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John H. Gaddum
Sir John Henry Gaddum (31 March 1900 – 30 June 1965) was an English pharmacologist who, with Ulf von Euler, co-discovered the neuropeptide Substance P in 1931. He was a founder member of the British Pharmacological Society and first editor of the ''British Journal of Pharmacology''. Early life and education He was born in Hale (now part of Manchester) the son of silk merchant, Henry Edwin Gaddum and his wife Phyllis Mary Barratt. He was educated at Moorland House School, Heswall, Cheshire; Rugby School; and Trinity College, Cambridge. He completed his BSc in Physiology at the University of Cambridge in 1922, and his MD at University College London in 1925. His first role was to assist J. W, Trevan at the Wellcome Physiological Research Laboratories. Career From 1927–33, Gaddum worked under Henry Dale at the National Institute for Medical Research, and helped develop the classical laws of drug antagonism. He showed that sympathetic nerves release adrenaline. Together ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pharmacology
Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemical or physiological effect on the cell, tissue, organ, or organism (sometimes the word ''pharmacon'' is used as a term to encompass these endogenous and exogenous bioactive species). More specifically, it is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function. If substances have medicinal properties, they are considered pharmaceuticals. The field encompasses drug composition and properties,functions,sources,synthesis and drug design, molecular and cellular mechanisms, organ/systems mechanisms, signal transduction/cellular communication, molecular diagnostics, interactions, chemical biology, therapy, and medical applications and antipathogenic capabilities. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Heswall
Heswall is a town on the Wirral, Merseyside, England. At the 2001 Census, the population was 16,012, including the nearby villages of Barnston and Gayton. Before local government reorganisation on 1 April 1974 it was part of the administrative county of Cheshire. Geography Located on the eastern side of the Dee Estuary, with views across the river to North Wales, Heswall is about 20 minutes' drive from the Roman city of Chester and about 20 minutes' drive from Liverpool. The towers of Liverpool's cathedrals can be seen on the horizon from high ground. History Early History Before the Norman Conquest The Norman Conquest (or the Conquest) was the 11th-century invasion and occupation of England by an army made up of thousands of Norman, Breton, Flemish, and French troops, all led by the Duke of Normandy, later styled William the Conq ..., Heswall has been cited as a possible location for Dingesmere, mentioned with regard to the Battle of Brunanburh, in ''E ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
James Ritchie (naturalist)
James Ritchie CBE PRSE (27 May 1882 – 19 October 1958) was a Scottish naturalist and archaeologist, who was Professor of Natural History at the University of Edinburgh 1936–52 and President of the Royal Society of Edinburgh 1952–1958. Life He was born on 27 May 1882 in Port Elphinstone in Aberdeenshire the son of James Ritchie, the local schoolmaster. He was educated at Gordon's College in Aberdeen then studied Science at Aberdeen University. In 1916 he was elected a Fellow of the Royal Society of Edinburgh. His proposers were Sir Thomas Carlaw Martin, James Cossar Ewart, James Hartley Ashworth and Cargill Gilston Knott. He won the Society's Keith Prize for the period 1941–43. He served as Secretary 1928–31; Vice President 1931–34, 1940–43 and 1951–54; and President 1954–58. From 1921 to 1930 he was Keeper of Natural History at the Royal Scottish Museum on Chambers Street in Edinburgh. In 1930 he left Edinburgh to take up a post of Regius Professor of Na ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thomas J
Clarence Thomas (born June 23, 1948) is an American jurist who serves as an associate justice of the Supreme Court of the United States. He was nominated by President George H. W. Bush to succeed Thurgood Marshall and has served since 1991. After Marshall, Thomas is the second African American to serve on the Court and its longest-serving member since Anthony Kennedy's retirement in 2018. Thomas was born in Pin Point, Georgia. After his father abandoned the family, he was raised by his grandfather in a poor Gullah community near Savannah. Growing up as a devout Catholic, Thomas originally intended to be a priest in the Catholic Church but was frustrated over the church's insufficient attempts to combat racism. He abandoned his aspiration of becoming a clergyman to attend the College of the Holy Cross and, later, Yale Law School, where he was influenced by a number of conservative authors, notably Thomas Sowell, who dramatically shifted his worldview from progressive to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
James Couper Brash
James Couper Brash, MC, FRCSE, FRSE (24 October 1886 in Cathcart – 19 January 1958 in Edinburgh) was a leading anatomist and embryologist in Britain. Early life and family James Couper Brash was born in Cathcart in Scotland, the son of James Brash, J.P. He was educated at George Watson's College and the University of Edinburgh. Brash graduated B.Sc. in 1908 and M.B., Ch.B. in 1910. In 1912 Brash married Margaret Henderson, daughter of William Henderson, of Leslie, Fife, and she survived him together with one son, James Couper Henderson Brash (d.1990) and one daughter, Nancy Brash. Neither had children, ending the line. Career After holding the post of resident physician at the Royal Infirmary and working as a demonstrator of anatomy at Edinburgh, he became an assistant in the anatomical department in the University of Leeds. During the First World War he served as a Major in the Royal Army Medical Corps in France and Belgium and was awarded the Military Cross for his b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
James Pickering Kendall
