially IgA), and glycoproteins such as lactoferrin and mucins, which are produced by goblet cells in the mucous membranes and submucosal glands. Mucus serves to protect epithelial cells in the linings of the respiratory, digestive, and urogenital systems, and structures in the visual and auditory systems from pathogenic fungi, bacteria and viruses. Most of the mucus in the body is produced in the gastrointestinal tract. Amphibians, fish, snails, slugs, and some other invertebrates also produce external mucus from their epidermis as protection against pathogens, and to help in movement and is also produced in fish to line the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Analytical Ultracentrifuge
An ultracentrifuge is a centrifuge optimized for spinning a rotor at very high speeds, capable of generating acceleration as high as (approx. ). There are two kinds of ultracentrifuges, the preparative and the analytical ultracentrifuge. Both classes of instruments find important uses in molecular biology, biochemistry, and polymer science.Susan R. Mikkelsen & Eduardo Cortón. Bioanalytical Chemistry, Ch. 13. Centrifugation Methods. John Wiley & Sons, Mar 4, 2004, pp. 247-267. History In 1924 Theodor Svedberg built a centrifuge capable of generating 7,000 g (at 12,000 rpm), and called it the ultracentrifuge, to juxtapose it with the Ultramicroscope that had been developed previously. In 1925-1926 Svedberg constructed a new ultracentrifuge that permitted fields up to 100,000 g (42,000 rpm). Modern ultracentrifuges are typically classified as allowing greater than 100,000 g. Svedberg won the Nobel Prize in Chemistry in 1926 for his research on colloids and proteins using the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rockefeller Foundation
The Rockefeller Foundation is an American private foundation and philanthropic medical research and arts funding organization based at 420 Fifth Avenue, New York City. The second-oldest major philanthropic institution in America, after the Carnegie Corporation, the foundation was ranked as the 39th largest U.S. foundation by total giving as of 2015. By the end of 2016, assets were tallied at $4.1 billion (unchanged from 2015), with annual grants of $173 million. According to the OECD, the foundation provided US$103.8 million for development in 2019. The foundation has given more than $14 billion in current dollars. The foundation was started by Standard Oil magnate John D. Rockefeller ("Senior") and son "Junior", and their primary business advisor, Frederick Taylor Gates, on May 14, 1913, when its charter was granted by New York. The foundation has had an international reach since the 1930s and major influence on global non-governmental organizations. The World Health Organiza ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Goswick Rail Crash
The Goswick rail crash occurred on 26 October 1947 near the village of Goswick, Northumberland, England. The '' Flying Scotsman'' express from Edinburgh Waverley to London King's Cross failed to slow down for a diversion and derailed. Twenty-eight people were killed, including the talented Scottish biochemist, John Masson Gulland. It was the last major accident to occur on British railways before their nationalisation on 1 January 1948. Overview The train was scheduled to divert from the fast line to a goods loop at Goswick, Northumberland, between Berwick-upon-Tweed and Morpeth, because of engineering work. This required a significant reduction in speed, but the driver failed to react to a cautionary signal approaching the diversion and the train entered a turnout at approximately . The engine, A3 Class No. 66 "Merry Hampton", and most of the train derailed and overturned. The driver, fireman and guard had all failed to read the notice of the diversion posted at Haymark ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Double Helix
''The Double Helix: A Personal Account of the Discovery of the Structure of DNA'' is an autobiographical account of the discovery of the double helix structure of DNA written by James D. Watson and published in 1968. It has earned both critical and public praise, along with continuing controversy about credit for the Nobel award and attitudes towards female scientists at the time of the discovery. Significance Watson is a U.S. molecular biologist, geneticist and zoologist, best known as one of the co-discoverers of the structure of DNA in 1953 with Francis Crick. In 1998, the Modern Library placed ''The Double Helix'' at number 7 on its list of the 100 best nonfiction books of the 20th century. In 2012, ''The Double Helix'' was named as one of the 88 "Books That Shaped America" by the Library of Congress. Though an important book about an immensely important subject, it was and remains a controversial account. Though it was originally slated to be ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Biochemical Society
