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Kolling Institute Of Medical Research
The Kolling Institute is located in the grounds of the Royal North Shore Hospital in St Leonards, New South Wales, St Leonards, Sydney Australia. The institute, founded in 1920, is the oldest medical research institute in New South Wales. The Kolling Institute is a part of the Northern Clinical School, University of Sydney. History The Institute of Pathological Research was established in a cottage within the grounds of the Royal North Shore Hospital in 1920 with the appointment of a biochemist. Doctor W. Wilson Ingram was appointed as the first director in 1928. He remained in the post for almost 50 years. During his tenure, he expanded the medical knowledge of diabetes, opening the first clinic for its treatment in Australia . He also accompanied Sir Douglas Mawson on two Antarctic expeditions as medical officer and research scientist between 1929 and 1931. A new two-story building was officially opened in 1931 and named the Kolling Institute after businessman Charles Kollin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal North Shore Hospital
The Royal North Shore Hospital (RNSH) is a major public teaching hospital in Sydney, Australia, located in St Leonards. It serves as a teaching hospital for Sydney Medical School at the University of Sydney and has over 600 beds. It is the principal tertiary referral hospital for the Northern Sydney Local Health District. Its primary referral area accommodates 5.7% of the Australian population or 17% of the NSW population. Introduction The Royal North Shore Hospital (RNSH) is a leading tertiary teaching hospital of The University of Sydney, University of Technology and Australian Catholic University. It is also a major Trauma Centre which provides specialised services in the areas of severe burns, neonatal intensive care, spinal cord injury and interventional radiology. The Kolling Institute of Medical Research is a health and medical research centre with a focus on research training. History The RNSH began as a cottage hospital located in Willoughby Rd, Crows Nest. The fo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immune Responses
An immune response is a reaction which occurs within an organism for the purpose of defending against foreign invaders. These invaders include a wide variety of different microorganisms including viruses, bacteria, parasites, and fungi which could cause serious problems to the health of the host organism if not cleared from the body. There are two distinct aspects of the immune response, the innate and the adaptive, which work together to protect against pathogens. The innate branch—the body's first reaction to an invader—is known to be a non-specific and quick response to any sort of pathogen. Components of the innate immune response include physical barriers like the skin and mucous membranes, immune cells such as neutrophils, macrophages, and monocytes, and soluble factors including cytokines and complement. On the other hand, the adaptive branch is the body's immune response which is catered against specific antigens and thus, it takes longer to activate the components involv ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurogenetics
Neurogenetics studies the role of genetics in the development and function of the nervous system. It considers neural characteristics as phenotypes (i.e. manifestations, measurable or not, of the genetic make-up of an individual), and is mainly based on the observation that the nervous systems of individuals, even of those belonging to the same species, may not be identical. As the name implies, it draws aspects from both the studies of neuroscience and genetics, focusing in particular how the genetic code an organism carries affects its expressed Phenotypic trait, traits. Mutations in this genetic sequence can have a wide range of effects on the quality of life of the individual. Neurological diseases, behavior and personality are all studied in the context of neurogenetics. The field of neurogenetics emerged in the mid to late 20th century with advances closely following advancements made in available technology. Currently, neurogenetics is the center of much research utilizing cut ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Renal Medicine
Nephrology (from Ancient Greek, Greek'' nephros'' "kidney", combined with the suffix ''-logy'', "the study of") is a Specialty (medicine), specialty of adult internal medicine and pediatric medicine that concerns the study of the kidneys, specifically normal renal function, kidney function (renal physiology) and kidney disease (renal pathophysiology), the preservation of kidney health, and the treatment of kidney disease, from diet and medication to renal replacement therapy (Kidney dialysis, dialysis and kidney transplantation). The word “renal” is an adjective meaning “relating to the kidneys”, and its roots are French or late Latin. Whereas according to some opinions, "renal" and "nephro" should be replaced with "kidney" in scientific writings such as "kidney medicine" (instead of nephrology) or "kidney replacement therapy", other experts have advocated preserving the use of renal and nephro as appropriate including in "nephrology" and "renal replacement therapy", res ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Perinatal
Prenatal development () includes the development of the embryo and of the fetus during a viviparous animal's gestation. Prenatal development starts with fertilization, in the germinal stage of embryonic development, and continues in fetal development until birth. In human pregnancy, prenatal development is also called antenatal development. The development of the human embryo follows fertilization, and continues as fetal development. By the end of the tenth week of gestational age the embryo has acquired its basic form and is referred to as a fetus. The next period is that of fetal development where many organs become fully developed. This fetal period is described both topically (by organ) and chronologically (by time) with major occurrences being listed by gestational age. The very early stages of embryonic development are the same in all mammals, but later stages of development, and the length of gestation varies. Terminology In the human: Different terms are used to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cancer Genetics
Oncogenomics is a sub-field of genomics that characterizes cancer-associated genes. It focuses on genomic, epigenomic and transcript alterations in cancer. Cancer is a genetic disease caused by accumulation of DNA mutations and epigenetic alterations leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment. Besides understanding the underlying genetic mechanisms that initiate or drive cancer progression, oncogenomics targets personalized cancer treatment. Cancer develops due to DNA mutations and epigenetic alterations that accumulate randomly. Identifying and targeting the mutations in an individual patient ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Development (biology)
Development of the human body is the process of growth to maturity. The process begins with fertilization, where an egg released from the ovary of a female is penetrated by a sperm cell from a male. The resulting zygote develops through mitosis and cell differentiation, and the resulting embryo then implants in the uterus, where the embryo continues development through a fetal stage until birth. Further growth and development continues after birth, and includes both physical and psychological development, influenced by genetic, hormonal, environmental and other factors. This continues throughout life: through childhood and adolescence into adulthood. Before birth Development before birth, or prenatal development () is the process in which a zygote, and later an embryo and then a fetus develops during gestation. Prenatal development starts with fertilization and the formation of the zygote, the first stage in embryonic development which continues in fetal develo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Association Of Australian Medical Research Institutes
Association may refer to: * Club (organization), an association of two or more people united by a common interest or goal * Trade association, an organization founded and funded by businesses that operate in a specific industry * Voluntary association, a body formed by individuals to accomplish a purpose, usually as volunteers Association in various fields of study *Association (archaeology), the close relationship between objects or contexts. * Association (astronomy), combined or co-added group of astronomical exposures *Association (chemistry) * Association (ecology), a type of ecological community *Genetic association, when one or more genotypes within a population co-occur *Association (object-oriented programming), defines a relationship between classes of objects * Association (psychology), a connection between two or more concepts in the mind or imagination * Association (statistics), a statistical relationship between two variables * File association, associates a file w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Health And Medical Research Council
The National Health and Medical Research Council (NHMRC) is the main statutory authority of the Australian Government responsible for medical research. It was the eighth largest research funding body in the world in 2016, and NHMRC-funded research is globally recognised for its high quality. Around 45% of all Australian medical research from 200812 was funded by the federal government, through the NHMRC. As an independent arm of the Department of Health, the NHMRC funds high quality health and medical research, builds research capability in Australia, support the translation of health and medical research into better health outcomes, and promote the ethics and integrity in research. Non-health research is funded by the Australian Research Council. Activities The National Health and Medical Research Council Act 1992' provides for NHMRC to pursue activities designed to: * raise the standard of individual and public health throughout Australia * foster the development of consi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carolyn Sue
Carolyn Mary Sue is an Australian physician-scientist, professor and research director. She has been the Executive Director of the Kolling Institute of Medical Research since 2019 and is also Director of Neurogenetics at Royal North Shore Hospital, Director of the Centre of Excellence for Parkinson's Disease and Movement Disorders, and Director of the National Centre for Adult Stem Cell Research (Sydney Node). Sue specialises in complex neurogenetic conditions and runs tertiary referral clinics for patients with diseases such as Parkinson's disease, Parkinson's, mitochondrial diseases, and other inherited movement disorders. Her research has identified several previously-unknown mutations that cause neurogenetic disease. Education and career Sue completed a medical degree at the University of New South Wales and a PhD at the University of Sydney in 1997. She then received an National Health and Medical Research Council, NHMRC Neil Hamilton Fairley Postdoctoral Fellowship to con ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
IGF Binding Proteins
The insulin-like growth factor-binding protein (IGFBP) serves as a transport protein for insulin-like growth factor 1 (IGF-1). Function Approximately 98% of IGF-1 is always bound to one of six binding proteins (IGF-BP). IGFBP-3, the most abundant protein, accounts for 80% of all IGF binding. IGF-1 binds to IGFBP-3 in a 1:1 molar ratio. IGF-BP also binds to IGF-1 inside the liver, allowing growth hormone to continuously act upon the liver to produce more IGF-1. IGF binding proteins (IGFBPs) are proteins of 24 to 45 kDa. All six IGFBPs share 50% homology with each other and have binding affinities for IGF-I and IGF-II at the same order of magnitude as the ligands have for the IGF-IR. The IGFBPs help to lengthen the half-life of circulating IGFs in all tissues, including the prostate. Individual IGFBPs may act to enhance or attenuate IGF signaling depending on their physiological context (i.e. cell type). Even with these similarities, some characteristics are different: chromo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Insulin Growth Factor
The insulin-like growth factors (IGFs) are proteins with high sequence similarity to insulin. IGFs are part of a complex system that cells use to communicate with their physiologic environment. This complex system (often referred to as the IGF "axis") consists of two cell-surface receptors (IGF1R and IGF2R), two ligands (IGF-1 and IGF-2), a family of seven high-affinity IGF-binding proteins (IGFBP1 to IGFBP7), as well as associated IGFBP degrading enzymes, referred to collectively as proteases. IGF1/GH axis The IGF "axis" is also commonly referred to as the Growth Hormone/IGF-1 Axis. Insulin-like growth factor 1 (commonly referred to as IGF-1 or at times using Roman numerals as IGF-I) is mainly secreted by the liver as a result of stimulation by growth hormone (GH). IGF-1 is important for both the regulation of normal physiology, as well as a number of pathological states, including cancer. The IGF axis has been shown to play roles in the promotion of cell proliferation and t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
