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Mercurophylline
Mercurophylline is a mercurial diuretic Mercurial diuretics are a form of renal diuretic containing mercury. Although previously widely used, they have largely been superseded by safer diuretics such as thiazides, and are hardly used anymore. History and mechanism Inorganic mercury co ..., having the form of white or yellow odorless powder under room temperature. It was formerly used as medicine, administered through injection or tablets. Mercurophyllin is poisonous when administered subcutaneously, intraperitoneally and intravenously. When administered intravenously, it can cause cardiac arrhythmia. Prolonged oral administration can lead to gastrointestinal irritation and kidney damage. References {{organic-compound-stub Mercurial diuretics ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mercurial Diuretic
Mercurial diuretics are a form of renal diuretic containing mercury. Although previously widely used, they have largely been superseded by safer diuretics such as thiazides, and are hardly used anymore. History and mechanism Inorganic mercury compounds, such as mercury(I)chloride ( calomel), were found to have diuretic properties when they were used to treat syphilis. Proposed use of these compounds date back at least to the 16th century, shortly after the beginning of the syphilis epidemic in 1497 following Columbus' return to Europe. Mercurial diuretics cause diuresis by reducing the reabsorption sodium in the ascending loop of Henle, thus causing more water being delivered to the distal convoluted tubule. Unfortunately, earlier physicians misconstrued hallmark symptoms of mercury poisoning such as excessive salivation as signs of mercury's efficacy, including up until the early 1960s when the use of mercurial diuretics was halted in medicine. Side effects Due to the id ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |