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LGBTIQ
Intersex people are born with sex characteristics (such as genitals, gonads, and chromosome patterns) that "do not fit the typical definitions for male or female bodies". They are substantially more likely to identify as lesbian, gay, bisexual, or transgender (LGBT) than the non-intersex population, with an estimated 52% identifying as non-heterosexual and 8.5% to 20% experiencing gender dysphoria. Although many intersex people are heterosexual and cisgender, this overlap and "shared experiences of harm arising from dominant societal sex and gender norms" has led to intersex people often being included under the LGBT umbrella, with the acronym sometimes expanded to LGBTI. However, some intersex activists and organisations have criticised this inclusion as distracting from intersex-specific issues such as involuntary medical interventions. Intersex and homosexuality Intersex can be contrasted with ''homosexuality'' or ''same-sex attraction''. Numerous studies have shown highe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
LGBT
' is an initialism that stands for lesbian, gay, bisexual, and transgender. In use since the 1990s, the initialism, as well as some of its common variants, functions as an umbrella term for sexuality and gender identity. The LGBT term is an adaptation of the initialism ', which began to replace the term ''gay'' (or ''gay and lesbian'') in reference to the broader LGBT community beginning in the mid-to-late 1980s. When not inclusive of transgender people, the shorter term LGB is still used instead of LGBT. It may refer to anyone who is non-heterosexual or non-cisgender, instead of exclusively to people who are lesbian, gay, bisexual, or transgender. To recognize this inclusion, a popular variant, ', adds the letter ''Q'' for those who identify as queer or are questioning their sexual or gender identity. The initialisms ''LGBT'' or ''GLBT'' are not agreed to by everyone that they are supposed to include. History of the term The first widely used term, '' homosexual'', ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intersex Rights In Australia
Intersex rights in Australia are protections and rights afforded to intersex people through statutes, regulations, and international human rights treaties, including through the ''Sex Discrimination Act 1984'' (Cth) which makes it unlawful to discriminate against a person based upon that person's intersex status in contexts such as work, education, provision of services, and accommodation. Discrimination on the ground of intersex status. Australia was the first country to conduct a parliamentary inquiry into involuntary or coerced medical interventions on intersex people. A 2016 Family Court case authorising a gonadectomy and consequential surgery on a young child has attracted public commentary for disclosing those medical interventions, their rationales, and a prior clitorectomy and labiaplasty. In March 2017, Australian and New Zealand community organizations issued a joint call for legal reform, including the criminalization of deferrable intersex medical interventions o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intersex
Intersex people are individuals born with any of several sex characteristics including chromosome patterns, gonads, or genitals that, according to the Office of the United Nations High Commissioner for Human Rights, "do not fit typical binary notions of male or female bodies". Sex assignment at birth usually aligns with a child's anatomical sex and phenotype. The number of births with ambiguous genitals is in the range of 1:2000–1:4500 (0.022%–0.05%). Other conditions involve atypical chromosomes, gonads, or hormones. Some persons may be assigned and raised as a girl or boy but then identify with another gender later in life, while most continue to identify with their assigned sex. The number of births where the baby is intersex has been reported differently depending on who reports and which definition of intersex is used. Anne Fausto-Sterling and her co-authors suggest that the prevalence of "nondimorphic sexual development" might be as high as 1.7%. A study publish ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intersex Human Rights
Intersex people are born with sex characteristics, such as chromosomes, gonads, or genitals, that, according to the UN Office of the High Commissioner for Human Rights, "do not fit typical binary notions of male or female bodies." Intersex people face Social stigma, stigmatisation and discrimination from birth, particularly when an intersex variation is visible. In some countries (particularly in Africa and Asia) this may include infanticide, abandonment and the stigmatization of families. Mothers in East Africa may be accused of witchcraft, and the birth of an intersex child may be described as a curse. Intersex infants and children, such as those with ambiguous outer genitalia, may be surgically and/or hormonally altered to fit perceived more socially acceptable sex characteristics. However, this is considered controversial, with no firm evidence of good outcomes. Such treatments may involve sterilization. Adults, including elite female athletes, have also been subjects of suc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Hastings Center
The Hastings Center is an independent, nonpartisan bioethics research institute and think tank based in Garrison, New York. It was instrumental in establishing the field of bioethics and is among the most prestigious bioethics and health policy institutes in the world. Its mission is to address ethical issues in health care, science, and technology. Through its projects and publications, the center aims to influence the ideas of health policy-makers, regulators, health care professionals, lawyers, journalists, and students. The center is funded by grants, private donations and journal subscriptions. Founding The Hastings Center was founded in 1969 by Daniel Callahan and Willard Gaylin, originally as the Institute of Society, Ethics, and the Life Sciences. It was first located in Hastings-on-Hudson, New York, and is now in Garrison, New York, on the former Woodlawn estate designed by Richard Upjohn. In the early years, the center identified four core issues as its domain: ''pop ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anne Tamar-Mattis
