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Laurence Pearl
Laurence Harris Pearl FRS FMedSci (born 18 June 1956) is a British biochemist and structural biologist who is currently Professor of Structural Biology in the Genome Damage and Stability Centre and was Head of the School of Life Sciences at the University of Sussex. Education Born in Manchester to a working class Jewish family, he went to Manchester Grammar School where he was very active in school drama productions, appearing alongside Nicholas Hytner in ''The Government Inspector''. Pearl read Biochemistry at University College London and then obtained MSc and PhD degrees in the Department of Crystallography at Birkbeck College, for studies of endothiapepsin under the supervision of Tom Blundell. He was part of the Birkbeck College University Challenge team who were semi-finalists in 1984, and achieved the 2nd highest score in the show's history - 430 against Exeter College, Oxford. Career Following Postdoctoral research positions at Birkbeck College and the Institute ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Manchester
Manchester () is a city in Greater Manchester, England. It had a population of 552,000 in 2021. It is bordered by the Cheshire Plain to the south, the Pennines to the north and east, and the neighbouring city of Salford to the west. The two cities and the surrounding towns form one of the United Kingdom's most populous conurbations, the Greater Manchester Built-up Area, which has a population of 2.87 million. The history of Manchester began with the civilian settlement associated with the Roman fort ('' castra'') of ''Mamucium'' or ''Mancunium'', established in about AD 79 on a sandstone bluff near the confluence of the rivers Medlock and Irwell. Historically part of Lancashire, areas of Cheshire south of the River Mersey were incorporated into Manchester in the 20th century, including Wythenshawe in 1931. Throughout the Middle Ages Manchester remained a manorial township, but began to expand "at an astonishing rate" around the turn of the 19th century. Manchest ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GSK-3
Glycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino acid residues. First discovered in 1980 as a regulatory kinase for its namesake, glycogen synthase (GS), GSK-3 has since been identified as a protein kinase for over 100 different proteins in a variety of different pathways. In mammals, including humans, GSK-3 exists in two isozymes encoded by two homologous genes GSK-3α ( GSK3A) and GSK-3β ( GSK3B). GSK-3 has been the subject of much research since it has been implicated in a number of diseases, including type 2 diabetes, Alzheimer's disease, inflammation, cancer, addiction and bipolar disorder. GSK-3 is a serine/threonine protein kinase that phosphorylate either threonine or serine, and this phosphorylation controls a variety of biological activities, such as glycogen metabolism, cell signaling, cellular transport, and others. GS inhibition by GSK-3β leads to a decrease ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Crystallography
Crystallography is the experimental science of determining the arrangement of atoms in crystalline solids. Crystallography is a fundamental subject in the fields of materials science and solid-state physics ( condensed matter physics). The word "crystallography" is derived from the Greek word κρύσταλλος (''krystallos'') "clear ice, rock-crystal", with its meaning extending to all solids with some degree of transparency, and γράφειν (''graphein'') "to write". In July 2012, the United Nations recognised the importance of the science of crystallography by proclaiming that 2014 would be the International Year of Crystallography. denote a direction vector (in real space). * Coordinates in ''angle brackets'' or ''chevrons'' such as <100> denote a ''family'' of directions which are related by symmetry operations. In the cubic crystal system for example, would mean 00 10 01/nowiki> or the negative of any of those directions. * Miller indices in ''parentheses ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Master Of Science
A Master of Science ( la, Magisterii Scientiae; abbreviated MS, M.S., MSc, M.Sc., SM, S.M., ScM or Sc.M.) is a master's degree in the field of science awarded by universities in many countries or a person holding such a degree. In contrast to the Master of Arts degree, the Master of Science degree is typically granted for studies in sciences, engineering and medicine and is usually for programs that are more focused on scientific and mathematical subjects; however, different universities have different conventions and may also offer the degree for fields typically considered within the humanities and social sciences. While it ultimately depends upon the specific program, earning a Master of Science degree typically includes writing a thesis. The Master of Science degree was first introduced at the University of Michigan in 1858. One of the first recipients of the degree was De Volson Wood, who was conferred a Master of Science degree at the University of Michigan in 1859. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Government Inspector
''The Government Inspector'', also known as ''The Inspector General'' ( rus, links=no, Ревизор, Revizor, literally: "Inspector"), is a satirical play by Russian dramatist and novelist, Nikolai Gogol. Originally published in 1836, the play was revised for an 1842 edition. Based upon an anecdote allegedly recounted to Gogol by Pushkin, the play is a comedy of errors, satirizing human greed, stupidity, and the extensive political corruption of Imperial Russia. The dream-like scenes of the play, often mirroring each other, whirl in the endless vertigo of self-deception around the main character, Khlestakov, who personifies irresponsibility, light-mindedness, and absence of measure. "He is full of meaningless movement and meaningless fermentation incarnate, on a foundation of placidly ambitious inferiority" (D. S. Mirsky). The publication of the play led to a great outcry in the reactionary press. It took the personal intervention of Tsar Nicholas I to have the play staged ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nicholas Hytner
