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List Of Drugs By Year Of Discovery
The following is a table of drugs organized by their year of discovery. Naturally occurring chemicals in plants, including alkaloids, have been used since pre-history. In the modern era, plant-based drugs have been isolated, purified and synthesised anew. Synthesis of drugs has led to novel drugs, including those that have not existed before in nature, particularly drugs based on known drugs which have been modified by chemical or biological processes. Antiquity Prehistory Archaeological evidence indicates that the use of medicinal plants dates back to the Paleolithic age. 4th millennium BCE In ancient Egypt, herbs are mentioned in Egyptian medical papyri, depicted in tomb illustrations, or on rare occasions found in medical jars containing trace amounts of herbs. Medical recipes from 4000 BCE were for liquid preparations rather than solids. In the 4th millennium BCE, Soma (drink) and Haoma are named, but is not clear what ingredients were used to prepare them. 3rd mil ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alkaloid
Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar structure may also be termed alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and, more rarely, other elements such as chlorine, bromine, and phosphorus.Chemical Encyclopedia: alkaloids xumuk.ru Alkaloids are produced by a large variety of organisms including , , Medicinal plant, plants, an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scopoletin
Scopoletin is a coumarin. It found in the root of plants in the genus ''Scopolia'' such as ''Scopolia carniolica'' and ''Scopolia japonica'', in chicory, in '' Artemisia scoparia'', in the roots and leaves of stinging nettle (''Urtica dioica''), in the passion flower, in '' Brunfelsia'', in ''Viburnum prunifolium'', in ''Solanum nigrum'', in ''Datura metel'', in '' Mallotus resinosus'', or and in '' Kleinhovia hospita''. It can also be found in fenugreek, vinegar, some whiskies or in dandelion coffee. A similar coumarin is scoparone. Scopoletin is highly fluorescent when dissolved in DMSO or water and is regularly used as a fluorimetric assay for the detection of hydrogen peroxide in conjunction with horseradish peroxidase. When oxidized, its fluorescence is strongly suppressed. Chemistry Biosynthesis Like most phenylpropanoids, the biosynthetic precursor to scopoletin acid is 4-coumaroyl-CoA. Scopoletin is derived from 1,2-benzopyrones which is the core structure of couma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Poultice
A poultice, also called a cataplasm, is a soft moist mass, often heated and medicated, that is spread on cloth and placed over the skin to treat an aching, inflamed, or painful part of the body. It can be used on wounds, such as cuts. 'Poultice' may also refer to a porous solid filled with a solvent used to remove stains from porous stone such as marble or granite. The word "poultice" comes from the Greek word "poltos" transformed in the Latin ''puls, pultes'', meaning "porridge". Types * Some Native Americans used mashed pumpkin or devil’s club as a poultice. *Native Americans have thousands of plants for the making of poultices. The known tribes who utilize(d) plants for poultices include the Abnaki, Aleut, some Algonquin bands, Anticosti, some Apache tribes, Atsugewi, Bella Coola, Blackfoot, Cahuilla, California Indian, Carrier bands, Catawba, Chehalis, Cherokee, some Cheyenne, Chickasaw, Chippewa, Choctaw, Clallam, Coahuilla, some Cocopa, Comanche, Concow, and many ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Herbal Teas
Herbal teas, also known as herbal infusions and less commonly called tisanes (UK and US , US also ), are beverages made from the infusion or decoction of herbs, spices, or other plant material in hot water. Oftentimes herb tea, or the plain term ''tea'', is used as a reference to all sorts of herbal teas. Many herbs are used in herbal medicine. Some herbal blends contain actual tea (e.g., the Indian classic masala chai). The term "herbal" tea is often used in contrast to the so-called ''true'' teas (e.g., black tea, black, green tea, green, white tea, white, yellow tea, yellow, oolong), which are prepared from the cured leaves of the tea plant, ''Camellia sinensis''. Unlike true teas (which are also available decaffeinated), most tisanes do not naturally contain caffeine. There are a number of plants, however, that ''do'' contain caffeine or another stimulant, like theobromine, cocaine or ephedrine. Some have the opposite effect, acting as a sedative. Some common Infusion, infusio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pill (pharmacy)
A tablet (also known as a pill) is a pharmaceutical oral dosage form (''oral solid dosage'', or OSD) or solid unit dosage form. Tablets may be defined as the solid unit dosage form of medicament or medicaments with suitable excipients. It comprises a mixture of active substances and excipients, usually in powder form, pressed or compacted from a powder into a solid dose. Tablets are prepared either by molding or by compression. The excipients can include diluents, binders or granulating agents, glidants (flow aids) and lubricants to ensure efficient tabletting; disintegrants to promote tablet break-up in the digestive tract; sweeteners or flavours to enhance taste; and pigments to make the tablets visually attractive or aid in visual identification of an unknown tablet. A polymer coating is often applied to make the tablet smoother and easier to swallow, to control the release rate of the active ingredient, to make it more resistant to the environment (extending its shelf li ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Edwin Smith Papyrus
