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MHC Class III
MHC class III is a group of proteins belonging the class of major histocompatibility complex (MHC). Unlike other MHC types such as MHC class I and MHC class II, of which their structure and functions in immune response are well defined, MHC class III are poorly defined structurally and functionally. They are not involved in antigen binding (the process called antigen presentation, a classic function of MHC proteins). Only few of them are actually involved in immunity while many are Cell signaling, signalling molecules in other cell communications. They are mainly known from their genes because their gene cluster is present between those of MHC class I, class I and MHC class II, class II. The gene cluster was discovered when genes (specifically those of complement components Complement component 2, C2, Complement component 4, C4, and Complement factor B, factor B) were found in between class I and class II genes on the short (p) arm of human chromosome 6. It was later found that it c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Major Histocompatibility Complex
The major histocompatibility complex (MHC) is a large Locus (genetics), locus on vertebrate DNA containing a set of closely linked polymorphic genes that code for Cell (biology), cell surface proteins essential for the adaptive immune system. These cell surface proteins are called MHC molecules. Its name comes from its discovery during the study of transplanted tissue compatibility. Later studies revealed that tissue rejection due to incompatibility is only a facet of the full function of MHC molecules, which is to bind an antigen derived from self-proteins, or from pathogens, and bring the antigen presentation to the cell surface for recognition by the appropriate T cell, T-cells. MHC molecules mediate the interactions of leukocytes, also called white blood cells (WBCs), with other leukocytes or with body cells. The MHC determines donor compatibility for organ transplant, as well as one's susceptibility to autoimmune diseases. In a cell, protein molecules of the host's own pheno ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Macrophage
Macrophages (; abbreviated MPhi, φ, MΦ or MP) are a type of white blood cell of the innate immune system that engulf and digest pathogens, such as cancer cells, microbes, cellular debris and foreign substances, which do not have proteins that are specific to healthy body cells on their surface. This self-protection method can be contrasted with that employed by Natural killer cell, Natural Killer cells. This process of engulfment and digestion is called phagocytosis; it acts to defend the host against infection and injury. Macrophages are found in essentially all tissues, where they patrol for potential pathogens by amoeboid movement. They take various forms (with various names) throughout the body (e.g., histiocytes, Kupffer cells, alveolar macrophages, microglia, and others), but all are part of the mononuclear phagocyte system. Besides phagocytosis, they play a critical role in nonspecific defense (innate immunity) and also help initiate specific defense mechanisms (adapti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genes On Human Chromosome 6
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and non-coding genes. During gene expression (the synthesis of RNA or protein from a gene), DNA is first copied into RNA. RNA can be directly functional or be the intermediate template for the synthesis of a protein. The transmission of genes to an organism's offspring, is the basis of the inheritance of phenotypic traits from one generation to the next. These genes make up different DNA sequences, together called a genotype, that is specific to every given individual, within the gene pool of the population of a given species. The genotype, along with environmental and developmental factors, ultimately determines the phenotype of the individual. Most biological traits occur under the combined influence of polygenes (a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immune System
The immune system is a network of biological systems that protects an organism from diseases. It detects and responds to a wide variety of pathogens, from viruses to bacteria, as well as Tumor immunology, cancer cells, Parasitic worm, parasitic worms, and also objects such as wood splinters, distinguishing them from the organism's own healthy biological tissue, tissue. Many species have two major subsystems of the immune system. The innate immune system provides a preconfigured response to broad groups of situations and stimuli. The adaptive immune system provides a tailored response to each stimulus by learning to recognize molecules it has previously encountered. Both use humoral immunity, molecules and cell-mediated immunity, cells to perform their functions. Nearly all organisms have some kind of immune system. Bacteria have a rudimentary immune system in the form of enzymes that protect against bacteriophage, viral infections. Other basic immune mechanisms evolved in ancien ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
LST1
Leukocyte-specific transcript 1 protein is a protein that in humans is encoded by the ''LST1'' gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei .... References Further reading * * * * * * * * * * * * * * * * {{gene-6-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NCR3
Natural cytotoxicity triggering receptor 3 is a protein that in humans is encoded by the ''NCR3'' gene. NCR3 has also been designated as CD337 (cluster of differentiation 337) and as NKp30. NCR3 belongs to the family of NCR membrane receptors together with NCR1 (NKp46) and NCR2 (NKp44). Identification NKp30 receptor was first identified in 1999. According to Western blot analysis specific monoclonal antibodies reacted with 30kDa molecule, therefore was the protein named NKp30. Structure Gene for NKp30 is located in the MHC class III region of the human MHC locus and encodes 190 amino acid long type I transmembrane receptor which belongs to immunoglobulin super family (IgSF). NKp30 has a mass of 30 kDa and includes one Ig-like extracellular domain which is 138 amino acids long, a 19 amino acid transmembrane (TM) domain and a 33 amino acid cytoplasmic tail. The Ig-like domain consists of 2 antiparallel beta-sheets linked by a disulphide bond. The extracellular domain conta ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gray Short-tailed Opossum
