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Lunenfeld-Tanenbaum Research Institute
The Lunenfeld-Tanenbaum Research Institute is a medical research institute in Toronto, Ontario and part of the Sinai Health System. It was originally established in 1985 as the Samuel Lunenfeld Research Institute, the research arm of Mount Sinai Hospital, by an endowment from the Lunenfeld and Kunin families. It was renamed to the current name on June 24, 2013, after a $35 million donation from Larry and Judy Tanenbaum. It comprises 36 principal investigators, has a budget of C$90 million (2005/6), has over 200 trainees and approximately 600 staff. The institute conducts research into various forms of cancer ( colon, breast, pancreatic, prostate, lung, etc.), neurological disorders and brain illnesses, women's and infants' health, diabetes, developmental biology, stem cell biology and tissue regeneration, mouse models of human disease, genomic medicine and systems biology. The institute has of space and is split between the main hospital and the Joseph and Wolf Lebovic Health ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Toronto
Toronto ( ; or ) is the capital city of the Canadian province of Ontario. With a recorded population of 2,794,356 in 2021, it is the most populous city in Canada and the fourth most populous city in North America. The city is the anchor of the Golden Horseshoe, an urban agglomeration of 9,765,188 people (as of 2021) surrounding the western end of Lake Ontario, while the Greater Toronto Area proper had a 2021 population of 6,712,341. Toronto is an international centre of business, finance, arts, sports and culture, and is recognized as one of the most multicultural and cosmopolitan cities in the world. Indigenous peoples have travelled through and inhabited the Toronto area, located on a broad sloping plateau interspersed with rivers, deep ravines, and urban forest, for more than 10,000 years. After the broadly disputed Toronto Purchase, when the Mississauga surrendered the area to the British Crown, the British established the town of York in 1793 and later designat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diabetes
Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased appetite. If left untreated, diabetes can cause many health complications. Acute complications can include diabetic ketoacidosis, hyperosmolar hyperglycemic state, or death. Serious long-term complications include cardiovascular disease, stroke, chronic kidney disease, foot ulcers, damage to the nerves, damage to the eyes, and cognitive impairment. Diabetes is due to either the pancreas not producing enough insulin, or the cells of the body not responding properly to the insulin produced. Insulin is a hormone which is responsible for helping glucose from food get into cells to be used for energy. There are three main types of diabetes mellitus: * Type 1 diabetes results from failure of the pancreas to produce enough insulin due to lo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
James Woodgett
James (Jim) Woodgett is a British-born biologist and the Principal Investigator of an active research laboratory at the Lunenfeld-Tanenbaum Research Institute, Sinai Health System (formerly Mount Sinai Hospital), in Toronto, Ontario, Canada. He was the Koffler Director of Research at the Lunenfeld-Tanenbaum Research Institute from November 2005 to January 2021. Woodgett's research spans the fields of Signal Transduction, Cancer Stem Cells, Diabetes, and Neurological Disorders. He is known for his co-discoveries of the molecules PKB/Akt and SAPK/JNKs, which have central roles in the evolution of cancer. Woodgett is also an authority on the functions of the GSK-3 genes, which play significant roles in insulin/diabetes and brain development/Alzheimer's disease, as well as bipolar disorder. Woodgett is a long-time advocate for increasing public support for science and medical research. He is known for his science communication and public science outreach, as well as his support for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anthony Pawson
Anthony James Pawson (18 October 1952 – 7 August 2013) was a British-born Canadian scientist whose research revolutionised the understanding of signal transduction, the molecular mechanisms by which cells respond to external cues, and how they communicate with each other. He identified the phosphotyrosine-binding Src homology 2 (SH2 domain) as the prototypic non-catalytic interaction module. SH2 domains serve as a model for a large family of protein modules that act together to control many aspects of cellular signalling. Since the discovery of SH2 domains, hundreds of different modules have been identified in many proteins. Biography Born in Maidstone, England, the son of the sportsman and writer Tony Pawson, and botanist and high-school teacher Hilarie, he was the eldest of three children. He was educated at Winchester College and Clare College, Cambridge, where he received an MA in biochemistry followed by a PhD from King's College London in 1976. From 1976 to 1980 he pur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alan Bernstein
Alan Bernstein (born June 25, 1947) is president and CEO of CIFAR (the Canadian Institute for Advanced Research). He is recognized as a leader in health research, science policy, mentorship and organizational leadership. Education Born in Toronto, Bernstein attended Oakwood Collegiate Institute, and then received his BSc. (Honours) and the James Loudon Gold Medal in Mathematics and Physics from the University of Toronto in 1968. He pursued biomedical research and obtained his Ph.D. at the University of Toronto in 1972 under the supervision of James Till with a thesis focusing on a genetic analysis of membrane mutants ''Escherichia coli''. Career Following his PhD, Bernstein undertook postdoctoral research in London at the Imperial Cancer Research Fund, where he began working on retroviruses and their oncogenes. Bernstein returned to Canada in 1974 to join the faculty of the Ontario Cancer Institute. In 1985, he joined the new Samuel Lunenfeld Research Institute at Mount Sinai ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Louis Siminovitch
