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Linker Protein
Linker or linkers may refer to: Computing * Linker (computing), a computer program that takes one or more object files generated by a compiler or generated by an assembler and links them with libraries, generating an executable program or shared library ** GNU linker, the classic GNU Project's implementation of the Unix linker command ld * Dynamic linker, the part of an operating system that loads and links the shared libraries for an executable program at run time People * Amy Linker (born 1966), American actress * Zita Linker (1917–2009), Israeli politician * Eduard Linkers (1912–2004), an Austrian actor Biology * Linker DNA, the part of a genomic DNA strand that connects two nucleosomes * Polylinker or multiple cloning site, a short segment of DNA with many restriction sites * Signal transducing adaptor protein, proteins that provide mechanisms by which receptors can amplify and regulate downstream effector proteins ** Linker of activated T cells, a protein in t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Linker (computing)
In computing, a linker or link editor is a computer system program that takes one or more object files (generated by a compiler or an assembler) and combines them into a single executable file, library file, or another "object" file. A simpler version that writes its output directly to memory is called the ''loader'', though loading is typically considered a separate process. Overview Computer programs typically are composed of several parts or modules; these parts/modules do not need to be contained within a single object file, and in such cases refer to each other by means of symbols as addresses into other modules, which are mapped into memory addresses when linked for execution. While the process of linking is meant to ultimately combine these independent parts, there are many good reasons to develop those separately at the source-level. Among these reasons are the ease of organizing several smaller pieces over a monolithic whole and the ability to better define the pur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GNU Linker
In computing, a linker or link editor is a computer system program that takes one or more object files (generated by a compiler or an assembler) and combines them into a single executable file, library file, or another "object" file. A simpler version that writes its output directly to memory is called the ''loader'', though loading is typically considered a separate process. Overview Computer programs typically are composed of several parts or modules; these parts/modules do not need to be contained within a single object file, and in such cases refer to each other by means of symbols as addresses into other modules, which are mapped into memory addresses when linked for execution. While the process of linking is meant to ultimately combine these independent parts, there are many good reasons to develop those separately at the source-level. Among these reasons are the ease of organizing several smaller pieces over a monolithic whole and the ability to better define the pur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dynamic Linker
In computing, a dynamic linker is the part of an operating system that loads and links the shared libraries needed by an executable when it is executed (at "run time"), by copying the content of libraries from persistent storage to RAM, filling jump tables and relocating pointers. The specific operating system and executable format determine how the dynamic linker functions and how it is implemented. Linking is often referred to as a process that is performed when the executable is compiled, while a dynamic linker is a special part of an operating system that loads external shared libraries into a running process and then binds those shared libraries dynamically to the running process. This approach is also called dynamic linking or late linking. Implementations Microsoft Windows Dynamic-link library, or DLL, is Microsoft's implementation of the shared library concept in the Microsoft Windows and OS/2 operating systems. These libraries usually have the file extension DL ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amy Linker
Amy is a female given name, sometimes short for Amanda, Amelia, Amélie, or Amita. In French, the name is spelled ''"Aimée"''. People A–E * Amy Acker (born 1976), American actress * Amy Vera Ackman, also known as Mother Giovanni (1886–1966), Australian hospital administrator * Amy Adams (born 1974), American actress * Amy Alcott (born 1956) – American Hall of Fame golfer * Amy Archer-Gilligan, (1873–1962), American serial killer * Amy Beach (1867–1944), American composer and pianist * Amy Birnbaum (born 1975), American voice actress * Amy Bishop (born 1965), American professor and mass shooter * Amy Braverman, American statistician * Amy Brenneman (born 1964), American actress * Amy Bruckner (born 1991), American actress and singer * Amy Callaghan (born 1992), British politician * Amy Carmichael (1867–1951), British missionary to India * Amy Castle (born 1990), American actress and internet personality * Amy Cimorelli (born 1995), American singer * Amy Carter (born ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zita Linker
Zita Linker ( he, ציטה לינקר, born 1 March 1917, died 26 January 2009) was an Israeli politician who briefly served as a member of the Knesset for Likud in 1977. Biography Born in Vienna in Austria-Hungary, Linker attended high school in her home city, and university in London. She emigrated to Mandatory Palestine in 1934. She joined the General Zionists, which merged into the Liberal Party in 1959. She became a member of the Board of Liberal Women, and of the party's central committee and executive council, as well as serving as a delegate to various Zionist Congresses. In 1973 she was on the Likud list (an alliance of the Liberal Party, Herut and several other right-wing parties) for the Knesset elections that year. Although she failed to win a seat, she entered the Knesset on 21 January 1977 as a replacement for Shmuel Tamir Shmuel M. Tamir ( he, שמואל תמיר, born Shmuel Katznelson; 10 March 1923 – 29 June 1987) was a prominent Israeli independence figh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eduard Linkers
