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Laura Landweber
Laura Faye Landweber is an American evolutionary biologist. , she is a professor of biochemistry and molecular biophysics and of biological sciences at Columbia University. Previously, she was a professor of ecology and evolutionary biology at Princeton University. She specializes in RNA-mediated epigenetic inheritance and molecular evolution. Education Landweber graduated summa cum laude with an A.B. in molecular biology from Princeton University in 1989 after completing a 50-page-long senior thesis titled "A Method for Evolutionary Sequence Analysis of Genes and Pseudogenes Using the Polymerase Chain Reaction: Applications to the Mouse Tcp-1 Gene." She received her M.A. and Ph.D. from Harvard University in 1991 and 1993, respectively. Her doctoral dissertation is titled "RNA editing and the evolution of mitochondrial DNA in kinetoplastid protozoa." Research career In 1994, Landweber became a faculty member of Princeton University at the age of 26. In a 2000 paper publish ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Steven Gubser
Steven Scott Gubser (May 4, 1972 – August 3, 2019) was a professor of physics at Princeton University. His research focused on theoretical particle physics, especially string theory, and the AdS/CFT correspondence. He was a widely cited scholar in these and other related areas. Gubser did foundational work in the AdS/CFT correspondence as a graduate student. In particular, his 1998 paper ''Gauge Theory Correlators from Non-Critical String Theory'' with his advisor Igor Klebanov and another Princeton physics professor Alexander Markovich Polyakov, made a precise statement of the AdS/CFT duality. It is one of the all-time top cited papers in theoretical high-energy physics, and is commonly known, along with Edward Witten's 1998 work ''Anti De Sitter Space And Holography'', as the GKPW dictionary. After receiving a Ph.D. in 1998 from Princeton, Gubser became a Junior Fellow at Harvard University before taking a position as an assistant professor at Princeton. In 2001, he moved ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
T-complex 1
T-complex protein 1 subunit alpha is a protein that in humans is encoded by the ''TCP1'' gene. Function This gene encodes a molecular chaperone that is a member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. Interactions T-complex 1 has been shown to interact with PPP4C and HDAC3. CCT also directly interacts with lectin type oxidized LDL receptor-1 (LOX-1) while its ligand oxidized low density lipoprotein (OxLDL) disassociates CCT from LOX-1 Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) also known as lectin-type oxidized LDL receptor 1 (LOX-1) is a protein that in humans is encoded by the ''OLR1'' gene. LOX-1 i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sigma Xi
Sigma Xi, The Scientific Research Honor Society () is a highly prestigious, non-profit honor society for scientists and engineers. Sigma Xi was founded at Cornell University by a junior faculty member and a small group of graduate students in 1886, making it one of the oldest honor societies. Membership in Sigma Xi is by invitation only, where members nominate others on the basis of their research achievements or potential. Sigma Xi goals aim to honor excellence in scientific investigation and encourage cooperation among researchers in all fields of science and engineering. Information about Sigma Xi has nearly 100,000 members who were elected to membership based on their research achievements and potential. It has more than 500 chapters in North America and around the world. In addition to publishing ''American Scientist'' magazine, Sigma Xi provides grants annually to promising young researchers and sponsors a variety of programs supporting ethics in research, science and engineer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Non-coding RNA
A non-coding RNA (ncRNA) is a functional RNA molecule that is not translated into a protein. The DNA sequence from which a functional non-coding RNA is transcribed is often called an RNA gene. Abundant and functionally important types of non-coding RNAs include transfer RNAs (tRNAs) and ribosomal RNAs (rRNAs), as well as small RNAs such as microRNAs, siRNAs, piRNAs, snoRNAs, snRNAs, exRNAs, scaRNAs and the long ncRNAs such as Xist and HOTAIR. The number of non-coding RNAs within the human genome is unknown; however, recent transcriptomic and bioinformatic studies suggest that there are thousands of non-coding transcripts. Many of the newly identified ncRNAs have not been validated for their function. There is no consensus in the literature on how much of non-coding transcription is functional. Some researchers have argued that many ncRNAs are non-functional (sometimes referred to as "junk RNA"), spurious transcriptions. Others, however, disagree, arguing instead that many ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Micronucleus
Micronucleus is the name given to the small nucleus that forms whenever a chromosome or a fragment of a chromosome is not incorporated into one of the daughter nuclei during cell division. It usually is a sign of genotoxic events and chromosomal instability. Micronuclei are commonly seen in cancerous cells and may indicate genomic damage events that can increase the risk of developmental or degenerative diseases. Micronuclei form during anaphase from lagging acentric chromosome or chromatid fragments caused by incorrectly repaired or unrepaired DNA breaks or by nondisjunction of chromosomes. This incorrect segregation of chromosomes may result from hypomethylation of repeat sequences present in pericentromeric DNA, irregularities in kinetochore proteins or their assembly, dysfunctional spindle apparatus, or flawed anaphase checkpoint genes. Micronuclei can contribute to genome instability by promoting a catastrophic mutational event called chromothripsis. Many micronucleus assays ha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genome
