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Lynne Jones
Lynne Mary Jones (born 26 April 1951) is a British Labour Party politician, who was the Member of Parliament (MP) for Birmingham Selly Oak from 1992 until the dissolution of parliament in April 2010. Early life Jones was born in Birmingham, and attended the local Bartley Green Girls' Grammar School (now the comprehensive Hillcrest School) in Woodgate. She studieBiochemistryat the University of Birmingham, eventually gaining her Ph.D. in 1979. She also has a post-graduate Diploma in Housing Studies from Birmingham Polytechnic (now Birmingham City University). She worked in research at the University of Birmingham from 1972–86. She was a housing association manager from 1987–92. She joined the Labour Party in 1974. She has worked in both science and housing, and was a Councillor on Birmingham City Council representing Kings Norton ward from 1980–94. Research interests She first studied stimulus-response coupling in the rat parotid gland and at alpha adrenergic rece ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Member Of Parliament (United Kingdom)
In the United Kingdom, a member of Parliament (MP) is an individual elected to serve in the House of Commons of the Parliament of the United Kingdom. Electoral system All 650 members of the UK House of Commons are elected using the first-past-the-post voting system in single member constituencies across the whole of the United Kingdom, where each constituency has its own single representative. Elections All MP positions become simultaneously vacant for elections held on a five-year cycle, or when a snap election is called. The Fixed-term Parliaments Act 2011 set out that ordinary general elections are held on the first Thursday in May, every five years. The Act was repealed in 2022. With approval from Parliament, both the 2017 and 2019 general elections were held earlier than the schedule set by the Act. If a vacancy arises at another time, due to death or resignation, then a constituency vacancy may be filled by a by-election. Under the Representation of the People Act 1981 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kings Norton
Kings Norton, alternatively King's Norton, is an area of Birmingham, England. Historic counties of England, Historically in Worcestershire, it was also a Birmingham City Council ward (politics), ward within the Government of Birmingham, England. The district lies 6.5 miles south-southwest of Birmingham city centre and is within 1.5 miles of the north Worcestershire border. Kings Norton has been split into two wards, Kings Norton North and Kings Norton South. History There was Romano-British occupation near the later town. Excavations at Kings Norton found signs of a small Romano-British settlement, including Roman pottery and a Roman ditch at Parsons Hill, near Icknield Street. Kings Norton derives its origin from the basic Early English ''Nor + tun'', meaning North settlement and belonging to or held by the king, when Kings Norton was the northernmost of the wikt:berewick, berewicks or outlying manors of Bromsgrove in Worcestershire. Before 1066 these manors with many othe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Socialist Campaign Group
The Socialist Campaign Group, officially the Socialist Campaign Group of Labour MPs and also known as the Campaign Group, is a left-wing, democratic socialist grouping of the Labour Party's Members of Parliament in the House of Commons of the United Kingdom. It was formed in December 1982 following the 1981 Labour Party deputy leadership election when a number of soft left MPs, led by Neil Kinnock, refused to back Tony Benn's campaign, leading a number of left-wing Benn-supporting MPs to split from the Tribune Group to form the Socialist Campaign Group. It was at a meeting of the Campaign Group in June 2015 that the decision was taken that Jeremy Corbyn would contest for the leadership of the Labour Party. The Campaign Group maintains close links with Momentum. Origins The Socialist Campaign Group was founded in 1982 due to a disagreement within the Labour left, traditionally organised around the Tribune Group, about whom to back in the 1981 deputy leadership election. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
House Of Commons Of The United Kingdom
The House of Commons is the lower house of the Parliament of the United Kingdom. Like the upper house, the House of Lords, it meets in the Palace of Westminster in London, England. The House of Commons is an elected body consisting of 650 members known as Members of Parliament (UK), members of Parliament (MPs). MPs are elected to represent United Kingdom constituencies, constituencies by the first-past-the-post system and hold their seats until Dissolution of the Parliament of the United Kingdom, Parliament is dissolved. The House of Commons of England started to evolve in the 13th and 14th centuries. In 1707 it became the House of Commons of Great Britain after the Acts of Union 1707, political union with Scotland, and from 1800 it also became the House of Commons for Ireland after the Acts of Union 1800, political union of Great Britain and Ireland. In 1922, the body became the House of Commons of the United Kingdom of Great Britain and Northern Ireland after the independenc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phospholipid
Phospholipids, are a class of lipids whose molecule has a hydrophilic "head" containing a phosphate group and two hydrophobic "tails" derived from fatty acids, joined by an alcohol residue (usually a glycerol molecule). Marine phospholipids typically have omega-3 fatty acids EPA and DHA integrated as part of the phospholipid molecule. The phosphate group can be modified with simple organic molecules such as choline, ethanolamine or serine. Phospholipids are a key component of all cell membranes. They can form lipid bilayers because of their amphiphilic characteristic. In eukaryotes, cell membranes also contain another class of lipid, sterol, interspersed among the phospholipids. The combination provides fluidity in two dimensions combined with mechanical strength against rupture. Purified phospholipids are produced commercially and have found applications in nanotechnology and materials science. The first phospholipid identified in 1847 as such in biological tissues wa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Filter Binding Assay