Eduard Linkers (11 October 1912 – 3 April 2004) was an Austrian actor. He appeared in more than 70 films between 1936 and 1988. Life He was born as Eduard Linker to a family of Jewish descent in Czernowitz, Austria-Hungary. He studied acting in Vienna, where he also started his acting career. After Anschluss he escaped to Czechoslovakia. He made his living by teaching English. That's how he met a Czech director František Čáp, who cast him in his movie ''Men Without Wings'' (1946). In 1952 he moved to Germany, where he acted in American productions. He spoke Romanian, German, English, Czech, French and Italian. Selected filmography * ''Catherine the Last'' (1936) - Steinschneider, Braun's secretary * ''Peter im Schnee'' (1937) - Theobald Flambach * ''Men Without Wings'' (1946) - Ullmann * ''Nadlidé'' (1946) * ''Uloupená hranice'' (1947) - Czapan * ''Nikdo nic neví'' (1947) - SS-man Fritz Heinecke * ''Krakatit'' (1948) - Carson * ''Getting on in the World'' (1948) - B ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Linker DNA
In molecular biology, linker DNA is double-stranded DNA (38-53 base pairs long) in between two nucleosome cores that, in association with histone H1, holds the cores together. Linker DNA is seen as the string in the "beads and string model", which is made by using an ionic solution on the chromatin. Linker DNA connects to histone H1 and histone H1 sits on the nucleosome core. Nucleosome is technically the consolidation of a nucleosome core and one adjacent linker DNA; however, the term nucleosome is used freely for solely the core. Linker DNA may be degraded by endonucleases.Molecular Biology of The Cell, Fifth Edition, Alberts et al., Garland Science, 2008 The linkers are short double stranded DNA segments which are formed of oligonucleotides. These contain target sites for the action of one or more restriction enzymes. The linkers can be synthesized chemically and can be ligated to the blunt end of foreign DNA or vector DNA In molecular cloning, a vector is any particle ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polylinker
A multiple cloning site (MCS), also called a polylinker, is a short segment of DNA which contains many (up to ~20) restriction sites - a standard feature of engineered plasmids. Restriction sites within an MCS are typically unique, occurring only once within a given plasmid. The purpose of an MCS in a plasmid is to allow a piece of DNA to be inserted into that region. An MCS is found in a variety of vectors, including cloning vectors to increase the number of copies of target DNA, and in expression vectors to create a protein product. In expression vectors, the MCS is located downstream of the promoter. Creating a multiple cloning site In some instances, a vector may not contain an MCS. Rather, an MCS can be added to a vector. The first step is designing complementary oligonucleotide sequences that contain restriction enzyme sites along with additional bases on the end that are complementary to the vector after digesting. Then the oligonucleotide sequences can be annealed and li ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Signal Transducing Adaptor Protein
Signal transducing adaptor proteins (STAPs) are proteins that are accessory to main proteins in a signal transduction pathway. Adaptor proteins contain a variety of protein-binding modules that link protein-binding partners together and facilitate the creation of larger signaling complexes. These proteins tend to lack any intrinsic enzymatic activity themselves, instead mediating specific protein–protein interactions that drive the formation of protein complexes. Examples of adaptor proteins include MYD88, Grb2 and SHC1. Signaling components Much of the specificity of signal transduction depends on the recruitment of several signalling components such as protein kinases and G-protein GTPases into short-lived active complexes in response to an activating signal such as a growth factor binding to its receptor. Domains Adaptor proteins usually contain several domains within their structure (e.g., Src homology 2 (SH2) and SH3 domains) that allow specific interactions with sev ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Linker Of Activated T Cells
The Linker for activation of T cells, also known as linker of activated T cells or LAT, is a protein involved in the T-cell antigen receptor signal transduction pathway which in humans is encoded by the ''LAT'' gene. Alternative splicing results in multiple transcript variants encoding different isoforms. Function The LAT protein encoded by the gene of the same name, plays a key role in the diversification of T cell signaling pathways following activation of the T-cell antigen receptor ( TCR) signal transduction pathway, which is first catalyzed by TCR binding to MHC class II. LAT is a transmembrane protein localizes to lipid rafts (also known as glycosphingolipid-enriched microdomains or GEMs) and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. In mouse thymocytes, lack of functiona ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
B-cell Linker
The B-cell linker protein is encoded by the ''BLNK'' gene and is an adaptor protein also known as SLP-65, BASH, and BCA. BLNK is expressed in B cells and macrophages and plays a large role in B cell receptor signalling, in a fashion analogous to the role its paralogue SLP-76 plays in T cell receptor signalling. As it has no known intrinsic enzymatic activity, the function of BLNK is to temporally and spatially coordinate and regulate signalling effectors downstream of the B cell receptor. Function The function of BLNK was first illustrated in BLNK deficient DT40 cells, a chicken B-cell line, which exhibited an abrogated intracellular calcium mobilisation response and impaired activation of MAP kinases p38, JNK, and to a lesser degree ERK upon B-cell receptor (BCR) activation as compared to wild type DT40 cells. In knockout mice, BLNK deficiency results in a partial block in B-cell development, and in humans BLNK deficiency results in a much more profound block in B-cell developm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peptide
Peptides (, ) are short chains of amino acids linked by peptide bonds. Long chains of amino acids are called proteins. Chains of fewer than twenty amino acids are called oligopeptides, and include dipeptides, tripeptides, and tetrapeptides. A polypeptide is a longer, continuous, unbranched peptide chain. Hence, peptides fall under the broad chemical classes of biological polymers and oligomers, alongside nucleic acids, oligosaccharides, polysaccharides, and others. A polypeptide that contains more than approximately 50 amino acids is known as a protein. Proteins consist of one or more polypeptides arranged in a biologically functional way, often bound to ligands such as coenzymes and cofactors, or to another protein or other macromolecule such as DNA or RNA, or to complex macromolecular assemblies. Amino acids that have been incorporated into peptides are termed residues. A water molecule is released during formation of each amide bond.. All peptides except cyclic pep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