In the fields of molecular biology and genetics, a genome is all the genetic information of an organism. It consists of nucleotide sequences of DNA (or RNA in RNA viruses). The nuclear genome includes protein-coding genes and non-coding genes, other functional regions of the genome such as regulatory sequences (see non-coding DNA), and often a substantial fraction of 'junk' DNA with no evident function. Almost all eukaryotes have mitochondria and a small mitochondrial genome. Algae and plants also contain chloroplasts with a chloroplast genome. The study of the genome is called genomics. The genomes of many organisms have been sequenced and various regions have been annotated. The International Human Genome Project reported the sequence of the genome for ''Homo sapiens'' in 200The Human Genome Project although the initial "finished" sequence was missing 8% of the genome consisting mostly of repetitive sequences. With advancements in technology that could handle sequenci ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amino Acid
Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although hundreds of amino acids exist in nature, by far the most important are the alpha-amino acids, which comprise proteins. Only 22 alpha amino acids appear in the genetic code. Amino acids can be classified according to the locations of the core structural functional groups, as Alpha and beta carbon, alpha- , beta- , gamma- or delta- amino acids; other categories relate to Chemical polarity, polarity, ionization, and side chain group type (aliphatic, Open-chain compound, acyclic, aromatic, containing hydroxyl or sulfur, etc.). In the form of proteins, amino acid '' residues'' form the second-largest component (water being the largest) of human muscles and other tissues. Beyond their role as residues in proteins, amino acids participate in a number of processes such as neurotransmitter transport and biosynthesis. It is thought that they played a key role in enabling life ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Codons
The genetic code is the set of rules used by living cells to translate information encoded within genetic material ( DNA or RNA sequences of nucleotide triplets, or codons) into proteins. Translation is accomplished by the ribosome, which links proteinogenic amino acids in an order specified by messenger RNA (mRNA), using transfer RNA (tRNA) molecules to carry amino acids and to read the mRNA three nucleotides at a time. The genetic code is highly similar among all organisms and can be expressed in a simple table with 64 entries. The codons specify which amino acid will be added next during protein biosynthesis. With some exceptions, a three-nucleotide codon in a nucleic acid sequence specifies a single amino acid. The vast majority of genes are encoded with a single scheme (see the RNA codon table). That scheme is often referred to as the canonical or standard genetic code, or simply ''the'' genetic code, though variant codes (such as in mitochondria) exist. History Efforts ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxytricha
''Oxytricha'' is a genus of ciliates in the family Oxytrichidae. Genomics The draft macronuclear genome of ''Oxytricha trifallax'' was published in 2013. Species References Spirotrichea Ciliate genera {{Ciliate-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ciliate
The ciliates are a group of alveolates characterized by the presence of hair-like organelles called cilia, which are identical in structure to flagellum, eukaryotic flagella, but are in general shorter and present in much larger numbers, with a different wikt:undulating, undulating pattern than flagella. Cilia occur in all members of the group (although the peculiar Suctoria only have them for part of their biological life cycle, life cycle) and are variously used in swimming, crawling, attachment, feeding, and sensation. Ciliates are an important group of protists, common almost anywhere there is water—in lakes, ponds, oceans, rivers, and soils. About 4,500 unique free-living species have been described, and the potential number of extant species is estimated at 27,000–40,000. Included in this number are many Ectosymbiosis, ectosymbiotic and endosymbiotic species, as well as some Obligate parasite, obligate and Facultative parasite, opportunistic parasites. Ciliate species r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetic Code
The genetic code is the set of rules used by living cells to translate information encoded within genetic material ( DNA or RNA sequences of nucleotide triplets, or codons) into proteins. Translation is accomplished by the ribosome, which links proteinogenic amino acids in an order specified by messenger RNA (mRNA), using transfer RNA (tRNA) molecules to carry amino acids and to read the mRNA three nucleotides at a time. The genetic code is highly similar among all organisms and can be expressed in a simple table with 64 entries. The codons specify which amino acid will be added next during protein biosynthesis. With some exceptions, a three-nucleotide codon in a nucleic acid sequence specifies a single amino acid. The vast majority of genes are encoded with a single scheme (see the RNA codon table). That scheme is often referred to as the canonical or standard genetic code, or simply ''the'' genetic code, though variant codes (such as in mitochondria) exist. History Effor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Computing
DNA computing is an emerging branch of unconventional computing which uses DNA, biochemistry, and molecular biology hardware, instead of the traditional electronic computing. Research and development in this area concerns theory, experiments, and applications of DNA computing. Although the field originally started with the demonstration of a computing application by Len Adleman in 1994, it has now been expanded to several other avenues such as the development of storage technologies, nanoscale imaging modalities, synthetic controllers and reaction networks, etc. A brief history of DNA computing and molecular programming Leonard Adleman of the University of Southern California initially developed this field in 1994. — The first DNA computing paper. Describes a solution for the directed Hamiltonian path problem. Also available here: Adleman demonstrated a proof-of-concept use of DNA as a form of computation which solved the seven-point Hamiltonian path problem. Since the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
