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Leica Biosystems
Leica Biosystems (founded 1989) is a medical devices company that develops and supplies clinical diagnostics to the pathology market. It is also a research, instrument, and medical device company as well as a division of Danaher Corporation. Company Description The company has headquarters in Germany with operations in the United Kingdom, Ireland, Netherlands, Bulgaria, Australia, India, China, Singapore, Mexico and the United States (California, Illinois, Massachusetts and Ohio). A research and development facility concentrating on companion diagnostics for cancer drugs has been in operation in Danvers, Massachusetts since August 2012.Seiffert, Don“Leica Biosystems plans to expand R&D facility in Mass.”Boston Business Journal. Feb. 1, 2013 The Massachusetts facility has partnered with Galena Biopharma to develop companion diagnostics for a breast cancer vaccine.Weintraub, Karen“Leica Biosystems plans R&D expansion in area.”The Boston Globe. Feb. 25, 2013 Leica Biosys ...
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Danvers, Massachusetts
Danvers is a town in Essex County, Massachusetts, United States, located on the Danvers River near the northeastern coast of Massachusetts. The suburb is a fairly short ride from Boston and is also in close proximity to the renowned beaches of Gloucester and Revere. Originally known as Salem Village, the town is most widely known for its association with the 1692 Salem witch trials. It was also the site of Danvers State Hospital, one of the state's 19th-century psychiatric hospitals. Danvers is a local center of commerce, hosting many car dealerships and the Liberty Tree Mall. As of the 2020 United States Census, the town's population was 28,087. History Pre-Columbian era The area was long settled by indigenous cultures of Native Americans. In the historic period, the Massachusett, a tribe of the Pequot language family, dominated the area. The land that is now Danvers was once owned by the Naumkeag branch of the Massachusett tribe. Salem Village Around 1630, English colonists im ...
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Danaher Subsidiaries
Danaher is a surname. Notable people with the surname include: * Declan Danaher, English Rugby union player * John Danaher (VC), Irish recipient of the Victoria Cross * John Danaher (martial artist), New Zealand Brazilian jiu-jitsu and mixed martial arts instructor * Kevin Danaher (Caoimhín Ó Danachair), (1913–2002), author and prominent Irish folklorist * Kevin Danaher (activist), Ph.D. in sociology, author of several books on Green Economy See also * Danaher Corporation Danaher Corporation is an American globally diversified conglomerate with its headquarters in Washington, D.C. The company designs, manufactures, and markets professional, medical, industrial, and commercial products and services. The company's ...
, a company headquartered in Washington, D.C. {{surname, Danaher ...
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Heinrich Wild
Heinrich Wild (Mitlödi, Canton of Glarus, November 15, 1877 – Baden, Switzerland, December 26, 1951) was a Swiss businessman, industrial designer, and inventor who was the founder of Wild Heerbrugg, a Swiss optical instruments manufacturing company. Biography At 15 years of age, Wild became an apprentice with the engineer Legler in Glarus (hydraulic engineer for the Linth River). He bought a small theodolite, and after a short time independently made expanded measurements of the flow of the river Linth. Later Wild joined the Geometerschule (geometer school) at Winterthur and came in 1899 as a trainee to the Landestopographie (Swisstopo is a popular designation for the Swiss Federal Office of Topography) in Bern. Due to his bad experiences with the high mountain triangulation with a theodolite of conventional design, he tried in 1905 to design a new theodolite with rotable circle with coincidence circle-readings. In 1907 he left the Landestopographie and moved to Jena, German ...
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Wild Heerbrugg
The Wild (Heerbrugg) company (pronounced "vilt") was founded in 1921 in Switzerland. The company manufactured optical instruments, such as surveying instruments, microscopes and instruments for photogrammetry among others. The company changed its name several times, first being known as "Heinrich Wild, Werkstätte für Feinmechanik und Optik", then "Verkaufs-Aktiengesellschaft Heinrich Wild's Geodätische Instrumente", later "Wild Heerbrugg AG", later "Wild-Leitz". The company was linked with Leica in 1989, then it became part of Leica Holding B.V. Its subsidiary Leica Geosystems AG became part of the Swedish Hexagon AB Group of companies in 2005. History On 26 April 1921 the company Heinrich Wild, Werkstätte für Feinmechanik und Optik was founded in Heerbrugg by three Swiss personalities: * the surveyor and inventor Heinrich Wild from Glarus * the investor Jacob Schmidheiny from Balgach * and the geologist Dr. Robert Helbling from Flums. Heinrich Wild (1877–1951), a l ...
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Mayo Clinic
The Mayo Clinic () is a nonprofit American academic medical center focused on integrated health care, education, and research. It employs over 4,500 physicians and scientists, along with another 58,400 administrative and allied health staff, across three major campuses: Rochester, Minnesota; Jacksonville, Florida; and Phoenix/Scottsdale, Arizona. The practice specializes in treating difficult cases through tertiary care and destination medicine. It is home to the top-15 ranked Mayo Clinic Alix School of Medicine in addition to many of the highest regarded residency education programs in the United States. It spends over $660 million a year on research and has more than 3,000 full-time research personnel. William Worrall Mayo settled his family in Rochester in 1864 and opened a sole proprietorship medical practice that evolved under his sons, Will and Charlie Mayo, along with practice partners Stinchfield, Graham, Plummer, Millet, Judd, and Balfour, into Mayo Clinic. Toda ...
