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Jennifer Loros
Jennifer Loros, also known as J.J. Loros, is a chronobiologist leading the field in the study of circadian rhythms in '' Neurospora''. Her research focuses on circadian oscillators and their control of gene expression in living cells. Currently, Loros is a professor of Biochemistry, Cell Biology, and Molecular and Systems Biology at the Giesel School of Medicine. Biography Education Loros is from Los Altos, California. She attended Homestead High School and graduated in 1968. Loros then attended both Cabrillo College and Monterey Peninsula College and received two associate degrees in Biology by 1971. By 1979, Loros received her bachelor's degree in Biology from UC Santa Cruz. She went on to complete her PhD in Genetics from Dartmouth Medical School. Career (1988-present) In 1988, Loros began her career in biology at Dartmouth Medical School as a postdoctoral researcher in Biochemistry. By 1994, Loros earned the position of Research Associate Professor of Bi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chronobiology
Chronobiology is a field of biology that examines timing processes, including periodic (cyclic) phenomena in living organisms, such as their adaptation to solar- and lunar-related rhythms. These cycles are known as biological rhythms. Chronobiology comes from the ancient Greek χρόνος (''chrónos'', meaning "time"), and biology, which pertains to the study, or science, of life. The related terms ''chronomics'' and ''chronome'' have been used in some cases to describe either the molecular mechanisms involved in chronobiological phenomena or the more quantitative aspects of chronobiology, particularly where comparison of cycles between organisms is required. Chronobiological studies include but are not limited to comparative anatomy, physiology, genetics, molecular biology and behavior of organisms related to their biological rhythms. Other aspects include epigenetics, development, reproduction, ecology and evolution. The subject Chronobiology studies variations of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Patricia DeCoursey
Patricia (Jackson) DeCoursey (28 December 1932 - 1 January 2022) was a leading researcher in the field of chronobiology. Her research focused on behavioral, physiological, and ecological aspects of mammalian circadian rhythms. She is credited with creating the first Phase Response Curve (PRC). PRC’s are used throughout the field today to help illustrate the change of a biological oscillation in response to an external stimulus. She worked as a biology professor at the University of South Carolina (USC) from 1967 until her retirement as director of the W. Gordon Belser Arboretum in 2019. Biography At an early age, DeCoursey expressed much interest in nature. She became fascinated with the outdoors though traveling with her father, a physician, and the rest of her family to remote wilderness areas While attending Hunter College High School in New York City she began collecting data on the songbirds of a hardwood forest in Long Island. She mapped the number and location of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Living People
Related categories * :Year of birth missing (living people) / :Year of birth unknown * :Date of birth missing (living people) / :Date of birth unknown * :Place of birth missing (living people) / :Place of birth unknown * :Year of death missing / :Year of death unknown * :Date of death missing / :Date of death unknown * :Place of death missing / :Place of death unknown * :Missing middle or first names See also * :Dead people * :Template:L, which generates this category or death years, and birth year and sort keys. : {{DEFAULTSORT:Living people 21st-century people People by status ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Geisel School Of Medicine Faculty , a village in Japan
{{disambiguation, surname ...
Geisel may refer to: * Ernesto Geisel (1907–1996), Brazilian military general and politician * Orlando Geisel (1905–1979), Brazilian general and Minister of the Army, Ernesto's brother * Dr. Seuss, pen name of Theodor Seuss Geisel (1904–1991), a children's book author * Theo Geisel (physicist) (born 1948), German physicist * Geisel (river), Saxony-Anhalt, Germany * Geisel valley, the valley of the river Geisel * Geisel Library, the main library building at the University of California San Diego, named after Dr. Seuss See also *Geisei, Kōchi 270px, Kotogahama beach is a village located in Aki District, Kōchi Prefecture, Japan. , the village had an estimated population of 3,636 in 1767 households and a population density of 92 persons per km².The total area of the village is . ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
21st-century American Biologists
The 1st century was the century spanning AD 1 ( I) through AD 100 ( C) according to the Julian calendar. It is often written as the or to distinguish it from the 1st century BC (or BCE) which preceded it. The 1st century is considered part of the Classical era, epoch, or historical period. The 1st century also saw the appearance of Christianity. During this period, Europe, North Africa and the Near East fell under increasing domination by the Roman Empire, which continued expanding, most notably conquering Britain under the emperor Claudius ( AD 43). The reforms introduced by Augustus during his long reign stabilized the empire after the turmoil of the previous century's civil wars. Later in the century the Julio-Claudian dynasty, which had been founded by Augustus, came to an end with the suicide of Nero in AD 68. There followed the famous Year of Four Emperors, a brief period of civil war and instability, which was finally brought to an end by Vespasian, ninth Roman em ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
White Collar-1
