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Kir (film)
KIR, Kir or kir may refer to: Biology *Inward-rectifier potassium channel Kir *Killer-cell immunoglobulin-like receptor, a receptor protein expressed on the surface of natural killer cells and some T-cells Bodies of water *Kir (river), in northern Albania * Kir Lake, near Dijon, France People * Kir Fard, Armenian nobleman of the 12th–13th centuries * Kir Nesis (1934–2003), Russian biologist *Kir Bulychev, Russian writer * Félix Kir (1876–1968), priest in the French Resistance *Kir, a character in ''Detective Conan'' Places *Republic of Kiribati in the central Pacific (ISO code: KIR) *Kir of Moab, biblical stronghold *Land of Kir, biblical location Transport * Katihar Junction railway station, Bihar; station code KIR * Kerry Airport, Ireland (IATA code: KIR) * Kirkby railway station, Merseyside, England; National Rail station code KIR Other * Kir (cocktail), alcoholic beverage * Kyrgyz language (ISO code: kir) * Krajowa Izba Rozliczeniowa, an automated clearing ho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Inward-rectifier Potassium Channel
Inward-rectifier potassium channels (Kir, IRK) are a specific lipid-gated subset of potassium channels. To date, seven subfamilies have been identified in various mammalian cell types, plants, and bacteria. They are activated by phosphatidylinositol 4,5-bisphosphate ( PIP2). The malfunction of the channels has been implicated in several diseases. IRK channels possess a pore domain, homologous to that of voltage-gated ion channels, and flanking transmembrane segments (TMSs). They may exist in the membrane as homo- or heterooligomers and each monomer possesses between 2 and 4 TMSs. In terms of function, these proteins transport potassium (K+), with a greater tendency for K+ uptake than K+ export. The process of inward-rectification was discovered by Denis Noble in cardiac muscle cells in 1960s and by Richard Adrian and Alan Hodgkin in 1970 in skeletal muscle cells. Overview of inward rectification A channel that is "inwardly-rectifying" is one that passes current (positive cha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |