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Joel Elkes
Joel Elkes (pronounced el' kez) (12 November 1913, Königsberg – 30 October 2015, Sarasota) was a leading medical researcher specialising in the chemistry of the brain. He qualified as a physician in London and later became a medical researcher who published the first double-blind scientific trial on chlorpromazine to treat schizophrenia. He is regarded as the father of modern neuropsychopharmacology and directed the first experimental psychiatric Uffculme Clinic in Birmingham, UK. He was responsible for the setting up of international organisations and university departments to further the investigation of the effects of psychopharmacy. He spent the latter part of his career endeavouring to bring higher levels of humanity, compassion and ethics to medical training. Early life Elkes was born of Jewish parents Elkhanan and Miriam in the city of Königsberg (now Kaliningrad).(BB) His father served in the Russian Army as a medical officer during the Russian Revolution of 1905 and Wo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Johns Hopkins School Of Medicine
The Johns Hopkins University School of Medicine (JHUSOM) is the medical school of Johns Hopkins University, a private research university in Baltimore, Maryland. Founded in 1893, the School of Medicine shares a campus with the Johns Hopkins Hospital and Johns Hopkins Children's Center, established in 1889. It has consistently ranked among the top medical schools in the United States in terms of the number/amount of research grants/funding awarded by the National Institutes of Health, among other measures. History The founding physicians (the "Four Doctors") of the Johns Hopkins School of Medicine included pathologist William Henry Welch (1850–1934), the first dean of the school and a mentor to generations of research scientists; a Canadian, internist Sir William Osler (1849–1919), regarded as the ''Father of Modern Medicine'', having been perhaps the most influential physician of the late 19th and early 20th centuries as author of '' The Principles and Practice of Medicine'' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paul Erlich
Paul Erlich (born 1972) is a guitarist and music theorist living near Boston, Massachusetts. He is known for his seminal role in developing the theory of regular temperaments, including being the first to define pajara temperament Accessed 2013-10-29.. and its decatonic scales in 22-ET. He holds a Bachelor of Science degree in physics from Yale University. His definition of harmonic entropy, a refinement of a model by van Eck influenced by Ernst Terhardt has received attention from music theorists such as William Sethares.Sethares, William (2005). Tuning, Timbre, Spectrum, Scale', p.371. Springer Science & Business Media. . "Harmonic entropy is a measure of the uncertainty in pitch perception, and it provides a physical correlate of tonalness the closeness of the partials of a complex sound to a harmonic series" one aspect of the psychoacoustic concept of dissonance....high tonalness corresponds to low entropy and low tonalness corresponds to high entropy." It is intended t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetylcholinesterase Inhibitor
Acetylcholinesterase inhibitors (AChEIs) also often called cholinesterase inhibitors, inhibit the enzyme acetylcholinesterase from breaking down the neurotransmitter acetylcholine into choline and acetate, thereby increasing both the level and duration of action of acetylcholine in the central nervous system, autonomic ganglia and neuromuscular junctions, which are rich in acetylcholine receptors. Acetylcholinesterase inhibitors are one of two types of cholinesterase inhibitors; the other being butyryl-cholinesterase inhibitors. Acetylcholinesterase is the primary member of the cholinesterase enzyme family. Acetylcholinesterase inhibitors are classified as reversible, irreversible, or quasi-irreversible (also called pseudo-irreversible). Mechanism of action Organophosphates Organophosphates like TEPP and sarin inhibit cholinesterases, enzymes that hydrolyze the neurotransmitter acetylcholine. The active centre of cholinesterases feature two important sites, namely the a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paracrystalline
In materials science, paracrystalline materials are defined as having short- and medium-range ordering in their lattice (similar to the liquid crystal phases) but lacking crystal-like long-range ordering at least in one direction. Origin and definition The words "paracrystallinity" and "paracrystal" were coined by the late Friedrich Rinne in the year 1933. Their German equivalents, e.g. "Parakristall", appeared in print one year earlier. A general theory of paracrystals has been formulated in a basic textbook, and then further developed/refined by various authors. Rolf Hosemann's definition of an ideal paracrystal is: "The electron density distribution of any material is equivalent to that of a paracrystal when there is for every building block one ideal point so that the distance statistics to other ideal points are identical for all of these points. The electron configuration of each building block around its ideal point is statistically independent of its counterpart in ne ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Myelin
Myelin is a lipid-rich material that surrounds nerve cell axons (the nervous system's "wires") to insulate them and increase the rate at which electrical impulses (called action potentials) are passed along the axon. The myelinated axon can be likened to an electrical wire (the axon) with insulating material (myelin) around it. However, unlike the plastic covering on an electrical wire, myelin does not form a single long sheath over the entire length of the axon. Rather, myelin sheaths the nerve in segments: in general, each axon is encased with multiple long myelinated sections with short gaps in between called nodes of Ranvier. Myelin is formed in the central nervous system (CNS; brain, spinal cord and optic nerve) by glial cells called oligodendrocytes and in the peripheral nervous system (PNS) by glial cells called Schwann cells. In the CNS, axons carry electrical signals from one nerve cell body to another. In the PNS, axons carry signals to muscles and glands or from senso ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lipoprotein