The Biochemical Society is a learned society in the United Kingdom in the field of biochemistry, including all the cellular and molecular biosciences. Structure It currently has around 7000 members, two-thirds in the UK. It is affiliated with the European body, Federation of European Biochemical Societies (FEBS). The Society's current President (2016) is Sir David Baulcombe. The Society's headquarters are in London. History The society was founded in 1911 by Benjamin Moore, W.D. Halliburton and others, under the name of the Biochemical Club. It acquired the existing ''Biochemical Journal'' in 1912. The society name changed to the Biochemical Society in 1913. In 2005, the headquarters of the society moved from Portland Place to purpose-built offices in Holborn. In 2009, the headquarters moved again to Charles Darwin House, near Gray's Inn Road. Past presidents include Professor Ron Laskey, Sir Philip Cohen, and Sir Tom Blundell. Awards The society makes a number of merit a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Independent
''The Independent'' is a British online newspaper. It was established in 1986 as a national morning printed paper. Nicknamed the ''Indy'', it began as a broadsheet and changed to tabloid format in 2003. The last printed edition was published on Saturday 26 March 2016, leaving only the online edition. The newspaper was controlled by Tony O'Reilly's Irish Independent News & Media from 1997 until it was sold to the Russian oligarch and former KGB Officer Alexander Lebedev in 2010. In 2017, Sultan Muhammad Abuljadayel bought a 30% stake in it. The daily edition was named National Newspaper of the Year at the 2004 British Press Awards. The website and mobile app had a combined monthly reach of 19,826,000 in 2021. History 1986 to 1990 Launched in 1986, the first issue of ''The Independent'' was published on 7 October in broadsheet format.Dennis Griffiths (ed.) ''The Encyclopedia of the British Press, 1422–1992'', London & Basingstoke: Macmillan, 1992, p. 330 It was produc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University College Nottingham
, mottoeng = A city is built on wisdom , established = 1798 – teacher training college1881 – University College Nottingham1948 – university status , type = Public , chancellor = Lola Young, Baroness Young of Hornsey , vice_chancellor = Shearer West , head_label = Visitor , head = Penny Mordaunt(as Lord President of the Council ''ex officio'') , students = domestic () 43,893 worldwide , undergrad = domestic () , postgrad = domestic () , city = Nottingham , country = England , coor = , colours = University: blue and white Sports: green and gold , endowment = £72.3 million (2021) , budget = £694.0 million (2020–21) , affiliations = ACUAssociation of MBAsEQUIS EUARussell Group Sutton 30Universita ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemistry
Chemistry is the science, scientific study of the properties and behavior of matter. It is a natural science that covers the Chemical element, elements that make up matter to the chemical compound, compounds made of atoms, molecules and ions: their composition, structure, properties, behavior and the changes they undergo during a Chemical reaction, reaction with other Chemical substance, substances. Chemistry also addresses the nature of chemical bonds in chemical compounds. In the scope of its subject, chemistry occupies an intermediate position between physics and biology. It is sometimes called the central science because it provides a foundation for understanding both Basic research, basic and Applied science, applied scientific disciplines at a fundamental level. For example, chemistry explains aspects of plant growth (botany), the formation of igneous rocks (geology), how atmospheric ozone is formed and how environmental pollutants are degraded (ecology), the properties ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Northampton Town And County Grammar School
Northampton School for Boys (NSB) is a secondary school in Northampton, England. It was founded as Northampton Town and County Grammar School in 1541 by Thomas Chipsey, Mayor of Northampton. Years 7 to 11 are boys-only, while Sixth Form classes are mixed. The school generally ranks among the best-performing in the county. Foundation and history The school was founded in 1541 by mayor Thomas Chipsey, as the town's free boys grammar school. In 1557, the school moved to St. Gregory's church, which was adapted for its use. The School remained on this site until 1864, when it moved to the Corn Exchange in the Market Square. In 1870, additional premises were opened in Abington Square to educate a further 200 pupils. Due to its popularity, the school moved again in 1911, to new buildings constructed on the present site at Billing Road. During this period the school was known as the Northampton Town and County Grammar School. In 1992, the school became Grant Maintained, later becoming ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
