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John Michael Ramsey
John Michael Ramsey is an American analytical chemist at the University of North Carolina at Chapel Hill. He currently holds the position of Minnie N. Goldby Distinguished Professor of Chemistry. His current research with the university focuses on microscale and nanoscale devices such as microchip electrospray, microscale Ion trap mass spectrometers, and microfluidic point of care devices. He is ranked #2 in the "Giants of Nano" field on The Analytical Scientist Power List. Career Early research Dr. Michael Ramsey attended Bowling Green State University for his undergraduate studies where he obtained his Bachelor of Science in Chemistry with dual minors in Physics and Mathematics in June 1974. He then went on to obtain his Doctor of Philosophy in Analytical chemistry from Indiana University Bloomington in January 1979. Dr. Ramsey conducted his research under the direction of Dr. Gary M. Hieftje from 1974-1979 culminating in his published dissertation "New Approaches for th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mansfield, Ohio
Mansfield is a city in and the county seat of Richland County, Ohio, United States. Located midway between Columbus and Cleveland via Interstate 71, it is part of Northeast Ohio region in the western foothills of the Allegheny Plateau. The city lies approximately southwest of Cleveland, southwest of Akron and northeast of Columbus. The city was founded in 1808 on a fork of the Mohican River in a hilly region surrounded by fertile farmlands, and became a manufacturing center owing to its location with numerous railroad lines. After the decline of heavy manufacturing, the city's economy has since diversified into a service economy, including retailing, education, and healthcare sectors. The 2020 Census showed that the city had a total population of 47,534, making it the 21st-largest city in Ohio. The city anchors the Mansfield Metropolitan Statistical Area (MSA), which had a population of 124,936 residents in 2020,Table of United States Metropolitan Statistical Areas while t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
High-throughput Screening
High-throughput screening (HTS) is a method for scientific experimentation especially used in drug discovery and relevant to the fields of biology, materials science and chemistry. Using robotics, data processing/control software, liquid handling devices, and sensitive detectors, high-throughput screening allows a researcher to quickly conduct millions of chemical, genetic, or pharmacological tests. Through this process one can quickly recognize active compounds, antibodies, or genes that modulate a particular biomolecular pathway. The results of these experiments provide starting points for drug design and for understanding the noninteraction or role of a particular location. Assay plate preparation The key labware or testing vessel of HTS is the microtiter plate, which is a small container, usually disposable and made of plastic, that features a grid of small, open divots called ''wells''. In general, microplates for HTS have either 96, 192, 384, 1536, 3456 or 6144 wells. The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eugene Wigner
Eugene Paul "E. P." Wigner ( hu, Wigner Jenő Pál, ; November 17, 1902 – January 1, 1995) was a Hungarian-American theoretical physicist who also contributed to mathematical physics. He received the Nobel Prize in Physics in 1963 "for his contributions to the theory of the atomic nucleus and the elementary particles, particularly through the discovery and application of fundamental symmetry principles". A graduate of the Technical University of Berlin, Wigner worked as an assistant to Karl Weissenberg and Richard Becker at the Kaiser Wilhelm Institute in Berlin, and David Hilbert at the University of Göttingen. Wigner and Hermann Weyl were responsible for introducing group theory into physics, particularly the theory of symmetry in physics. Along the way he performed ground-breaking work in pure mathematics, in which he authored a number of mathematical theorems. In particular, Wigner's theorem is a cornerstone in the mathematical formulation of quantum mechanics. He is also ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PerkinElmer
PerkinElmer, Inc., previously styled Perkin-Elmer, is an American global corporation focused in the business areas of diagnostics, life science research, food, environmental and industrial testing. Its capabilities include detection, imaging, informatics, and service. PerkinElmer produces analytical instruments, genetic testing and diagnostic tools, medical imaging components, software, instruments, and consumables for multiple end markets. PerkinElmer is part of the S&P 500 Index and operates in 190 countries. History Founding Richard Perkin was attending the Pratt Institute in Brooklyn to study chemical engineering, but left after a year to try his hand on Wall Street. Still interested in the sciences, he gave public lectures on various topics. Charles Elmer ran a firm that supplied court reporters and was nearing retirement when he attended one of Perkin's lectures on astronomy being held at the Brooklyn Institute of Arts and Sciences. The two struck up a friendship ove ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lab-on-a-chip
A lab-on-a-chip (LOC) is a device that integrates one or several laboratory functions on a single integrated circuit (commonly called a "chip") of only millimeters to a few square centimeters to achieve automation and high-throughput screening. LOCs can handle extremely small fluid volumes down to less than pico-liters. Lab-on-a-chip devices are a subset of microelectromechanical systems (MEMS) devices and sometimes called "micro total analysis systems" (µTAS). LOCs may use microfluidics, the physics, manipulation and study of minute amounts of fluids. However, strictly regarded "lab-on-a-chip" indicates generally the scaling of single or multiple lab processes down to chip-format, whereas "µTAS" is dedicated to the integration of the total sequence of lab processes to perform chemical analysis. The term "lab-on-a-chip" was introduced when it turned out that µTAS technologies were applicable for more than only analysis purposes. History After the invention of microtechnolo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Caliper Life Sciences
