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Kurt Hellmann
Kurt Hellmann (12 May 1922 – 2 April 2013) was a Bavarian clinical pharmacologist best known for his discovery of the biologic activity of two important drugs: Razoxane and Dexrazoxane. Career From 1962 until 1987, Hellmann served the Cancer Research UK, Imperial Cancer Research Fund London as founding director of its Department of Cancer Chemotherapy. In 1972, Hellmann published the results of his breakthrough work with DL-razoxane (ICRF-159), the first fully antimetastatic compound discovered for the treatment of cancer. He was the co-founder and long-term editor (1974-1991) of the journal ''Cancer Treatment Reviews.'' In 1974, he co-created with Silvio Garattini, the Director of the Mario Negri Institute for Pharmacological Research, Mario Negri Institute for Pharmacological Research, Milan, an international body of medical experts called the E.O.R.T.C. Metastasis Club, which evolved in the 1980s into the Metastasis Research Society. He co-edited the organization's official jo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Razoxane
Dexrazoxane hydrochloride (Zinecard, Cardioxane) is a cardioprotective agent. It was discovered by Eugene Herman in 1972. The IV administration of dexrazoxane is in acidic condition with HCl adjusting the pH. Uses Dexrazoxane has been used to protect the heart against the cardiotoxic side effects of chemotherapeutic drugs such as anthracyclines, such as daunorubicin or doxorubicin or other chemotherapeutic agents. However, in July 2011 the European Medicines Agency (EMA) released a statement restricting use only in adult patients with cancer who have received > 300 mg/m2 doxorubicin or > 540 mg/m2 epirubicin and general approval for use for cardioprotection. That showed a possibly higher rate of secondary malignancies and acute myelogenous leukemia in pediatric patients treated for different cancers with both dexrazoxane and other chemotherapeutic agents that are associated with secondary malignancies. On July 19, 2017, based on evaluation of the currently available dat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |