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JacSue Kehoe
JacSue Kehoe (October 23, 1935 – June 25, 2019) was an American neuroscientist and neuroscience researcher. She spent decades working with the neurons of '' Aplysia californica'', studying post-synaptic nerve response. She discovered that one neurotransmitter can have multiple types of receptors, which could vary in level and type of response. Kehoe worked for the Centre national de la recherche scientifique, where she made many other discoveries in neuroscience. Early life JacSue Kehoe was born on October 23, 1935 in Cleveland, Ohio. Her mother was a former doctoral candidate turned English teacher. Her father was an employee of the Chrysler Corporation. The youngest of three, Kehoe and her family moved to Evansville, Indiana for the duration of World War II for her father’s work. After the war they migrated back to the city, where Kehoe discovered her interest in the performing arts. She became assistant to the dramatic arts teacher at her high school: this position inspi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cleveland, Ohio
Cleveland ( ), officially the City of Cleveland, is a city in the U.S. state of Ohio and the county seat of Cuyahoga County. Located in the northeastern part of the state, it is situated along the southern shore of Lake Erie, across the U.S. maritime border with Canada, northeast of Cincinnati, northeast of Columbus, and approximately west of Pennsylvania. The largest city on Lake Erie and one of the major cities of the Great Lakes region, Cleveland ranks as the 54th-largest city in the U.S. with a 2020 population of 372,624. The city anchors both the Greater Cleveland metropolitan statistical area (MSA) and the larger Cleveland–Akron–Canton combined statistical area (CSA). The CSA is the most populous in Ohio and the 17th largest in the country, with a population of 3.63 million in 2020, while the MSA ranks as 34th largest at 2.09 million. Cleveland was founded in 1796 near the mouth of the Cuyahoga River by General Moses Cleaveland, after whom the city was named ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Curare
Curare ( /kʊˈrɑːri/ or /kjʊˈrɑːri/; ''koo-rah-ree'' or ''kyoo-rah-ree'') is a common name for various alkaloid arrow poisons originating from plant extracts. Used as a paralyzing agent by indigenous peoples in Central and South America for hunting and for therapeutic purposes, curare only becomes active when it contaminates a wound. These poisons cause weakness of the skeletal muscles and, when administered in a sufficient dose, eventual death by asphyxiation due to paralysis of the diaphragm. Curare is prepared by boiling the bark of one of the dozens of plant sources, leaving a dark, heavy paste that can be applied to arrow or dart heads. In medicine, curare has been used as a treatment for tetanus or strychnine poisoning and as a paralyzing agent for surgical procedures. History The word 'curare' is derived from ''wurari'', from the Carib language of the Macusi of Guyana. It has its origins in the Carib phrase "mawa cure" meaning of the Mawa vine, scienti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Journal Of Physiology
''The Journal of Physiology'' is a biweekly peer-reviewed scientific journal that was established in 1878 and is published by Wiley-Blackwell on behalf of The Physiological Society. It covers research on all aspects of physiology, with an emphasis on human and mammalian physiology, including work at the molecular level, at the level of the cell membrane, single cells, tissues or organs, and systems physiology. The journal is produced both on paper and online. Accepted articles are first published online, ahead of print. The full archive back to 1878 up to issues published 12 months from the current date is freely available online. The editor-in-chief is currently Peter Kohl. According to the ''Journal Citation Reports'', the journal has a 2021 impact factor of 6.228, ranking it ninth out of 84 journals in the category "Physiology" History ''The Journal of Physiology'' was first published in 1878 and edited by Michael Foster. In 1893–94 Foster's colleague John Newport Langle ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Philippe Ascher
Philippe Ascher (28 July 1936 – 4 October 2022) was a French neuroscientist who was professor emeritus at the Université Paris Diderot. He devoted his research mainly to the characterization of cholinergic and glutamatergic neurotransmitter receptors. He was a corresponding member of the French Academy of Sciences since 1990. Biography Education Ascher was a student at the École normale supérieure from 1955 to 1959 and passed the Agrégation of biology in his final year, a highly competitive postgraduate examination which serves as a national ranking of students. Then he devoted his thesis to a problem of organization of nerves (the analysis of the circuits involved in the startle reaction of the anaesthetized cat to chloralose). He became a Doctor of Science in 1965. Career Philippe Ascher was interested in the ionic mechanisms associated with the action of neurotransmitters. On Aplysian neurons, he studied the inhibitory and excitatory effects of dopamine, and the r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glutamate
Glutamic acid (symbol Glu or E; the ionic form is known as glutamate) is an α-amino acid that is used by almost all living beings in the biosynthesis of proteins. It is a non-essential nutrient for humans, meaning that the human body can synthesize enough for its use. It is also the most abundant excitatory neurotransmitter in the vertebrate nervous system. It serves as the precursor for the synthesis of the inhibitory gamma-aminobutyric acid (GABA) in GABA-ergic neurons. Its molecular formula is . Glutamic acid exists in three optically isomeric forms; the dextrorotatory -form is usually obtained by hydrolysis of gluten or from the waste waters of beet-sugar manufacture or by fermentation.Webster's Third New International Dictionary of the English Language Unabridged, Third Edition, 1971. Its molecular structure could be idealized as HOOC−CH()−()2−COOH, with two carboxyl groups −COOH and one amino group −. However, in the solid state and mildly acidic water solu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cold Spring Harbor Laboratory
