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Lynette Cegelski
Lynette Cegelski is an American physical chemist and chemical biologist who studies extracellular structures such as biofilms and membrane proteins. She is an associate professor of chemistry and, by courtesy, of chemical engineering at Stanford University. She is a Stanford Bio-X and Stanford ChEM-H affiliated faculty member. Education Cegelski studied chemistry at SUNY Binghamton in New York and graduated ''summa cum laude'' and a member of Phi Beta Kappa in 1998. She then worked in the lab of Jacob Schaefer at Washington University in St. Louis (WUSTL), earning a PhD in Biophysical Chemistry in 2004. Her post-doctoral work was in Molecular Microbiology at the Washington University School of Medicine. Research The Cegelski Lab investigates the structure and function of bacterial cell walls and extracellular structures, including amyloid fibers and biofilms. Key Publications Cegelski has authored or co-authored multiple publications that have been cited 100 or more ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Physical Chemistry
Physical chemistry is the study of macroscopic and microscopic phenomena in chemical systems in terms of the principles, practices, and concepts of physics such as motion, energy, force, time, thermodynamics, quantum chemistry, statistical mechanics, analytical dynamics and chemical equilibria. Physical chemistry, in contrast to chemical physics, is predominantly (but not always) a supra-molecular science, as the majority of the principles on which it was founded relate to the bulk rather than the molecular or atomic structure alone (for example, chemical equilibrium and colloids). Some of the relationships that physical chemistry strives to resolve include the effects of: # Intermolecular forces that act upon the physical properties of materials ( plasticity, tensile strength, surface tension in liquids). # Reaction kinetics on the rate of a reaction. # The identity of ions and the electrical conductivity of materials. # Surface science and electrochemistry of cell membrane ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemical Engineering
Chemical engineering is an engineering field which deals with the study of operation and design of chemical plants as well as methods of improving production. Chemical engineers develop economical commercial processes to convert raw materials into useful products. Chemical engineering uses principles of chemistry, physics, mathematics, biology, and economics to efficiently use, produce, design, transport and transform energy and materials. The work of chemical engineers can range from the utilization of nanotechnology and nanomaterials in the laboratory to large-scale industrial processes that convert chemicals, raw materials, living cells, microorganisms, and energy into useful forms and products. Chemical engineers are involved in many aspects of plant design and operation, including safety and hazard assessments, process design and analysis, modeling, control engineering, chemical reaction engineering, nuclear engineering, biological engineering, construction specification, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amyloid
Amyloids are aggregates of proteins characterised by a Fibril, fibrillar morphology of 7–13 Nanometer, nm in diameter, a beta sheet (β-sheet) Secondary structure of proteins, secondary structure (known as cross-β) and ability to be Staining, stained by particular dyes, such as Congo red. In the human body, amyloids have been linked to the development of various diseases. Pathogenic amyloids form when previously healthy proteins lose their normal Protein structure, structure and physiology, physiological functions (Protein misfolding, misfolding) and form fibrous deposits in amyloid plaques around cells which can disrupt the healthy function of tissues and organs. Such amyloids have been associated with (but not necessarily as the cause of) more than 50 human diseases, known as amyloidosis, and may play a role in some neurodegenerative diseases. Some of these diseases are mainly sporadic and only a few cases are Genetic disorder, familial. Others are only Genetic disorder, fam ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Escherichia Coli
''Escherichia coli'' (),Wells, J. C. (2000) Longman Pronunciation Dictionary. Harlow ngland Pearson Education Ltd. also known as ''E. coli'' (), is a Gram-negative, facultative anaerobic, rod-shaped, coliform bacterium of the genus ''Escherichia'' that is commonly found in the lower intestine of warm-blooded organisms. Most ''E. coli'' strains are harmless, but some serotypes ( EPEC, ETEC etc.) can cause serious food poisoning in their hosts, and are occasionally responsible for food contamination incidents that prompt product recalls. Most strains do not cause disease in humans and are part of the normal microbiota of the gut; such strains are harmless or even beneficial to humans (although these strains tend to be less studied than the pathogenic ones). For example, some strains of ''E. coli'' benefit their hosts by producing vitamin K2 or by preventing the colonization of the intestine by pathogenic bacteria. These mutually beneficial relationships between ''E. col ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Small Molecule
Within the fields of molecular biology and pharmacology, a small molecule or micromolecule is a low molecular weight (≤ 1000 daltons) organic compound that may regulate a biological process, with a size on the order of 1 nm. Many drugs are small molecules; the terms are equivalent in the literature. Larger structures such as nucleic acids and proteins, and many polysaccharides are not small molecules, although their constituent monomers (ribo- or deoxyribonucleotides, amino acids, and monosaccharides, respectively) are often considered small molecules. Small molecules may be used as research tools to probe biological function as well as leads in the development of new therapeutic agents. Some can inhibit a specific function of a protein or disrupt protein–protein interactions. Pharmacology usually restricts the term "small molecule" to molecules that bind specific biological macromolecules and act as an effector, altering the activity or function of the target. Small ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature Reviews Microbiology
