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Islanditoxin
Cyclochlorotine (CC), also known as islanditoxin is a mycotoxin produced by the fungus '' Penicillium islandicum'' that causes liver damage and has carcinogenic properties. Japanese researchers confirmed that it was one of three strains of ''Penicillin'' fungi responsible for yellowed rice. It is listed as an IARC Group 3 carcinogen. Chemically, it is a dichlorinated cyclic peptide. Structurally, the only thing that differentiates cyclochlorotine from the plant-derived astins of ''Aster tataricus'', is replacement of a serine Serine (symbol Ser or S) is an α-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated − form under biological conditions), a carboxyl group (which is in the deprotonated − form un ... with a second 2-aminobutyrate. Cyclochlorotine are one of the toxins usually found in foods in the grains group like rice , wheat, soybeans, peanuts , beans, bread and flour etc. Such foods serve as mediu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Penicillium Islandicum
''Penicillium islandicum'' is an anamorph species of the genus of ''Penicillium'' which produces luteoskyrin, simatoxin, cyclochlorotine, rugulosin, islanditoxin and chitosanase Chitosanase () is an enzyme with systematic name ''chitosan N-acetylglucosaminohydrolase''. This enzyme catalyses the following chemical reaction : Endohydrolysis of beta-(1->4)-linkages between D-glucosamine residues in a partly acetylated chito .... Further reading * * * * * * * * * References {{Taxonbar, from=Q10622959 islandicum Fungi described in 1912 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mycotoxin
A mycotoxin (from the Greek μύκης , "fungus" and τοξίνη , "toxin") is a toxic secondary metabolite produced by organisms of kingdom Fungi and is capable of causing disease and death in both humans and other animals. The term 'mycotoxin' is usually reserved for the toxic chemical products produced by fungi that readily colonize crops. Examples of mycotoxins causing human and animal illness include aflatoxin, citrinin, fumonisins, ochratoxin A, patulin, trichothecenes, zearalenone, and ergot alkaloids such as ergotamine. One mold species may produce many different mycotoxins, and several species may produce the same mycotoxin. Production Most fungi are aerobic (use oxygen) and are found almost everywhere in extremely small quantities due to the diminute size of their spores. They consume organic matter wherever humidity and temperature are sufficient. Where conditions are right, fungi proliferate into colonies and mycotoxin levels become high. The reason for the product ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Liver Damage
Liver disease, or hepatic disease, is any of many diseases of the liver. If long-lasting it is termed chronic liver disease. Although the diseases differ in detail, liver diseases often have features in common. Signs and symptoms Some of the signs and symptoms of a liver disease are the following: * Jaundice * Confusion and altered consciousness caused by hepatic encephalopathy. * Thrombocytopenia and coagulopathy. * Risk of bleeding symptoms particularly taking place in gastrointestinal tract Liver diseases File:Ground glass hepatocytes high mag cropped 2.jpg, Ground glass hepatocytes File:Primary biliary cirrhosis intermed mag much cropping.jpg, Primary biliary cirrhosis File:Buddchiari2.PNG, Budd-chiari syndrome File:Non-alcoholic_fatty_liver_disease1.jpg, Micrograph of non-alcoholic fatty liver disease There are more than a hundred different liver diseases. Some of the most common are: * Fascioliasis, a parasitic infection of liver caused by a liver fluke of the genus ''F ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carcinogenic
A carcinogen is any substance, radionuclide, or radiation that promotes carcinogenesis (the formation of cancer). This may be due to the ability to damage the genome or to the disruption of cellular metabolic processes. Several radioactive substances are considered carcinogens, but their carcinogenic activity is attributed to the radiation, for example gamma rays and alpha particles, which they emit. Common examples of non-radioactive carcinogens are inhaled asbestos, certain dioxins, and tobacco smoke. Although the public generally associates carcinogenicity with synthetic chemicals, it is equally likely to arise from both natural and synthetic substances. Carcinogens are not necessarily immediately toxic; thus, their effect can be insidious. Carcinogens, as mentioned, are agents in the environment capable of contributing to cancer growth. Carcinogens can be categorized into two different types: activation-dependent and activation-independent, and each nature impacts their level ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Penicillin
Penicillins (P, PCN or PEN) are a group of β-lactam antibiotics originally obtained from ''Penicillium'' moulds, principally '' P. chrysogenum'' and '' P. rubens''. Most penicillins in clinical use are synthesised by P. chrysogenum using deep tank fermentation and then purified. A number of natural penicillins have been discovered, but only two purified compounds are in clinical use: penicillin G (intramuscular or intravenous use) and penicillin V (given by mouth). Penicillins were among the first medications to be effective against many bacterial infections caused by staphylococci and streptococci. They are still widely used today for different bacterial infections, though many types of bacteria have developed resistance following extensive use. 10% of the population claims penicillin allergies but because the frequency of positive skin test results decreases by 10% with each year of avoidance, 90% of these patients can tolerate penicillin. Additionally, those with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Yellowed Rice
