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James Neel
James Van Gundia Neel (March 22, 1915 – February 1, 2000) was an American geneticist who played a key role in the development of human genetics as a field of research in the United States. He made important contributions to the emergence of genetic epidemiology and pursued an understanding of the influence of environment on genes. In his early work, he studied sickle-cell disease and thalassemia conducted research on the effects of radiation on survivors of the Hiroshima atomic bombing. Life Neel attended the College of Wooster with a degree in biology in 1935 and went on to receive his Ph.D. at the University of Rochester. In 1956, Neel established the University of Michigan Department of Genetics, the first department of human genetics at a medical school in the United States. He was elected a Fellow of the American Academy of Arts and Sciences in 1971. Neel developed the "thrifty gene hypothesis" that paleolithic humans, facing long periods of hunger punctuated by brief ...
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Human Genetics
Human genetics is the study of inheritance as it occurs in human beings. Human genetics encompasses a variety of overlapping fields including: classical genetics, cytogenetics, molecular genetics, biochemical genetics, genomics, population genetics, developmental genetics, clinical genetics, and genetic counseling. Genes are the common factor of the qualities of most human-inherited traits. Study of human genetics can answer questions about human nature, can help understand diseases and the development of effective treatment and help us to understand the genetics of human life. This article describes only basic features of human genetics; for the genetics of disorders please see: medical genetics. Genetic differences and inheritance patterns Inheritance of traits for humans are based upon Gregor Mendel's model of inheritance. Mendel deduced that inheritance depends upon discrete units of inheritance, called factors or genes. Autosomal dominant inheritance Autosomal tr ...
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Human Genome
The human genome is a complete set of nucleic acid sequences for humans, encoded as DNA within the 23 chromosome pairs in cell nuclei and in a small DNA molecule found within individual mitochondria. These are usually treated separately as the nuclear genome and the mitochondrial genome. Human genomes include both protein-coding DNA sequences and various types of DNA that does not encode proteins. The latter is a diverse category that includes DNA coding for non-translated RNA, such as that for ribosomal RNA, transfer RNA, ribozymes, small nuclear RNAs, and several types of regulatory RNAs. It also includes promoters and their associated gene-regulatory elements, DNA playing structural and replicatory roles, such as scaffolding regions, telomeres, centromeres, and origins of replication, plus large numbers of transposable elements, inserted viral DNA, non-functional pseudogenes and simple, highly-repetitive sequences. Introns make up a large percentage of non-coding DNA. ...
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Atomic Bomb Casualty Commission
The Atomic Bomb Casualty Commission (ABCC) (Japanese:原爆傷害調査委員会, ''Genbakushōgaichōsaiinkai'') was a commission established in 1946 in accordance with a presidential directive from Harry S. Truman to the National Academy of Sciences-National Research Council to conduct investigations of the late effects of radiation among the atomic-bomb survivors in Hiroshima and Nagasaki. As it was erected purely for scientific research and study, not as a provider of medical care and also because it was heavily supported by the United States, the ABCC was generally mistrusted by most survivors and Japanese alike. It operated for nearly thirty years before its dissolution in 1975. History The Atomic Bomb Casualty Commission (ABCC) was formed after the United States attack on Hiroshima and Nagasaki on August 6 and August 9, 1945. The ABCC originally began as the Joint Commission The ABCC set out to obtain first-hand technical information and make a report to let people know ...
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Radiation Damage
Radiation damage is the effect of ionizing radiation on physical objects including non-living structural materials. It can be either detrimental or beneficial for materials. Radiobiology is the study of the action of ionizing radiation on living things, including the health effects of radiation in humans. High doses of ionizing radiation can cause damage to living tissue such as radiation burning and harmful mutations such as causing cells to become cancerous, and can lead to health problems such as radiation poisoning. Causes This radiation may take several forms: *Cosmic rays and subsequent energetic particles caused by their collision with the atmosphere and other materials. *Radioactive daughter products (radioisotopes) caused by the collision of cosmic rays with the atmosphere and other materials, including living tissues. *Energetic particle beams from a particle accelerator. *Energetic particles or electro-magnetic radiation (X-rays) released from collisions of such part ...
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Nuclear Fallout
Nuclear fallout is the residual radioactive material propelled into the upper atmosphere following a nuclear blast, so called because it "falls out" of the sky after the explosion and the shock wave has passed. It commonly refers to the radioactive dust and ash created when a nuclear weapon explodes. The amount and spread of fallout is a product of the size of the weapon and the altitude at which it is detonated. Fallout may get entrained with the products of a pyrocumulus cloud and fall as black rain (rain darkened by soot and other particulates, which fell within 30–40 minutes of the atomic bombings of Hiroshima and Nagasaki). This radioactive dust, usually consisting of fission products mixed with bystanding atoms that are neutron-activated by exposure, is a form of radioactive contamination. Types of fallout Fallout comes in two varieties. The first is a small amount of carcinogenic material with a long half-life. The second, depending on the height of detonation, is ...
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Measles
Measles is a highly contagious infectious disease caused by measles virus. Symptoms usually develop 10–12 days after exposure to an infected person and last 7–10 days. Initial symptoms typically include fever, often greater than , cough, runny nose, and inflamed eyes. Small white spots known as Koplik's spots may form inside the mouth two or three days after the start of symptoms. A red, flat rash which usually starts on the face and then spreads to the rest of the body typically begins three to five days after the start of symptoms. Common complications include diarrhea (in 8% of cases), middle ear infection (7%), and pneumonia (6%). These occur in part due to measles-induced immunosuppression. Less commonly seizures, blindness, or inflammation of the brain may occur. Other names include ''morbilli'', ''rubeola'', ''red measles'', and ''English measles''. Both rubella, also known as ''German measles'', and roseola are different diseases caused by unrelated viruses. Mea ...
