Isaria Sinclairii
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Isaria Sinclairii
''Isaria sinclairii'' is a species of entomopathogenic fungus mostly infecting the underground nymphs of cicadas. It produces myriocin, from which the synthetic drug fingolimod, a treatment for multiple sclerosis, was developed. Taxonomy ''Isaria sinclairii'' is the name of the anamorph; the teleomorph is ''Cordyceps sinclairii'', Cordycipitaceae. The species was first described in 1855 by Miles Joseph Berkeley from specimens collected in the garden of Archdeacon William Williams at Tūranga, Poverty Bay. It was moved to the genus ''Isaria'' in 1923 by Curtis Gates Lloyd. Ecology ''Isaria sinclairii'' is a fungus which attacks insects, including cicada larvae. The larvae typically die just beneath the soil surface, and the fungus produces white tufts which grow up from the soil and release powdery white spores. ''I. sinclairii'' is found from Asia (particularly China, Japan, and Korea) through to New Zealand. In New Zealand it attacks cicadas of the genera '' Amphipsalta'' an ...
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Miles Joseph Berkeley
Miles Joseph Berkeley (1 April 1803 – 30 July 1889) was an English cryptogamist and clergyman, and one of the founders of the science of plant pathology. Life Berkeley was born at Biggin Hall, Benefield, Northamptonshire, and educated at Rugby School and Christ's College, Cambridge. Taking holy orders, he became incumbent of Apethorpe in 1837, and vicar of Sibbertoft, near Market Harborough, in 1868. He acquired an enthusiastic love of cryptogamic botany (lichens) in his early years, and soon was recognized as the leading British authority on fungi and plant pathology. Christ's College made him an honorary fellow in 1883. He was well known as a systematist in mycology with some 6000 species of fungi being credited to him, but his ''Introduction to Cryptogamic Botany'', published in 1857, and his papers on Vegetable Pathology in the ''Gardener's Chronicle'' in 1854 and onwards, show that he had a broad grasp of the whole domain of physiology and morphology as understood in ...
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Genus
Genus ( plural genera ) is a taxonomic rank used in the biological classification of extant taxon, living and fossil organisms as well as Virus classification#ICTV classification, viruses. In the hierarchy of biological classification, genus comes above species and below family (taxonomy), family. In binomial nomenclature, the genus name forms the first part of the binomial species name for each species within the genus. :E.g. ''Panthera leo'' (lion) and ''Panthera onca'' (jaguar) are two species within the genus ''Panthera''. ''Panthera'' is a genus within the family Felidae. The composition of a genus is determined by taxonomy (biology), taxonomists. The standards for genus classification are not strictly codified, so different authorities often produce different classifications for genera. There are some general practices used, however, including the idea that a newly defined genus should fulfill these three criteria to be descriptively useful: # monophyly – all descendants ...
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Radio New Zealand
Radio New Zealand ( mi, Te Reo Irirangi o Aotearoa), commonly known as Radio NZ or simply RNZ, is a New Zealand public-service radio broadcaster and Crown entity that was established under the Radio New Zealand Act 1995. It operates news and current-affairs network, RNZ National, and a classical-music and jazz network, RNZ Concert, with full government funding from NZ on Air. Since 2014, the organisation's focus has been to transform RNZ from a radio broadcaster to a multimedia outlet, increasing its production of digital content in audio, video, and written forms. The organisation plays a central role in New Zealand public broadcasting. The New Zealand Parliament fully funds its AM network, used in part for the broadcast of parliamentary proceedings. RNZ has a statutory role under the Civil Defence Emergency Management Act 2002 to act as a "lifeline utility" in emergency situations. It is also responsible for an international service (known as RNZ Pacific); this is broadcas ...
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Food And Drug Administration
The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food safety, tobacco products, caffeine products, dietary supplements, Prescription drug, prescription and Over-the-counter drug, over-the-counter pharmaceutical drugs (medications), vaccines, biopharmaceuticals, blood transfusions, medical devices, electromagnetic radiation emitting devices (ERED), cosmetics, Animal feed, animal foods & feed and Veterinary medicine, veterinary products. The FDA's primary focus is enforcement of the Federal Food, Drug, and Cosmetic Act (FD&C), but the agency also enforces other laws, notably Section 361 of the Public Health Service Act, as well as associated regulations. Much of this regulatory-enforcement work is not d ...
