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KIF1C
Kinesin-like protein KIF1C is a protein that in humans is encoded by the ''KIF1C'' gene. Kif1C is a fast, plus-end directed microtubule motor. Kif1C transports α5β1-integrins in human cells. Kif1C has been shown to be non-essential in mouse with other proteins able to perform the same function. However, mutations in KIF1C lead to spastic paraplegia and cerebellar dysfunction in humans. Interactions KIF1C has been shown to interact with PTPN21 and YWHAG 14-3-3 protein gamma is a protein that in humans is encoded by the ''YWHAG'' gene. This gene product belongs to the 14-3-3 protein family which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved p .... KIF1C is a dimeric molecule that is held in an autoinhibited state by interaction of its stalk with the microtubule binding interface of the motor domain. Upon binding of PTPN21 or the cargo adapter HOOK3 to the KIF1C stalk, the motor domain is released, engages with microtu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PTPN21
Tyrosine-protein phosphatase non-receptor type 21 is an enzyme that in humans is encoded by the ''PTPN21'' gene. Function The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. Interactions PTPN21 has been shown to Protein-protein interact ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
YWHAG
14-3-3 protein gamma is a protein that in humans is encoded by the ''YWHAG'' gene. This gene product belongs to the 14-3-3 protein family which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. Interactions YWHAG has been shown to interact with C-Raf, EPB41L3, KIF1C Kinesin-like protein KIF1C is a protein that in humans is encoded by the ''KIF1C'' gene. Kif1C is a fast, plus-end directed microtubule motor. Kif1C transports α5β1-integrins in human cells. Kif1C has been shown to be non-essential in mouse wit .. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residue ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Esra Battaloğlu
Esra Battaloğlu is a Turkish geneticist researching the human genetics of inherited peripheral neuropathies. She is an assistant professor at Boğaziçi University. Education Battaloğlu graduated from High School TED Ankara Koleji in 1982. She completed a B.S. in the department of biology at the Middle East Technical University in 1986. Battaloğlu earned an M.S. (1989) and Ph.D. (1992) in the department of biology at Boğaziçi University. Career and research In September 1993, she joined the faculty at Boğaziçi University as an assistant professor in the department of molecular biology and genetics. She researches the human genetics of inherited peripheral neuropathies Peripheral neuropathy, often shortened to neuropathy, is a general term describing disease affecting the peripheral nerves, meaning nerves beyond the brain and spinal cord. Damage to peripheral nerves may impair sensation, movement, gland, or or .... References External links * Living ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HOOK3
Protein Hook homolog 3 is a protein that in humans is encoded by the ''HOOK3'' gene. Function Hook proteins are cytosolic coiled coil proteins that contain conserved N-terminus, N-terminal domains, which attach to microtubules, and more divergent C-terminus, C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment. References Further reading * * * * * * * * * * {{gene-8-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Biology
Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physical structure of biological macromolecules is known as molecular biology. Molecular biology was first described as an approach focused on the underpinnings of biological phenomena - uncovering the structures of biological molecules as well as their interactions, and how these interactions explain observations of classical biology. In 1945 the term molecular biology was used by physicist William Astbury. In 1953 Francis Crick, James Watson, Rosalind Franklin, and colleagues, working at Medical Research Council unit, Cavendish laboratory, Cambridge (now the MRC Laboratory of Molecular Biology), made a double helix model of DNA which changed the entire research scenario. They proposed the DNA structure based on previous research done by Ro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Motor Proteins
Motor proteins are a class of molecular motors that can move along the cytoplasm of cells. They convert chemical energy into mechanical work by the hydrolysis of ATP. Flagellar rotation, however, is powered by a proton pump. Cellular functions Motor proteins are the driving force behind most active transport of proteins and vesicles in the cytoplasm. Kinesins and cytoplasmic dyneins play essential roles in intracellular transport such as axonal transport and in the formation of the spindle apparatus and the separation of the chromosomes during mitosis and meiosis. Axonemal dynein, found in cilia and flagella, is crucial to cell motility, for example in spermatozoa, and fluid transport, for example in trachea. The muscle protein myosin "motors" the contraction of muscle fibers in animals. Diseases associated with motor protein defects The importance of motor proteins in cells becomes evident when they fail to fulfill their function. For example, kinesin deficiencies have ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Genes
This article is an index of lists of human genes. By chromosome Below is a list of articles on human chromosomes, each of which contains an incomplete list of genes located on that chromosome. * Chromosome 1 (human) * Chromosome 2 (human) * Chromosome 3 (human) * Chromosome 4 (human) * Chromosome 5 (human) * Chromosome 6 (human) * Chromosome 7 (human) * Chromosome 8 (human) * Chromosome 9 (human) * Chromosome 10 (human) * Chromosome 11 (human) * Chromosome 12 (human) * Chromosome 13 (human) * Chromosome 14 (human) * Chromosome 15 (human) * Chromosome 16 (human) * Chromosome 17 (human) * Chromosome 18 (human) * Chromosome 19 (human) * Chromosome 20 (human) * Chromosome 21 (human) * Chromosome 22 (human) * Chromosome X (human) * Chromosome Y (human) Protein-coding genes The lists below constitute a complete list of all known human protein-coding genes. Transcription factors This is a list of 1639 genes which encode proteins that are known or expected to function as human transc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
