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Johan Auwerx
Johan Auwerx (born 1958 in Diepenbeek, Belgium) is a Belgian biologist, and a professor at the École Polytechnique Fédérale de Lausanne (EPFL). His research in the fields of cellular metabolism has contributed to a better understanding of the regulation of mitochondrial function by signaling pathways. Career Johan Auwerx studied medicine at the Université catholique de Louvain and received his doctoral degree in 1982. He then worked as a post-doctoral researcher at the University of Washington in Seattle, and was appointed professor at the Louis Pasteur University in Strasbourg, and at the École polytechnique fédérale de Lausanne in 2008. He leads the Laboratory of Integrative Systems Physiology (LISP) and occupies the Nestlé chair on energy metabolism. Johan Auwerx's lab studies how factors such as diet, physical exercise or hormones regulate metabolism by altering gene expression through modulating the activity of transcription factors and co-factors. Distinc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diepenbeek
Diepenbeek (; li, Diepenbik) is a municipality located in the Belgian province of Limburg near Hasselt. On January 1, 2012, Diepenbeek had a total population of 18,337. Its total area is 41.19 km² (15.9 sq mi) which gives a population density of 430 inhabitants per km² (1,203/sq mi). The municipality includes the communities and hamlets of Bijenberg, het Crijt, Dorpheide, Keizel, Lutselus, Pampert, Piannesberg, Reitje, Rooierheide, Rozendaal, and Zwartveld. It is home to Hasselt University, slowly expanding towards Hasselt itself. The Limburg Science Park is located on the university campus. References External links * Official website- Only available in Dutch Dutch commonly refers to: * Something of, from, or related to the Netherlands * Dutch people () * Dutch language () Dutch may also refer to: Places * Dutch, West Virginia, a community in the United States * Pennsylvania Dutch Country People E ... Municipalities of Limburg (Belgium) {{LimburgBE-ge ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Louis Pasteur University
Louis Pasteur University (''Université Louis-Pasteur''), also known as Strasbourg I or ULP was a large university in Strasbourg, Alsace, France. As of 15 January 2007, there were 18,847 students enrolled at the university, including around 3,000 foreign students. Research and teaching at ULP concentrated on the natural sciences, technology and medicine. On 1 January 2009, Louis Pasteur University became part of the refounded University of Strasbourg and lost its status as an independent university. The university was a member of the LERU (League of European Research Universities). It was named after the famous 19th-century French scientist Louis Pasteur. Nineteen Nobel laureates and two laureates of the Fields Medal have studied, taught or conducted research at Louis Pasteur University, underlining the excellent reputation of the university. Notable staff and students * Louis Pasteur (1822–1895), professor of chemistry * Adolf von Baeyer (1835–1917), professor of chem ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Minkowski Prize
The Minkowski Prize is given by the European Association for the Study of Diabetes (EASD) in recognition to research which has been carried out by a person normally residing in Europe, as manifested by publications which contribute to the advancement of knowledge concerning diabetes mellitus. The Prize honors the name of Oskar Minkowski (1858–1931), a physician and physiologist who was the discoverer of the role of pancreas in the control of glucose metabolism. It has been awarded annually since 1966, and the winner is invited to pronounce a Minkowski Lecture during the EASD Annual Conference. It is traditionally seen as the most prestigious European prize in the field of diabetes research. Since 1966, the award is sponsored by a pharmaceutical company Sanofi-Aventis. The prize consists of a certificate and 20,000 euros plus travel expenses. The candidate must be less than 45 years of age on 1 January of the year of award. Self-nomination is possible. Winners With the city wher ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Metabolic Disorder
A metabolic disorder is a disorder that negatively alters the body's processing and distribution of macronutrients, such as proteins, fats, and carbohydrates. Metabolic disorders can happen when abnormal chemical reactions in the body alter the normal metabolic process. It can also be defined as inherited single gene anomaly, most of which are autosomal recessive. Signs and symptoms Some of the symptoms that can occur with metabolic disorders are lethargy, weight loss, jaundice and seizures. The symptoms expressed would vary with the type of metabolic disorder. There are four categories of symptoms: acute symptoms, late-onset acute symptoms, progressive general symptoms and permanent symptoms. Causes Inherited metabolic disorders are one cause of metabolic disorders, and occur when a defective gene causes an enzyme deficiency. These diseases, of which there are many subtypes, are known as inborn errors of metabolism. Metabolic diseases can also occur when the liver or pancre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nutrient
A nutrient is a substance used by an organism to survive, grow, and reproduce. The requirement for dietary nutrient intake applies to animals, plants, fungi, and protists. Nutrients can be incorporated into cells for metabolic purposes or excreted by cells to create non-cellular structures, such as hair, scales, feathers, or exoskeletons. Some nutrients can be metabolically converted to smaller molecules in the process of releasing energy, such as for carbohydrates, lipids, proteins, and fermentation products (ethanol or vinegar), leading to end-products of water and carbon dioxide. All organisms require water. Essential nutrients for animals are the energy sources, some of the amino acids that are combined to create proteins, a subset of fatty acids, vitamins and certain minerals. Plants require more diverse minerals absorbed through roots, plus carbon dioxide and oxygen absorbed through leaves. Fungi live on dead or living organic matter and meet nutrient needs from their host. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mitochondria
