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Kohzoh Imai
is a Japanese physician and oncologist specializing in molecular diagnosis and novel medical treatment of cancer. He is well known for the discovery of a melanoma-related antigen (later, it is called, Chondroitin Sulfate Proteoglycan-4 (CSPG4)) by producing a monoclonal antibody. In addition, he produced monoclonal antibodies against CEA or ICAM-1 and found out they are usable in the diagnosis and the pathological analysis. He is a former professor and president of Sapporo Medical University. He was a Council Member of the Science Council of Japan (The 20th and 21st term). Also he was invited by the Emperor and Empress to their spring garden party in 2009. He was a professor and the director at Research Hospital, The Institute of Medical Science, the University of Tokyo , abbreviated as or UTokyo, is a public research university located in Bunkyō, Tokyo, Japan. Established in 1877, the university was the first Imperial University and is currently a Top Type university of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CSPG4
Chondroitin sulfate proteoglycan 4, also known as melanoma-associated chondroitin sulfate proteoglycan (MCSP) or neuron-glial antigen 2 (NG2), is a chondroitin sulfate proteoglycan that in humans is encoded by the ''CSPG4'' gene. Function CSPG4 plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. It represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells. Implications in disease CSPG4/NG2 is also a hallmark protein of oligodendrocyte progenitor cells (OPCs) and OPC dysfunction has been implicated as a candidate pathophysiological mechanism of familial schizophrenia. A research group investigating the role of genetics in schizophrenia, reported, two rare missense mutations in ''CSPG4'' gene'','' segregating within families (''CSPG4A131T'' and ''CSPG4V901G'' mutations). The researchers also demonstrate that the induced pluripotent stem cells ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Monoclonal Antibody
A monoclonal antibody (mAb, more rarely called moAb) is an antibody produced from a cell Lineage made by cloning a unique white blood cell. All subsequent antibodies derived this way trace back to a unique parent cell. Monoclonal antibodies can have monovalent affinity, binding only to the same epitope (the part of an antigen that is recognized by the antibody). In contrast, polyclonal antibodies bind to multiple epitopes and are usually made by several different antibody-secreting plasma cell lineages. Bispecific monoclonal antibodies can also be engineered, by increasing the therapeutic targets of one monoclonal antibody to two epitopes. It is possible to produce monoclonal antibodies that specifically bind to virtually any suitable substance; they can then serve to detect or purify it. This capability has become an investigative tool in biochemistry, molecular biology, and medicine. Monoclonal antibodies are being used on a clinical level for both the diagnosis and thera ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ICAM-1
ICAM-1 ( Intercellular Adhesion Molecule 1) also known as CD54 (Cluster of Differentiation 54) is a protein that in humans is encoded by the ''ICAM1'' gene. This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by rhinovirus as a receptor for entry into respiratory epithelium. Structure ICAM-1 is a member of the immunoglobulin superfamily, the superfamily of proteins including antibodies and T-cell receptors. ICAM-1 is a transmembrane protein possessing an amino-terminus extracellular domain, a single transmembrane domain, and a carboxy-terminus cytoplasmic domain. The structure of ICAM-1 is characterized by heavy glycosylation, and the protein’s extracellular domain is composed of multiple loops created by disulfide bridges within the protein. The dominant secondary structure of the protein is the beta sheet, leadi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sapporo Medical University
is a public university in Chūō-ku, Sapporo, Hokkaidō, Japan. The precursor of the school was founded in 1945, and it was chartered as a university in 1950. History The , the precursor of the university, was founded in 1945. The Sapporo Medical University was established in 1950 with the School of Medicine, and the Graduate School of Medicine was also founded in 1956, as part of Hokkaidō's development project. In 1968, Jurō Wada, one of the pioneers of heart surgery, performed a heart transplant for the first time in Japan, which was later accused of a failure in the Wada Heart Transplant Incident. The Sapporo Medical University Hygiene Junior College was established in 1983, and it was reorganized and incorporated to its current School of Health Science in 1993. Overview The University has a hospital in affiliation, called Sapporo Medical University Hospital, and has performed a number of surgeries including organ transplant. It hosts the Bilomedical Research Center, th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Science Council Of Japan
The Science Council of Japan (SCJ) is a representative organization of Japanese scholars and scientists in all fields of sciences, including humanities, social sciences, life sciences, natural sciences, and engineering. , president of Toyohashi Tech, is the elected president as of 2016, having been elected for two consecutive terms starting in 2013. The SCJ is headquartered in Roppongi, a district of Minato, Tokyo. Members of the SCJ are elected by scientists of all levels, including research scholars. Elected members are confirmed by the Government of Japan, a method similar to that of the National Academy of Sciences in the United States, upon which the structure of the SCJ was based. It was officially founded in January 1949 to function as an independent scientific statutory body under the jurisdiction of the Prime Minister of Japan. As of 2015, the SCJ consists of 210 elected members appointed by the prime minister and 2,000 associate members. Its organizational setup inclu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Tokyo