The Edwin Smith Papyrus is an ancient Egyptian medical text, named after Edwin Smith who bought it in 1862, and the oldest known surgical treatise on trauma. From a cited quotation in another text, it may have been known to ancient surgeons as the "Secret Book of the Physician". This document, which may have been a manual of military surgery, describes 48 cases of injuries, fractures, wounds, dislocations and tumors. It dates to Dynasties 16– 17 of the Second Intermediate Period in ancient Egypt, 1600 BCE. The papyrus is unique among the four principal medical papyri in existence that survive today. While other papyri, such as the Ebers Papyrus and London Medical Papyrus, are medical texts based in magic, the Edwin Smith Papyrus presents a rational and scientific approach to medicine in ancient Egypt, in which medicine and magic do not conflict. Magic would be more prevalent had the cases of illness been mysterious, such as internal disease. The Edwin Smith papyrus is a sc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Catechin-7-O-glucoside
Catechin-7-''O''-glucoside is a flavan-3-ol glycoside formed from catechin. Natural occurrences Catechin-7-''O''-glucoside can be isolated from the hemolymph of the European pine sawfly ('' Neodiprion sertifer''). It also occurs in relatively large quantities in cowpea (''Vigna unguiculata'') as the dominant flavan-3-ol monomer, and actually accounts for up to 70% of cowpea proanthocyanidins (tannins). It can also be produced by biotransformation of (+)-catechin by cultured cells of '' Eucalyptus perriniana''. Presence in natural traditional drugs Catechin-7-''O''-glucoside can be found in ''Paeoniae Radix'', the crude drug made from roots of the Chinese peony (''Paeonia lactiflora''), in the red knotweed ('' Bistorta macrophylla'', also known as ''Polygonum macrophyllum''), in the stem barks of the Nepali hog plum ('' Choerospondias axillaris''), in the Korean plum yew ('' Cephalotaxus koreana'') and in Huanarpo Macho (''Jatropha macrantha''). (−)-Catechin 7-O-β-d-gluco ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rhaponticin
Rhaponticin is a stilbenoid glucoside compound. Its aglycone is called rhapontigenin. It can be found in rhubarb rhizomes. It has beneficial effects on diabetic mice, and ''in vitro'' results suggest it may be relevant to Alzheimer's disease with an action on beta amyloid. It is a phytoestrogen and has estrogen Estrogen or oestrogen is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics. There are three major endogenous estrogens that have estrogenic hormonal acti ...ic activity. References Stilbenoid glycosides Phenol glucosides {{Aromatic-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stilbenoid
Stilbenoids are hydroxylated derivatives of stilbene. They have a C6–C2–C6 structure. In biochemical terms, they belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones. Most stilbenoids are produced by plants, and the only known exception is the antihelminthic and antimicrobial stilbenoid, 2-isopropyl-5- ''E'')-2-phenylvinylenzene-1,3-diol, biosynthesized by the Gram-negative bacterium '' Photorhabdus luminescens.'' Chemistry Stilbenoids are hydroxylated derivatives of stilbene and have a C6–C2–C6 structure. They belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones. Under UV irradiation, stilbene and its derivatives undergo intramolecular cyclization, called stilbene photocyclization to form dihydrophenanthrenes. Oligomeric forms are known as oligostilbenoids. Types ;Aglycones * Piceatannol in the roots of Norway spruces * Pinosylvin is a fungal toxin protecting wood f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Laxative
Laxatives, purgatives, or aperients are substances that loosen stools and increase bowel movements. They are used to treat and prevent constipation. Laxatives vary as to how they work and the side effects they may have. Certain stimulant, lubricant and saline laxatives are used to evacuate the colon for rectal and bowel examinations, and may be supplemented by enemas under certain circumstances. Sufficiently high doses of laxatives may cause diarrhea. Some laxatives combine more than one active ingredient. Laxatives may be administered orally or rectally. Types Bulk-forming agents Bulk-forming laxatives, also known as roughage, are substances, such as fiber in food and hydrophilic agents in over-the-counter drugs, that add bulk and water to stools so that they can pass more easily through the intestines (lower part of the digestive tract). Properties * Site of action: small and large intestines * Onset of action: 12–72 hours * Examples: dietary fiber, Metamucil, Citru ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cathartic
In medicine, a cathartic is a substance that ''accelerates'' defecation. This is similar to a laxative, which is a substance that ''eases'' defecation, usually by softening feces. It is possible for a substance to be both a laxative and a cathartic. However, agents such as psyllium seed husks increase the bulk of the feces. Cathartics such as sorbitol, magnesium citrate, magnesium sulfate, or sodium sulfate were previously used as a form of gastrointestinal decontamination following poisoning via ingestion. They are no longer routinely recommended for poisonings. High-dose cathartics may be an effective means of ridding the lower gastrointestinal tract of toxins; however, they carry a risk of electrolyte imbalances and dehydration. Catharsis can be an effect of pesticide poisonings, such as with elemental sulfur Sulfur (or sulphur in British English) is a chemical element with the symbol S and atomic number 16. It is abundant, multivalent and nonmetallic. Under normal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
