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James F. Holland
James Frederick Holland (May 16, 1925 – March 22, 2018) was an American physician and Distinguished Professor of Neoplastic Diseases at the Icahn School of Medicine at Mount Sinai in New York. Early in his career, he had worked for the National Cancer Institute and Roswell Park Comprehensive Cancer Center. Holland was considered a key figure in the development of cancer chemotherapy. His 1953 clinical trial on acute leukemia resulted in the formation of Acute Leukemia Group B, a research collaboration that later became known as the Cancer and Leukemia Group B. He served as president of the American Society of Clinical Oncology and the American Association for Cancer Research. Early life Holland was born on May 16, 1925, in Morristown, New Jersey. His Jewish father, Albert H. Holland Sr. (1891–?), was from New York City and a county judge. James Holland was initially drawn to cardiology because his father suffered from heart disease. Holland's mother, Mary Louise Layer Holland ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Morristown, New Jersey
Morristown () is a town and the county seat of Morris County, in the U.S. state of New Jersey.New Jersey County Map New Jersey Department of State. Accessed July 10, 2017. Morristown has been called "the military capital of the " because of its strategic role in the war for independence from Great Britain. Today this history is visible in a variety of locations throughout the town that collectively make up |
Princeton University
Princeton University is a private university, private research university in Princeton, New Jersey. Founded in 1746 in Elizabeth, New Jersey, Elizabeth as the College of New Jersey, Princeton is the List of Colonial Colleges, fourth-oldest institution of higher education in the United States and one of the nine colonial colleges chartered before the American Revolution. It is one of the highest-ranked universities in the world. The institution moved to Newark, New Jersey, Newark in 1747, and then to the current site nine years later. It officially became a university in 1896 and was subsequently renamed Princeton University. It is a member of the Ivy League. The university is governed by the Trustees of Princeton University and has an endowment of $37.7 billion, the largest List of colleges and universities in the United States by endowment, endowment per student in the United States. Princeton provides undergraduate education, undergraduate and graduate education, graduate in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Roswell Park Cancer Institute
Roswell Park Comprehensive Cancer Center is a cancer research and treatment center located in Buffalo, New York. Founded by surgeon Roswell Park in 1898, the center was the first in the United States to specifically focus on cancer research. The center is usually called Roswell Park in short form. The center, which conducts clinical research on cancer as well as the development new drugs, provides advanced treatment for all forms of adult and pediatric cancer, and serves as a member of the National Comprehensive Cancer Network. Roswell Park Comprehensive Cancer Center is currently the only upstate New York facility to hold the National Cancer Institute designation of "comprehensive cancer center". The Roswell Park campus, spread out in 15 separate buildings of approximately two million square feet, occupies on the Buffalo Niagara Medical Campus (BNMC) in downtown Buffalo, and includes of space equally distributed between clinical programs and research/education functions. A sep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vincent DeVita
Vincent Theodore DeVita Jr. (born March 7, 1935) is the Amy and Joseph Perella Professor of Medicine at Yale Cancer Center, and a Professor of Epidemiology and Public Health. He directed the Yale Cancer Center from 1993 to 2003. He has been president of the American Cancer Society (2012-2013). He is internationally recognized as a pioneer in the field of oncology for his work on combination-chemotherapy treatments. Early life and education Vincent DeVita was born in The Bronx, New York. DeVita attended the College of William and Mary, receiving his Bachelor of Science degree in 1957. In 1961 he earned his MD degree with distinction from the George Washington University School of Medicine. Career DeVita joined the National Cancer Institute (NCI) in 1963 as a clinical fellow, working with Emil "Tom" Frei, Emil J. Freireich and others. He returned as a senior investigator in 1966 after completing his training at Yale-New Haven Medical Center in 1965. At NCI, DeVita held ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prednisone
Prednisone is a glucocorticoid medication mostly used to immunosuppressive drug, suppress the immune system and decrease inflammation in conditions such as asthma, COPD, and rheumatologic diseases. It is also used to treat high blood calcium due to cancer and adrenal insufficiency along with other steroids. It is taken Oral administration, by mouth. Common side effects with long-term use include cataracts, Osteoporosis, bone loss, easy bruising, muscle weakness, and oral candidiasis, thrush. Other side effects include weight gain, swelling, high blood sugar, increased risk of infection, and psychosis. It is generally considered safe in pregnancy and low doses appear to be safe when breastfeeding. After prolonged use, prednisone needs to be stopped gradually. Prednisone is a prodrug and must be converted to prednisolone by the liver before it becomes active. Prednisolone then binds to glucocorticoid receptors, activating them and triggering changes in gene expression. Pred ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vincristine
