Kupe Orthonairovirus
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Kupe Orthonairovirus
''Kupe orthonairovirus'', also called Kupe virus, is a species of virus in the genus '' Orthonairovirus''. History The virus was isolated from pooled ticks (''Amblyomma gemma'' and ''Rhipicephalus pulchellus The zebra tick or yellow back tick (''Rhipicephalus pulchellus'') is a species of hard tick. It is common in the Horn of Africa, with a habitat of the Rift Valley and eastward. It feeds upon a wide variety of species, including livestock, wild m ...'') collected from cattle hides in Nairobi, Kenya, in October 1999.Sang R, Onyango C, Gachoya J, Mabinda E, Konongoi S, Ofula V, Dunster L, Okoth F, Coldren R, Tesh R, da Rossa AT, Finkbeiner S, Wang D, Crabtree M, Miller B (2006) Tickborne arbovirus surveillance in market livestock, Nairobi, Kenya. Emerg Infect Dis. 2006 Jul;12(7):1074-1080 The word 'Kupe' is Kiswahili for tick. Genome The genome is composed a single strand of negative sense RNA in three parts - small (S), medium (M0 and large(L). The L segment RNA is 1 ...
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Orthonairovirus
''Orthonairovirus'' is a genus of viruses in the family ''Nairoviridae'' of the order Bunyavirales that include viruses with circular, negative-sense single stranded RNA. It got its name from the Nairobi sheep disease that affects the gastrointestinal tracts of sheep and goats. The vast majority, and perhaps all viruses in this genus are tick-borne viruses that can have human or other vertebrate hosts.Crabtree, Mary B., Rosemary Sang, and Barry R. Miller. "Kupe Virus, a New Virus in the Family Bunyaviridae, Genus Nairovirus, Kenya." Emerging Infectious Diseases 15 (2009): 147–54. Structure The virions for viruses in this genus have a spherical shape."Nairovirus." Nairovirus. Viral Zone. . They range in size from about 80–120 nm in diameter, with 50% of their weight attributed to proteins and 20–30% of their weight attributed to lipids. The ribonucleocapsid is filamentous, having a length of about 200-300 nm and a width of about 2–2.5 nm. These nuc ...
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Tick
Ticks (order Ixodida) are parasitic arachnids that are part of the mite superorder Parasitiformes. Adult ticks are approximately 3 to 5 mm in length depending on age, sex, species, and "fullness". Ticks are external parasites, living by feeding on the blood of mammals, birds, and sometimes reptiles and amphibians. The timing of the origin of ticks is uncertain, though the oldest known tick fossils are from the Cretaceous period, around 100 million years old. Ticks are widely distributed around the world, especially in warm, humid climates. Ticks belong to two major families, the Ixodidae or hard ticks, and the Argasidae, or soft ticks. ''Nuttalliella,'' a genus of tick from southern Africa is the only member of the family Nuttalliellidae, and represents the most primitive living lineage of ticks. Adults have ovoid/pear-shaped bodies (idiosomas) which become engorged with blood when they feed, and eight legs. Their cephalothorax and abdomen are completely fused. In addit ...
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Amblyomma Gemma
''Amblyomma'' is a genus of hard ticks. Some are disease vectors, for example the Rocky Mountain spotted fever in Brazil or ehrlichiosis in the United States. This genus is the third largest in the family Ixodidae, with its species primarily occupying the torrid zones of all the continents. The centre of species diversity is on the American continent, where half of all the species occur. On this continent, ''Amblyomma'' species reach far beyond the torrid zone, up to the 40th parallel in the Northern Hemisphere, to the 50th parallel in the Southern Hemisphere, and even reaches the alpine zone of the Andes. They also occur in Eurasia, Africa and Australia.
G. V. Kolonin, Fauna of Ixodid Ticks of the World (Acari, Ixodidae), Moscow 2009


Species

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Rhipicephalus Pulchellus
The zebra tick or yellow back tick (''Rhipicephalus pulchellus'') is a species of hard tick. It is common in the Horn of Africa, with a habitat of the Rift Valley and eastward. It feeds upon a wide variety of species, including livestock, wild mammals, and humans, and can be a vector for various pathogens. The adult male has a distinctive black and ivory ornamentation on its scutum. Taxonomy and names ''Rhipicephalus pulchellus'' was described by Carl Eduard Adolph Gerstaecker, who initially placed it in the genus ''Dermacentor'' due to the ornamentation; all ''Dermacentor'' ticks are ornate. Its syntypes are at the Museum für Naturkunde. transferred this species to ''Rhipicephalus'' in 1897. R. I. Pocock described a junior synonym, ''R. marmoreus'', in 1900; its holotype was deposited at the Natural History Museum, London. By 1901, Neumann had synonymized it with ''R. pulchellus''. In 1926, Maria Tonelli-Rondelli described a subspecies ''R. p. humeralis'', but in 1949, F ...