Sir Nicholas Robert Hytner (; born 7 May 1956) is an English theatre director, film director, and film producer. He was previously the Artistic Director of London's National Theatre. His major successes as director include '' Miss Saigon'', ''The History Boys'' and ''One Man, Two Guvnors''. He has also known for directing films such as ''The Madness of King George'' (1994), ''The Crucible'' (1996), ''The History Boys'' (2006), and ''The Lady in the Van'' (2015). Hytner was knighted in the 2010 New Year Honours for services to drama by Queen Elizabeth II. Early life and education Hytner was born in the prosperous suburbs of south Manchester in 1956,Andrew Dickson"A life in theatre: Nicholas Hytner" ''The Guardian'', 16 October 2010. Retrieved 28 October 2012. to barrister Benet Hytner and his wife, Joyce.Paul Harris"A Knight At The Theater – But Just Call Him Nick" ''Jewish Telegraph ''. Retrieved 28 October 2012. He is the eldest child of four, and has described his upbri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Manchester Grammar School
The Manchester Grammar School (MGS) in Manchester, England, is the largest independent school (UK), independent day school for boys in the United Kingdom. Founded in 1515 as a Grammar school#free tuition, free grammar school next to Manchester Cathedral, Manchester Parish Church, it moved in 1931 to its present site at Rusholme. In accordance with its founder's wishes, MGS remains a predominantly academic school and belongs to the Headmasters' and Headmistresses' Conference. In the post-war period, MGS was a direct-grant grammar school. It chose to become an independent school in 1976 after the Labour Party (UK), Labour government abolished the Direct grant grammar school, Direct Grant System. Fees for 2016–2017 were £11,970 per annum. Motto, coat of arms and school badges The school's motto is ''wikt:sapere aude, Sapere Aude'' ("Dare to be Wise"), which was also the motto of the County Borough Council, council of the former County Borough of Oldham (now, with the same coat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Life Science
Life is a quality that distinguishes matter that has biological processes, such as signaling and self-sustaining processes, from that which does not, and is defined by the capacity for growth, reaction to stimuli, metabolism, energy transformation, and reproduction. Various forms of life exist, such as plants, animals, fungi, protists, archaea, and bacteria. Biology is the science that studies life. The gene is the unit of heredity, whereas the cell is the structural and functional unit of life. There are two kinds of cells, prokaryotic and eukaryotic, both of which consist of cytoplasm enclosed within a membrane and contain many biomolecules such as proteins and nucleic acids. Cells reproduce through a process of cell division, in which the parent cell divides into two or more daughter cells and passes its genes onto a new generation, sometimes producing genetic variation. Organisms, or the individual entities of life, are generally thought to be open systems ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Structural Biologist
Structural biology is a field that is many centuries old which, and as defined by the Journal of Structural Biology, deals with structural analysis of living material (formed, composed of, and/or maintained and refined by living cells) at every level of organization. Early structural biologists throughout the 19th and early 20th centuries were primarily only able to study structures to the limit of the naked eye's visual acuity and through magnifying glasses and light microscopes. In the 20th century, a variety of experimental techniques were developed to examine the 3D structures of biological molecules. The most prominent techniques are X-ray crystallography, nuclear magnetic resonance, and electron microscopy. Through the discovery of X-rays and its applications to protein crystals, structural biology was revolutionized, as now scientists could obtain the three-dimensional structures of biological molecules in atomic detail. Likewise, NMR spectroscopy allowed information about p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biochemist
Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and cell parts. The word "biochemist" is a portmanteau of "biological chemist." Biochemists also research how certain chemical reactions happen in cells and tissues and observe and record the effects of products in food additives and medicines. Biochemist researchers focus on playing and constructing research experiments, mainly for developing new products, updating existing products and analyzing said products. It is also the responsibility of a biochemist to present their research findings and create grant proposals to obtain funds for future research. Biochemists study aspects of the immune system, the expressions of genes, isolating, analyzing, and synthesizing different products, mutations that lead to cancers, and manage laboratory teams and monitor laboratory work. Biochemists also have to have ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Academia Europaea
The Academia Europaea is a pan-European Academy of Humanities, Letters, Law, and Sciences. The Academia was founded in 1988 as a functioning Europe-wide Academy that encompasses all fields of scholarly inquiry. It acts as co-ordinator of European interests in national research agencies. History The concept of a 'European Academy of Sciences' was raised at a meeting in Paris of the European Ministers of Science in 1985. The initiative was taken by the Royal Society (United Kingdom) which resulted in a meeting in London in June 1986 of Arnold Burgen (United Kingdom), Hubert Curien (France), Umberto Colombo (Italy), David Magnusson (Sweden), Eugen Seibold (Germany) and Ruurd van Lieshout (the Netherlands) – who agreed to the need for a new body. The two key purposes of Academia Europaea are: * express ideas and opinions of individual scientists from Europe * act as co-ordinator of European interests in national research agencies It does not aim to replace existing national ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
European Molecular Biology Organization
The European Molecular Biology Organization (EMBO) is a professional, non-profit organization of more than 1,800 life scientists. Its goal is to promote research in life science and enable international exchange between scientists. It co-funds courses, workshops and conferences, publishes five scientific journals and supports individual scientists. The organization was founded in 1964 and is a founding member of the Initiative for Science in Europe. the Director of EMBO is Fiona Watt, a stem cell researcher, professor at King's College London and a group leader at the European Molecular Biology Laboratory. Conferences and journals EMBO funds or co-funds over 90 meetings involving more than 11,000 participants every year. EMBO publishes five peer-reviewed scientific journals: '' The EMBO Journal'', '' EMBO Reports'', '' Molecular Systems Biology'', '' EMBO Molecular Medicine'', and ''Life Science Alliance'', History The European Molecular Biology Organization (EMBO) was lau ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