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Biopsy
A biopsy is a medical test commonly performed by a surgeon, interventional radiologist, or an interventional cardiologist. The process involves extraction of sample cells or tissues for examination to determine the presence or extent of a disease. The tissue is then fixed, dehydrated, embedded, sectioned, stained and mounted before it is generally examined under a microscope by a pathologist; it may also be analyzed chemically. When an entire lump or suspicious area is removed, the procedure is called an excisional biopsy. An incisional biopsy or core biopsy samples a portion of the abnormal tissue without attempting to remove the entire lesion or tumor. When a sample of tissue or fluid is removed with a needle in such a way that cells are removed without preserving the histological architecture of the tissue cells, the procedure is called a needle aspiration biopsy. Biopsies are most commonly performed for insight into possible cancerous or inflammatory conditions. History T ...
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Galena Biopharma
Galena Biopharma (originally RXi Pharmaceuticals) was a publicly traded pharmaceutical company based in San Ramon, California. The company was founded in Worcester, Massachusetts. In 2011, it moved to Oregon, and in 2015 moved to San Ramon, California. Mark Schwartz was the company's president and chief executive officer. As of December 29, 2017, the company was acquired by Sellas Life Sciences Group Ltd. through a reverse merger transaction. Galena Biopharma was renamed to Sellas Life Sciences Group, Inc (). History In November 2006, Argonaut Pharmaceuticals, Inc. changed the name to RXi Pharmaceuticals Corporation. RXi was a subsidiary of CytRx Corp., which provided $15 million in financing in April 2007. RXi was founded in part by Nobel Prize winner Craig Mello. In September 2007, RXi signed a licensing deal with TriLink Biotechnologies, a competitor in the RNA interference (RNAi) field, in which RXi would pay TriLink to use three of TriLink's technologies. In March 2011, the c ...
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Germany
Germany,, officially the Federal Republic of Germany, is a country in Central Europe. It is the second most populous country in Europe after Russia, and the most populous member state of the European Union. Germany is situated between the Baltic and North seas to the north, and the Alps to the south; it covers an area of , with a population of almost 84 million within its 16 constituent states. Germany borders Denmark to the north, Poland and the Czech Republic to the east, Austria and Switzerland to the south, and France, Luxembourg, Belgium, and the Netherlands to the west. The nation's capital and most populous city is Berlin and its financial centre is Frankfurt; the largest urban area is the Ruhr. Various Germanic tribes have inhabited the northern parts of modern Germany since classical antiquity. A region named Germania was documented before AD 100. In 962, the Kingdom of Germany formed the bulk of the Holy Roman Empire. During the 16th ce ...
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Wetzlar
Wetzlar () is a city in the state of Hesse, Germany. It is the twelfth largest city in Hesse with currently 55,371 inhabitants at the beginning of 2019 (including second homes). As an important cultural, industrial and commercial center, the university town is one of the ten regional centers in the state of Hesse. A former free imperial city, it gained much of its fame as the seat of the Imperial Supreme Court (''Reichskammergericht'') of the Holy Roman Empire. Located 51 kilometers north of Frankfurt, at 8° 30′ E, 50° 34′ N, Wetzlar straddles the river Lahn and is on the German Timber-Frame Road, which passes mile upon mile of half-timbered houses. Historically, the city has acted as the hub of the Lahn-Dill-Kreis on the north edge of the Taunus. Tourists know the city for its ancient town and its medieval Catholic/Protestant shared cathedral of St. Mary. Notable architectural features include the Eisenmarkt and the steep gradients and tightly-packed street layout of a me ...
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Medical Devices
A medical device is any device intended to be used for medical purposes. Significant potential for hazards are inherent when using a device for medical purposes and thus medical devices must be proved safe and effective with reasonable assurance before regulating governments allow marketing of the device in their country. As a general rule, as the associated risk of the device increases the amount of testing required to establish safety and efficacy also increases. Further, as associated risk increases the potential benefit to the patient must also increase. Discovery of what would be considered a medical device by modern standards dates as far back as c. 7000 BC in Baluchistan where Neolithic dentists used flint-tipped drills and bowstrings. Study of archeology and Roman medical literature also indicate that many types of medical devices were in widespread use during the time of ancient Rome. In the United States it wasn't until the Federal Food, Drug, and Cosmetic Act (FD& ...
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Vibratome
A vibratome is an instrument used to cut thin slices of material (although, usually thicker slices than those cut in paraffin-embedded samples using a microtome). It is similar to a microtome but uses a vibrating blade to cut through tissue. The vibration amplitude, the speed, and the angle of the blade can all be controlled. Fixed or fresh tissue pieces are embedded in low gelling temperature agarose. The resulting agarose block containing the tissue piece is then attached to a metal block and sectioned while submerged in a water or buffer bath. Individual sections are then collected with a fine brush and transferred to slides or multiwell plates for staining. Vibratome is not a generic name but a registered trademark of Leica Biosystems Richmond, Inc. in the USA. Advantages *No need to dehydrate tissues prior to embedding, thus decreased loss of cell constituents *No messy paraffin Paraffin may refer to: Substances * Paraffin wax, a white or colorless soft solid that is us ...
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