Anne Tamar-Mattis is an American attorney, human rights advocate, and founder of interACT (formerly Advocates for Informed Choice). She currently serves as interACT's Legal Director. Career Anne Tamar-Mattis spent six years as the Director of the National Youth Talkline at Lavender Youth Recreation & Information Center, a national peer-support line for LGBTQ youth. She became the first Program Director for the San Francisco LGBT Community Center in 2001. In 2003 she took a hiatus to attend law school and graduated from the University of California, Berkeley School of Law in 2006. Tamar-Mattis founded interACT with the support of fellowships from Equal Justice Works (2006) and Echoing Green (2008). She has been an adjunct professor at the University of California, Berkeley School of Law since 2008 where she teaches Sexual Orientation & the Law. Selected bibliography Selected publications include: * * * * * * * * * * * Awards and recognition In 2010, Anne Tamar-Mat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alice Dreger
Alice Domurat Dreger () is an American historian, bioethicist, author, and former professor of clinical medical humanities and bioethics at the Feinberg School of Medicine, Northwestern University in Chicago, Illinois. Dreger engages in academic work and activism in support of individuals born with atypical sex characteristics (intersex or disorders of sex development) and individuals born as conjoined twins. She challenges the perception that those with physical differences are somehow "broken" and need to be "fixed". She has opposed the use of "corrective" surgery on babies whose genitalia are considered "ambiguous". She has criticized the failure to follow such patients in later life, and reported longer-term medical and psychological difficulties experienced by some of the people whose sex is arbitrarily assigned. She supported J. Michael Bailey in the face of controversy over his book ''The Man Who Would Be Queen''. Dreger has been criticized by transgender activist Lynn Co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Congenital Adrenal Hyperplasia
Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders characterized by impaired cortisol synthesis. It results from the deficiency of one of the five enzymes required for the synthesis of cortisol in the adrenal cortex. Most of these disorders involve excessive or deficient production of hormones such as glucocorticoids, mineralocorticoids, or sex steroids, and can alter development of primary or secondary sex characteristics in some affected infants, children, or adults. It is one of the most common autosomal recessive disorders in humans. Types CAH can occur in various forms. The clinical presentation of each form is different and depends to a large extent on the underlying enzyme defect, its precursor retention, and deficient products. Classical forms appear in infancy, and nonclassical forms appear in late childhood. The presentation in patients with classic CAH can be further subdivided into two forms: salt-wasting and simple-virilizing, depending ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Maria New
Maria Iandolo New is a professor of Pediatrics, Genomics and Genetics at Icahn School of Medicine at Mount Sinai in New York City. She is an expert in congenital adrenal hyperplasia (CAH), a genetic condition affecting the adrenal gland that can affect sexual development. Medical education New received her undergraduate degree from Cornell University in Ithaca, New York, in 1950, and her M. D. from the Perelman School of Medicine at the University of Pennsylvania in Philadelphia, in 1954. She completed an internship in medicine at Bellevue Hospital in New York, followed by a residency in pediatrics at the New York Hospital. From 1957 to 1958 she studied renal functioning under a fellowship from the National Institutes of Health (NIH). She was a research pediatrician to the Diabetic Study Group of the Comprehensive Care Teaching Program at the New York Hospital-Cornell Medical Center from 1958 to 1961, and had a second NIH fellowship under Ralph E. Peterson from 1961 to 1964, to s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
17β-Hydroxysteroid Dehydrogenase III Deficiency
17β-Hydroxysteroid dehydrogenase III deficiency is a rare autosomal recessive disorder of sexual development condition that is a cause of 46,XY disorder of sex development (46,XY DSD). The impaired testosterone biosynthesis by 17β-hydroxysteroid dehydrogenase III (17β-HSD III), presents as atypical genitalia in affected males. Signs and symptoms 17-β-Hydroxysteroid dehydrogenase III deficiency is a cause of 46,XY disorder of sex development (46,XY DSD) that presents in males with variable effects on genitalia which can be complete or predominantly female with a blind vaginal pouch. Testes are often found in the inguinal canal or in a bifid scrotum. Wolffian derivatives including the epididymides, vas deferens, seminal vesicles, and ejaculatory ducts are present. The autosomal recessive deficiency arises are a result of homozygous or compound heterozygous mutations in HSD17B3 gene which encodes the 17β-hydroxysteroid dehydrogenase III enzyme, impairing of the conver ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
5α-Reductase Deficiency
5α-Reductases, also known as 3-oxo-5α-steroid 4-dehydrogenases, are enzymes involved in steroid metabolism. They participate in three metabolic pathways: bile acid biosynthesis, androgen and estrogen metabolism. There are three isozymes of 5α-reductase encoded by the genes SRD5A1, SRD5A2, and SRD5A3. 5α-Reductases catalyze the following generalized chemical reaction: :a 3-oxo-5α-steroid + acceptor a 3-oxo-Δ4-steroid + reduced acceptor Where a 3-oxo-5α-steroid and acceptor are substrates, and a corresponding 3-oxo-Δ4-steroid and the reduced acceptor are products. An instance of this generalized reaction that 5α-reductase type 2 catalyzes is: :dihydrotestosterone + NADP+ \rightleftharpoons testosterone + NADPH + H+ where dihydrotestosterone is the 3-oxo-5α-steroid, NADP+ is the acceptor and testosterone is the 3-oxo-Δ4-steroid and NADPH the reduced acceptor. Production and activity The enzyme is produced in many tissues in both males and females, in the rep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Partial Androgen Insensitivity Syndrome
Partial androgen insensitivity syndrome (PAIS) is a condition that results in the partial inability of the Eukaryote#Animal cell, cell to respond to androgens. It is an X linked recessive condition. The partial unresponsiveness of the cell to the presence of androgenic hormones impairs the Development of the reproductive system#External genitalia, masculinization of male genitalia in the developing fetus, as well as the development of male Secondary sex characteristics, secondary sexual characteristics at puberty, but does not significantly impair female genital or sexual development. As such, the insensitivity to androgens is clinically significant only when it occurs in individuals with a Y chromosome (or more specifically, an SRY, SRY gene). Clinical features include ambiguous genitalia at birth and primary amenhorrhoea with clitoromegaly with inguinal masses. Mullerian structures are not present in the individual. PAIS is one of three types of androgen insensitivity syndrome, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