Caliper, A PerkinElmer Company produces products and services for life sciences research. The firm, founded in 1995, is based in Hopkinton, Massachusetts with direct sales, service and application-support operations in countries around the globe. The firm's products include instruments, software and reagents, laboratory automation tools microfluidics, lab automation & liquid handling, optical imaging technologies, and services for drug discovery & drug development. Products Microfluidic platform Caliper is a pioneer in microfluidic lab-on-a-chip technology. Its microfluidic lab-on-a-chip products, including a proprietary microfluidic sipper chip, are a high-throughput complement to the firm's planar chips. The microfluidic technology forms the basis of the firm's reader systems used for drug screening and profiling and for molecular biology DNA, RNA and protein analysis. Optical imaging Through its acquisition of Xenogen Corporation in 2006, the firm is now ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Federal Laboratory Consortium
The Federal Laboratory Consortium for Technology Transfer (FLC) is a U.S.-based nationwide network of federal laboratories that provides a forum to develop strategies and opportunities to help transfer laboratory mission technologies into commercial products for the global marketplace. The FLC was organized in 1974 and formally chartered by the Federal Technology Transfer Act of 1986. Its host agency is the National Institute of Standards and Technology. More than 250 federal laboratories and centers and their parent departments and agencies are currently FLC members. In accordance with the Act and related federal policy, the FLC's mission is to promote and facilitate the rapid movement of federal laboratory research results and technologies into the mainstream of the U.S. economy. Specifically, the FLC develops and tests transfer methods, addresses barriers to the process, provides training, highlights grass-roots transfer efforts, and emphasizes national initiatives in which t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mass Spectrometry
Mass spectrometry (MS) is an analytical technique that is used to measure the mass-to-charge ratio of ions. The results are presented as a ''mass spectrum'', a plot of intensity as a function of the mass-to-charge ratio. Mass spectrometry is used in many different fields and is applied to pure samples as well as complex mixtures. A mass spectrum is a type of plot of the ion signal as a function of the mass-to-charge ratio. These spectra are used to determine the elemental or isotopic signature of a sample, the masses of particles and of molecules, and to elucidate the chemical identity or structure of molecules and other chemical compounds. In a typical MS procedure, a sample, which may be solid, liquid, or gaseous, is ionized, for example by bombarding it with a beam of electrons. This may cause some of the sample's molecules to break up into positively charged fragments or simply become positively charged without fragmenting. These ions (fragments) are then separated accordin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nanofluidics
Nanofluidics is the study of the behavior, manipulation, and control of fluids that are confined to structures of nanometer (typically 1–100 nm) characteristic dimensions (1 nm = 10−9 m). Fluids confined in these structures exhibit physical behaviors not observed in larger structures, such as those of micrometer dimensions and above, because the characteristic physical scaling lengths of the fluid, (''e.g.'' Debye length, hydrodynamic radius) very closely coincide with the dimensions of the nanostructure itself. When structures approach the size regime corresponding to molecular scaling lengths, new physical constraints are placed on the behavior of the fluid. For example, these physical constraints induce regions of the fluid to exhibit new properties not observed in bulk, ''e.g.'' vastly increased viscosity near the pore wall; they may effect changes in thermodynamic properties and may also alter the chemical reactivity of species at the fluid-solid interface. A p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Microfluidics
Microfluidics refers to the behavior, precise control, and manipulation of fluids that are geometrically constrained to a small scale (typically sub-millimeter) at which surface forces dominate volumetric forces. It is a multidisciplinary field that involves engineering, physics, chemistry, biochemistry, nanotechnology, and biotechnology. It has practical applications in the design of systems that process low volumes of fluids to achieve multiplexing, automation, and high-throughput screening. Microfluidics emerged in the beginning of the 1980s and is used in the development of inkjet printheads, DNA chips, lab-on-a-chip technology, micro-propulsion, and micro-thermal technologies. Typically, micro means one of the following features: * Small volumes (μL, nL, pL, fL) * Small size * Low energy consumption * Microdomain effects Typically microfluidic systems transport, mix, separate, or otherwise process fluids. Various applications rely on passive fluid control using capillary fo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Environmental Monitoring
Environmental monitoring describes the processes and activities that need to take place to characterize and monitor the quality of the environment. Environmental monitoring is used in the preparation of environmental impact assessments, as well as in many circumstances in which human activities carry a risk of harmful effects on the natural environment. All monitoring strategies and programs have reasons and justifications which are often designed to establish the current status of an environment or to establish trends in environmental parameters. In all cases, the results of monitoring will be reviewed, analyzed statistically, and published. The design of a monitoring program must therefore have regard to the final use of the data before monitoring starts. Environmental monitoring includes monitoring of air quality, soils and water quality. Air quality monitoring Air pollutants are atmospheric substances—both naturally occurring and anthropogenic—which may potentially ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Health Care
Health care or healthcare is the improvement of health via the prevention, diagnosis, treatment, amelioration or cure of disease, illness, injury, and other physical and mental impairments in people. Health care is delivered by health professionals and allied health fields. Medicine, dentistry, pharmacy, midwifery, nursing, optometry, audiology, psychology, occupational therapy, physical therapy, athletic training, and other health professions all constitute health care. It includes work done in providing primary care, secondary care, and tertiary care, as well as in public health. Access to health care may vary across countries, communities, and individuals, influenced by social and economic conditions as well as health policies. Providing health care services means "the timely use of personal health services to achieve the best possible health outcomes". Factors to consider in terms of health care access include financial limitations (such as insurance coverage), geo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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