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Life Sciences Institute
The Life Sciences Institute (LSI) is a collaborative, multidisciplinary research institution located on the campus of the University of Michigan in Ann Arbor. It encompasses 27 faculty-led teams from 13 schools and departments throughout U-M. The LSI brings together leading scientists from a variety of life science disciplines, working with a range of models systems and cutting-edge research tools, to accelerate breakthroughs and discoveries that will broaden understanding of the basic processes of life and lead to new treatments to improve human health. Of the university's $823 million in research expenditures, more than half is allocated for research in the life sciences, and the LSI is a cornerstone of this effort.


History

In 1998, the University of Michigan formed a commission to ...
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Basic Research
Basic research, also called pure research or fundamental research, is a type of scientific research with the aim of improving scientific theories for better understanding and prediction of natural or other phenomena. In contrast, applied research uses scientific theories to develop technology or techniques which can be used to intervene and ''alter'' natural or other phenomena. Though often driven simply by curiosity,"Curiosity creates cures: The value and impact of basic research
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Mary Sue Coleman
Mary Sue Wilson Coleman (born October 2, 1943) is an American chemist and academic administrator who served as the president of the University of Iowa from 1995 to 2002, the 13th president of the University of Michigan from 2002 to 2014, and as the interim president of the University of Michigan in 2022. She formerly served as Professor of Biological Chemistry in the University of Michigan Medical School and Professor of Chemistry in the College of Literature, Science and the Arts. Early life and education Mary Sue Wilson was born on October 2, 1943, in Madison County, Kentucky. She graduated from a high school in Cedar Falls, Iowa. Coleman received a bachelor of science in chemistry from Grinnell College in 1965, and a doctor of philosophy in biochemistry from the University of North Carolina at Chapel Hill in 1969. Career For nineteen years, Coleman was on the biochemistry faculty at the University of Kentucky. She served as the 18th President of the University of Iowa from ...
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Life Sciences Institute, University Of Michigan
Life is a quality that distinguishes matter that has biological processes, such as signaling and self-sustaining processes, from that which does not, and is defined by the capacity for growth, reaction to stimuli, metabolism, energy transformation, and reproduction. Various forms of life exist, such as plants, animals, fungi, protists, archaea, and bacteria. Biology is the science that studies life. The gene is the unit of heredity, whereas the cell is the structural and functional unit of life. There are two kinds of cells, prokaryotic and eukaryotic, both of which consist of cytoplasm enclosed within a membrane and contain many biomolecules such as proteins and nucleic acids. Cells reproduce through a process of cell division, in which the parent cell divides into two or more daughter cells and passes its genes onto a new generation, sometimes producing genetic variation. Organisms, or the individual entities of life, are generally thought to be open systems that maint ...
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Janet L
Janet may refer to: Names * Janet (given name) * Janet (French singer) (1939–2011) Surname * Charles Janet (1849–1932), French engineer, inventor and biologist, known for the Left Step periodic table * Jules Janet (1861–1945), French psychologist and psychotherapist * Maurice Janet (1888–1983), French mathematician * Paul Janet (1823–1899), French philosopher and writer * Pierre Janet (1859–1947), French psychologist, philosopher and psychotherapist * Roberto Janet (born 1986), Cuban hammer thrower Other uses * Janet, Alberta, a Canadian hamlet * Janet (airline), a military transport fleet known for servicing the US Air Force "Area 51" facility * JANET, a high-speed network for the UK research and education community * ''Janet'' (album), by Janet Jackson * ''Janet'' (video), a video compilation by Janet Jackson * Janet, a character in the TV series ''The Good Place'' * Hurricane Janet, 1955 * Janet, a character in the video game ''Brawl Stars ''Brawl Stars'' i ...
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Alison R
Alison may refer to: People * Alison (given name), including a list of people with the name * Alison (surname) Music * ''Alison'' (album), aka ''Excuse Me'', a 1975 album by Australian singer Alison MacCallum * "Alison" (song), song by Elvis Costello * "Alison (C'est ma copine à moi)", a 1993 single by Jordy * "Alison", 1994 single by Slowdive Places * Alison, New South Wales, suburb of the Central Coast region in NSW, Australia * Alison Sound, an inlet on the Central Coast of British Columbia, Canada * Point Alison, Alberta, a summer village in Alberta, Canada Other uses * ''Alison'' (film), a South African documentary film * ALISON (company), an educational technology company * Alison, common name for plants of the genus ''Alyssum'', including: ** Sweet alison, a decorative plant * ''Alison'' (katydid) a genus in the Hexacentrinae subfamily of bush crickets See also * Alisoun (other) * Alisson (other) * Allison (other) * Allisson (disambi ...
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Anna K
Anna K may refer to: *Anna K (designer) (born 1995), Ukrainian fashion designer *Anna K (singer) (born 1965), Czech singer *Anna K. or Anna Kjellberg, bassist for Drain STH and Revolting Cocks Revolting Cocks, also known as RevCo, are an American-Belgian industrial rock band, and sometimes supergroup, that began as a musical side project for Richard23 of Front 242, Luc van Acker, and Al Jourgensen of Ministry. History 1984: Or ... {{dab ...
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Daniel J
Daniel is a masculine given name and a surname of Hebrew origin. It means "God is my judge"Hanks, Hardcastle and Hodges, ''Oxford Dictionary of First Names'', Oxford University Press, 2nd edition, , p. 68. (cf. Gabriel—"God is my strength"), and derives from two early biblical figures, primary among them Daniel from the Book of Daniel. It is a common given name for males, and is also used as a surname. It is also the basis for various derived given names and surnames. Background The name evolved into over 100 different spellings in countries around the world. Nicknames (Dan, Danny) are common in both English and Hebrew; "Dan" may also be a complete given name rather than a nickname. The name "Daniil" (Даниил) is common in Russia. Feminine versions (Danielle, Danièle, Daniela, Daniella, Dani, Danitza) are prevalent as well. It has been particularly well-used in Ireland. The Dutch names "Daan" and "Daniël" are also variations of Daniel. A related surname developed ...
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University Of Michigan August 2013 126 (Life Sciences Institute)
A university () is an institution of higher (or tertiary) education and research which awards academic degrees in several academic disciplines. ''University'' is derived from the Latin phrase ''universitas magistrorum et scholarium'', which roughly means "community of teachers and scholars". Universities typically offer both undergraduate and postgraduate programs. The first universities in Europe were established by Catholic Church monks. The University of Bologna (), Italy, which was founded in 1088, is the first university in the sense of: *being a high degree-awarding institute. *using the word ''universitas'' (which was coined at its foundation). *having independence from the ecclesiastic schools and issuing secular as well as non-secular degrees (with teaching conducted by both clergy and non-clergy): grammar, rhetoric, logic, theology, canon law, notarial law.Hunt Janin: "The university in medieval life, 1179–1499", McFarland, 2008, , p. 55f.de Ridder-Symoens ...
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Natural Product
A natural product is a natural compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life. Natural products can also be prepared by chemical synthesis (both semisynthesis and total synthesis) and have played a central role in the development of the field of organic chemistry by providing challenging synthetic targets. The term natural product has also been extended for commercial purposes to refer to cosmetics, dietary supplements, and foods produced from natural sources without added artificial ingredients. Within the field of organic chemistry, the definition of natural products is usually restricted to organic compounds isolated from natural sources that are produced by the pathways of primary or secondary metabolism. Within the field of medicinal chemistry, the definition is often further restricted to secondary metabolites. Secondary metabolites (or specialized metabolites ...
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Cryo Electron Tomography
Electron cryotomography (CryoET) is an imaging technique used to produce high-resolution (~1–4 nm) three-dimensional views of samples, often (but not limited to) biological macromolecules and cells. CryoET is a specialized application of transmission electron cryomicroscopy (CryoTEM) in which samples are imaged as they are tilted, resulting in a series of 2D images that can be combined to produce a 3D reconstruction, similar to a CT scan of the human body. In contrast to other electron tomography techniques, samples are imaged under cryogenic conditions (< −150 °C). For cellular material, the structure is immobilized in non-crystalline, vitreous ice, allowing them to be imaged without dehydration or chemical fixation, which would otherwise disrupt or distort biological structures.