James Pickering Kendall FRS FRSE (30 July 1889, in Chobham, Surrey – 14 June 1978, in Edinburgh) was a British chemist. Life Kendall was born in Chobham, Surrey to soldier William Henry Kendall of the Royal Horse Artillery, and his second wife Rebecca Pickering. He attended the local village school and then, from 1900, Farnham Grammar School. From 1907 to 1910, he studied at the University of Edinburgh graduating with both a BSc and MA. In 1912, with the support of a scholarship, he went to the Nobel Institute for Physical Chemistry in Stockholm to work with Arrhenius on electrolytes. In 1913, he accepted the position as Professor of Chemistry at Columbia University, New York. He also served in 1917 as a Lieutenant Commander in the United States Naval Reserve, acting as Liaison Officer with Allied Services on Chemical Warfare. His candidacy for the Royal Society of London in 1924 read: ''"Distinguished as an investigator in physical and general chemistry. Has published si ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal Society Of Edinburgh
The Royal Society of Edinburgh is Scotland's national academy of science and letters. It is a registered charity that operates on a wholly independent and non-partisan basis and provides public benefit throughout Scotland. It was established in 1783. , there are around 1,800 Fellows. The Society covers a broader selection of fields than the Royal Society of London, including literature and history. Fellowship includes people from a wide range of disciplines – science & technology, arts, humanities, medicine, social science, business, and public service. History At the start of the 18th century, Edinburgh's intellectual climate fostered many clubs and societies (see Scottish Enlightenment). Though there were several that treated the arts, sciences and medicine, the most prestigious was the Society for the Improvement of Medical Knowledge, commonly referred to as the Medical Society of Edinburgh, co-founded by the mathematician Colin Maclaurin in 1731. Maclaurin was unhappy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Second World War
World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the vast majority of the world's countries—including all of the great powers—forming two opposing military alliances: the Allies and the Axis powers. World War II was a total war that directly involved more than 100 million personnel from more than 30 countries. The major participants in the war threw their entire economic, industrial, and scientific capabilities behind the war effort, blurring the distinction between civilian and military resources. Aircraft played a major role in the conflict, enabling the strategic bombing of population centres and deploying the only two nuclear weapons ever used in war. World War II was by far the deadliest conflict in human history; it resulted in 70 to 85 million fatalities, mostly among civilians. Tens of millions died due to genocides (including the Holocaust), starvation, ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Autonomic Ganglia
An autonomic ganglion is a cluster of nerve cell bodies (a ganglion) in the autonomic nervous system The autonomic nervous system (ANS), formerly referred to as the vegetative nervous system, is a division of the peripheral nervous system that supplies viscera, internal organs, smooth muscle and glands. The autonomic nervous system is a control .... The two types are the sympathetic ganglion and the parasympathetic ganglion. References {{Authority control Autonomic nervous system ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetylcholine
Acetylcholine (ACh) is an organic chemical that functions in the brain and body of many types of animals (including humans) as a neurotransmitter. Its name is derived from its chemical structure: it is an ester of acetic acid and choline. Parts in the body that use or are affected by acetylcholine are referred to as cholinergic. Substances that increase or decrease the overall activity of the cholinergic system are called cholinergics and anticholinergics, respectively. Acetylcholine is the neurotransmitter used at the neuromuscular junction—in other words, it is the chemical that motor neurons of the nervous system release in order to activate muscles. This property means that drugs that affect cholinergic systems can have very dangerous effects ranging from paralysis to convulsions. Acetylcholine is also a neurotransmitter in the autonomic nervous system, both as an internal transmitter for the sympathetic nervous system and as the final product released by the parasymp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sympathetic Nerves
The sympathetic nervous system (SNS) is one of the three divisions of the autonomic nervous system, the others being the parasympathetic nervous system and the enteric nervous system. The enteric nervous system is sometimes considered part of the autonomic nervous system, and sometimes considered an independent system. The autonomic nervous system functions to regulate the body's unconscious actions. The sympathetic nervous system's primary process is to stimulate the body's fight or flight response. It is, however, constantly active at a basic level to maintain homeostasis. The sympathetic nervous system is described as being antagonistic to the parasympathetic nervous system which stimulates the body to "feed and breed" and to (then) "rest-and-digest". Structure There are two kinds of neurons involved in the transmission of any signal through the sympathetic system: pre-ganglionic and post-ganglionic. The shorter preganglionic neurons originate in the thoracolumbar division of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Receptor Antagonist
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist. Antagonist drugs interfere in the natural operation of receptor proteins.Pharmacology Guide: In vitro pharmacology: concentration-response curves " '' GlaxoWellcome.'' Retrieved on December 6, 2007. They are sometimes called blockers; examples include alpha blockers, |
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