Metacresol Purple
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Metacresol Purple
Metacresol purple or ''m''-cresol purple, also called ''m''-cresolsulfonphthalein, is a triarylmethane dye and a pH indicator. It is used as a capnographic indicator for detecting detect end-tidal carbon dioxide to ensure successful tracheal intubation in an emergency. It can be used to measure the pH in subzero temperatures of saline or hypersaline media. In colorimetric capnography, the indicator is incorporated in an aqueous matrix that provides a pH just above the indicator's colour change. When exposed to carbon dioxide (CO2), it undergoes a colour change from purple to yellow, because when CO2 dissolves in the matrix, it forms carbonic acid. In chemistry, it has two useful indicator ranges: * pH 1.2–2.8: red to yellow * pH 7.4–9.0: yellow to purple See also * Bromocresol purple Bromocresol purple (BCP) or 5′,5″-dibromo-''o''-cresolsulfophthalein, is a dye of the triphenylmethane family ( triarylmethane dyes) and a pH indicator. It is colored yellow below pH 5.2 ...
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Triarylmethane Dye
Triarylmethane dyes are synthetic organic compounds containing triphenylmethane backbones. As dyes, these compounds are intensely colored. They are produced industrially as dyes. Families Triarylmethane dyes can be grouped into families according to the nature of the substituents on the aryl groups. In some cases, the anions associated with the cationic dyes (say crystal violet) vary even though the name of the dye does not. Often it is shown as chloride. Methyl violet dyes Methyl violet dyes have dimethylamino groups at the ''p''-positions of two aryl groups. Image:Methyl Violet 2B.png, Methyl violet 2B Image:Methyl Violet 6B.png, Methyl violet 6B Image:Methyl Violet 10B.png, Methyl violet 10B Fuchsine dyes Fuchsine dyes have primary or secondary amines (NH2 or NHMe) functional groups at the ''p''-positions of each aryl group. File:Pararosaniline.png, Pararosaniline File:Rosaniline hydrochloride.svg, Fuchsine (hydrochloride salt) Neofuchsin.svg, New fuchsine (As chlorid ...
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PH Indicator
A pH indicator is a halochromic chemical compound added in small amounts to a solution so the pH (acidity or basicity) of the solution can be determined visually or spectroscopically by changes in absorption and/or emission properties. Hence, a pH indicator is a chemical detector for hydronium ions (H3O+) or hydrogen ions (H+) in the Arrhenius model. Normally, the indicator causes the color of the solution to change depending on the pH. Indicators can also show change in other physical properties; for example, olfactory indicators show change in their odor. The pH value of a neutral solution is 7.0 at 25°C ( standard laboratory conditions). Solutions with a pH value below 7.0 are considered acidic and solutions with pH value above 7.0 are basic. Since most naturally occurring organic compounds are weak electrolytes, such as carboxylic acids and amines, pH indicators find many applications in biology and analytical chemistry. Moreover, pH indicators form one of the three main ...
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Capnography
Capnography is the monitoring of the concentration or partial pressure of carbon dioxide () in the respiratory gases. Its main development has been as a monitoring tool for use during anesthesia and intensive care. It is usually presented as a graph of (measured in kilopascals, "kPa" or millimeters of mercury, "mmHg") plotted against time, or, less commonly, but more usefully, expired volume (known as volumetric capnography). The plot may also show the inspired , which is of interest when rebreathing systems are being used. When the measurement is taken at the end of a breath (exhaling), it is called "end tidal" (PETCO2). The capnogram is a direct monitor of the inhaled and exhaled concentration or partial pressure of , and an indirect monitor of the partial pressure in the arterial blood. In healthy individuals, the difference between arterial blood and expired gas partial pressures is very small (normal difference 4-5 mmHg). In the presence of most forms of lung disease, an ...
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Carbon Dioxide
Carbon dioxide (chemical formula ) is a chemical compound made up of molecules that each have one carbon atom covalently double bonded to two oxygen atoms. It is found in the gas state at room temperature. In the air, carbon dioxide is transparent to visible light but absorbs infrared radiation, acting as a greenhouse gas. It is a trace gas in Earth's atmosphere at 421 parts per million (ppm), or about 0.04% by volume (as of May 2022), having risen from pre-industrial levels of 280 ppm. Burning fossil fuels is the primary cause of these increased CO2 concentrations and also the primary cause of climate change.IPCC (2022Summary for policy makersiClimate Change 2022: Mitigation of Climate Change. Contribution of Working Group III to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change Cambridge University Press, Cambridge, United Kingdom and New York, NY, USA Carbon dioxide is soluble in water and is found in groundwater, lakes, ice caps, ...
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Tracheal Intubation
Tracheal intubation, usually simply referred to as intubation, is the placement of a flexible plastic catheter, tube into the vertebrate trachea, trachea (windpipe) to maintain an open airway or to serve as a conduit through which to administer certain drugs. It is frequently performed in critically injured, ill, or anesthetized patients to facilitate Ventilation (physiology), ventilation of the lungs, including mechanical ventilation, and to prevent the possibility of asphyxiation or airway obstruction. The most widely used route is orotracheal, in which an tracheal tube, endotracheal tube is passed through the mouth and larynx, vocal apparatus into the trachea. In a nasotracheal procedure, an endotracheal tube is passed through the nose and vocal apparatus into the trachea. Other methods of intubation involve surgery and include the cricothyrotomy (used almost exclusively in emergency circumstances) and the tracheotomy, used primarily in situations where a prolonged need for airw ...