A lipoprotein is a biochemical assembly whose primary function is to transport hydrophobic lipid (also known as fat) molecules in water, as in blood plasma or other extracellular fluids. They consist of a triglyceride and cholesterol center, surrounded by a phospholipid outer shell, with the hydrophilic portions oriented outward toward the surrounding water and lipophilic portions oriented inward toward the lipid center. A special kind of protein, called apolipoprotein, is embedded in the outer shell, both stabilising the complex and giving it a functional identity that determines its role. Many enzymes, transporters, structural proteins, antigens, adhesins, and toxins are lipoproteins. Examples include plasma lipoprotein particles ( HDL, LDL, IDL, VLDL and chylomicrons). Subgroups of these plasma particles are primary drivers or modulators of atherosclerosis. Scope Transmembrane lipoproteins Some transmembrane proteolipids, especially those found in bacteria, are referred ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Birmingham
, mottoeng = Through efforts to heights , established = 1825 – Birmingham School of Medicine and Surgery1836 – Birmingham Royal School of Medicine and Surgery1843 – Queen's College1875 – Mason Science College1898 – Mason University College1900 – gained university status by royal charter , city = Birmingham , province = West Midlands , country = England, UK , coor = , campus = Urban, suburban , academic_staff = 5,495 (2020) , administrative_staff = , head_label = Visitor , head = The Rt Hon Penny Mordaunt MP , chancellor = Lord Bilimoria , vice_chancellor = Adam Tickell , type = Public , endowment = £134.5 million (2021) , budget = £774.1 million (2020–21) , students = () , undergrad = () , postgrad = () , affiliations = Universitas 21Universities UK EUA ACUSutton 13Russell Group , free_label = , free = , colours = The University , website = , logo = The University of Birmingham (informally Birmingham University) i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Second World War
World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the World War II by country, vast majority of the world's countries—including all of the great powers—forming two opposing military alliances: the Allies of World War II, Allies and the Axis powers. World War II was a total war that directly involved more than 100 million Military personnel, personnel from more than 30 countries. The major participants in the war threw their entire economic, industrial, and scientific capabilities behind the war effort, blurring the distinction between civilian and military resources. Air warfare of World War II, Aircraft played a major role in the conflict, enabling the strategic bombing of population centres and deploying the Atomic bombings of Hiroshima and Nagasaki, only two nuclear weapons ever used in war. World War II was by far the List of wars by death toll, deadliest conflict in hu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Journal Of Physiology
''The Journal of Physiology'' is a biweekly peer-reviewed scientific journal that was established in 1878 and is published by Wiley-Blackwell on behalf of The Physiological Society. It covers research on all aspects of physiology, with an emphasis on human and mammalian physiology, including work at the molecular level, at the level of the cell membrane, single cells, tissues or organs, and systems physiology. The journal is produced both on paper and online. Accepted articles are first published online, ahead of print. The full archive back to 1878 up to issues published 12 months from the current date is freely available online. The editor-in-chief is currently Peter Kohl. According to the ''Journal Citation Reports'', the journal has a 2021 impact factor of 6.228, ranking it ninth out of 84 journals in the category "Physiology" History ''The Journal of Physiology'' was first published in 1878 and edited by Michael Foster. In 1893–94 Foster's colleague John Newport Langle ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Daily Telegraph
''The Daily Telegraph'', known online and elsewhere as ''The Telegraph'', is a national British daily broadsheet newspaper published in London by Telegraph Media Group and distributed across the United Kingdom and internationally. It was founded by Arthur B. Sleigh in 1855 as ''The Daily Telegraph & Courier''. Considered a newspaper of record over ''The Times'' in the UK in the years up to 1997, ''The Telegraph'' generally has a reputation for high-quality journalism, and has been described as being "one of the world's great titles". The paper's motto, "Was, is, and will be", appears in the editorial pages and has featured in every edition of the newspaper since 19 April 1858. The paper had a circulation of 363,183 in December 2018, descending further until it withdrew from newspaper circulation audits in 2019, having declined almost 80%, from 1.4 million in 1980.United Newspapers PLC and Fleet Holdings PLC', Monopolies and Mergers Commission (1985), pp. 5–16. Its si ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aleck Bourne
Aleck William Bourne (4 June 1886 – 30 December 1974) was a prominent British gynaecologist and writer, known for his 1938 trial, a landmark case, in which he was prosecuted for performing a termination of pregnancy on a 14-year-old rape victim. He was subsequently charged with procuring an illegal abortion but was acquitted. He later became an anti-abortion activist. Early life and career Born in 1886, the only son of the Reverend W. C. Bourne in Barnet, Bourne was educated at Rydal School and at Downing College, Cambridge where, in 1908, he received a first class Natural Science Tripos. Granted a senior university scholarship, he entered St Mary's Hospital in 1908 and he qualified as an MRCS, LRCP in 1910. He obtained an MB, BCh, (Cambridge), and a FRCS (England) the following year). From 1910 to 1914 he was a resident and subsequently held other appointments at St Mary's, Queen Charlotte's, and the Samaritan hospitals. In 1912, he married Bessie Hayward, the eldest daug ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alexander Fleming
Sir Alexander Fleming (6 August 1881 – 11 March 1955) was a Scottish physician and microbiologist, best known for discovering the world's first broadly effective antibiotic substance, which he named penicillin. His discovery in 1928 of what was later named benzylpenicillin (or penicillin G) from the mould ''Penicillium rubens'' is described as the "single greatest victory ever achieved over disease." For this discovery, he shared the Nobel Prize in Physiology or Medicine in 1945 with Howard Florey and Ernst Boris Chain. He also discovered the enzyme lysozyme from his nasal discharge in 1922, and along with it a bacterium he named ''Micrococcus Lysodeikticus'', later renamed ''Micrococcus luteus''. Fleming was knighted for his scientific achievements in 1944. In 1999, he was named in ''Time'' magazine's list of the 100 Most Important People of the 20th century. In 2002, he was chosen in the BBC's television poll for determining the 100 Greatest Britons, and in 2009, h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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