, abbreviated as or UTokyo, is a public research university located in Bunkyō, Tokyo, Japan. Established in 1877, the university was the first Imperial University and is currently a Top Type university of the Top Global University Project by the Japanese government. UTokyo has 10 faculties, 15 graduate schools and enrolls about 30,000 students, about 4,200 of whom are international students. In particular, the number of privately funded international students, who account for more than 80%, has increased 1.75 times in the 10 years since 2010, and the university is focusing on supporting international students. Its five campuses are in Hongō, Komaba, Kashiwa, Shirokane and Nakano. It is considered to be the most selective and prestigious university in Japan. As of 2021, University of Tokyo's alumni, faculty members and researchers include seventeen prime ministers, 18 Nobel Prize laureates, four Pritzker Prize laureates, five astronauts, and a Fields Medalist. H ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medals Of Honor (Japan)
are medals awarded by the Government of Japan. They are awarded to individuals who have done meritorious deeds and also to those who have achieved excellence in their field of work. The Medals of Honor were established on December 7, 1881, and were first awarded the following year. Several expansions and amendments have been made since then. The medal design for all six types are the same, bearing the stylized characters on a gilt central disc surrounded by a silver ring of cherry blossoms on the obverse; only the colors of the ribbon differ. If for some reason an individual were to receive a second medal of the same ribbon colour, then a second medal is not issued but rather a new bar is added to their current medal. The Medals of Honor are awarded twice each year, on April 29 (the birthday of the Shōwa Emperor) and November 3 (the birthday of the Meiji Emperor). Types Red ribbon First awarded in 1882. Awarded to individuals who have risked their own lives to save the live ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cancer Researchers
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements. While these symptoms may indicate cancer, they can also have other causes. Over 100 types of cancers affect humans. Tobacco use is the cause of about 22% of cancer deaths. Another 10% are due to obesity, poor diet, lack of physical activity or excessive drinking of alcohol. Other factors include certain infections, exposure to ionizing radiation, and environmental pollutants. In the developing world, 15% of cancers are due to infections such as '' Helicobacter pylori'', hepatitis B, hepatitis C, human papillomavirus infection, Epstein–Barr virus and human immunodeficiency virus (HIV). These factors act, at least partly, by changing the genes of a ce ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
People From Hakodate
A person ( : people) is a being that has certain capacities or attributes such as reason, morality, consciousness or self-consciousness, and being a part of a culturally established form of social relations such as kinship, ownership of property, or legal responsibility. The defining features of personhood and, consequently, what makes a person count as a person, differ widely among cultures and contexts. In addition to the question of personhood, of what makes a being count as a person to begin with, there are further questions about personal identity and self: both about what makes any particular person that particular person instead of another, and about what makes a person at one time the same person as they were or will be at another time despite any intervening changes. The plural form "people" is often used to refer to an entire nation or ethnic group (as in "a people"), and this was the original meaning of the word; it subsequently acquired its use as a plural form of pe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Academic Staff Of The University Of Tokyo
An academy (Attic Greek: Ἀκαδήμεια; Koine Greek Ἀκαδημία) is an institution of secondary or tertiary higher learning (and generally also research or honorary membership). The name traces back to Plato's school of philosophy, founded approximately 385 BC at Akademia, a sanctuary of Athena, the goddess of wisdom and skill, north of Athens, Greece. Etymology The word comes from the ''Academy'' in ancient Greece, which derives from the Athenian hero, ''Akademos''. Outside the city walls of Athens, the gymnasium was made famous by Plato as a center of learning. The sacred space, dedicated to the goddess of wisdom, Athena, had formerly been an olive grove, hence the expression "the groves of Academe". In these gardens, the philosopher Plato conversed with followers. Plato developed his sessions into a method of teaching philosophy and in 387 BC, established what is known today as the Old Academy. By extension, ''academia'' has come to mean the accumulation, dev ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1948 Births
Events January * January 1 ** The General Agreement on Tariffs and Trade (GATT) is inaugurated. ** The Constitution of New Jersey (later subject to amendment) goes into effect. ** The railways of Britain are nationalized, to form British Railways. * January 4 – Burma gains its independence from the United Kingdom, becoming an independent republic, named the ''Union of Burma'', with Sao Shwe Thaik as its first President, and U Nu its first Prime Minister. * January 5 ** Warner Brothers shows the first color newsreel ('' Tournament of Roses Parade'' and the '' Rose Bowl Game''). ** The first Kinsey Report, ''Sexual Behavior in the Human Male'', is published in the United States. * January 7 – Mantell UFO incident: Kentucky Air National Guard pilot Thomas Mantell crashes while in pursuit of an unidentified flying object. * January 12 – Mahatma Gandhi begins his fast-unto-death in Delhi, to stop communal violence during the Partition of India. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Living People
Related categories * :Year of birth missing (living people) / :Year of birth unknown * :Date of birth missing (living people) / :Date of birth unknown * :Place of birth missing (living people) / :Place of birth unknown * :Year of death missing / :Year of death unknown * :Date of death missing / :Date of death unknown * :Place of death missing / :Place of death unknown * :Missing middle or first names See also * :Dead people * :Template:L, which generates this category or death years, and birth year and sort keys. : {{DEFAULTSORT:Living people 21st-century people People by status ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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