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Colorimetric Capnography
Colorimetric capnography is a qualitative measurement method that detects the presence of carbon dioxide (CO2, a relatively acidic gas) in a given gaseous environment. From a medical perspective, the method is usually applied by exposing litmus paper/film to an environment containing a patient's airway gases (i.e. placing it into their breathing circuit/airway circuit), where it will then change color depending on the amount of exhaled CO2 within the circuit. Although there are multiple uses, the colorimetric capnography method is most frequently used to quickly confirm that an advanced airway device such as an endotracheal tube (ETT) or nasotracheal tube (NTT) has been placed in the desired location. Correct placement is evidenced by sufficient color change of the litmus paper while exposed to the airway gases which, if the device is properly placed, will contain relatively high amounts of exhaled CO2. Conversely, lack of detection of CO2 suggests many possible issues, includi ...
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Aqueous
An aqueous solution is a solution in which the solvent is water. It is mostly shown in chemical equations by appending (aq) to the relevant chemical formula. For example, a solution of table salt, or sodium chloride (NaCl), in water would be represented as . The word ''aqueous'' (which comes from ''aqua'') means pertaining to, related to, similar to, or dissolved in, water. As water is an excellent solvent and is also naturally abundant, it is a ubiquitous solvent in chemistry. Since water is frequently used as the solvent in experiments, the word solution refers to an aqueous solution, unless the solvent is specified. A ''non-aqueous solution'' is a solution in which the solvent is a liquid, but is not water. (See also Solvent and Inorganic nonaqueous solvent.) Characteristics Substances that are ''hydrophobic'' ('water-fearing') do not dissolve well in water, whereas those that are ''hydrophilic'' ('water-friendly') do. An example of a hydrophilic substance is sodium chlori ...
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Elsevier Health Sciences
Elsevier () is a Dutch academic publishing company specializing in scientific, technical, and medical content. Its products include journals such as ''The Lancet'', ''Cell'', the ScienceDirect collection of electronic journals, '' Trends'', the '' Current Opinion'' series, the online citation database Scopus, the SciVal tool for measuring research performance, the ClinicalKey search engine for clinicians, and the ClinicalPath evidence-based cancer care service. Elsevier's products and services also include digital tools for data management, instruction, research analytics and assessment. Elsevier is part of the RELX Group (known until 2015 as Reed Elsevier), a publicly traded company. According to RELX reports, in 2021 Elsevier published more than 600,000 articles annually in over 2,700 journals; as of 2018 its archives contained over 17 million documents and 40,000 e-books, with over one billion annual downloads. Researchers have criticized Elsevier for its high profit marg ...
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Bromocresol Purple
Bromocresol purple (BCP) or 5′,5″-dibromo-''o''-cresolsulfophthalein, is a dye of the triphenylmethane family (triarylmethane dyes) and a pH indicator. It is colored yellow below pH 5.2, and violet above pH 6.8. In its cyclic sulfonate ester form, it has a p''K''a value of 6.3, and is usually prepared as a 0.04% aqueous solution. Uses Bromocresol purple is used in medical laboratories to measure albumin. Use of BCP in this application may provide some advantage over older methods using bromocresol green. In microbiology, it is used for staining dead cells based on their acidity, and for the isolation and assaying of lactic acid bacteria. In photographic processing, it can be used as an additive to acid stop baths to indicate that the bath has reached neutral pH and needs to be replaced. Bromocresol purple milk solids glucose agar is used as a medium used to distinguish dermatophytes from bacteria and other organisms in cases of ringworm fungus ('' T. verrucosum'') infest ...
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PH Indicators
A pH indicator is a halochromism, halochromic chemical compound added in small amounts to a Solution (chemistry), solution so the pH (acidity or Base (chemistry), basicity) of the solution can be determined visually or spectroscopically by changes in absorption and/or emission properties. Hence, a pH indicator is a Chemical substance, chemical detector for hydronium ions (H3O+) or hydrogen ions (H+) in the Acid-base reaction theories, Arrhenius model. Normally, the indicator causes the color of the solution to change depending on the pH. Indicators can also show change in other physical properties; for example, olfactory indicators show change in their odor. The pH value of a neutral solution is 7.0 at 25°C (Standard_conditions_for_temperature_and_pressure#Standard_laboratory_conditions, standard laboratory conditions). Solutions with a pH value below 7.0 are considered acidic and solutions with pH value above 7.0 are basic. Since most naturally occurring Organic compound, organ ...
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Chemicals In Medicine
A chemical substance is a form of matter having constant chemical composition and characteristic properties. Some references add that chemical substance cannot be separated into its constituent elements by physical separation methods, i.e., without breaking chemical bonds. Chemical substances can be simple substances (substances consisting of a single chemical element), chemical compounds, or alloys. Chemical substances are often called 'pure' to set them apart from mixtures. A common example of a chemical substance is pure water; it has the same properties and the same ratio of hydrogen to oxygen whether it is isolated from a river or made in a laboratory. Other chemical substances commonly encountered in pure form are diamond (carbon), gold, table salt ( sodium chloride) and refined sugar ( sucrose). However, in practice, no substance is entirely pure, and chemical purity is specified according to the intended use of the chemical. Chemical substances exist as solids, liqu ...
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