Lysidine A
Lysidine may refer to either of two unrelated chemical compounds: * Lysidine (nucleoside) Lysidine is an uncommon nucleoside, rarely seen outside of tRNA. It is a derivative of cytidine in which the carbonyl is replaced by the amino acid lysine. The third position in the anti-codon of the Isoleucine-specific tRNA, is typically changed ... (C15H25N5O6), a nucleoside * Lysidine (chemical) (C4H8N2), an imidazoline {{Chemistry index ...
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Lysidine (nucleoside)
Lysidine is an uncommon nucleoside, rarely seen outside of tRNA. It is a derivative of cytidine in which the carbonyl is replaced by the amino acid lysine. The third position in the anti-codon of the Isoleucine-specific tRNA, is typically changed from a cytidine which would pair with guanosine to a lysidine which will base pair with adenosine. Uridine could not be used at this position even though it is a conventional partner for adenosine since it will also "wobble base pair A wobble base pair is a pairing between two nucleotides in RNA molecules that does not follow Watson-Crick base pair rules. The four main wobble base pairs are guanine-uracil (G-U), hypoxanthine-uracil (I-U), hypoxanthine-adenine (I-A), and hypox ..." with guanosine. So lysidine allows better translation fidelity. Lysidine is denoted as L or k2C (lysine bound to C2 atom of cytidine). : References {{reflist Nucleosides Pyrimidines Hydroxymethyl compounds ...
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