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Innate Immunotherapeutics
Innate Immunotherapeutics (INNM) was a biopharmaceutical company, previously known as Virionyx, with headquarters in Sydney, Australia and a branch in Auckland, New Zealand. Their focus in 2009 was the "development of a new generation of immune response modifier for potential use in the treatment of a range of infectious diseases, certain cancers, and as a novel cellular and humoral adjuvant, " and developed a proprietary multiple sclerosis drug, MIS416. In April 2009 the firm changed its name to Innate Immunotherapeutics to reflect their focus on the development of MIS416, and moved their headquarters from Auckland, New Zealand to Sydney, Australia. Contact Joan E. Kureczka, Kureczka/Martin Associates, MSEM Founder and Principal and the Vivant Group, San Francisco, California On June 22, 2017, Innate Immunotherapeutics announced that the MIS416 clinical trials undertaken to evaluate its efficacy in managing secondary progressive multiple sclerosis (SPMS), had "failed to show any ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MIS416
MIS416 is an experimental drug developed by Innate Immunotherapeutics which underwent clinical trials to treat secondary progressive multiple sclerosis. It is derived from the bacteria that causes acne and targets myeloid cells through TLR9 and NOD2. In one of its first rounds of clinical trials, the drug was shown to be "safe and well tolerated", with 80% of secondary-progressive multiple sclerosis patients exhibiting more than 30% improvement in at least one area of their MS status. However, Phase II clinical trials were unable to prove that the drug provided a benefit to patients. It is also being researched as a potential treatment for cancer. Development MIS416 is a microparticle derived from the cytoskeleton of '' P. acnes'', a species of bacteria present on the skin of most adults that causes acne. MIS416 was originally developed as a vaccine adjuvant, a component of vaccines that helps to activate an immune response against the vaccine target. Bacteria-derived micropart ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tom Price (American Politician)
Thomas Edmunds Price (born October 8, 1954) is an American physician and Republican Party politician who served as the U.S. representative for , encompassing the northern suburbs of Atlanta, from 2005 to 2017. He was appointed Secretary of Health and Human Services by President Donald Trump and served in that role from February to September 2017. On September 29, 2017, he resigned as head of HHS following criticism of his use of private charters and military aircraft for travel. In July 2018, the HHS inspector general urged the HHS to recoup at least $341,000 from Price for wasteful expenditures. While in Congress, Price chaired the House Committee on the Budget, Republican Study Committee and Republican Policy Committee. Early life, education, and medical career Price was born in Lansing, Michigan, and grew up in Dearborn, where he attended Adams Jr. High and Dearborn High School. Price's father and grandfather were both doctors. As a child, Price occasionally accompanied ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vaccine
A vaccine is a biological Dosage form, preparation that provides active acquired immunity to a particular infectious disease, infectious or cancer, malignant disease. The safety and effectiveness of vaccines has been widely studied and verified. A vaccine typically contains an agent that resembles a disease-causing microorganism and is often made from weakened or Antigen, killed forms of the microbe, its toxins, or one of its surface proteins. The agent stimulates the body's immune system to recognize the agent as a threat, destroy it, and to further recognize and destroy any of the microorganisms associated with that agent that it may encounter in the future. Vaccines can be prophylaxis, prophylactic (to prevent or ameliorate the effects of a future infection by a natural or "wild" pathogen), or therapeutic vaccines, therapeutic (to fight a disease that has already occurred, such as cancer vaccine, cancer). [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adjuvant
In pharmacology, an adjuvant is a drug or other substance, or a combination of substances, that is used to increase the efficacy or potency of certain drugs. Specifically, the term can refer to: * Adjuvant therapy in cancer management * Analgesic adjuvant in pain management * Immunologic adjuvant In immunology, an adjuvant is a substance that increases or modulates the immune response to a vaccine. The word "adjuvant" comes from the Latin word ''adiuvare'', meaning to help or aid. "An immunologic adjuvant is defined as any substance that ... in vaccines This is a specialized usage of a word (derived from the Latin verb "adjuvare", ''to help''), which also has a more general meaning as someone or something assisting in any operation or effect. {{sia Adjuvants ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunologic Adjuvant
In immunology, an adjuvant is a substance that increases or modulates the immune response to a vaccine. The word "adjuvant" comes from the Latin word ''adiuvare'', meaning to help or aid. "An immunologic adjuvant is defined as any substance that acts to accelerate, prolong, or enhance antigen-specific immune responses when used in combination with specific vaccine antigens." In the early days of vaccine manufacture, significant variations in the efficacy of different batches of the same vaccine were correctly assumed to be caused by contamination of the reaction vessels. However, it was soon found that more scrupulous cleaning actually seemed to ''reduce'' the effectiveness of the vaccines, and some contaminants actually enhanced the immune response. There are many known adjuvants in widespread use, including aluminium salts, oils and virosomes. Overview Adjuvants in immunology are often used to modify or augment the effects of a vaccine by stimulating the immune system to re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Buffalo News
''The Buffalo News'' is the daily newspaper of the Buffalo–Niagara Falls metropolitan area, located in downtown Buffalo, New York. It recently sold its headquarters to Uniland Development Corp. It was for decades the only paper fully owned by Warren Buffett's Berkshire Hathaway. On January 29, 2020, the paper reported that it was being sold to Lee Enterprises. History The ''News'' was founded in 1873 by Edward Hubert Butler, Sr. as a Sunday paper.Frequently Asked Questions , www.buffalonews.com On October 11, 1880, it began publishing daily editions as well, and in 1914, it became an inversion of its original existence by publishing Monday to Saturday, with no publication on Sunday. During most of its life, the ''News'' was known as ''The Buffalo Evening News''. A gentleman's agreement between the ''Ev ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Office Of Congressional Ethics