A mitochondrion (; ) is an organelle found in the Cell (biology), cells of most Eukaryotes, such as animals, plants and Fungus, fungi. Mitochondria have a double lipid bilayer, membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which is used throughout the cell as a source of chemical energy. They were discovered by Albert von Kölliker in 1857 in the voluntary muscles of insects. The term ''mitochondrion'' was coined by Carl Benda in 1898. The mitochondrion is popularly nicknamed the "powerhouse of the cell", a phrase coined by Philip Siekevitz in a 1957 article of the same name. Some cells in some multicellular organisms lack mitochondria (for example, mature mammalian red blood cells). A large number of unicellular organisms, such as microsporidia, parabasalids and diplomonads, have reduced or transformed their mitochondria into mitosome, other structures. One eukaryote, ''Monocercomonoides'', is known to have completely lost its mitocho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
European Molecular Biology Organization
The European Molecular Biology Organization (EMBO) is a professional, non-profit organization of more than 1,800 life scientists. Its goal is to promote research in life science and enable international exchange between scientists. It co-funds courses, workshops and conferences, publishes five scientific journals and supports individual scientists. The organization was founded in 1964 and is a founding member of the Initiative for Science in Europe. the Director of EMBO is Fiona Watt, a stem cell researcher, professor at King's College London and a group leader at the European Molecular Biology Laboratory. Conferences and journals EMBO funds or co-funds over 90 meetings involving more than 11,000 participants every year. EMBO publishes five peer-reviewed scientific journals: ''The EMBO Journal'', ''EMBO Reports'', ''Molecular Systems Biology'', ''EMBO Molecular Medicine'', and ''Life Science Alliance'', History The European Molecular Biology Organization (EMBO) was launched ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transcription Factors
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The function of TFs is to regulate—turn on and off—genes in order to make sure that they are expressed in the desired cells at the right time and in the right amount throughout the life of the cell and the organism. Groups of TFs function in a coordinated fashion to direct cell division, cell growth, and cell death throughout life; cell migration and organization (body plan) during embryonic development; and intermittently in response to signals from outside the cell, such as a hormone. There are up to 1600 TFs in the human genome. Transcription factors are members of the proteome as well as regulome. TFs work alone or with other proteins in a complex, by promoting (as an activator), or blocking (as a repressor) the recruitment of RNA po ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene Expression
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product that enables it to produce end products, protein or non-coding RNA, and ultimately affect a phenotype, as the final effect. These products are often proteins, but in non-protein-coding genes such as transfer RNA (tRNA) and small nuclear RNA (snRNA), the product is a functional non-coding RNA. Gene expression is summarized in the central dogma of molecular biology first formulated by Francis Crick in 1958, further developed in his 1970 article, and expanded by the subsequent discoveries of reverse transcription and RNA replication. The process of gene expression is used by all known life—eukaryotes (including multicellular organisms), prokaryotes (bacteria and archaea), and utilized by viruses—to generate the macromolecular machinery for life. In genetics, gene expression is the most fundamental level at which the genotype gives rise to the phenotype, '' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hormones
A hormone (from the Ancient Greek, Greek participle , "setting in motion") is a class of cell signaling, signaling molecules in multicellular organisms that are sent to distant organs by complex biological processes to regulate physiology and behavior. Hormones are required for the correct development of animals, plants and fungi. Due to the broad definition of a hormone (as a signaling molecule that exerts its effects far from its site of production), numerous kinds of molecules can be classified as hormones. Among the substances that can be considered hormones, are eicosanoids (e.g. prostaglandins and thromboxanes), steroids (e.g. Estrogen, oestrogen and brassinosteroid), amino acid derivatives (e.g. epinephrine and auxin), protein or peptides (e.g. insulin and CLE peptides), and gases (e.g. ethylene and nitric oxide). Hormones are used to communicate between organ (anatomy), organs and Tissue (biology), tissues. In vertebrates, hormones are responsible for regulating a variety ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Physical Exercise
Exercise is a body activity that enhances or maintains physical fitness and overall health and wellness. It is performed for various reasons, to aid growth and improve strength, develop muscles and the cardiovascular system, hone athletic skills, weight loss or maintenance, improve health, or simply for enjoyment. Many individuals choose to exercise outdoors where they can congregate in groups, socialize, and improve well-being as well as mental health. In terms of health benefits, the amount of recommended exercise depends upon the goal, the type of exercise, and the age of the person. Even doing a small amount of exercise is healthier than doing none. Classification Physical exercises are generally grouped into three types, depending on the overall effect they have on the human body: * Aerobic exercise is any physical activity that uses large muscle groups and causes the body to use more oxygen than it would while resting. The goal of aerobic exercise is to increa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diet (nutrition)
In nutrition, diet is the sum of food consumed by a person or other organism. The word diet often implies the use of specific intake of nutrition for health or weight-management reasons (with the two often being related). Although humans are omnivores, each culture and each person holds some food preferences or some food taboos. This may be due to personal tastes or ethical reasons. Individual dietary choices may be more or less healthy. Complete nutrition requires ingestion and absorption of vitamins, minerals, essential amino acids from protein and essential fatty acids from fat-containing food, also food energy in the form of carbohydrate, protein, and fat. Dietary habits and choices play a significant role in the quality of life, health and longevity. Health A healthy diet can improve and maintain health, which can include aspects of mental and physical health. Specific diets, such as the DASH diet, can be used in treatment and management of chronic conditions. Dietar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