The gray short-tailed opossum (''Monodelphis domestica'') is a small South American member of the family Didelphidae. Unlike most other marsupials, the gray short-tailed opossum does not have a true pouch. The scientific name ''Monodelphis'' is derived from Greek and means "single womb" (referring to the lack of a pouch) and the Latin word ''domestica'' which means "domestic" (chosen because of the species' habit of entering human dwellings). It was the first marsupial to have its genome sequenced. The gray short-tailed opossum is used as a research model in science, and is also frequently found in the exotic pet trade. It is also known as the Brazilian opossum, rainforest opossum and in a research setting the laboratory opossum. Description Gray short-tailed opossums are relatively small animals, with a superficial resemblance to voles. In the wild they have head-body length of and weigh ; males are larger than females. However, individuals kept in captivity are typically mu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Xenopus Tropicalis
The western clawed frog (''Xenopus tropicalis'') is a species of frog in the family Pipidae, also known as tropical clawed frog. It is the only species in the genus ''Xenopus'' to have a diploid genome. Its genome has been sequenced, making it a significant model organism for genetics that complements the related species ''Xenopus laevis'' (the African clawed frog), a widely used vertebrate model for developmental biology. ''X. tropicalis'' also has a number of advantages over ''X. laevis'' in research, such as a much shorter generation time (<5 months), smaller size ( body length), and a larger number of eggs per . It is found in , |
CYP21
Steroid 21-hydroxylase is a protein that in humans is encoded by the ''CYP21A2'' gene. The protein is an enzyme that hydroxylates steroids at the C21 position on the molecule. Naming conventions for enzymes are based on the substrate acted upon and the chemical process performed. Biochemically, this enzyme is involved in the biosynthesis of the adrenal gland hormones aldosterone and cortisol, which are important in blood pressure regulation, sodium homeostasis and blood sugar control. The enzyme converts progesterone and 17α-hydroxyprogesterone into 11-deoxycorticosterone and 11-deoxycortisol, respectively, within metabolic pathways which in humans ultimately lead to aldosterone and cortisol creation—deficiency in the enzyme may cause congenital adrenal hyperplasia. Steroid 21-hydroxylase is a member of the cytochrome P450 family of monooxygenase enzymes that use an iron-containing heme cofactor to oxidize substrates. In humans, the enzyme is localized in endoplasmic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
STK19
Serine/threonine-protein kinase 19 is a protein that in humans is encoded by the ''STK19'' gene and is involved in DNA repair, specifically the Transcription Coupled Nucleotide Excision Repair Pathway (TC-NER). The name is misleading — although STK19 was initially identified as a serine/threonine kinase, analysis of the crystal structure revealed absence of the kinase domain and it does not seem to possess any kinase activity. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 and expresses two transcript variants. Structure STK19 contains 3 different protein-interaction domains, which are essential to its function in DNA repair: the CSA interacting domain, RNA Polymerase II RNA polymerase II (RNAP II and Pol II) is a Protein complex, multiprotein complex that Transcription (biology), transcribes DNA into precursors of messenger RNA (mRNA) and most small nuclear RNA (snRNA) and microRNA. It is one of the three RNA pol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alu Element
An Alu element is a short stretch of DNA originally characterized by the action of the ''Arthrobacter luteus (Alu)'' restriction endonuclease. ''Alu'' elements are the most abundant transposable elements in the human genome, present in excess of one million copies. Most ''Alu'' elements are thought to be selfish or parasitic DNA. However, it has been suggested that at least some are likely to play a role in evolution and have been used as genetic markers. They are derived from the small cytoplasmic 7SL RNA, a component of the signal recognition particle. ''Alu'' elements are not highly conserved within primate genomes, as only a minority have retained activity, and originated in the genome of an ancestor of Supraprimates. ''Alu'' insertions have been implicated in several inherited human diseases and in various forms of cancer. The study of Alu elements has also been important in elucidating human population genetics and the evolution of primates, including the evolution of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Endogenous Retrovirus
Endogenous retroviruses (ERVs) are endogenous viral elements in the genome that closely resemble and can be derived from retroviruses. They are abundant in the genomes of Gnathostomata, jawed vertebrates, and they comprise up to 5–8% of the human genome (lower estimates of ~1%). An ERV is a vertically inherited Provirus, proviral sequence and a subclass of a type of gene called a transposon, which can normally be packaged and moved within the genome to serve a vital role in gene expression and in Gene regulation, regulation. ERVs, however, lack most transposon functions, are typically not infectious, and are often defective genomic remnants of the retroviral replication cycle. They are distinguished as germline provirus retroelements due to their integration and Reverse transcriptase, reverse-transcription into the nuclear genome of the host cell. Researchers have suggested that retroviruses evolved from a type of transposon called a retrotransposon, a Class I element; these g ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
