Jacquelyn S. Fetrow
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Jacquelyn S. Fetrow
Jacquelyn S. (Jacque) Fetrow (born 1960) is a computational biologist, college administrator, and the 15th president of Albright College. Previously, she served as Provost, Vice President of Academic Affairs, and Professor of Chemistry at the University of Richmond, in Richmond, Virginia. Prior to that appointment, she served as Dean of the College at Wake Forest University in Winston-Salem, North Carolina. She also co-founded a company, GeneFormatics, for which she served as Director and Chief Scientific Officer for four years. Early life and education Fetrow is a native of Camp Hill, Pennsylvania. Her mother, Mildred F. Fetrow, was a public school teacher in the West Shore School District, teaching kindergarten, first grade and second grade for many years. Her father, David E. Fetrow, was a carpenter. He also worked as a truck salesman, real estate salesman, and office manager. Fetrow attended Camp Hill public schools through twelfth grade, Albright College for her ...
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Brackets
A bracket is either of two tall fore- or back-facing punctuation marks commonly used to isolate a segment of text or data from its surroundings. Typically deployed in symmetric pairs, an individual bracket may be identified as a 'left' or 'right' bracket or, alternatively, an "opening bracket" or "closing bracket", respectively, depending on the Writing system#Directionality, directionality of the context. Specific forms of the mark include parentheses (also called "rounded brackets"), square brackets, curly brackets (also called 'braces'), and angle brackets (also called 'chevrons'), as well as various less common pairs of symbols. As well as signifying the overall class of punctuation, the word "bracket" is commonly used to refer to a specific form of bracket, which varies from region to region. In most English-speaking countries, an unqualified word "bracket" refers to the parenthesis (round bracket); in the United States, the square bracket. Glossary of mathematical sym ...
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Penn State College Of Medicine
Pennsylvania State University College of Medicine (PSCOM), known simply as Penn State College of Medicine is the medical school of Pennsylvania State University, a public university system in Pennsylvania. It is located in Hershey near the Penn State Milton S. Hershey Medical Center and Penn State Children's Hospital, the medical school's principal affiliate. The medical school includes 26 basic science and clinical departments and a broad range of clinical programs conducted at its hospital affiliates and numerous ambulatory care sites in the region. History In 1963, the M. S. Hershey Foundation offered $50 million to the Pennsylvania State University to establish a medical school and teaching hospital in Hershey, Pennsylvania. Penn State Health Penn State Health was formed in 2014 to consolidate health care providers in the area. In 2015, it acquired St. Joseph Regional Health Network in Berks County from Catholic Health Initiatives. Statistics , the Penn State C ...
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Peroxiredoxin Classification Index
PeroxiRedoxin classification indEX (PREX ) is a database of peroxiredoxins (Prxs) classified into one of six distinct subfamilies. Classification relies on the Deacon Active Site Profiling (DASP) approach that utilizes a position specific scoring matrix (PSSM) created from aligned signatures (built from sequence fragments surrounding active sites of structurally-characterized Prx group members) to search sequence databases. Searches of PREX for Prxs of interest can be conducted using protein annotation, accession number, PDB ID, organism name, or protein sequence (using BLAST) for Prx proteins extracted from January 2008, November 2010, or October 2011 versions of GenBank (over 8000 validated Prx sequences represented). Output includes the subfamily to which each classified Prx belongs, accession and GI numbers, genus and species, and the active site signature used for classification. The query sequence is also presented aligned with a select group of Prxs for manual evaluation an ...
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Protein Structure
Protein structure is the three-dimensional arrangement of atoms in an amino acid-chain molecule. Proteins are polymers specifically polypeptides formed from sequences of amino acids, the monomers of the polymer. A single amino acid monomer may also be called a ''residue'' indicating a repeating unit of a polymer. Proteins form by amino acids undergoing condensation reactions, in which the amino acids lose one water molecule per reaction in order to attach to one another with a peptide bond. By convention, a chain under 30 amino acids is often identified as a peptide, rather than a protein. To be able to perform their biological function, proteins fold into one or more specific spatial conformations driven by a number of non-covalent interactions such as hydrogen bonding, ionic interactions, Van der Waals forces, and hydrophobic packing. To understand the functions of proteins at a molecular level, it is often necessary to determine their three-dimensional structure. This is t ...
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Functional Site
In biology and biochemistry, the active site is the region of an enzyme where substrate molecules bind and undergo a chemical reaction. The active site consists of amino acid residues that form temporary bonds with the substrate (binding site) and residues that catalyse a reaction of that substrate (catalytic site). Although the active site occupies only ~10–20% of the volume of an enzyme, it is the most important part as it directly catalyzes the chemical reaction. It usually consists of three to four amino acids, while other amino acids within the protein are required to maintain the tertiary structure of the enzymes. Each active site is evolved to be optimised to bind a particular substrate and catalyse a particular reaction, resulting in high specificity. This specificity is determined by the arrangement of amino acids within the active site and the structure of the substrates. Sometimes enzymes also need to bind with some cofactors to fulfil their function. The active si ...