Description of technique


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Cryo-Electron Microscopy
Cryogenic electron microscopy (cryo-EM) is a cryomicroscopy technique applied on samples cooled to cryogenic temperatures. For biological specimens, the structure is preserved by embedding in an environment of vitreous ice. An aqueous sample solution is applied to a grid-mesh and plunge-frozen in liquid ethane or a mixture of liquid ethane and propane. While development of the technique began in the 1970s, recent advances in detector technology and software algorithms have allowed for the determination of biomolecular structures at near-atomic resolution. This has attracted wide attention to the approach as an alternative to X-ray crystallography or NMR spectroscopy for macromolecular structure determination without the need for crystallization. In 2017, the Nobel Prize in Chemistry was awarded to Jacques Dubochet, Joachim Frank, and Richard Henderson "for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution." ''Nature M ...
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Argonne National Laboratory
Argonne National Laboratory is a science and engineering research United States Department of Energy National Labs, national laboratory operated by University of Chicago, UChicago Argonne LLC for the United States Department of Energy. The facility is located in Lemont, Illinois, outside of Chicago, and is the largest national laboratory by size and scope in the Midwest. Argonne had its beginnings in the Metallurgical Laboratory of the University of Chicago, formed in part to carry out Enrico Fermi's work on nuclear reactors for the Manhattan Project during World War II. After the war, it was designated as the first national laboratory in the United States on July 1, 1946. In the post-war era the lab focused primarily on non-weapon related nuclear physics, designing and building the first power-producing nuclear reactors, helping design the reactors used by the United States' nuclear navy, and a wide variety of similar projects. In 1994, the lab's nuclear mission ended, and today ...
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