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Mexican Yam
''Dioscorea mexicana'', Mexican yam or ''cabeza de negro'' is a species of yam in the genus '' Dioscorea''. ''Dioscorea mexicana'' is a caudiciform dioscorea having either a partly to completely above-ground dome-shaped caudex with a thick, woody outer layer up to 3 feet (90 cm) in diameter and 8–10 inches (20 to 25 cm) in height. The caudex of ''D. mexicana'' is divided into regular polygonal plates that become protuberant with age, and separated by deep fissures. The vigorous annual vines which may reach 30 feet (9 m) long before dying back in winter, that grow up from the caudex, bear heart-shaped leaves. ''Dioscorea mexicana'' ranges from the state of San Luis Potosí in northeastern Mexico south to Panama. It is notable for its production of diosgenin, which is a precursor for the synthesis of hormones such as progesterone. Russell Marker developed the extraction and manufacture of hormones from ''D. mexicana'' at Syntex. Later the Mexican barbasco ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Yam (vegetable)
Yam is the common name for some plant species in the genus '' Dioscorea'' (family Dioscoreaceae) that form edible tubers. Yams are perennial herbaceous vines cultivated for the consumption of their starchy tubers in many temperate and tropical regions, especially in West Africa, South America and the Caribbean, Asia, and Oceania. The tubers themselves, also called "yams", come in a variety of forms owing to numerous cultivars and related species. Yams were independently domesticated on three different continents: Africa (''Dioscorea rotundata''), Asia (''Dioscorea alata''), and the Americas (''Dioscorea trifida''). Etymology The name "yam" appears to derive from Portuguese ''inhame'' or Canarian (Spain) ''ñame'', which derived from West African languages during trade. However in both languages, this name commonly refers to the taro plant (''Colocasia esculenta'') from the genus ''Colocasia'', as opposed to '' Dioscorea''. The main derivations borrow from verbs me ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hormone
A hormone (from the Greek participle , "setting in motion") is a class of signaling molecules in multicellular organisms that are sent to distant organs by complex biological processes to regulate physiology and behavior. Hormones are required for the correct development of animals, plants and fungi. Due to the broad definition of a hormone (as a signaling molecule that exerts its effects far from its site of production), numerous kinds of molecules can be classified as hormones. Among the substances that can be considered hormones, are eicosanoids (e.g. prostaglandins and thromboxanes), steroids (e.g. oestrogen and brassinosteroid), amino acid derivatives (e.g. epinephrine and auxin), protein or peptides (e.g. insulin and CLE peptides), and gases (e.g. ethylene and nitric oxide). Hormones are used to communicate between organs and tissues. In vertebrates, hormones are responsible for regulating a variety of physiological processes and behavioral activities such as diges ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Flora Of Mexico
Mexico (Spanish: México), officially the United Mexican States, is a country in the southern portion of North America. It is bordered to the north by the United States; to the south and west by the Pacific Ocean; to the southeast by Guatemala, Belize, and the Caribbean Sea; and to the east by the Gulf of Mexico. Mexico covers ,Mexico ''''. . making it the world's 13th-largest country by are ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Flora Of Central America
Flora is all the plant life present in a particular region or time, generally the naturally occurring (indigenous) native plants. Sometimes bacteria and fungi are also referred to as flora, as in the terms '' gut flora'' or '' skin flora''. Etymology The word "flora" comes from the Latin name of Flora, the goddess of plants, flowers, and fertility in Roman mythology. The technical term "flora" is then derived from a metonymy of this goddess at the end of the sixteenth century. It was first used in poetry to denote the natural vegetation of an area, but soon also assumed the meaning of a work cataloguing such vegetation. Moreover, "Flora" was used to refer to the flowers of an artificial garden in the seventeenth century. The distinction between vegetation (the general appearance of a community) and flora (the taxonomic composition of a community) was first made by Jules Thurmann (1849). Prior to this, the two terms were used indiscriminately.Thurmann, J. (1849). ''Essai de ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dioscorea Composita
''Dioscorea composita'', or barbasco, is a species of yam in the genus '' Dioscorea'', native to Mexico. It is notable for its role in the production of diosgenin, which is a precursor for the synthesis of hormones such as progesterone. Russell Marker developed the extraction and manufacture of hormones from ''D. mexicana'' at Syntex, starting the trade of ''D. composita'' in Mexico. Marker also discovered that the ''composita'' variety had a much higher content of diosgenin than the ''mexicana'' variety, and therefore it came to replace the latter in the production of synthetic hormones. Chemical constituents Steroidal sapogenin, diosgenin. Medicinal use It is a source of diosgenin, which is used to prepare synthetic hormones such as progesterone and cortisone. Diosgenin extracted from ''Dioscorea composita'' was instrumental in the development of the combined oral contraceptive pill in the 1960s – and also for the development of cortisone treatments of arthritis. St ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mexican Barbasco Trade
The Mexican barbasco trade was the trade of the diosgenin-rich yam species ''Dioscorea mexicana'', '' Dioscorea floribunda'' and ''Dioscorea composita'' which emerged in Mexico in the 1950s as part of the Mexican steroid industry. The trade consisted in Mexican campesinos harvesting the root in the jungle, selling it to middlemen who brought it to processing plants where the root was fermented and the diosgenin extracted and sold to pharmaceutical companies such as Syntex who used it to produce synthetic hormones. History Scientific discovery of medicinal properties The trade started when Russell Marker, a chemist looking for a plant source from which to extract diosgenin and saponin, traveled to Veracruz looking for the yam ''Dioscorea mexicana'' which he suspected might be suitable. He hired two Mexican campesinos to bring him exemplars of the tuber. When he discovered that the root was indeed a significant source of diosgenin he established Syntex, the first Mexican fine che ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Syntex