''Nature Reviews Microbiology'' is a monthly peer-reviewed review journal published by Nature Portfolio. It was established in 2003. The journal publishes reviews and perspectives on microbiology, bridging fundamental research and its clinical, industrial, and environmental applications. The editor-in-chief is Ashley York. Abstracting and indexing This journal is indexed and abstracted by the following databases: *BIOSIS Previews *Current Contents/Life Sciences *Science Citation Index *Medline *PubMed *Index Medicus Other services that index this journal are: * Scopus , Academic Search Premier , Biotechnology Research Abstracts , CAB Abstracts , Chemical Abstracts Service, and EMBASE. According to the ''Journal Citation Reports'', the journal has a 2021 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the las ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antivirulence
Antivirulence is the concept of blocking virulence factors. In regards to bacteria, the idea is to design agents that block virulence rather than kill bacteria en masse, as the current regime results in much more selective pressure (on antibiotic resistance). From the early 1950s onwards, a large number of antibiotics, due to the emergence of multidrug-resistant common pathogen strains (both gram-negative and gram-positive), became scarcely effective and not-useful. This scenario has stimulated the research for an alternative strategy focused on agents (antivirulence or antipathogenic agents) aimed to disarm microorganisms cause of infectious disease, without killing or inhibiting the growth of microorganisms themselves and therefore with limited selective pressure to promote the antibiotic resistance phenomenon. The antivirulence strategy needs the knowledge of the pathogenic mechanisms and of the virulence factors that underlie them. Virulence factors are the weapons possesse ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Washington University School Of Medicine
Washington University School of Medicine (WUSM) is the medical school of Washington University in St. Louis in St. Louis, Missouri. Founded in 1891, the School of Medicine has 1,260 students, 604 of which are pursuing a medical degree with or without a combined Doctor of Philosophy or other advanced degree. It also offers doctorate degrees in biomedical research through the Division of Biology and Biological Sciences. The School has developed large physical therapy (273 students) and occupational therapy (233 students) programs, as well as the Program in Audiology and Communication Sciences (100 students) which includes a Doctor of Audiology (Au.D.) degree and a Master of Science in Deaf Education (M.S.D.E.) degree. There are 1,772 faculty, 1,022 residents, and 765 fellows. The clinical service is provided by Washington University Physicians, a comprehensive medical and surgical practice providing treatment in more than 75 medical specialties. Washington University Physicians ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biophysical Chemistry
Biophysical chemistry is a physical science that uses the concepts of physics and physical chemistry for the study of biological systems. The most common feature of the research in this subject is to seek explanation of the various phenomena in biological systems in terms of either the molecules that make up the system or the supra-molecular structure of these systems. Techniques Biophysical chemists employ various techniques used in physical chemistry to probe the structure of biological systems. These techniques include spectroscopic methods such as nuclear magnetic resonance (NMR) and other techniques like X-ray diffraction and cryo-electron microscopy. An example of research in biophysical chemistry includes the work for which the 2009 Nobel Prize in Chemistry was awarded. The prize was based on X-ray crystallographic studies of the ribosome that helped to unravel the physical basis of its biological function as a molecular machine that translates mRNA into polypeptides. O ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Doctor Of Philosophy
A Doctor of Philosophy (PhD, Ph.D., or DPhil; Latin: or ') is the most common Academic degree, degree at the highest academic level awarded following a course of study. PhDs are awarded for programs across the whole breadth of academic fields. Because it is an earned research degree, those studying for a PhD are required to produce original research that expands the boundaries of knowledge, normally in the form of a Thesis, dissertation, and defend their work before a panel of other experts in the field. The completion of a PhD is often a requirement for employment as a university professor, researcher, or scientist in many fields. Individuals who have earned a Doctor of Philosophy degree may, in many jurisdictions, use the title ''Doctor (title), Doctor'' (often abbreviated "Dr" or "Dr.") with their name, although the proper etiquette associated with this usage may also be subject to the professional ethics of their own scholarly field, culture, or society. Those who teach at ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phi Beta Kappa
The Phi Beta Kappa Society () is the oldest academic honor society in the United States, and the most prestigious, due in part to its long history and academic selectivity. Phi Beta Kappa aims to promote and advocate excellence in the liberal arts and sciences, and to induct the most outstanding students of arts and sciences at only select American colleges and universities. It was founded at the College of William and Mary on December 5, 1776, as the first collegiate Greek-letter fraternity and was among the earliest collegiate fraternal societies. Since its inception, 17 U.S. Presidents, 40 U.S. Supreme Court Justices, and 136 Nobel Laureates have been inducted members. Phi Beta Kappa () stands for ('), which means "Wisdom it. love of knowledgeis the guide it. helmsmanof life". Membership Phi Beta Kappa has chapters in only about 10% of American higher learning institutions, and only about 10% of these schools' Arts and Sciences graduates are invited to join the society. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Summa Cum Laude
Latin honors are a system of Latin phrases used in some colleges and universities to indicate the level of distinction with which an academic degree has been earned. The system is primarily used in the United States. It is also used in some Southeastern Asian countries with European colonial history, such as Indonesia and the Philippines, although sometimes translations of these phrases are used instead of the Latin originals. The honors distinction should not be confused with the honors degrees offered in some countries, or with honorary degrees. The system usually has three levels of honor: ''cum laude'', ''magna cum laude'', and ''summa cum laude''. Generally, a college or university's regulations set out definite criteria a student must meet to obtain a given honor. For example, the student might be required to achieve a specific grade point average, submit an honors thesis for evaluation, be part of an honors program, or graduate early. Each school sets its own standards. S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