Vincristine, also known as leurocristine and marketed under the brand name Oncovin among others, is a chemotherapy medication used to treat a number of types of cancer. This includes acute lymphocytic leukemia, acute myeloid leukemia, Hodgkin's disease, neuroblastoma, and small cell lung cancer among others. It is given intravenously. Most people experience some side effects from vincristine treatment. Commonly it causes a change in sensation, hair loss, constipation, difficulty walking, and headaches. Serious side effects may include neuropathic pain, lung damage, or low white blood cells which increases the risk of infection. Use during pregnancy may result in birth defects. It works by stopping cells from dividing properly. It is vital that it not be given intrathecally, as this causes paralysis and in most cases, death. Vincristine was first isolated in 1961. It is on the World Health Organization's List of Essential Medicines. It is a vinca alkaloid that can be obtained ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the development of large numbers of immature lymphocytes. Symptoms may include feeling tired, pale skin color, fever, easy bleeding or bruising, enlarged lymph nodes, or bone pain. As an acute leukemia, ALL progresses rapidly and is typically fatal within weeks or months if left untreated. In most cases, the cause is unknown. Genetic risk factors may include Down syndrome, Li-Fraumeni syndrome, or neurofibromatosis type 1. Environmental risk factors may include significant radiation exposure or prior chemotherapy. Evidence regarding electromagnetic fields or pesticides is unclear. Some hypothesize that an abnormal immune response to a common infection may be a trigger. The underlying mechanism involves multiple genetic mutations that results in rapid cell division. The excessive immature lymphocytes in the bone marrow interfere with the production of new red blood cells, whi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Emil Freireich
Emil J. Freireich (March 16, 1927 – February 1, 2021) was an American hematologist, oncologist, and cancer biologist. He was recognized as a pioneer in the treatment of cancer and use of chemotherapy and is often known as the father of modern leukemia therapy. Early life Freireich was born in Chicago on March 16, 1927. His Jewish parents, Mary (Klein) and David Freireich, immigrated to the United States from Hungary. He grew up in poverty during the Great Depression. His father died when he was two years old, and his mother worked in a factory to support Emil and his elder sister. After winning a science fair, a teacher recommended that he consider going to college. He attended the University of Illinois at Urbana–Champaign at the age of 16 with the help of donations from neighbors, and later from scholarships. He was medically excused from being drafted into World War II because of a broken leg. He earned his M.D. from the University of Illinois College of Medicine i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Emil Frei
Emil "Tom" Frei III (February 21, 1924 – April 30, 2013) was an American physician and oncologist. He was the former director and former physician-in-chief of the Dana–Farber Cancer Institute in Boston, Massachusetts. He was also the Richard and Susan Smith Distinguished Professor of Medicine at Harvard Medical School. Early life and education Frei was born in 1924 in St. Louis. His family owned the stained glass manufacturer Emil Frei & Associates. Frei completed an accelerated pre-med Colgate University in 1944 after only 2 years of study and his medical degree from Yale University in 1948. Career He interned at Firmin Desloge Hospital, now St. Louis University Hospital in St. Louis, Missouri and served as a physician in the Korean War. He worked at the National Cancer Institute from 1955 to 1965 and the M. D. Anderson Cancer Center from 1965 to 1972; while at M.D. Anderson he was the founding director of the Department of Development Therapeutics, which evolved int ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clinical Cancer Research
''Clinical Cancer Research'' is a peer-reviewed medical journal on oncology, including the cellular and molecular characterization, prevention, diagnosis, and therapy of human cancer, medical and hematological oncology, radiation therapy, pediatric oncology, pathology, surgical oncology, and clinical genetics. The applications of the disciplines of pharmacology, immunology, cell biology, and molecular genetics to intervention in human cancer are also included. One of the main interests of ''Clinical Cancer Research'' is on clinical trials that evaluate new treatments together with research on pharmacology and molecular alterations or biomarkers that predict response or resistance to treatment. Another priority for ''Clinical Cancer Research'' is laboratory and animal studies of new drugs as well as molecule-targeted agents with the potential to lead to clinical trials, and studies of targetable mechanisms of oncogenesis, progression of the malignant phenotype, and metastatic disease. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Women & Children's Hospital Of Buffalo
Women & Children's Hospital of Buffalo (1892–2017) was a children's hospital in Buffalo, New York. It was a pediatric facility serving patients in Western New York and parts of Southern Ontario. It was a teaching hospital loosely affiliated with the State University of New York at Buffalo. The hospital treated infants, children, teens, and young adults aged 0–21 and also had extensive women's health facilities. History The hospital was founded in 1892 as The Children's Hospital of Buffalo. During the first year of operation, so many patients were turned away for lack of space that in 1893 the hospital was forced to increase the capacity by 40 beds. During the next few decades, the hospital renovated and added modern medical equipment, and by the 1950s, hospital had about 200 pediatric beds and 75 beds for women and bassinets. Over the years the hospital was recognized many times by '' U.S. News & World Report'' for its leading national pediatric programs. After a merger ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gordon Zubrod
Charles Gordon Zubrod (January 22, 1914 – January 19, 1999) was an American oncologist who played a prominent role in the introduction of chemotherapy for cancer. He was one of the recipients of the 1972 Albert Lasker Awards in recognition of his contributions to the field, amongst many other doctorates and awards. Life and work Zubrod, an alumnus of the Georgetown Preparatory School (class of 1932), the College of the Holy Cross (class of 1936), and Columbia University College of Physicians and Surgeons (1940 class), served in the U.S. army medical corps during World War II, where he worked on a replacement for quinine in the treatment of malaria. The unit eventually discovered chloroquine. In 1946 he commenced work at Johns Hopkins University Medical School, and was appointed assistant professor of medicine and director of research at Saint Louis University in 1953. This position lasted briefly: he became clinical director of the National Institutes of Health in 1954 and b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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