Yellowed rice (also yellow rice, Japanese: 黄変米 Ouhenmai) refers to three kinds of rice grains contaminated with different strains of Penicillium fungi—Yellow rice (''P. citreonigrum''), Citrinum yellow rice (''P. citrinum''), and Islandia yellow rice (''P. islandicum''). These rice grains were first identified in Japan in 1964, after the research was interrupted by World War II. The first of the yellowed rice strains has been linked to shoshin-kakke (heart-attacking paralysis). Citrinum yellow rice and Islandia yellow rice are not known to have caused any adverse effects in human populations. Discovery Yellow rice (''P. citreonigrum'') In 1891, Junjiro Sakaki began studying molded rice and inferred that mycotoxins contained in the rice were linked to paralysis. In 1937, the research was taken over by the Rice Utilization Institute. Although research was interrupted by World War II, it was resumed afterward and in 1964 the mycotoxin citreoviridin was isolated. Kenj ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of IARC Group 3 Carcinogens
Substances, mixtures and exposure circumstances in this list have been classified by the International Agency for Research on Cancer (IARC) as ''group 3: The agent (mixture or exposure circumstance) is not classifiable as to its carcinogenicity to humans.'' This category is used most commonly for agents, mixtures and exposure circumstances for which the evidence of carcinogenicity is inadequate in humans and inadequate or limited in experimental animals. Exceptionally, agents (mixtures) for which the evidence of carcinogenicity is inadequate in humans but sufficient in experimental animals may be placed in this category when there is strong evidence that the mechanism of carcinogenicity in experimental animals does not operate in humans. Agents, mixtures and exposure circumstances that do not fall into any other group are also placed in this category. Further details can be found in thIARC Monographs Agents and groups of agents A * Acenaphthene * Acepyrene *Aciclovir * Acridine ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chlorine
Chlorine is a chemical element with the Symbol (chemistry), symbol Cl and atomic number 17. The second-lightest of the halogens, it appears between fluorine and bromine in the periodic table and its properties are mostly intermediate between them. Chlorine is a yellow-green gas at room temperature. It is an extremely reactive element and a strong oxidising agent: among the elements, it has the highest electron affinity and the third-highest electronegativity on the revised Electronegativity#Pauling electronegativity, Pauling scale, behind only oxygen and fluorine. Chlorine played an important role in the experiments conducted by medieval Alchemy, alchemists, which commonly involved the heating of chloride Salt (chemistry), salts like ammonium chloride (sal ammoniac) and sodium chloride (common salt), producing various chemical substances containing chlorine such as hydrogen chloride, mercury(II) chloride (corrosive sublimate), and hydrochloric acid (in the form of ). However ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cyclic Peptide
Cyclic peptides are polypeptide chains which contain a circular sequence of bonds. This can be through a connection between the amino and carboxyl ends of the peptide, for example in cyclosporin; a connection between the amino end and a side chain, for example in bacitracin; the carboxyl end and a side chain, for example in colistin; or two side chains or more complicated arrangements, for example in amanitin. Many cyclic peptides have been discovered in nature and many others have been synthesized in the laboratory. Their length ranges from just two amino acid residues to hundreds. In nature they are frequently antimicrobial or toxic; in medicine they have various applications, for example as antibiotics and immunosuppressive agents. Thin-Layer Chromatography (TLC) is a convenient method to detect cyclic peptides in crude extract from bio-mass. Classification Cyclic peptides can be classified according to the types of bonds that comprise the ring. *Homodetic cyclic peptides, suc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aster Tataricus
''Aster tataricus'', also called Tatarinow's aster, is a member of the ''Aster'' genus of flowering plants. Uses Culinary Known as ''gaemichwi'' () in Korean, the plant is considered a ''chwinamul'' (edible ''Aster'') variety used in Korean cuisine. Medicinal It is one of the 50 fundamental herbs of Traditional Chinese medicine, where it has the name ''zǐwǎn'' (). It has an antibacterial action, inhibiting the growth of ''Staphylococcus aureus'', '' E. coli'', '' Bacillus dysenteriae'', '' B. typhi'', ''Pseudomonas'' and '' Vibrio proteus''. In culture In Japan, ''Aster tataricus'' is known as ''shion'', or . The flower has a meaning in ''hanakotoba is the Japanese form of the language of flowers. The language was meant to convey emotion and communicate directly to the recipient or viewer without needing the use of words. Flowers and their meanings See also *Language of flowers * *Plant ...'', the Japanese language of flowers, which corresponds to "I won't forget y ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Serine
Serine (symbol Ser or S) is an α-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated − form under biological conditions), a carboxyl group (which is in the deprotonated − form under biological conditions), and a side chain consisting of a hydroxymethyl group, classifying it as a polar amino acid. It can be synthesized in the human body under normal physiological circumstances, making it a nonessential amino acid. It is encoded by the codons UCU, UCC, UCA, UCG, AGU and AGC. Occurrence This compound is one of the naturally occurring proteinogenic amino acids. Only the L-stereoisomer appears naturally in proteins. It is not essential to the human diet, since it is synthesized in the body from other metabolites, including glycine. Serine was first obtained from silk protein, a particularly rich source, in 1865 by Emil Cramer. Its name is derived from the Latin for silk, ''sericum''. Serine's structure was estab ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
IARC Group 3 Carcinogens , South Korean architecture firm
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IARC may refer to: * International Aerial Robotics Competition * International Age Rating Coalition * International Agency for Research on Cancer * International Arctic Research Center * Israel Amateur Radio Club * iArc IARC may refer to: * International Aerial Robotics Competition * International Age Rating Coalition * International Agency for Research on Cancer * International Arctic Research Center * Israel Amateur Radio Club The Israel Amateur Radio Club (IA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