White Collar-1 (''wc''-1) is a gene in '' Neurospora crassa'' encoding the protein WC-1 (127 kDa). WC-1 has two separate roles in the cell. First, it is the primary photoreceptor for ''Neurospora'' and the founding member of the class of principle blue light photoreceptors in all of the fungi. Second, it is necessary for regulating circadian rhythms in FRQ. It is a key component of a circadian molecular pathway that regulates many behavioral activities, including conidiation. WC-1 and WC-2, an interacting partner of WC-1, comprise the White Collar Complex (WCC) that is involved in the '' Neurospora ''circadian clock. WCC is a complex of nuclear transcription factor proteins, and contains transcriptional activation domains, PAS domains, and zinc finger DNA-binding domains ( GATA). WC-1 and WC-2 heterodimerize through their PAS domains to form the White Collar Complex (WCC). Discovery The '' Neurospora ''circadian clock was discovered in 1959, when Pittendrigh et al. first ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Negative Feedback
Negative feedback (or balancing feedback) occurs when some function (Mathematics), function of the output of a system, process, or mechanism is feedback, fed back in a manner that tends to reduce the fluctuations in the output, whether caused by changes in the input or by other disturbances. Whereas positive feedback tends to lead to instability via exponential growth, oscillation or chaos theory, chaotic behavior, negative feedback generally promotes stability. Negative feedback tends to promote a settling to List of types of equilibrium, equilibrium, and reduces the effects of perturbations. Negative feedback loops in which just the right amount of correction is applied with optimum timing can be very stable, accurate, and responsive. Negative feedback is widely used in mechanical and electronic engineering, and also within living organisms, and can be seen in many other fields from chemistry and economics to physical systems such as the climate. General negative feedback ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Suppression Subtractive Hybridization
Subtractive hybridization is a technology that allows for PCR-based amplification of only cDNA fragments that differ between a control (driver) and experimental transcriptome. cDNA is produced from mRNA. Differences in relative abundance of transcripts are highlighted, as are genetic differences between species. The technique relies on the removal of dsDNA formed by hybridization between a control and test sample, thus eliminating cDNAs or gDNAs of similar abundance, and retaining differentially expressed, or variable in sequence, transcripts or genomic sequences. Suppression subtractive hybridization has also been successfully used to identify strain- or species-specific DNA sequences in a variety of bacteria including ''Vibrio'' species (Metagenomics). See also * Representational difference analysis Representational difference analysis (RDA) is a technique used in biological research to find sequence differences in two genomic or cDNA samples. Genomes or cDNA sequences from ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Frequency (gene)
The frequency (''frq'') gene encodes the protein frequency (FRQ) that functions in the ''Neurospora crassa'' circadian clock. The FRQ protein plays a key role in circadian oscillator, serving to nucleate the negative element complex in the auto regulatory transcription-translation negative feedback-loop (TTFL) that is responsible for circadian rhythms in ''N. crassa''. Similar rhythms are found in mammals, ''Drosophila'' and cyanobacteria. Recently, FRQ homologs have been identified in several other species of fungi. Expression of frq is controlled by the two transcription factors white collar-1 (WC-1) and white collar-2 (WC-2) that act together as the White Collar Complex (WCC) and serve as the positive element in the TTFL. Expression of frq can also be induced through light exposure in a WCC dependent manner. Forward genetics has generated many alleles of ''frq'' resulting in strains whose circadian clocks vary in period length. Discovery The ''frq'' locus was discovered ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Codon Usage Bias
Codon usage bias refers to differences in the frequency of occurrence of synonymous codons in coding DNA. A codon is a series of three nucleotides (a triplet) that encodes a specific amino acid residue in a polypeptide chain or for the termination of translation (stop codons). There are 64 different codons (61 codons encoding for amino acids and 3 stop codons) but only 20 different translated amino acids. The overabundance in the number of codons allows many amino acids to be encoded by more than one codon. Because of such redundancy it is said that the genetic code is degenerate. The genetic codes of different organisms are often biased towards using one of the several codons that encode the same amino acid over the others—that is, a greater frequency of one will be found than expected by chance. How such biases arise is a much debated area of molecular evolution. Codon usage tables detailing genomic codon usage bias for organisms in GenBank and RefSeq can be found in thHIVE-Co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Luciferase
Luciferase is a generic term for the class of oxidative enzymes that produce bioluminescence, and is usually distinguished from a photoprotein. The name was first used by Raphaël Dubois who invented the words ''luciferin'' and ''luciferase'', for the substrate and enzyme, respectively. Both words are derived from the Latin word ''lucifer'', meaning "lightbearer", which in turn is derived from the Latin words for "light" (''lux)'' and "to bring or carry" (''ferre)''.Luciferases are widely used in biotechnology, for bioluminescence imaging microscopy and as reporter genes, for many of the same applications as fluorescent proteins. However, unlike fluorescent proteins, luciferases do not require an external light source, but do require addition of luciferin, the consumable substrate. Examples A variety of organisms regulate their light production using different luciferases in a variety of light-emitting reactions. The majority of studied luciferases have been found in animals, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