Louis Siminovitch (May 1, 1920 – April 6, 2021) was a Canadian molecular biologist. He was a pioneer in human genetics, researcher into the genetic basis of muscular dystrophy and cystic fibrosis, and helped establish Ontario programs exploring genetic roots of cancer. Life and career Siminovitch was born in Montreal, Quebec, the son of Goldie and Nathan Siminovitch, who were Jewish emigrants from Eastern Europe. He won a scholarship in chemistry to McGill University, earning a doctorate in 1944. He then studied at the Pasteur Institute in Paris. In 1953 he joined Toronto's Connaught Medical Research Laboratories. Later he joined the University of Toronto and worked there from 1956 to 1985. One of his doctoral students was Joyce Taylor-Papadimitriou. He helped establish the Department of Genetics at the Hospital for Sick Children as geneticist in chief, where he worked from 1970 to 1985. From 1983 to 1994 he was the founding director of research at the Samuel Lunenfeld Res ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intestinal Infectious Diseases
Intestinal infectious diseases include a large number of infections of the bowels including: cholera, typhoid fever, paratyphoid fever, other types of salmonella infections, shigellosis, botulism, gastroenteritis, and amoebiasis Amoebiasis, or amoebic dysentery, is an infection of the intestines caused by a parasitic amoeba '' Entamoeba histolytica''. Amoebiasis can be present with no, mild, or severe symptoms. Symptoms may include lethargy, loss of weight, colonic ... among others. Typhoid and paratyphoid resulted in 221,000 deaths in 2013 down from 259,000 deaths in 1990. Other diseases which result in diarrhea caused another 1.3 million additional deaths in 2013 down from 2.6 million deaths in 1990. References {{Reflist Infectious diseases ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diabetes
Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased appetite. If left untreated, diabetes can cause many health complications. Acute complications can include diabetic ketoacidosis, hyperosmolar hyperglycemic state, or death. Serious long-term complications include cardiovascular disease, stroke, chronic kidney disease, foot ulcers, damage to the nerves, damage to the eyes, and cognitive impairment. Diabetes is due to either the pancreas not producing enough insulin, or the cells of the body not responding properly to the insulin produced. Insulin is a hormone which is responsible for helping glucose from food get into cells to be used for energy. There are three main types of diabetes mellitus: * Type 1 diabetes results from failure of the pancreas to produce enough insulin due to lo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Systems Biology
Systems biology is the computational modeling, computational and mathematical analysis and modeling of complex biological systems. It is a biology-based interdisciplinary field of study that focuses on complex interactions within biological systems, using a holistic approach (holism instead of the more traditional reductionist, reductionism) to biological research. Particularly from the year 2000 onwards, the concept has been used widely in biology in a variety of contexts. The Human Genome Project is an example of applied systems thinking in biology which has led to new, collaborative ways of working on problems in the biological field of genetics. One of the aims of systems biology is to model and discover emergent property, emergent properties, properties of cell (biology), cells, tissue (biology), tissues and organisms functioning as a system whose theoretical description is only possible using techniques of systems biology. These typically involve metabolic networks or cell ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Systems Biology
Systems biology is the computational modeling, computational and mathematical analysis and modeling of complex biological systems. It is a biology-based interdisciplinary field of study that focuses on complex interactions within biological systems, using a holistic approach (holism instead of the more traditional reductionist, reductionism) to biological research. Particularly from the year 2000 onwards, the concept has been used widely in biology in a variety of contexts. The Human Genome Project is an example of applied systems thinking in biology which has led to new, collaborative ways of working on problems in the biological field of genetics. One of the aims of systems biology is to model and discover emergent property, emergent properties, properties of cell (biology), cells, tissue (biology), tissues and organisms functioning as a system whose theoretical description is only possible using techniques of systems biology. These typically involve metabolic networks or cell ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genomic Medicine
Medical genetics is the branch tics in that human genetics is a field of scientific research that may or may not apply to medicine, while medical genetics refers to the application of genetics to medical care. For example, research on the causes and inheritance of genetic disorders would be considered within both human genetics and medical genetics, while the diagnosis, management, and counselling people with genetic disorders would be considered part of medical genetics. In contrast, the study of typically non-medical phenotypes such as the genetics of eye color would be considered part of human genetics, but not necessarily relevant to medical genetics (except in situations such as albinism). ''Genetic medicine'' is a newer term for medical genetics and incorporates areas such as gene therapy, personalized medicine, and the rapidly emerging new medical specialty, predictive medicine. Scope Medical genetics encompasses many different areas, including clinical practice of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mouse Models Of Human Disease
A model organism (often shortened to model) is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the model organism will provide insight into the workings of other organisms. Model organisms are widely used to research human disease when human experimentation would be unfeasible or unethical. This strategy is made possible by the common descent of all living organisms, and the conservation of metabolic and developmental pathways and genetic material over the course of evolution. Studying model organisms can be informative, but care must be taken when generalizing from one organism to another. In researching human disease, model organisms allow for better understanding the disease process without the added risk of harming an actual human. The species chosen will usually meet a determined taxonomic equivalency to humans, so as to react to disease or its treatment in a way that resemble ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