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Measles Vaccine
Measles vaccine protects against becoming infected with measles. Nearly all of those who do not develop immunity after a single dose develop it after a second dose. When rate of vaccination within a population is greater than 92%, outbreaks of measles typically no longer occur; however, they may occur again if the rate of vaccination decrease. The vaccine's effectiveness lasts many years. It is unclear if it becomes less effective over time. The vaccine may also protect against measles if given within a couple of days after exposure to measles. The vaccine is generally safe, even for those infected by HIV. Most children do not experience any side effects; those that do occur are usually mild, such as fever, rash, pain at the site of injection, and joint stiffness; and are short-lived. Anaphylaxis has been documented in about 3.5–10 cases per million doses. Rates of Guillain–Barré syndrome, autism and inflammatory bowel disease do not appear to be increased by measles vac ...
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Darkness In El Dorado
''Darkness in El Dorado: How Scientists and Journalists Devastated the Amazon'' is a polemical book written by author Patrick Tierney in 2000, in which the author accuses geneticist James Neel and anthropologist Napoleon Chagnon of conducting human research without regard for their subjects' well-being while conducting long-term ethnographic field work among the indigenous Yanomamö, in the Amazon Basin between Venezuela and Brazil. He also wrote that the researchers had exacerbated a measles epidemic among the Native Americans, and that Jacques Lizot and Kenneth Good committed acts of sexual impropriety with Yanomamö. While the book was positively reviewed and well received at first, later investigations by multiple independent organizations found Tierney's main allegations to be false and libelous. Major claims and evaluations of these claims Claims made in ''Darkness in El Dorado'' included the following: * Napoleon Chagnon and James Neel directly and indirectly caused ...
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Venezuela
Venezuela (; ), officially the Bolivarian Republic of Venezuela ( es, link=no, República Bolivariana de Venezuela), is a country on the northern coast of South America, consisting of a continental landmass and many islands and islets in the Caribbean Sea. It has a territorial extension of , and its population was estimated at 29 million in 2022. The capital and largest urban agglomeration is the city of Caracas. The continental territory is bordered on the north by the Caribbean Sea and the Atlantic Ocean, on the west by Colombia, Brazil on the south, Trinidad and Tobago to the north-east and on the east by Guyana. The Venezuelan government maintains a claim against Guyana to Guayana Esequiba. Venezuela is a federal presidential republic consisting of 23 states, the Capital District and federal dependencies covering Venezuela's offshore islands. Venezuela is among the most urbanized countries in Latin America; the vast majority of Venezuelans live in the cities of the n ...
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Brazil
Brazil ( pt, Brasil; ), officially the Federative Republic of Brazil (Portuguese: ), is the largest country in both South America and Latin America. At and with over 217 million people, Brazil is the world's fifth-largest country by area and the seventh most populous. Its capital is Brasília, and its most populous city is São Paulo. The federation is composed of the union of the 26 States of Brazil, states and the Federal District (Brazil), Federal District. It is the largest country to have Portuguese language, Portuguese as an List of territorial entities where Portuguese is an official language, official language and the only one in the Americas; one of the most Multiculturalism, multicultural and ethnically diverse nations, due to over a century of mass Immigration to Brazil, immigration from around the world; and the most populous Catholic Church by country, Roman Catholic-majority country. Bounded by the Atlantic Ocean on the east, Brazil has a Coastline of Brazi ...
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Xavante People
The Xavante (also Shavante, Chavante, Akuen, A'uwe, Akwe, Awen, or Akwen) are an indigenous people, comprising 15,315 individuals within the territory of eastern Mato Grosso state in Brazil. They speak the Xavante language, part of the Jê language family. History They were enslaved in the 18th century, after which they have tried to avoid contact. A temporary coexistence with westernized society in the 19th century in the state of Goiás,Giccaria, Bartolomeu. Xavante: Povo Autêntico. Editora Salesiana Dom Bosco, 1984, p. 35 was followed by withdrawal to Mato Grosso (between 1830–1860). They were "re-discovered" during the 1930s. From 1946 to 1957, they were brought under Getúlio Vargas’ National Integration Program, but still experienced massacres and disease. Due to this history, they have a distrust of non-Xavante people. Today they are still wary of any approach of non-Xavante, called "waradzu". The Xavante leader Mário Juruna was the first indigenous Brazilian to b ...
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Yanomamo
The Yanomami, also spelled Yąnomamö or Yanomama, are a group of approximately 35,000 indigenous people who live in some 200–250 villages in the Amazon rainforest on the border between Venezuela and Brazil. Etymology The ethnonym ''Yanomami'' was produced by anthropologists on the basis of the word , which, in the expression , signifies "human beings." This expression is opposed to the categories (game animals) and (invisible or nameless beings), but also (enemy, stranger, non-Indian). According to ethnologist : History The first report of the Yanomami to the Northern world is from 1654, when an El Salvadorian expedition under Apolinar Diez de la Fuente visited some Ye'kuana people living on the Padamo River. Diez wrote: From approximately 1630 to 1720, the other river-based indigenous societies who lived in the same region were wiped out or reduced as a result of slave-hunting expeditions by the conquistadors and bandeirantes. How this affected the Yanomami is unkno ...
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