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Lewy Body Dementia
Lewy body dementias are two similar and common subtypes of dementia— dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD). Both are characterized by changes in thinking, movement, behavior, and mood. The two conditions have similar features and may have similar causes, and are believed to belong on a spectrum of Lewy body disease that includes Parkinson's disease. As of 2014, they were more often misdiagnosed than any other common dementia. The exact cause is unknown, but involves widespread deposits of abnormal clumps of protein that form in neurons of the diseased brain. Known as Lewy bodies (discovered in 1912 by Frederic Lewy) and Lewy neurites, these clumps affect both the central nervous system and the autonomic nervous system. The fifth revision of the '' Diagnostic and Statistical Manual of Mental Disorders'' ( DSM-5) gives Lewy body disease as the causative subtype of dementia with Lewy bodies, and Parkinson's disease as the causative subtype of P ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dementia
Dementia is a disorder which manifests as a set of related symptoms, which usually surfaces when the brain is damaged by injury or disease. The symptoms involve progressive impairments in memory, thinking, and behavior, which negatively affects a person's ability to function and carry out everyday activities. Aside from memory impairment and a disruption in thought patterns, the most common symptoms include emotional problems, difficulties with language, and decreased motivation. The symptoms may be described as occurring in a continuum over several stages. Consciousness is not affected. Dementia ultimately has a significant effect on the individual, caregivers, and on social relationships in general. A diagnosis of dementia requires the observation of a change from a person's usual mental functioning, and a greater cognitive decline than what is caused by normal aging. Several diseases and injuries to the brain, such as a stroke, can give rise to dementia. However, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Visual Hallucination
A hallucination is a perception in the absence of an external stimulus that has the qualities of a real perception. Hallucinations are vivid, substantial, and are perceived to be located in external objective space. Hallucination is a combination of 2 conscious states of brain wakefulness and REM sleep. They are distinguishable from several related phenomena, such as dreaming (REM sleep), which does not involve wakefulness; pseudohallucination, which does not mimic real perception, and is accurately perceived as unreal; illusion, which involves distorted or misinterpreted real perception; and mental imagery, which does not mimic real perception, and is under voluntary control. Hallucinations also differ from "delusional perceptions", in which a correctly sensed and interpreted stimulus (i.e., a real perception) is given some additional significance. Many hallucinations happen also during sleep paralyses. Hallucinations can occur in any sensory modality—visual, auditory, olfac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paranoia
Paranoia is an instinct or thought process that is believed to be heavily influenced by anxiety or fear, often to the point of delusion and irrationality. Paranoid thinking typically includes persecutory beliefs, or beliefs of conspiracy concerning a perceived threat towards oneself (i.e. ''"Everyone is out to get me"''). Paranoia is distinct from phobias, which also involve irrational fear, but usually no blame. Making false accusations and the general distrust of other people also frequently accompany paranoia. For example, a paranoid person might believe an incident was intentional when most people would view it as an accident or coincidence. Paranoia is a central symptom of psychosis.Green, C., Freeman, D., Kuipers, E., Bebbington, P., Fowler, D., Dunn, G., & Garety, P. (2008). Measuring ideas of persecution and social reference: the Green et al. Paranoid Thought Scales (GPTS). ''Psychological Medicine, 38'', 101 - 111. Signs and symptoms A common symptom of paranoia ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anxiety
Anxiety is an emotion which is characterized by an unpleasant state of inner turmoil and includes feelings of dread over anticipated events. Anxiety is different than fear in that the former is defined as the anticipation of a future threat whereas the latter is defined as the emotional response to a real threat. It is often accompanied by nervous behavior such as pacing back and forth, somatic complaints, and rumination. Anxiety is a feeling of uneasiness and worry, usually generalized and unfocused as an overreaction to a situation that is only subjectively seen as menacing. It is often accompanied by muscular tension, restlessness, fatigue, inability to catch one's breath, tightness in the abdominal region, nausea, and problems in concentration. Anxiety is closely related to fear, which is a response to a real or perceived immediate threat ( fight or flight response); anxiety involves the expectation of future threat including dread. People facing anxiety may withdraw ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Robin Williams
Robin McLaurin Williams (July 21, 1951August 11, 2014) was an American actor and comedian. Known for his improvisational skills and the wide variety of characters he created on the spur of the moment and portrayed on film, in dramas and comedies alike, he is regarded as one of the greatest comedians of all time. Williams began performing stand-up comedy in San Francisco and Los Angeles during the mid-1970s, and rose to fame playing the alien Mork in the ABC sitcom '' Mork & Mindy'' (1978–1982). After his first leading film role in '' Popeye'' (1980), he starred in several critically and commercially successful films, including ''The World According to Garp'' (1982), '' Moscow on the Hudson'' (1984), '' Good Morning, Vietnam'' (1987), '' Dead Poets Society'' (1989), '' Awakenings'' (1990), '' The Fisher King'' (1991), ''Patch Adams'' (1998), ''One Hour Photo'' (2002), and '' World's Greatest Dad'' (2009). He also starred in box office successes such as '' Hook'' (1991), '' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Robin Williams 2011a
Robin may refer to: Animals * Australasian robins, red-breasted songbirds of the family Petroicidae * Many members of the subfamily Saxicolinae (Old World chats), including: **European robin (''Erithacus rubecula'') **Bush-robin **Forest robin **Magpie-robin ** Scrub-robin ** Robin-chat, two bird genera **Bagobo robin **White-starred robin **White-throated robin **Blue-fronted robin **Larvivora (6 species) ** Myiomela (3 species) * Some red-breasted New-World true thrushes (''Turdus'') of the family Turdidae, including: ** American robin (''T. migratorius'') (so named by 1703) ** Rufous-backed thrush (''T. rufopalliatus'') ** Rufous-collared thrush (''T. rufitorques'') ** Formerly other American thrushes, such as the clay-colored thrush (''T. grayi'') * Pekin robin or Japanese (hill) robin, archaic names for the red-billed leiothrix (''Leiothrix lutea''), red-breasted songbirds * Sea robin, a fish with small "legs" (actually spines) Arts, entertainment, and media Fictional ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lewy Body Society
Lewy may refer to: * Lewy (surname) * Levi, a biblical personage * Lewy body Lewy bodies are the inclusion bodies – abnormal aggregations of protein – that develop inside nerve cells affected by Parkinson's disease (PD), the Lewy body dementias (Parkinson's disease dementia and dementia with Lewy bodies (DLB)), and ..., abnormal aggregates of protein that develop inside nerve cells of the brain * Dementia with Lewy bodies, progressive brain disease associated with degenerative dementia in the elderly * A nickname for Polish footballer Robert Lewandowski (born 1988) See also * {{disambiguation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lewy Body Dementia Association
The Lewy Body Dementia Association (LBDA) is a US nonprofit organization based in Lilburn, Georgia, and "dedicated to raising awareness of the Lewy body dementias (LBD), supporting people with LBD, their families and caregivers and promoting scientific advances". Through "outreach, education and research", their mission is to support people affected by LBD. Work According to a 2014 review, the LBDA provides services that aid society and families with LBD. They provide support and awareness, reduce stress on individuals and families with LBD, and may reduce use of healthcare. They help enable better diagnoses and better understanding of LBD. A 2013 journal review of treatment of dementia with Lewy bodies suggests that caregivers join support groups including the LBDA for helpful information. In 2018, the LBDA launched a collaboration of 24 US Research Centers of Excellence, coordinated by Mayo Clinic The Mayo Clinic () is a nonprofit American academic medical center foc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antipsychotic
Antipsychotics, also known as neuroleptics, are a class of psychotropic medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia but also in a range of other psychotic disorders. They are also the mainstay together with mood stabilizers in the treatment of bipolar disorder. Prior research has shown that use of any antipsychotic is associated with smaller brain tissue volumes, including white matter reduction and that this brain shrinkage is dose dependent and time dependent. A more recent controlled trial suggests that second generation antipsychotics combined with intensive psychosocial therapy may potentially prevent pallidal brain volume loss in first episode psychosis. The use of antipsychotics may result in many unwanted side effects such as involuntary movement disorders, gynecomastia, impotence, weight gain and metabolic syndrome. Long-term use can produce adverse effec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Caregiver
A caregiver or carer is a paid or unpaid member of a person's social network who helps them with activities of daily living. Since they have no specific professional training, they are often described as informal caregivers. Caregivers most commonly assist with impairments related to old age, disability, a disease, or a mental disorder. Typical duties of a caregiver might include taking care of someone who has a chronic illness or disease; managing medications or talking to doctors and nurses on someone's behalf; helping to bathe or dress someone who is frail or disabled; or taking care of household chores, meals, or processes both formal and informal documentation related to health for someone who cannot do these things alone. With an aging population in all developed societies, the role of caregiver has been increasingly recognized as an important one, both functionally and economically. Many organizations that provide support for persons with disabilities have developed var ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alzheimer's Disease
Alzheimer's disease (AD) is a neurodegenerative disease that usually starts slowly and progressively worsens. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in remembering recent events. As the disease advances, symptoms can include problems with language, disorientation (including easily getting lost), mood swings, loss of motivation, self-neglect, and behavioral issues. As a person's condition declines, they often withdraw from family and society. Gradually, bodily functions are lost, ultimately leading to death. Although the speed of progression can vary, the typical life expectancy following diagnosis is three to nine years. The cause of Alzheimer's disease is poorly understood. There are many environmental and genetic risk factors associated with its development. The strongest genetic risk factor is from an allele of APOE. Other risk factors include a history of head injury, clinical depression, and high blood pre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Misfolded Protein
Protein folding is the physical process by which a protein chain is translated to its native three-dimensional structure, typically a "folded" conformation by which the protein becomes biologically functional. Via an expeditious and reproducible process, a polypeptide folds into its characteristic three-dimensional structure from a random coil. Each protein exists first as an unfolded polypeptide or random coil after being translated from a sequence of mRNA to a linear chain of amino acids. At this stage the polypeptide lacks any stable (long-lasting) three-dimensional structure (the left hand side of the first figure). As the polypeptide chain is being synthesized by a ribosome, the linear chain begins to fold into its three-dimensional structure. Folding of many proteins begins even during translation of the polypeptide chain. Amino acids interact with each other to produce a well-defined three-dimensional structure, the folded protein (the right hand side of the figur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
