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Isabelle Dinoire
Isabelle Dinoire (3 February 1967 – 22 April 2016) was a French woman who was the first person to undergo a partial face transplant, after her Labrador retriever cross breed mauled her in May 2005. She underwent a 15-hour operation in November 2005 in which surgeons transplanted the nose, lips and chin from a brain-dead donor at a hospital in Amiens. She died at age 49 in April 2016, though her death was not announced until more than four months later. Personal life Dinoire lived in Valenciennes, northern France, and she was the mother of two children. Mutilation incident Dinoire's dog mauled her face after she passed out from an overdose of sleeping pills.''Associated_Press'',_11_April_2009,_accessed_11_April_2009_Some_reports_following_the_initial_surgery_claim_that_her_daughter_said_that_the_black_Labrador_cross_(named_Tania)_was_"frantically"_trying_to_wake_Dinoire_after_she_took_Associated_Press">''Associated_Press'',_11_April_2009,_accessed_11_April_2009_Some_reports_foll ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Maubeuge
Maubeuge (; historical nl, Mabuse or nl, Malbode; pcd, Maubeuche) is a commune in the Nord department in northern France. It is situated on both banks of the Sambre (here canalized), east of Valenciennes and about from the Belgian border. History Maubeuge (ancient ''Malbodium'', from Latin, derived from the Old Frankish name ''Malboden'', meaning "assizes of Boden") owes its origin to Maubeuge Abbey, a double monastery, for men and women, founded in the 7th century by Saint Aldego, the relics of whom are preserved in the church. It subsequently belonged to the territory of Hainaut. The town was part of the Spanish Netherlands and changed hands a number of times before it was finally ceded to France in the 1678 Treaty of Nijmegen. As part of Vauban's ''pré carré'' plan that protected France's northern borders with a double line of fortresses, it was extensively fortified as directed by Louis XIV of France. Besieged in 1793 by Prince Josias of Saxe-Coburg-Saalfeld, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brain-dead
Brain death is the permanent, irreversible, and complete loss of brain activity, brain function which may include cessation of involuntary activity necessary to sustain life. It differs from persistent vegetative state, in which the person is alive and some autonomic functions remain. It is also distinct from comas as long as some brain and bodily activity and function remain, and it is also not the same as the condition locked-in syndrome. A differential diagnosis can medically distinguish these differing conditions. Brain death is used as an indicator of legal death in many jurisdictions, but it is Medical definition of death, defined inconsistently and often confused by the public. Various parts of the brain may keep functioning when others do not anymore, and the term "brain death" has been used to refer to various combinations. For example, although one major medical dictionary considers "brain death" to be synonymous with "cerebral death" (death of the cerebrum), the US Nat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Connie Culp
Connie Culp (March 26, 1963 – July 29, 2020) was the first United States recipient of a partial face transplant, performed at the Cleveland Clinic in December 2008. Facial disfigurement Culp was shot in the face by her husband Thomas G. "Tom" Culp in a failed murder–suicide on September 21, 2004 inside their bar in Hopedale, Ohio. He also survived and was convicted in 2005 of aggravated attempted murder with a seven-year prison sentence.Kroenig, Julie (April 13, 2005)Man Shoots Wife in Face...Sentenced to 7 Years. WTRF Culp forgave her husband at the sentencing and said she would be waiting when he gets out of prison,Mazure, Steve (April 14, 2005Gunman Sentenced--Wife Forgives Him. WBOYStaff report (February 25, 2008)Woman Speaks Out After Husband Shoots Her In Face. WTOV but on September 22, 2009, Culp said on an episode of ''Oprah'' that she no longer planned to wait for her former husband after her daughter asked her, "Mom, what kind of example would you be setting for me i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Daily Telegraph
''The Daily Telegraph'', known online and elsewhere as ''The Telegraph'', is a national British daily broadsheet newspaper published in London by Telegraph Media Group and distributed across the United Kingdom and internationally. It was founded by Arthur B. Sleigh in 1855 as ''The Daily Telegraph & Courier''. Considered a newspaper of record over ''The Times'' in the UK in the years up to 1997, ''The Telegraph'' generally has a reputation for high-quality journalism, and has been described as being "one of the world's great titles". The paper's motto, "Was, is, and will be", appears in the editorial pages and has featured in every edition of the newspaper since 19 April 1858. The paper had a circulation of 363,183 in December 2018, descending further until it withdrew from newspaper circulation audits in 2019, having declined almost 80%, from 1.4 million in 1980.United Newspapers PLC and Fleet Holdings PLC', Monopolies and Mergers Commission (1985), pp. 5–16. Its si ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunosuppressive Drug
Immunosuppressive drugs, also known as immunosuppressive agents, immunosuppressants and antirejection medications, are drugs that inhibit or prevent activity of the immune system. Classification Immunosuppressive drugs can be classified into five groups: * glucocorticoids * cytostatics * antibodies * drugs acting on immunophilins * other drugs Glucocorticoids In pharmacologic (supraphysiologic) doses, glucocorticoids, such as prednisone, dexamethasone, and hydrocortisone are used to suppress various allergic, inflammatory, and autoimmune disorders. They are also administered as posttransplantory immunosuppressants to prevent the acute transplant rejection and graft-versus-host disease. Nevertheless, they do not prevent an infection and also inhibit later reparative processes. Immunosuppressive mechanism Glucocorticoids suppress cell-mediated immunity. They act by inhibiting genes that code for the cytokines Interleukin 1 (IL-1), IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transplant Rejection