In biochemistry or chemistry, filter binding assay is a simple way to quickly study many samples. One of the ways to learn about an interaction between two molecules is to determine the binding constant, which is a number that describes the ratio of unbound and bound molecules. This information reveals the affinity between the two molecules and allows prediction of the amount bound given any set of initial conditions. In order to measure a binding constant, one must find a way to measure the amount of complex formed over a range of starting concentrations. This can be achieved by "labeling" one of the species with a fluorescent, or in this case, a radioactive tag. The DNA is "labeled" by the addition of radioactive phosphate derived from adenosine triphosphate. Description A filter binding assay measures affinities between two molecules (often protein and DNA) using a filter. The filter is constructed of nitrocellulose paper, which is negatively charged. Since most proteins ha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Membrane
The cell membrane (also known as the plasma membrane (PM) or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates and protects the interior of all cells from the outside environment (the extracellular space). The cell membrane consists of a lipid bilayer, made up of two layers of phospholipids with cholesterols (a lipid component) interspersed between them, maintaining appropriate membrane fluidity at various temperatures. The membrane also contains membrane proteins, including integral proteins that span the membrane and serve as membrane transporters, and peripheral proteins that loosely attach to the outer (peripheral) side of the cell membrane, acting as enzymes to facilitate interaction with the cell's environment. Glycolipids embedded in the outer lipid layer serve a similar purpose. The cell membrane controls the movement of substances in and out of cells and organelles, being selectively permeable to io ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lipid Signaling
Lipid signaling, broadly defined, refers to any biological signaling event involving a lipid messenger that binds a protein target, such as a receptor, kinase or phosphatase, which in turn mediate the effects of these lipids on specific cellular responses. Lipid signaling is thought to be qualitatively different from other classical signaling paradigms (such as monoamine neurotransmission) because lipids can freely diffuse through membranes (''see osmosis''). One consequence of this is that lipid messengers cannot be stored in vesicles prior to release and so are often biosynthesized "on demand" at their intended site of action. As such, many lipid signaling molecules cannot circulate freely in solution but, rather, exist bound to special carrier proteins in serum. Sphingolipid second messengers Ceramide Ceramide (Cer) can be generated by the breakdown of sphingomyelin (SM) by sphingomyelinases (SMases), which are enzymes that hydrolyze the phosphocholine group fr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Calcium In Biology
Calcium ions (Ca2+) contribute to the physiology and biochemistry of organisms' cells. They play an important role in signal transduction pathways, where they act as a second messenger, in neurotransmitter release from neurons, in contraction of all muscle cell types, and in fertilization. Many enzymes require calcium ions as a cofactor, including several of the coagulation factors. Extracellular calcium is also important for maintaining the potential difference across excitable cell membranes, as well as proper bone formation. Plasma calcium levels in mammals are tightly regulated, electronic-book electronic- with bone acting as the major mineral storage site. Calcium ions, Ca2+, are released from bone into the bloodstream under controlled conditions. Calcium is transported through the bloodstream as dissolved ions or bound to proteins such as serum albumin. Parathyroid hormone secreted by the parathyroid gland regulates the resorption of Ca2+ from bone, reabsorption ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Signal Transduction
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular response. Proteins responsible for detecting stimuli are generally termed receptors, although in some cases the term sensor is used. The changes elicited by ligand binding (or signal sensing) in a receptor give rise to a biochemical cascade, which is a chain of biochemical events known as a signaling pathway. When signaling pathways interact with one another they form networks, which allow cellular responses to be coordinated, often by combinatorial signaling events. At the molecular level, such responses include changes in the transcription or translation of genes, and post-translational and conformational changes in proteins, as well as changes in their location. These molecular events are the basic mechanisms controlling cell gro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurotransmitter
A neurotransmitter is a signaling molecule secreted by a neuron to affect another cell across a synapse. The cell receiving the signal, any main body part or target cell, may be another neuron, but could also be a gland or muscle cell. Neurotransmitters are released from synaptic vesicles into the synaptic cleft where they are able to interact with neurotransmitter receptors on the target cell. The neurotransmitter's effect on the target cell is determined by the receptor it binds. Many neurotransmitters are synthesized from simple and plentiful precursors such as amino acids, which are readily available and often require a small number of biosynthetic steps for conversion. Neurotransmitters are essential to the function of complex neural systems. The exact number of unique neurotransmitters in humans is unknown, but more than 100 have been identified. Common neurotransmitters include glutamate, GABA, acetylcholine, glycine and norepinephrine. Mechanism and cycle ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Receptor (biochemistry)
In biochemistry and pharmacology, receptors are chemical structures, composed of protein, that receive and transduce signals that may be integrated into biological systems. These signals are typically chemical messengers which bind to a receptor and cause some form of cellular/tissue response, e.g. a change in the electrical activity of a cell. There are three main ways the action of the receptor can be classified: relay of signal, amplification, or integration. Relaying sends the signal onward, amplification increases the effect of a single ligand, and integration allows the signal to be incorporated into another biochemical pathway. Receptor proteins can be classified by their location. Transmembrane receptors include ligand-gated ion channels, G protein-coupled receptors, and enzyme-linked hormone receptors. Intracellular receptors are those found inside the cell, and include cytoplasmic receptors and nuclear receptors. A molecule that binds to a receptor is called a ligan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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