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Irving Innerfield
Irving Innerfield (died 4 December 1976) was a medical researcher in the United States of America. A specialist in inflammation, he discovered that the enzyme trypsin could be used to dissolve blood clots. In November 1952, on hearing that Elizabeth Kenny (the Australian who developed physical therapy as a treatment for Poliomyelitis, polio and established many clinics for polio victims in the USA using her methods) was dying in Toowoomba, Queensland, Australia from a cerebral thrombosis, Innerfield dispatched his experimental drug based on trypsin by air to Brisbane to treat her thrombosis. Unfortunately Kenny was close to death when the drug arrived and was administered, dying the following day. References {{DEFAULTSORT:Innerfield, Irving American medical researchers 1976 deaths ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Research
Medical research (or biomedical research), also known as experimental medicine, encompasses a wide array of research, extending from "basic research" (also called ''bench science'' or ''bench research''), – involving fundamental scientific principles that may apply to a ''preclinical'' understanding – to clinical research, which involves studies of people who may be subjects in clinical trials. Within this spectrum is applied research, or translational research, conducted to expand knowledge in the field of medicine. Both clinical and preclinical research phases exist in the pharmaceutical industry's drug development pipelines, where the clinical phase is denoted by the term ''clinical trial''. However, only part of the clinical or preclinical research is oriented towards a specific pharmaceutical purpose. The need for fundamental and mechanism-based understanding, diagnostics, medical devices, and non-pharmaceutical therapies means that pharmaceutical research i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Inflammation
Inflammation (from la, wikt:en:inflammatio#Latin, inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or Irritation, irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators. The function of inflammation is to eliminate the initial cause of cell injury, clear out necrotic cells and tissues damaged from the original insult and the inflammatory process, and initiate tissue repair. The five cardinal signs are heat, pain, redness, swelling, and Functio laesa, loss of function (Latin ''calor'', ''dolor'', ''rubor'', ''tumor'', and ''functio laesa''). Inflammation is a generic response, and therefore it is considered as a mechanism of innate immune system, innate immunity, as compared to adaptive immune system, adaptive immunity, which is specific for each pathogen. Too little inflammation could lead to progressive tissue destruction by the harmful stimulus (e.g. b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trypsin
Trypsin is an enzyme in the first section of the small intestine that starts the digestion of protein molecules by cutting these long chains of amino acids into smaller pieces. It is a serine protease from the PA clan superfamily, found in the digestive system of many vertebrates, where it hydrolyzes proteins. Trypsin is formed in the small intestine when its proenzyme form, the trypsinogen produced by the pancreas, is activated. Trypsin cuts peptide chains mainly at the carboxyl side of the amino acids lysine or arginine. It is used for numerous biotechnological processes. The process is commonly referred to as trypsin proteolysis or trypsinization, and proteins that have been digested/treated with trypsin are said to have been trypsinized. Trypsin was discovered in 1876 by Wilhelm Kühne and was named from the Ancient Greek word for rubbing since it was first isolated by rubbing the pancreas with glycerin. Function In the duodenum, trypsin catalyzes the hydrolysis of pept ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Blood Clots
A thrombus (plural thrombi), colloquially called a blood clot, is the final product of the blood coagulation step in hemostasis. There are two components to a thrombus: aggregated platelets and red blood cells that form a plug, and a mesh of cross-linked fibrin protein. The substance making up a thrombus is sometimes called cruor. A thrombus is a healthy response to injury intended to stop and prevent further bleeding, but can be harmful in thrombosis, when a clot obstructs blood flow through healthy blood vessels in the circulatory system. In the microcirculation consisting of the very small and smallest blood vessels the capillaries, tiny thrombi known as microclots can obstruct the flow of blood in the capillaries. This can cause a number of problems particularly affecting the pulmonary alveolus, alveoli in the lungs of the respiratory system resulting from reduced oxygen supply. Microclots have been found to be a characteristic feature in severe cases of COVID-19, and in lon ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New York Times
''The New York Times'' (''the Times'', ''NYT'', or the Gray Lady) is a daily newspaper based in New York City with a worldwide readership reported in 2020 to comprise a declining 840,000 paid print subscribers, and a growing 6 million paid digital media, digital subscribers. It also is a producer of popular podcasts such as ''The Daily (podcast), The Daily''. Founded in 1851 by Henry Jarvis Raymond and George Jones (publisher), George Jones, it was initially published by Raymond, Jones & Company. The ''Times'' has won List of Pulitzer Prizes awarded to The New York Times, 132 Pulitzer Prizes, the most of any newspaper, and has long been regarded as a national "newspaper of record". For print it is ranked List of newspapers by circulation, 18th in the world by circulation and List of newspapers in the United States, 3rd in the U.S. The paper is owned by the New York Times Company, which is Public company, publicly traded. It has been governed by the Sulzberger family since 189 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Elizabeth Kenny
Sister Elizabeth Kenny (20 September 1880 – 30 November 1952) was a self-trained Australian bush nurse who developed an approach to treating polio that was controversial at the time. Her method, promoted internationally while working in Australia, Europe and the United States, differed from the conventional one of placing affected limbs in plaster casts. Instead she applied hot compresses, followed by passive movement of the areas to reduce what she called "spasm". Her principles of muscle rehabilitation became the foundation of physical therapy or physiotherapy in such cases. Her life story was told in a 1946 film, ''Sister Kenny'', where she was portrayed by Rosalind Russell, who was nominated for the Academy Award for Best Actress for her performance. Early life Elizabeth Kenny was born in Warialda, New South Wales, on 20 September 1880, to the Australian-born Mary Kenny, née Moore, and Michael Kenny, a farmer from Ireland. She was called Lisa by her family. Kenny was ho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Physical Therapy