Laboratorios Syntex SA (later Syntex Laboratories, Inc.) was a pharmaceutical company formed in Mexico City in January 1944 by Russell Marker, Emeric Somlo, and Federico Lehmann to manufacture therapeutic steroids from the Mexican yams called ''cabeza de negro'' (''Dioscorea mexicana'') and ''Barbasco'' (''Dioscorea composita''). The demand for barbasco by Syntex initiated the Mexican barbasco trade. As the American Chemistry Society later explained: “In early 1944, the new Mexican company was chartered and named Syntex, S.A. (‘Synthesis and Mexico’). Russell Marker, shortly thereafter, left Syntex on account of his ruthless cofounder. Luis E. Miramontes, George Rosenkranz and Carl Djerassi's successful synthesis of norethindrone (also known as norethindrone) — which was later proven to be an effective pregnancy inhibitor — led to an infusion of capital into Syntex and the Mexican steroid pharmaceutical industry. George Rosenkranz and Carl Djerassi went on to synthesize ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hormones
A hormone (from the Ancient Greek, Greek participle , "setting in motion") is a class of cell signaling, signaling molecules in multicellular organisms that are sent to distant organs by complex biological processes to regulate physiology and behavior. Hormones are required for the correct development of animals, plants and fungi. Due to the broad definition of a hormone (as a signaling molecule that exerts its effects far from its site of production), numerous kinds of molecules can be classified as hormones. Among the substances that can be considered hormones, are eicosanoids (e.g. prostaglandins and thromboxanes), steroids (e.g. Estrogen, oestrogen and brassinosteroid), amino acid derivatives (e.g. epinephrine and auxin), protein or peptides (e.g. insulin and CLE peptides), and gases (e.g. ethylene and nitric oxide). Hormones are used to communicate between organ (anatomy), organs and Tissue (biology), tissues. In vertebrates, hormones are responsible for regulating a variety ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Russell Marker
Russell Earl Marker (March 12, 1902 – March 3, 1995) was an American chemist who invented the octane rating system when he was working at the Ethyl Corporation. Later in his career, he went on to found a steroid industry in Mexico when he successfully made semisynthetic progesterone from chemical constituents found in Mexican yams in a process known as Marker degradation. This eventually led to the development at Syntex of the combined oral contraceptive pill and synthetic cortisone – and to the development of the Mexican barbasco trade. Biography He was born on March 12, 1902, in Hagerstown, Maryland. He received his B.S. in 1923 from the University of Maryland and an M.S. in physical chemistry in 1924 from the same institution. In 1926, he married Mildred Collins (1899–1985) and worked as an analytical chemist at the Naval Powder Factory in Indian Head, Maryland. He then began work at the Ethyl Corporation where he came up with the concept of the octane rating. In ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Progesterone
Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. It belongs to a group of steroid hormones called the progestogens and is the major progestogen in the body. Progesterone has a variety of important functions in the body. It is also a crucial metabolic intermediate in the production of other endogenous steroids, including the sex hormones and the corticosteroids, and plays an important role in brain function as a neurosteroid. In addition to its role as a natural hormone, progesterone is also used as a medication, such as in combination with estrogen for contraception, to reduce the risk of uterine or cervical cancer, in hormone replacement therapy, and in feminizing hormone therapy. It was first prescribed in 1934. Biological activity Progesterone is the most important progestogen in the body. As a potent agonist of the nuclear progesterone receptor (nPR) ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Precursor (chemistry)
In chemistry, a precursor is a compound that participates in a chemical reaction that produces another compound. In biochemistry, the term "precursor" often refers more specifically to a chemical compound preceding another in a metabolic pathway, such as a protein precursor. Illicit drug precursors In 1988, the United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances introduced detailed provisions and requirements relating the control of precursors used to produce drugs of abuse. In Europe the Regulation (EC) No. 273/2004 of the European Parliament and of the Council on drug precursors was adopted on 11 February 2004. ( European law on drug precursors) Illicit explosives precursors On January 15, 2013, the Regulation (EU) No. 98/2013 of the European Parliament and of the Council on the marketing and use of explosives precursors was adopted. The Regulation harmonises rules across Europe on the making available, introduction, possession and u ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dioscorea
''Dioscorea'' is a genus of over 600 species of flowering plants in the family Dioscoreaceae, native throughout the tropical and warm temperate regions of the world. The vast majority of the species are tropical, with only a few species extending into temperate climates. It was named by the monk Charles Plumier after the ancient Greek physician and botanist Dioscorides. Description Wild Yam (''Dioscorea'') is a vine that is invasive, deciduous, and herbaceous. This species is native to Asia, though, in the U.S., it is commonly found in Florida. They can grow over in length. Wild yams are an important crop, as they have been used to prevent menstrual cramps, stomach cramps, and general pain for centuries. During the 1950s scientists found that the roots of wild yams contained diosgenin which is a plant-based estrogen; diosgenin is hypothesized to aid in chemical defense against herbivores. This was used to create the first birth control pills during the 60s. In addition, some '' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