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Cytochrome C Family
Cytochromes ''c'' (cyt ''c'', c-type cytochromes) cytochromes, or heme-containing proteins, that have heme C covalently attached to the peptide backbone via one or two thioether bonds. These bonds are in most cases part of a specific Cys-X-X-Cys-His (CXXCH) binding motif, where X denotes a miscellaneous amino acid. Two thioether bonds of cysteine residues bind to the vinyl sidechains of heme, and the histidine residue coordinates one axial binding site of the heme iron. Less common binding motifs can include a single thioether linkage, a lysine or a methionine instead of the axial histidine or a CXnCH binding motif with n>2. The second axial site of the iron can be coordinated by amino acids of the protein, substrate molecules or water. Cytochromes ''c'' possess a wide range of properties and function as electron transfer proteins or catalyse chemical reactions involving redox processes. A prominent member of this family is mitochondrial cytochrome c. Classification Cytoc ...
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Omega Loop
The omega loop is a non-regular protein structural motif, consisting of a loop of six or more amino acid residues and any amino acid sequence. The defining characteristic is that residues that make up the beginning and end of the loop are close together in space with no intervening lengths of regular secondary structural motifs. It is named after its shape, which resembles the upper-case Greek letter Omega (Ω). Structure Omega loops, being non-regular, non-repeating secondary structural units, have a variety of three-dimensional shapes. Omega loop shapes are analyzed to identify recurring patterns in dihedral angles and overall loop shape to help identify potential roles in protein folding and function. Since loops are almost always at the protein surface, it is often assumed that these structures are flexible; however, different omega loops exhibit ranges of flexibility across different time scales of protein motion and have been identified as playing a role in the folding of so ...
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The Scripps Research Institute
Scripps Research, previously known as The Scripps Research Institute (TSRI), is a nonprofit American medical research facility that focuses on research and education in the biomedical sciences. Headquartered in San Diego, California, the institute has over 170 laboratories employing 2,100 scientists, technicians, graduate students, and administrative and other staff, making it the largest private, non-profit biomedical research organization in the United States and among the largest in the world. The institute holds over 1,100 patents, has produced 11 FDA-approved therapeutics, and has generated over 50 spin-off companies. According to the 2017 Nature Innovation Index, Scripps Research is the #1 most influential research institution in the world. The Scripps Research graduate program is ranked 9th nationally in the biological sciences, 6th for organic chemistry, and 6th for biochemistry. In 2022, their Jupiter, FL campus became a part of the University of Florida. Jupiter-based ...
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University At Albany, SUNY
The State University of New York at Albany, commonly referred to as the University at Albany, UAlbany or SUNY Albany, is a public research university with campuses in Albany, Rensselaer, and Guilderland, New York. Founded in 1844, it is one of the four "university centers" of the State University of New York (SUNY) system. The university enrolls 16,648 students in nine schools and colleges, which offer 50 undergraduate majors and 125 graduate degree programs. The university's academic choices include new and emerging fields in public policy, homeland security, globalization, documentary studies, biotechnology, and informatics. Through the UAlbany and SUNY-wide exchange programs, students have more than 600 study-abroad programs to choose from, as well as government and business internship opportunities in New York's capital and surrounding region. It is classified among "R1: Doctoral Universities – Very high research activity". The research enterprise totaled expenditur ...
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Peter S
Peter may refer to: People * List of people named Peter, a list of people and fictional characters with the given name * Peter (given name) ** Saint Peter (died 60s), apostle of Jesus, leader of the early Christian Church * Peter (surname), a surname (including a list of people with the name) Culture * Peter (actor) (born 1952), stage name Shinnosuke Ikehata, Japanese dancer and actor * ''Peter'' (album), a 1993 EP by Canadian band Eric's Trip * ''Peter'' (1934 film), a 1934 film directed by Henry Koster * ''Peter'' (2021 film), Marathi language film * "Peter" (''Fringe'' episode), an episode of the television series ''Fringe'' * ''Peter'' (novel), a 1908 book by Francis Hopkinson Smith * "Peter" (short story), an 1892 short story by Willa Cather Animals * Peter, the Lord's cat, cat at Lord's Cricket Ground in London * Peter (chief mouser), Chief Mouser between 1929 and 1946 * Peter II (cat), Chief Mouser between 1946 and 1947 * Peter III (cat), Chief Mouser between 1947 a ...
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Massachusetts Institute Of Technology
The Massachusetts Institute of Technology (MIT) is a private land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a key role in the development of modern technology and science, and is one of the most prestigious and highly ranked academic institutions in the world. Founded in response to the increasing industrialization of the United States, MIT adopted a European polytechnic university model and stressed laboratory instruction in applied science and engineering. MIT is one of three private land grant universities in the United States, the others being Cornell University and Tuskegee University. The institute has an urban campus that extends more than a mile (1.6 km) alongside the Charles River, and encompasses a number of major off-campus facilities such as the MIT Lincoln Laboratory, the Bates Center, and the Haystack Observatory, as well as affiliated laboratories such as the Broad and Whitehead Institutes. , 98 ...
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