Physical therapy (PT), also known as physiotherapy, is one of the allied health professions. It is provided by physical therapists who promote, maintain, or restore health through physical examination, diagnosis, management, prognosis, patient education, physical intervention, rehabilitation, disease prevention, and health promotion. Physical therapists are known as physiotherapists in many countries. In addition to clinical practice, other aspects of physical therapist practice include research, education, consultation, and health administration. Physical therapy is provided as a primary care treatment or alongside, or in conjunction with, other medical services. In some jurisdictions, such as the United Kingdom, physical therapists have the authority to prescribe medication. Overview Physical therapy addresses the illnesses or injuries that limit a person's abilities to move and perform functional activities in their daily lives. PTs use an individual's history and physic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Poliomyelitis
Poliomyelitis, commonly shortened to polio, is an infectious disease caused by the poliovirus. Approximately 70% of cases are asymptomatic; mild symptoms which can occur include sore throat and fever; in a proportion of cases more severe symptoms develop such as headache, neck stiffness, and paresthesia. These symptoms usually pass within one or two weeks. A less common symptom is permanent paralysis, and possible death in extreme cases.. Years after recovery, post-polio syndrome may occur, with a slow development of muscle weakness similar to that which the person had during the initial infection. Polio occurs naturally only in humans. It is highly infectious, and is spread from person to person either through fecal-oral transmission (e.g. poor hygiene, or by ingestion of food or water contaminated by human feces), or via the oral-oral route. Those who are infected may spread the disease for up to six weeks even if no symptoms are present. The disease may be diagnosed by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Toowoomba
Toowoomba ( , nicknamed 'The Garden City' and 'T-Bar') is a city in the Toowoomba Region of the Darling Downs, Queensland, Australia. It is west of Queensland's capital city Brisbane by road. The urban population of Toowoomba as of the 2021 Census was 142,163, having grown at an average annual rate of 1.45% over the previous two decades. Toowoomba is the second-most-populous inland city in the country after the national capital of Canberra and hence the largest city on the Darling Downs, and it is among the largest regional centres in Queensland. It is also referred to as the capital of the Darling Downs. The Toowoomba region is the home of two main Aboriginal language groups, the Giabal whose lands extend south of the city and Jarowair whose lands extend north of the city. The Jarowair lands include the site of one of Australia's most important sacred Bora ceremonial ground, the ‘Gummingurru stone arrangement’ dated to c.4000 BC. The site marked one of the major routes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Queensland
) , nickname = Sunshine State , image_map = Queensland in Australia.svg , map_caption = Location of Queensland in Australia , subdivision_type = Country , subdivision_name = Australia , established_title = Before federation , established_date = Colony of Queensland , established_title2 = Separation from New South Wales , established_date2 = 6 June 1859 , established_title3 = Federation , established_date3 = 1 January 1901 , named_for = Queen Victoria , demonym = , capital = Brisbane , largest_city = capital , coordinates = , admin_center_type = Administration , admin_center = 77 local government areas , leader_title1 = Monarch , leader_name1 = Charles III , leader_title2 = Governor , leader_name2 = Jeannette Young , leader_title3 = Premier , leader_name3 = Annastacia Palaszczuk ( ALP) , legislature = Parliament of Queensland , judiciary = Supreme Court of Queensland , national_representation = Parliament of Australia , national_representation_type ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brisbane
Brisbane ( ) is the capital and most populous city of the states and territories of Australia, Australian state of Queensland, and the list of cities in Australia by population, third-most populous city in Australia and Oceania, with a population of approximately 2.6 million. Brisbane lies at the centre of the South East Queensland metropolitan region, which encompasses a population of around 3.8 million. The Brisbane central business district is situated within a peninsula of the Brisbane River about from its mouth at Moreton Bay, a bay of the Coral Sea. Brisbane is located in the hilly floodplain of the Brisbane River Valley between Moreton Bay and the Taylor Range, Taylor and D'Aguilar Range, D'Aguilar mountain ranges. It sprawls across several local government in Australia, local government areas, most centrally the City of Brisbane, Australia's most populous local government area. The demonym of Brisbane is ''Brisbanite''. The Traditional Owners of the Brisbane a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Queensland Times
''The Queensland Times'' is an online newspaper serving Ipswich, Queensland, Ipswich and surrounds in Queensland, Australia. The newspaper is owned by News Corp Australia. The circulation of ''The Queensland Times'' is 10,804 Monday to Friday and 14,153 on Saturday. ''The Queensland Times'' is circulated to the Ipswich city area (all residential suburbs including the new the suburbs Springfield, Springfield Lakes and Brookwater) and the Ipswich rural area including Harrisville, Queensland, Harrisville, Rosewood, Queensland, Rosewood, Laidley, Queensland, Laidley, Forest Hill, Queensland, Forest Hill, Lowood, Queensland, Lowood, Boonah, Queensland, Boonah, Aratula, Queensland, Aratula, Gatton, Queensland, Gatton, Esk, Queensland, Esk and Toogoolawah, Queensland, Toogoolawah. ''The Queensland Times'' website is part of the APN Regional News Network. History ''The Queensland Times'' is the oldest surviving provincial paper in Queensland. Founded on 4 July 1859 as the ''Ipswich H ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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