Cold Spring Harbor Laboratory (CSHL) is a private, non-profit institution with research programs focusing on cancer, neuroscience, plant biology, genomics, and quantitative biology. It is one of 68 institutions supported by the Cancer Centers Program of the U.S. National Cancer Institute (NCI) and has been an NCI-designated Cancer Center since 1987. The Laboratory is one of a handful of institutions that played a central role in the development of molecular genetics and molecular biology. It has been home to eight scientists who have been awarded the Nobel Prize in Physiology or Medicine. CSHL is ranked among the leading basic research institutions in molecular biology and genetics with Thomson Reuters ranking it #1 in the world. CSHL was also ranked #1 in research output worldwide by ''Nature''. The Laboratory is led by Bruce Stillman, a biochemist and cancer researcher. Since its inception in 1890, the institution's campus on the North Shore of Long Island has also been ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
James Watson
James Dewey Watson (born April 6, 1928) is an American molecular biologist, geneticist, and zoologist. In 1953, he co-authored with Francis Crick the academic paper proposing the double helix structure of the DNA molecule. Watson, Crick and Maurice Wilkins were awarded the 1962 Nobel Prize in Physiology or Medicine "for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material". In subsequent years, it has been recognized that Watson and his colleagues did not properly attribute colleague Rosalind Franklin for her contributions to the discovery of the double helix structure. Watson earned degrees at the University of Chicago ( BS, 1947) and Indiana University (PhD, 1950). Following a post-doctoral year at the University of Copenhagen with Herman Kalckar and Ole Maaløe, Watson worked at the University of Cambridge's Cavendish Laboratory in England, where he first met his future collaborator Franc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvard University
Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher learning in the United States and one of the most prestigious and highly ranked universities in the world. The university is composed of ten academic faculties plus Harvard Radcliffe Institute. The Faculty of Arts and Sciences offers study in a wide range of undergraduate and graduate academic disciplines, and other faculties offer only graduate degrees, including professional degrees. Harvard has three main campuses: the Cambridge campus centered on Harvard Yard; an adjoining campus immediately across Charles River in the Allston neighborhood of Boston; and the medical campus in Boston's Longwood Medical Area. Harvard's endowment is valued at $50.9 billion, making it the wealthiest academic institution in the world. Endowment inco ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
École Normale Supérieure , a Japanese video-games developer/publisher
{{disambiguation, geo ...
École may refer to: * an elementary school in the French educational stages normally followed by secondary education establishments (collège and lycée) * École (river), a tributary of the Seine flowing in région Île-de-France * École, Savoie, a French commune * École-Valentin, a French commune in the Doubs département * Grandes écoles, higher education establishments in France * The École, a French-American bilingual school in New York City Ecole may refer to: * Ecole Software This is a list of Notability, notable video game companies that have made games for either computers (like PC or Mac), video game consoles, handheld or mobile devices, and includes companies that currently exist as well as now-defunct companies. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
King's College, Cambridge
King's College is a constituent college of the University of Cambridge. Formally The King's College of Our Lady and Saint Nicholas in Cambridge, the college lies beside the River Cam and faces out onto King's Parade in the centre of the city. King's was founded in 1441 by King Henry VI soon after he had founded its sister institution at Eton College. Initially, King's accepted only students from Eton College. However, the king's plans for King's College were disrupted by the Wars of the Roses and the resultant scarcity of funds, and then his eventual deposition. Little progress was made on the project until 1508, when King Henry VII began to take an interest in the college, probably as a political move to legitimise his new position. The building of the college's chapel, begun in 1446, was finished in 1544 during the reign of Henry VIII. King's College Chapel is regarded as one of the finest examples of late English Gothic architecture. It has the world's largest fan vaul ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
High Table
The high table is a table for the use of fellows (members of the Senior Common Room) and their guests in large university dining halls in anglo-saxon countries, where the students eat in the main space of the hall at the same time. They remain the norm at Oxford, Cambridge, Dublin and Durham universities, where the university is organized into colleges. Other academic institutions (such as University of London; University of St Andrews; University of Manchester, University of Bristol and St.David’s University College in the UK, Queen's University, the University of Notre Dame in the United States, The University of Trinity College and Massey College at the University of Toronto, and the University of Hong Kong) also have high tables. The table is normally at the end of the dining hall on a raised platform, although this is not always the case. Typically, the high table is set across the breadth of the hall, and is thus at right angles to the tables in use by the main body ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gabriel Horn
Sir Gabriel Horn, MD, ScD, FRS, FRCP (9 December 1927 – 2 August 2012) was a British neuroscientist and Professor in Natural Sciences (Zoology) at the University of Cambridge. His research was into the neural mechanisms of learning and memory. Early life Horn was born on 9 December 1927. He attended Handsworth Technical School in Handsworth, Birmingham. He left the school at 16 to work in his parents' shop and studied part-time for a National Certificate in Mechanical Engineering, achieving distinction. He served in the Royal Air Force before studying for a Bachelor of Medicine, Bachelor of Surgery at the University of Birmingham. Academic career Horn's first academic position was in 1956 at the Department of Anatomy, University of Cambridge as a Demonstrator in Anatomy. He became a Lecturer and then a Reader, before leaving to become Professor of Anatomy at the University of Bristol in 1974. In 1975, while at Bristol, he obtained his DSc degree. In 1977, he returned to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