The Office of Congressional Ethics (OCE), established by the U.S. House of Representatives in March 2008, is a nonpartisan, independent entity charged with reviewing allegations of misconduct against members of the House of Representatives and their staff and, when appropriate, referring matters to the United States House Committee on Ethics. Overview The OCE's mission is "to assist the House in upholding high standards of ethical conduct for its Members, officers, and staff and, in so doing, to serve the American people"; within that framework it strives to foster transparency by keeping the public informed of its activities.About . Office of Congressional Ethics. oce.house.gov. Retrieved 2017-01-03. With its online presence, it aims to “give the public a 'window' into ethics enforcement in the United States House of Representatives.” The office is governed ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Over-the-counter (finance)
Over-the-counter (OTC) or off-exchange trading or pink sheet trading is done directly between two parties, without the supervision of an exchange (organized market), exchange. It is contrasted with exchange trading, which occurs via exchanges. A stock exchange has the benefit of facilitating liquidity, providing transparency, and maintaining the current market price. In an OTC trade, the price is not necessarily publicly disclosed. OTC trading, as well as exchange trading, occurs with commodities, financial instruments (including stocks), and derivative (finance), derivatives of such products. Products traded traditional stock exchanges, and other regulated bourse platforms, must be well standardized. This means that exchanged deliverables match a narrow range of quantity, quality, and identity which is defined by the exchange and identical to all transactions of that product. This is necessary for there to be transparency in stock exchange-based equities trading. The OTC ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ron Wyden
Ronald Lee Wyden (; born May 3, 1949) is an American politician and retired educator serving as the Seniority in the United States Senate, senior United States Senate, United States senator from Oregon, a seat he has held since 1996 United States Senate special election in Oregon, 1996. A member of the Democratic Party of Oregon, Democratic Party, he served in the United States House of Representatives from 1981 until 1996. He is the dean of United States congressional delegations from Oregon, Oregon's congressional delegation and chairs the Senate Finance Committee. Early life, education, and early career Ronald Wyden was born in Wichita, Kansas, the son of Edith (née Rosenow) and Peter H. Wyden (originally Weidenreich, 1923–1998), both of whom were Jewish and had fled Nazi Germany. He grew up in Palo Alto, California, where he played basketball for Palo Alto High School. He attended the University of California, Santa Barbara, on a basketball scholarship, and later transfer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United States Secretary Of Health And Human Services
The United States secretary of health and human services is the head of the United States Department of Health and Human Services, and serves as the principal advisor to the president of the United States on all health matters. The secretary is a member of the United States Cabinet. The office was formerly Secretary of Health, Education, and Welfare. In 1980, the United States Department of Health, Education, and Welfare, Department of Health, Education, and Welfare was renamed the Department of Health and Human Services, and its education functions and Rehabilitation Services Administration were transferred to the new United States Department of Education. Patricia Roberts Harris headed the department before and after it was renamed. Nominations to the office of Secretary of HHS are referred to the United States Senate Committee on Health, Education, Labor, and Pensions, Health, Education, Labor and Pensions Committee and the United States Senate Committee on Finance, which has ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Australian
''The Australian'', with its Saturday edition, ''The Weekend Australian'', is a broadsheet newspaper published by News Corp Australia since 14 July 1964.Bruns, Axel. "3.1. The active audience: Transforming journalism from gatekeeping to gatewatching." (2008). "''The Australian'' has long positioned itself as a loyal supporter of the incumbent government of Prime Minister John Howard, and is widely regarded as generally favouring the conservative side of politics." As the only Australian daily newspaper distributed nationally, its readership of both print and online editions was 2,394,000. Its editorial line has been self-described over time as centre-right. Parent companies ''The Australian'' is published by News Corp Australia, an asset of News Corp, which also owns the sole daily newspapers in Brisbane, Adelaide, Hobart, and Darwin, and the most circulated metropolitan daily newspapers in Sydney and Melbourne. News Corp's Chairman and Founder is Rupert Murdoch. ''Th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Multiple Sclerosis
Multiple (cerebral) sclerosis (MS), also known as encephalomyelitis disseminata or disseminated sclerosis, is the most common demyelinating disease, in which the insulating covers of nerve cells in the brain and spinal cord are damaged. This damage disrupts the ability of parts of the nervous system to transmit signals, resulting in a range of signs and symptoms, including physical, mental, and sometimes psychiatric problems. Specific symptoms can include double vision, blindness in one eye, muscle weakness, and trouble with sensation or coordination. MS takes several forms, with new symptoms either occurring in isolated attacks (relapsing forms) or building up over time (progressive forms). In the relapsing forms of MS, between attacks, symptoms may disappear completely, although some permanent neurological problems often remain, especially as the disease advances. While the cause is unclear, the underlying mechanism is thought to be either destruction by the immune system ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
