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Kashin–Beck Disease
Kashin–Beck disease (KBD) is a chronic condition, chronic, endemic (epidemiology), endemic type of osteochondropathy (disease of the bone) that is mainly distributed from northeastern to southwestern China, including 15 provinces of China, provinces. As of 2011, Tibet has the highest incidence rate of KBD in China. Southeast Siberia and North Korea are other affected areas. KBD usually involves children ages 5–15. To date, more than a million individuals have had KBD. The symptoms of KBD include joint pain, morning stiffness in the joints, disturbances of flexion and extension in the elbows, enlarged inter-phalangeal joints, and limited motion in many joints of the body. Death of cartilage cells in the growth plate and articular surface is the basic pathologic feature; this can result in growth retardation and secondary osteoarthrosis. Histological diagnosis of KBD is particularly difficult; clinical and radiological examinations have proved to be the best means for identifying ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rheumatology
Rheumatology (Greek ''ῥεῦμα'', ''rheûma'', flowing current) is a branch of medicine devoted to the diagnosis and management of disorders whose common feature is inflammation in the bones, muscles, joints, and internal organs. Rheumatology covers more than 100 different complex diseases, collectively known as rheumatic diseases, which includes many forms of arthritis as well as lupus and Sjögren's syndrome. Doctors who have undergone formal training in rheumatology are called rheumatologists. Many of these diseases are now known to be disorders of the immune system, and rheumatology has significant overlap with immunology, the branch of medicine that studies the immune system. Rheumatologist A rheumatologist is a physician who specializes in the field of medical sub-specialty called rheumatology. A rheumatologist holds a board certification after specialized training. In the United States, training in this field requires four years undergraduate school, four year ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mycotoxin
A mycotoxin (from the Greek μύκης , "fungus" and τοξίνη , "toxin") is a toxic secondary metabolite produced by organisms of kingdom Fungi and is capable of causing disease and death in both humans and other animals. The term 'mycotoxin' is usually reserved for the toxic chemical products produced by fungi that readily colonize crops. Examples of mycotoxins causing human and animal illness include aflatoxin, citrinin, fumonisins, ochratoxin A, patulin, trichothecenes, zearalenone, and ergot alkaloids such as ergotamine. One mold species may produce many different mycotoxins, and several species may produce the same mycotoxin. Production Most fungi are aerobic (use oxygen) and are found almost everywhere in extremely small quantities due to the diminute size of their spores. They consume organic matter wherever humidity and temperature are sufficient. Where conditions are right, fungi proliferate into colonies and mycotoxin levels become high. The reason for the product ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PPARGC1B
Peroxisome proliferator-activated receptor gamma coactivator 1-beta is a protein that in humans is encoded by the ''PPARGC1B'' gene. See also * PPARGC1A * Peroxisome proliferator-activated receptor * Peroxisome proliferator-activated receptor alpha * Peroxisome proliferator-activated receptor delta Peroxisome proliferator-activated receptor delta (PPAR-delta), or (PPAR-beta), also known as Nuclear hormone receptor 1 (NUC1) is a nuclear receptor that in humans is encoded by the ''PPARD'' gene. This gene encodes a member of the peroxisome pr ... * Peroxisome proliferator-activated receptor gamma * Transcription coregulator References Further reading * * * * * * * * * * * * * * * * * * External links * * Gene expression Transcription coregulators {{gene-5-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drechslera
''Drechslera'' is a genus of fungi. Many of the species in this genus are plant pathogens. Species The following species are accepted within ''Drechslera'':Drechslera S.Ito in GBIF Secretariat (2017). GBIF Backbone Taxonomy. Checklist dataset https://doi.org/10.15468/39omei accessed via https://www.gbif.org/species/2587966 on 2018-08-02. *'' Drechslera andersenii'' A.Lam *'' Drechslera apii'' ( Göbelez) M.J.Richardson & E.M.Fraser *''Drechslera arizonica'' ( R.Sprague) Subram. & B.L.Jain *'' Drechslera avenacea'' ( M.A.Curtis ex Cooke) Shoemaker *''Drechslera avenicola'' B.D.Sun & T.Y.Zhang *''Drechslera boeremae'' A.S.Patil & V.G.Rao *'' Drechslera campanulata'' ( Lév.) B.Sutton *''Drechslera chattopadhyayi'' N.C.Mandal & M.K.Dasgupta *''Drechslera cymmartinii'' A.P.Misra & R.A.Singh *'' Drechslera dematioidea'' *''Drechslera elliptica'' H.F.Wang & T.Y.Zhang, 2017 *''Drechslera ellisii'' Danquah *'' Drechslera eragrostidis'' ( Henn.) Subram. & B.L.Jain *' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cladosporium
''Cladosporium'' is a genus of fungi including some of the most common indoor and outdoor molds. Species produce olive-green to brown or black colonies, and have dark-pigmented conidia that are formed in simple or branching chains. Many species of ''Cladosporium'' are commonly found on living and dead plant material. Some species are endophytes or plant pathogens, while others parasitize fungi. ''Cladosporium'' spores are wind-dispersed and they are often extremely abundant in outdoor air. Indoors ''Cladosporium'' species may grow on surfaces when moisture is present. '' Cladosporium fulvum'', cause of tomato leaf mould, has been an important genetic model, in that the genetics of host resistance are understood. In the 1960s, it was estimated that the genus ''Cladosporium'' contained around 500 plant-pathogenic and saprotrophic species, but this number has since been increased to over 772 species. The genus ''Cladosporium'' is very closely related to black yeasts in the order Do ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Iodine Deficiency In China
Iodine deficiency is a widespread problem in western, southern and eastern parts of China, as their iodized salt intake level is much lower than the average national level. Iodine deficiency is a range of disorders that affect many different populations. It is estimated that IDDs affect between 800 million and 2 billion people worldwide; countries have spent millions of dollars in implementing iodized salt as a means to counteract the iodine deficiencies prevalent today. With China accounting for "40% of the total population", it bears a large portion of those who are iodine deficient. Iodine is a micronutrient the body needs to properly produce thyroid hormones. The human body is not able to produce it, and iodine is an essential nutrient. Iodine is not readily available in many foods, thus making it difficult for many people to obtain it. One particular source, found in great supply, is ocean water although it is not an effective dietary source. Iodine deficiency diseases (ID ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxidative Stress
Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily Detoxification, detoxify the reactive intermediates or to repair the resulting damage. Disturbances in the normal redox state of cells can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell, including proteins, lipids, and DNA. Oxidative stress from Cellular respiration, oxidative metabolism causes base damage, as well as DNA damage (naturally occurring), strand breaks in DNA. Base damage is mostly indirect and caused by the reactive oxygen species generated, e.g., O2− (superoxide radical), OH (hydroxyl radical) and H2O2 (hydrogen peroxide). Further, some reactive oxidative species act as cellular messengers in redox signaling. Thus, oxidative stress can cause disruptions in normal mechanisms of cellular signaling. In humans, oxidative stress is thought to be involved in the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fusarium
''Fusarium'' is a large genus of filamentous fungi, part of a group often referred to as hyphomycetes, widely distributed in soil and associated with plants. Most species are harmless saprobes, and are relatively abundant members of the soil microbial community. Some species produce mycotoxins in cereal crops that can affect human and animal health if they enter the food chain. The main toxins produced by these ''Fusarium'' species are fumonisins and trichothecenes. Despite most species apparently being harmless (some existing on the skin as commensal members of the skin flora), some ''Fusarium'' species and subspecific groups are among the most important fungal pathogens of plants and animals. The name of ''Fusarium'' comes from Latin ''fusus'', meaning a spindle. Taxonomy The taxonomy of the genus is complex. A number of different schemes have been used, and up to 1,000 species have been identified at times, with approaches varying between wide and narrow concepts of speci ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alternaria
''Alternaria'' is a genus of Deuteromycetes fungi. All species are known as major plant pathogens. They are also common allergens in humans, growing indoors and causing hay fever or hypersensitivity reactions that sometimes lead to asthma. They are present in the human mycobiome and readily cause opportunistic infections in immunocompromised people such as AIDS patients. There are 299 species in the genus; they are ubiquitous in the environment and are a natural part of fungal flora almost everywhere. They are normal agents of decay and decomposition. The spores are airborne and found in the soil and water, as well as indoors and on objects. The club-shaped spores are single or form long chains. They can grow thick colonies which are usually green, black, or gray. At least 20% of agricultural spoilage is caused by ''Alternaria'' species, with the most severe losses reaching 80% of yield. Many human health disorders can be caused by these fungi, which grow on skin and mucous me ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Risk Factor
In epidemiology, a risk factor or determinant is a variable associated with an increased risk of disease or infection. Due to a lack of harmonization across disciplines, determinant, in its more widely accepted scientific meaning, is often used as a synonym. The main difference lies in the realm of practice: medicine (clinical practice) versus public health. As an example from clinical practice, low ingestion of dietary sources of vitamin C is a known risk factor for developing scurvy. Specific to public health policy, a determinant is a health risk that is general, abstract, related to inequalities, and difficult for an individual to control. For example, poverty is known to be a determinant of an individual's standard of health. Correlation vs causation Risk factors or determinants are correlational and not necessarily causal, because correlation does not prove causation. For example, being young cannot be said to cause measles, but young people have a higher rate of meas ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Gastrointestinal Tract
The gastrointestinal tract (GI tract, digestive tract, alimentary canal) is the tract or passageway of the digestive system that leads from the mouth to the anus. The GI tract contains all the major organs of the digestive system, in humans and other animals, including the esophagus, stomach, and intestines. Food taken in through the mouth is digested to extract nutrients and absorb energy, and the waste expelled at the anus as feces. ''Gastrointestinal'' is an adjective meaning of or pertaining to the stomach and intestines. Most animals have a "through-gut" or complete digestive tract. Exceptions are more primitive ones: sponges have small pores ( ostia) throughout their body for digestion and a larger dorsal pore (osculum) for excretion, comb jellies have both a ventral mouth and dorsal anal pores, while cnidarians and acoels have a single pore for both digestion and excretion. The human gastrointestinal tract consists of the esophagus, stomach, and intestines, and is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lymphatic System
The lymphatic system, or lymphoid system, is an organ system in vertebrates that is part of the immune system, and complementary to the circulatory system. It consists of a large network of lymphatic vessels, lymph nodes, lymphatic or lymphoid organs, and lymphoid tissues. The vessels carry a clear fluid called lymph (the Latin word ''lympha'' refers to the deity of fresh water, "Lympha") back towards the heart, for re-circulation. Unlike the circulatory system that is a closed system, the lymphatic system is open. The human circulatory system processes an average of 20 litres of blood per day through capillary filtration, which removes plasma from the blood. Roughly 17 litres of the filtered blood is reabsorbed directly into the blood vessels, while the remaining three litres are left in the interstitial fluid. One of the main functions of the lymphatic system is to provide an accessory return route to the blood for the surplus three litres. The other main function is that of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