Transplant rejection occurs when Organ transplant, transplanted tissue is rejected by the recipient's immune system, which destroys the transplanted tissue. Transplant rejection can be lessened by determining the molecular similitude between donor and recipient and by use of immunosuppressant drugs after transplant. Types of transplant rejection Transplant rejection can be classified into three types: hyperacute, acute, and chronic. These types are differentiated by how quickly the recipient's immune system is activated and the specific aspect or aspects of immunity involved. Hyperacute rejection Hyperacute rejection is a form of rejection that manifests itself in the minutes to hours following transplantation. It is caused by the presence of pre-existing Antibody, antibodies in the recipient that recognize antigens in the donor organ. These antigens are located on the endothelial lining of blood vessels within the transplanted organ and, once antibodies bind, will lead to the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Le Figaro
''Le Figaro'' () is a French daily morning newspaper founded in 1826. It is headquartered on Boulevard Haussmann in the 9th arrondissement of Paris. The oldest national newspaper in France, ''Le Figaro'' is one of three French newspapers of record, along with ''Le Monde'' and ''Libération''. It was named after Figaro, a character in a play by polymath Beaumarchais (1732–1799); one of his lines became the paper's motto: "''Sans la liberté de blâmer, il n'est point d'éloge flatteur''" ("Without the freedom to criticise, there is no flattering praise"). With a centre-right editorial line, it is the largest national newspaper in France, ahead of ''Le Parisien'' and ''Le Monde''. In 2019, the paper had an average circulation of 321,116 copies per issue. The paper is published in Berliner format. Since 2012 its editor (''directeur de la rédaction'') has been Alexis Brézet. The newspaper has been owned by Dassault Group since 2004. Other Groupe Figaro publications include ''Le ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CTV News
CTV News is the news division of the CTV Television Network in Canada. The name ''CTV News'' is also applied as the title of local and regional newscasts on the network's owned-and-operated stations (O&Os), which are closely tied to the national news division. Local newscasts on CTV 2 are also branded as ''CTV News'', although in most cases they are managed separately from the newscasts on the main CTV network. National programs CTV's national news division produces the following programs: * '' CTV National News'', the nightly newscast anchored by Omar Sachedina (weekdays) and Sandie Rinaldo (weekends); * '' W5'', a weekly newsmagazine series; * ''Question Period'', a weekly news and interview series;. CTV News also operates the national 24-hour news channel CTV News Channel and the 24-hour national business news channel BNN Bloomberg, both of which are available across Canada on cable and satellite. The news division produced the weekday morning news and entertainment pro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kidney Failure
Kidney failure, also known as end-stage kidney disease, is a medical condition in which the kidneys can no longer adequately filter waste products from the blood, functioning at less than 15% of normal levels. Kidney failure is classified as either acute kidney failure, which develops rapidly and may resolve; and chronic kidney failure, which develops slowly and can often be irreversible. Symptoms may include leg swelling, feeling tired, vomiting, loss of appetite, and confusion. Complications of acute and chronic failure include uremia, high blood potassium, and volume overload. Complications of chronic failure also include heart disease, high blood pressure, and anemia. Causes of acute kidney failure include low blood pressure, blockage of the urinary tract, certain medications, muscle breakdown, and hemolytic uremic syndrome. Causes of chronic kidney failure include diabetes, high blood pressure, nephrotic syndrome, and polycystic kidney disease. Diagnosis of acute failure ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New England Journal Of Medicine
''The New England Journal of Medicine'' (''NEJM'') is a weekly medical journal published by the Massachusetts Medical Society. It is among the most prestigious peer-reviewed medical journals as well as the oldest continuously published one. History In September 1811, John Collins Warren, a Boston physician, along with James Jackson, submitted a formal prospectus to establish the ''New England Journal of Medicine and Surgery and Collateral Branches of Science'' as a medical and philosophical journal. Subsequently, the first issue of the ''New England Journal of Medicine and Surgery and the Collateral Branches of Medical Science'' was published in January 1812. The journal was published quarterly. In 1823, another publication, the ''Boston Medical Intelligencer'', appeared under the editorship of Jerome V. C. Smith. The editors of the ''New England Journal of Medicine and Surgery and the Collateral Branches of Medical Science'' purchased the weekly ''Intelligencer'' for $600 in 1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Times
''The Times'' is a British daily national newspaper based in London. It began in 1785 under the title ''The Daily Universal Register'', adopting its current name on 1 January 1788. ''The Times'' and its sister paper ''The Sunday Times'' (founded in 1821) are published by Times Newspapers, since 1981 a subsidiary of News UK, in turn wholly owned by News Corp. ''The Times'' and ''The Sunday Times'', which do not share editorial staff, were founded independently and have only had common ownership since 1966. In general, the political position of ''The Times'' is considered to be centre-right. ''The Times'' is the first newspaper to have borne that name, lending it to numerous other papers around the world, such as ''The Times of India'', ''The New York Times'', and more recently, digital-first publications such as TheTimesBlog.com (Since 2017). In countries where these other titles are popular, the newspaper is often referred to as , or as , although the newspaper is of nationa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Washington Post
''The Washington Post'' (also known as the ''Post'' and, informally, ''WaPo'') is an American daily newspaper published in Washington, D.C. It is the most widely circulated newspaper within the Washington metropolitan area and has a large national audience. Daily broadsheet editions are printed for D.C., Maryland, and Virginia. The ''Post'' was founded in 1877. In its early years, it went through several owners and struggled both financially and editorially. Financier Eugene Meyer purchased it out of bankruptcy in 1933 and revived its health and reputation, work continued by his successors Katharine and Phil Graham (Meyer's daughter and son-in-law), who bought out several rival publications. The ''Post'' 1971 printing of the Pentagon Papers helped spur opposition to the Vietnam War. Subsequently, in the best-known episode in the newspaper's history, reporters Bob Woodward and Carl Bernstein led the American press's investigation into what became known as the Watergate scandal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
