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Mean Glandular Dose
Mean glandular dose (MGD) is a quantity used to describe the absorbed dose of radiation to the breast in mammography. It is based on a measurement of air kerma and conversion factors. MGD can be calculated from measurements made with PMMA blocks. It is often used to compare typical doses to patients between different centres or internationally, and is the preferred measure of the potential risk from mammography. Calculation MGD can be calculated from a measured incident air kerma at the top of the breast, K, as follows: D=Kgcs g converts from incident air kerma to MGD, with a glandularity of 50%, based on breast thickness and HVL. c corrects for glandularity other than 50%, depending on the breast thickness and HVL, with two versions for ages 50–64 and 40–49. s corrects for the x-ray spectra in use with a table of target/filter combinations. Applications MGD is typically used to define limits on mammography exposures by national and international organisations such as the ...
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Absorbed Dose
Absorbed dose is a dose quantity which is the measure of the energy deposited in matter by ionizing radiation per unit mass. Absorbed dose is used in the calculation of dose uptake in living tissue in both radiation protection (reduction of harmful effects), and radiology (potential beneficial effects for example in cancer treatment). It is also used to directly compare the effect of radiation on inanimate matter such as in radiation hardening. The SI unit of measure is the gray (Gy), which is defined as one Joule of energy absorbed per kilogram of matter. The older, non-SI CGS unit rad, is sometimes also used, predominantly in the USA. Deterministic effects Conventionally, in radiation protection, unmodified absorbed dose is only used for indicating the immediate health effects due to high levels of acute dose. These are tissue effects, such as in acute radiation syndrome, which are also known as deterministic effects. These are effects which are certain to happen in a short ...
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Breast
The breast is one of two prominences located on the upper ventral region of a primate's torso. Both females and males develop breasts from the same embryological tissues. In females, it serves as the mammary gland, which produces and secretes milk to feed infants. Subcutaneous fat covers and envelops a network of ducts that converge on the nipple, and these tissues give the breast its size and shape. At the ends of the ducts are lobules, or clusters of alveoli, where milk is produced and stored in response to hormonal signals. During pregnancy, the breast responds to a complex interaction of hormones, including estrogens, progesterone, and prolactin, that mediate the completion of its development, namely lobuloalveolar maturation, in preparation of lactation and breastfeeding. Humans are the only animals with permanent breasts. At puberty, estrogens, in conjunction with growth hormone, cause permanent breast growth in female humans. This happens only to a much lesser ...
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Mammography
Mammography (also called mastography) is the process of using low-energy X-rays (usually around 30 kVp) to examine the human breast for diagnosis and screening. The goal of mammography is the early detection of breast cancer, typically through detection of characteristic masses or microcalcifications. As with all X-rays, mammograms use doses of ionizing radiation to create images. These images are then analyzed for abnormal findings. It is usual to employ lower-energy X-rays, typically Mo (K-shell X-ray energies of 17.5 and 19.6 keV) and Rh (20.2 and 22.7 keV) than those used for radiography of bones. Mammography may be 2D or 3D (tomosynthesis), depending on the available equipment and/or purpose of the examination. Ultrasound, ductography, positron emission mammography (PEM), and magnetic resonance imaging (MRI) are adjuncts to mammography. Ultrasound is typically used for further evaluation of masses found on mammography or palpable masses that may or may not be seen on mammogr ...
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Kerma (physics)
In radiation physics, kerma is an acronym for "kinetic energy released per unit mass" (alternately, "kinetic energy released in matter", "kinetic energy released in material",, or "kinetic energy released in materials"), defined as the sum of the initial kinetic energies of all the charged particles liberated by uncharged ionizing radiation (i.e., indirectly ionizing radiation such as photons and neutrons) in a sample of matter, divided by the mass of the sample. It is defined by the quotient K = \operatorname\!E_\text/\operatorname\!m. Units The SI unit of kerma is the gray (Gy) (or joule per kilogram), the same as the unit of absorbed dose. However, kerma can be different from absorbed dose, depending on the energies involved. This is because ionization energy is not accounted for. While kerma approximately equals absorbed dose at low energies, kerma is much higher than absorbed dose at higher energies, because some energy escapes from the absorbing volume in the form of brems ...
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Poly(methyl Methacrylate)
Poly(methyl methacrylate) (PMMA) belongs to a group of materials called engineering plastics. It is a transparent thermoplastic. PMMA is also known as acrylic, acrylic glass, as well as by the trade names and brands Crylux, Plexiglas, Acrylite, Astariglas, Lucite, Perclax, and Perspex, among several others ( see below). This plastic is often used in sheet form as a lightweight or shatter-resistant alternative to glass. It can also be used as a casting resin, in inks and coatings, and for many other purposes. Although not a type of familiar silica-based glass, the substance, like many thermoplastics, is often technically classified as a type of glass, in that it is a non-crystalline vitreous substance—hence its occasional historic designation as ''acrylic glass''. Chemically, it is the synthetic polymer of methyl methacrylate. It was developed in 1928 in several different laboratories by many chemists, such as William Chalmers, Otto Röhm, and Walter Bauer, and first brought ...
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Half-value Layer
material's half-value layer (HVL), or half-value thickness, is the thickness of the material at which the intensity of radiation entering it is reduced by one half. HVL can also be expressed in terms of air kerma rate (AKR), rather than intensity: the half-value layer is the thickness of specified material that, "attenuates the beam of radiation to an extent such that the AKR is reduced to one-half of its original value. In this definition the contribution of all scattered radiation, other than any ..present initially in the beam concerned, is deemed to be excluded." Rather than AKR, measurements of air kerma, exposure, or exposure rate can be used to determine half value layer, as long as it is given in the description. Half-value layer refers to the first half-value layer, where subsequent (i.e. second) half-value layers refer to the amount of specified material that will reduce the air kerma rate by one-half after material has been inserted into the beam that is equal to t ...
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Energy Spectrum
A spectrum (plural ''spectra'' or ''spectrums'') is a condition that is not limited to a specific set of values but can vary, without gaps, across a continuum. The word was first used scientifically in optics to describe the rainbow of colors in visible light after passing through a prism. As scientific understanding of light advanced, it came to apply to the entire electromagnetic spectrum. It thereby became a mapping of a range of magnitudes (wavelengths) to a range of qualities, which are the perceived "colors of the rainbow" and other properties which correspond to wavelengths that lie outside of the visible light spectrum. Spectrum has since been applied by analogy to topics outside optics. Thus, one might talk about the " spectrum of political opinion", or the "spectrum of activity" of a drug, or the "autism spectrum". In these uses, values within a spectrum may not be associated with precisely quantifiable numbers or definitions. Such uses imply a broad range of condition ...
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X-ray Filter
An X-ray filter is a material placed in front of an X-ray source in order to reduce the intensity of particular wavelengths from its spectrum and selectively alter the distribution of X-ray wavelengths within a given beam. When X-rays hit matter, part of the incoming beam is transmitted through the material and part of it is absorbed by the material. The amount absorbed is dependent on the material's mass absorption coefficient and tends to decrease for incident photons of greater energy. True absorption occurs when X-rays of sufficient energy cause electron energy level transitions in the atoms of the absorbing material. The energy from these X-rays are used to excite the atoms and do not continue past the material (thus being "filtered" out). Because of this, despite the general trend of decreased absorption at higher energy wavelengths, there are periodic spikes in the absorption characteristics of any given material corresponding to each of the atomic energy level transitions. Th ...
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European Union
The European Union (EU) is a supranational political and economic union of member states that are located primarily in Europe. The union has a total area of and an estimated total population of about 447million. The EU has often been described as a '' sui generis'' political entity (without precedent or comparison) combining the characteristics of both a federation and a confederation. Containing 5.8per cent of the world population in 2020, the EU generated a nominal gross domestic product (GDP) of around trillion in 2021, constituting approximately 18per cent of global nominal GDP. Additionally, all EU states but Bulgaria have a very high Human Development Index according to the United Nations Development Programme. Its cornerstone, the Customs Union, paved the way to establishing an internal single market based on standardised legal framework and legislation that applies in all member states in those matters, and only those matters, where the states have agreed to act ...
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International Atomic Energy Agency
The International Atomic Energy Agency (IAEA) is an intergovernmental organization that seeks to promote the peaceful use of nuclear energy and to inhibit its use for any military purpose, including nuclear weapons. It was established in 1957 as an autonomous organization within the United Nations system; though governed by its own founding treaty, the organization reports to both the General Assembly and the Security Council of the United Nations, and is headquartered at the UN Office at Vienna, Austria. The IAEA was created in response to growing international concern toward nuclear weapons, especially amid rising tensions between the foremost nuclear powers, the United States and the Soviet Union. U.S. President Dwight D. Eisenhower's " Atoms for Peace" speech, which called for the creation of an international organization to monitor the global proliferation of nuclear resources and technology, is credited with catalyzing the formation of the IAEA, whose treaty came into ...
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Milligray
The gray (symbol: Gy) is the unit of ionizing radiation dose in the International System of Units (SI), defined as the absorption of one joule of radiation energy per kilogram of matter. It is used as a unit of the radiation quantity absorbed dose that measures the energy deposited by ionizing radiation in a unit mass of matter being irradiated, and is used for measuring the delivered dose in radiotherapy, food irradiation and radiation sterilization. It is important in predicting likely acute health effects, such as acute radiation syndrome and is used to calculate equivalent dose using the sievert, which is a measure of the stochastic health effect on the human body. The gray is also used in radiation metrology as a unit of the radiation quantity kerma; defined as the sum of the initial kinetic energies of all the charged particles liberated by uncharged ionizing radiation in a sample of matter per unit mass. The gray is an important unit in ionising radiation measurement ...
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Radiology
Radiology ( ) is the medical discipline that uses medical imaging to diagnose diseases and guide their treatment, within the bodies of humans and other animals. It began with radiography (which is why its name has a root referring to radiation), but today it includes all imaging modalities, including those that use no electromagnetic radiation (such as ultrasonography and magnetic resonance imaging), as well as others that do, such as computed tomography (CT), fluoroscopy, and nuclear medicine including positron emission tomography (PET). Interventional radiology is the performance of usually minimally invasive medical procedures with the guidance of imaging technologies such as those mentioned above. The modern practice of radiology involves several different healthcare professions working as a team. The radiologist is a medical doctor who has completed the appropriate post-graduate training and interprets medical images, communicates these findings to other physicians ...
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