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Marian Koshland
Marian Elliott "Bunny" Koshland (October 25, 1921 – October 28, 1997) was an American immunologist who discovered that the differences in amino acid composition of antibodies explain the efficiency and effectiveness with which they combat a huge range of foreign invaders. Biography Marian Elliott was born on October 25, 1921, in New Haven, Connecticut, to Margrethe Schmidt Elliott and Walter Elliott. Her mother was a teacher who had immigrated from Denmark and her father was a hardware salesman of Southern Baptist background. When she was four, her younger brother contracted typhoid fever, and she was tutored by two neighbor girls. She was something of a tomboy, befriending three Jewish boys with whom she would attend Works Progress Administration theater productions. She was the only girl in her class who dared to handle a three-foot black constrictor snake, for which she won a can of rattlesnake meat. Marian attended Vassar College in New York and graduated in 1942 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New Haven, Connecticut
New Haven is a city in the U.S. state of Connecticut. It is located on New Haven Harbor on the northern shore of Long Island Sound in New Haven County, Connecticut and is part of the New York City metropolitan area. With a population of 134,023 as determined by the 2020 U.S. census, New Haven is the third largest city in Connecticut after Bridgeport and Stamford and the principal municipality of Greater New Haven, which had a total 2020 population of 864,835. New Haven was one of the first planned cities in the U.S. A year after its founding by English Puritans in 1638, eight streets were laid out in a four-by-four grid, creating the "Nine Square Plan". The central common block is the New Haven Green, a square at the center of Downtown New Haven. The Green is now a National Historic Landmark, and the "Nine Square Plan" is recognized by the American Planning Association as a National Planning Landmark. New Haven is the home of Yale University, New Haven's biggest taxpayer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antibody
An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses. The antibody recognizes a unique molecule of the pathogen, called an antigen. Each tip of the "Y" of an antibody contains a paratope (analogous to a lock) that is specific for one particular epitope (analogous to a key) on an antigen, allowing these two structures to bind together with precision. Using this binding mechanism, an antibody can ''tag'' a microbe or an infected cell for attack by other parts of the immune system, or can neutralize it directly (for example, by blocking a part of a virus that is essential for its invasion). To allow the immune system to recognize millions of different antigens, the antigen-binding sites at both tips of the antibody come in an equally wide variety. In contrast, the remainder of the antibody is relatively constant. It only occurs in a few varia ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brookhaven National Laboratory
Brookhaven National Laboratory (BNL) is a United States Department of Energy national laboratory located in Upton, Long Island, and was formally established in 1947 at the site of Camp Upton, a former U.S. Army base and Japanese internment camp. Its name stems from its location within the Town of Brookhaven, approximately 60 miles east of New York City. It is managed by Stony Brook University and Battelle Memorial Institute. Research at BNL includes nuclear and high energy physics, energy science and technology, environmental and bioscience, nanoscience, and national security. The 5,300 acre campus contains several large research facilities, including the Relativistic Heavy Ion Collider and National Synchrotron Light Source II. Seven Nobel Prizes have been awarded for work conducted at Brookhaven Lab. Overview BNL is staffed by approximately 2,750 scientists, engineers, technicians, and support personnel, and hosts 4,000 guest investigators every year. The laboratory has ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvard Medical School
Harvard Medical School (HMS) is the graduate medical school of Harvard University and is located in the Longwood Medical Area of Boston, Massachusetts. Founded in 1782, HMS is one of the oldest medical schools in the United States and is consistently ranked first for research among medical schools by '' U.S. News & World Report''. Unlike most other leading medical schools, HMS does not operate in conjunction with a single hospital but is directly affiliated with several teaching hospitals in the Boston area. Affiliated teaching hospitals and research institutes include Dana–Farber Cancer Institute, Massachusetts General Hospital, Brigham and Women's Hospital, Beth Israel Deaconess Medical Center, Boston Children's Hospital, McLean Hospital, Cambridge Health Alliance, The Baker Center for Children and Families, and Spaulding Rehabilitation Hospital. History Harvard Medical School was founded on September 19, 1782, after President Joseph Willard presented a report with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Manhattan Project
The Manhattan Project was a research and development undertaking during World War II that produced the first nuclear weapons. It was led by the United States with the support of the United Kingdom and Canada. From 1942 to 1946, the project was under the direction of Major General Leslie Groves of the United States Army Corps of Engineers, U.S. Army Corps of Engineers. Nuclear physicist Robert Oppenheimer was the director of the Los Alamos Laboratory that designed the actual bombs. The Army component of the project was designated the Manhattan District as its first headquarters were in Manhattan; the placename gradually superseded the official codename, Development of Substitute Materials, for the entire project. Along the way, the project absorbed its earlier British counterpart, Tube Alloys. The Manhattan Project began modestly in 1939, but grew to employ more than 130,000 people and cost nearly US$2 billion (equivalent to about $ billion in ). Over 90 percent of th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oak Ridge, Tennessee
Oak Ridge is a city in Anderson and Roane counties in the eastern part of the U.S. state of Tennessee, about west of downtown Knoxville. Oak Ridge's population was 31,402 at the 2020 census. It is part of the Knoxville Metropolitan Area. Oak Ridge's nicknames include ''the Atomic City'', ''the Secret City'', ''the Ridge'', ''the Town the Atomic Bomb Built'', and ''the City Behind the Fence''. In 1942, the United States federal government purchased nearly of farmland in the Clinch River Valley for the development of a planned city supporting 75,000 residents. It was constructed with assistance from architectural and engineering firm Skidmore, Owings & Merrill, from 1942 to 1943. Oak Ridge was established in 1942 as a production site for the Manhattan Project—the massive American, British, and Canadian operation that developed the atomic bomb. Being the site of Oak Ridge National Laboratory and Y-12 National Security Complex, scientific and technological development still pla ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Levi Strauss