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Nairobi
Nairobi ( ) is the capital and largest city of Kenya. The name is derived from the Maasai phrase ''Enkare Nairobi'', which translates to "place of cool waters", a reference to the Nairobi River which flows through the city. The city proper had a population of 4,397,073 in the 2019 census, while the metropolitan area has a projected population in 2022 of 10.8 million. The city is commonly referred to as the Green City in the Sun. Nairobi was founded in 1899 by colonial authorities in British East Africa, as a rail depot on the Uganda - Kenya Railway.Roger S. Greenway, Timothy M. Monsma, ''Cities: missions' new frontier'', (Baker Book House: 1989), p.163. The town quickly grew to replace Mombasa as the capital of Kenya in 1907. After independence in 1963, Nairobi became the capital of the Republic of Kenya. During Kenya's colonial period, the city became a centre for the colony's coffee, tea and sisal industry. The city lies in the south central part of Kenya, at an elevation ...
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Kenya
) , national_anthem = "Ee Mungu Nguvu Yetu"() , image_map = , map_caption = , image_map2 = , capital = Nairobi , coordinates = , largest_city = Nairobi , official_languages = Constitution (2009) Art. 7 ational, official and other languages"(1) The national language of the Republic is Swahili. (2) The official languages of the Republic are Swahili and English. (3) The State shall–-–- (a) promote and protect the diversity of language of the people of Kenya; and (b) promote the development and use of indigenous languages, Kenyan Sign language, Braille and other communication formats and technologies accessible to persons with disabilities." , languages_type = National language , languages = Swahili , ethnic_groups = , ethnic_groups_year = 2019 census , religion = , religion_year = 2019 census , demonym = ...
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Kiswahili
Swahili, also known by its local name , is the native language of the Swahili people, who are found primarily in Tanzania, Kenya and Mozambique (along the East African coast and adjacent litoral islands). It is a Bantu language, though Swahili has borrowed a number of words from foreign languages, particularly Arabic, but also words from Portuguese, English and German. Around forty percent of Swahili vocabulary consists of Arabic loanwords, including the name of the language ( , a plural adjectival form of an Arabic word meaning 'of the coast'). The loanwords date from the era of contact between Arab slave traders and the Bantu inhabitants of the east coast of Africa, which was also the time period when Swahili emerged as a lingua franca in the region. The number of Swahili speakers, be they native or second-language speakers, is estimated to be approximately 200 million. Due to concerted efforts by the government of Tanzania, Swahili is one of three official languages (th ...
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Nucleotide
Nucleotides are organic molecules consisting of a nucleoside and a phosphate. They serve as monomeric units of the nucleic acid polymers – deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), both of which are essential biomolecules within all life-forms on Earth. Nucleotides are obtained in the diet and are also synthesized from common nutrients by the liver. Nucleotides are composed of three subunit molecules: a nucleobase, a five-carbon sugar (ribose or deoxyribose), and a phosphate group consisting of one to three phosphates. The four nucleobases in DNA are guanine, adenine, cytosine and thymine; in RNA, uracil is used in place of thymine. Nucleotides also play a central role in metabolism at a fundamental, cellular level. They provide chemical energy—in the form of the nucleoside triphosphates, adenosine triphosphate (ATP), guanosine triphosphate (GTP), cytidine triphosphate (CTP) and uridine triphosphate (UTP)—throughout the cell for the many cellular func ...
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Open Reading Frame
In molecular biology, open reading frames (ORFs) are defined as spans of DNA sequence between the start and stop codons. Usually, this is considered within a studied region of a prokaryotic DNA sequence, where only one of the six possible reading frames will be "open" (the "reading", however, refers to the RNA produced by transcription of the DNA and its subsequent interaction with the ribosome in translation). Such an ORF may contain a start codon (usually AUG in terms of RNA) and by definition cannot extend beyond a stop codon (usually UAA, UAG or UGA in RNA). That start codon (not necessarily the first) indicates where translation may start. The transcription termination site is located after the ORF, beyond the translation stop codon. If transcription were to cease before the stop codon, an incomplete protein would be made during translation. In eukaryotic genes with multiple exons, introns are removed and exons are then joined together after transcription to yield the final ...
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