Levi Strauss (; born Löb Strauß ; February 26, 1829 – September 26, 1902) was a German-born American businessman who founded the first company to manufacture blue jeans. His firm of Levi Strauss & Co. (Levi's) began in 1853 in San Francisco, California. Early life Levi Strauss was born in an Ashkenazi Jewish family in Buttenheim on February 26, 1829, in the Franconia region of the Kingdom of Bavaria in the German Confederation. He was the son of Hirsch Strauss and his second wife Rebecca Strauss (née Haas). In 1847, aged 18, Strauss travelled with his mother and two sisters to the United States to join his brothers Jonas and Louis, who had begun a wholesale dry goods business in New York City called J. Strauss Brother & Co., at 108 Liberty Street in Manhattan. After arriving in New York, Strauss worked as an itinerant peddler of goods from his brother's store: kettles, blankets and sewing goods. Business career Levi's sister Fanny and her husband David Stern moved to S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cholera
Cholera is an infection of the small intestine by some strains of the bacterium ''Vibrio cholerae''. Symptoms may range from none, to mild, to severe. The classic symptom is large amounts of watery diarrhea that lasts a few days. Vomiting and muscle cramps may also occur. Diarrhea can be so severe that it leads within hours to severe dehydration and electrolyte imbalance. This may result in sunken eyes, cold skin, decreased skin elasticity, and wrinkling of the hands and feet. Dehydration can cause the skin to turn bluish. Symptoms start two hours to five days after exposure. Cholera is caused by a number of types of ''Vibrio cholerae'', with some types producing more severe disease than others. It is spread mostly by unsafe water and unsafe food that has been contaminated with human feces containing the bacteria. Undercooked shellfish is a common source. Humans are the only known host for the bacteria. Risk factors for the disease include poor sanitation, not enough clea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cholera Vaccine
Cholera vaccines are vaccines that are effective at preventing cholera. For the first six months after vaccination they provide about 85percent protection, which decreases to 50percent or 62percent during the first year. After two years the level of protection decreases to less than 50percent. When enough of the population is immunized, it may protect those who have not been immunized (known as herd immunity). The World Health Organization (WHO) recommends the use of cholera vaccines in combination with other measures among those at high risk. With the oral vaccine, two or three doses are typically recommended. The duration of protection is two years in adults and six months in children aged 2–5 years. A single dose vaccine is available for those traveling to an area where cholera is common. In 2010, in some countries an injectable cholera vaccine was available. The available types of oral vaccine are generally safe. Mild abdominal pain or diarrhea may occur. They are safe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Annual Review Of Immunology
The ''Annual Review of Immunology'' is a peer-reviewed scientific journal published by Annual Reviews. It releases an annual volume of review articles relevant to the field of immunology. It was first published in 1983 with inaugural editor William E. Paul; Paul remained editor for the journal's first thirty years. As of 2022, its editor is Wayne M. Yokoyama and its 2021 impact factor is 32.481, ranking it third of 161 journals in the category "Immunology". History During the 1982 Midwinter Conference of Immunologists at the Asilomar Conference Grounds, a meeting of prominent immunologists was convened to discuss the need for a new journal that published review articles about immunological topics. Interest was high, with many meeting attendees agreeing that such a journal would be useful and offering to write a review for the first volume. The ''Annual Review of Immunology'' was first published in 1983, making it the twenty-fifth journal title published by the nonprofit publishe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Works Progress Administration
The Works Progress Administration (WPA; renamed in 1939 as the Work Projects Administration) was an American New Deal agency that employed millions of jobseekers (mostly men who were not formally educated) to carry out public works projects, including the construction of public buildings and roads. It was set up on May 6, 1935, by presidential order, as a key part of the Second New Deal. The WPA's first appropriation in 1935 was $4.9 billion (about $15 per person in the U.S., around 6.7 percent of the 1935 GDP). Headed by Harry Hopkins, the WPA supplied paid jobs to the unemployed during the Great Depression in the United States, while building up the public infrastructure of the US, such as parks, schools, and roads. Most of the jobs were in construction, building more than 620,000 miles (1,000,000 km) of streets and over 10,000 bridges, in addition to many airports and much housing. The largest single project of the WPA was the Tennessee Valley Authority. At its peak ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tomboy
A tomboy is a term for a girl or a young woman with masculine qualities. It can include wearing androgynous or unfeminine clothing and actively engage in physical sports or other activities and behaviors usually associated with boys or men. Who Are Tomboys and Why Should We Study Them?, '' SpringerLink'', ''Archives of Sexual Behavior'', Volume 31, Number 4 Etymology The word "tomboy" combines a generic male name "Tom" with "boy". Nowadays, this word refers to boyish girls, but the etymology suggests the meaning of tomboy has changed drastically over time. Records show that Tomboy used to refer to "boisterous male children" in the mid 16th century.” To understand why the typical male name "Tom" is incorporated in the term tomboy, "Tom" is an abbreviation for the male name "Thomas," and can be utilized as a generic term for men. Slangs invented in the early 16 century, such as “every Tom, Dick, and Harry,” and "Tom of all trades” suggest English speakers utilize “t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