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The Journal Of Antibiotics
''The Journal of Antibiotics'' is a peer-reviewed medical journal published by the Nature Publishing Group Nature Portfolio (formerly known as Nature Publishing Group and Nature Research) is a division of the international scientific publishing company Springer Nature that publishes academic journals, magazines, online databases, and services in scien ... for the Japan Antibiotics Research Association. The journal seeks to endorse studies on antibiotics and associated types of biologically substances. In June 2020, the journal published a pioneer systematic review on Ivermectin and COVID-19 by Fatemeh Heiday and Reza Gharebaghi which later identified as highly cited in this field. References External links * Microbiology journals Nature Research academic journals Monthly journals Publications established in 1948 English-language journals Academic journals associated with learned and professional societies {{med-journal-stub ...
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Immunosuppression
Immunosuppression is a reduction of the activation or efficacy of the immune system. Some portions of the immune system itself have immunosuppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to treatment of other conditions. In general, deliberately induced immunosuppression is performed to prevent the body from rejecting an organ transplant. Additionally, it is used for treating graft-versus-host disease after a bone marrow transplant, or for the treatment of auto-immune diseases such as systemic lupus erythematosus, rheumatoid arthritis, Sjögren's syndrome, or Crohn's disease. This is typically done using medications, but may involve surgery (splenectomy), plasmapheresis, or radiation. A person who is undergoing immunosuppression, or whose immune system is weak for some other reasons (such as chemotherapy or HIV), is said to be ''immunocompromised''. Deliberately induced Administration of immunosuppressive medic ...
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Sphingolipid
Sphingolipids are a class of lipids containing a backbone of sphingoid bases, a set of aliphatic amino alcohols that includes sphingosine. They were discovered in brain extracts in the 1870s and were named after the mythological sphinx because of their enigmatic nature. These compounds play important roles in signal transduction and cell recognition. Sphingolipidoses, or disorders of sphingolipid metabolism, have particular impact on neural tissue. A sphingolipid with an R group consisting of a hydrogen atom only is a ceramide. Other common R groups include phosphocholine, yielding a sphingomyelin, and various sugar monomers or dimers, yielding cerebrosides and globosides, respectively. Cerebrosides and globosides are collectively known as glycosphingolipids. Structure The long-chain bases, sometimes simply known as sphingoid bases, are the first non-transient products of '' de novo'' sphingolipid synthesis in both yeast and mammals. These compounds, specifically known as phy ...
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Eternal Youth
Eternal youth is the concept of human physical immortality free of ageing. The youth referred to is usually meant to be in contrast to the depredations of aging, rather than a specific age of the human lifespan. Eternal youth is common in mythology, and is a popular theme in fiction. Religion and mythology Eternal youth is a characteristic of the inhabitants of Paradise in Abrahamic religions. The Hindus believe that the Vedic and the post-Vedic rishis have attained immortality, which implies the ability to change one's body's age or even shape at will. These are some of the siddhas in Yoga. Markandeya is said to always stay at the age of 16. The difference between eternal life and the more specific eternal youth is a recurrent theme in Greek and Roman mythology. The mytheme of requesting the boon of immortality from a god, but forgetting to ask for eternal youth appears in the story of Tithonus. A similar theme is found in Ovid regarding the Cumaean Sibyl. In Norse myt ...
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Traditional Chinese Medicine
Traditional Chinese medicine (TCM) is an alternative medical practice drawn from traditional medicine in China. It has been described as "fraught with pseudoscience", with the majority of its treatments having no logical mechanism of action. Medicine in traditional China encompassed a range of sometimes competing health and healing practices, folk beliefs, literati theory and Confucian philosophy, herbal remedies, food, diet, exercise, medical specializations, and schools of thought. In the early twentieth century, Chinese cultural and political modernizers worked to eliminate traditional practices as backward and unscientific. Traditional practitioners then selected elements of philosophy and practice and organized them into what they called "Chinese medicine" (''Zhongyi''). In the 1950s, the Chinese government sponsored the integration of Chinese and Western medicine, and in the Great Proletarian Cultural Revolution of the 1960s, promoted Chinese medicine as inexpensive a ...
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Traditional Tibetan Medicine
Traditional Tibetan medicine (), also known as Sowa-Rigpa medicine, is a centuries-old traditional medical system that employs a complex approach to diagnosis, incorporating techniques such as pulse analysis and urinalysis, and utilizes behavior and dietary modification, medicines composed of natural materials (e.g., herbs and minerals) and physical therapies (e.g. Tibetan acupuncture, moxabustion, etc.) to treat illness. The Tibetan medical system is based upon Indian Buddhist literature (for example Abhidharma and Vajrayana tantras) and Ayurveda. It continues to be practiced in Tibet, India, Nepal, Bhutan, Ladakh, Siberia, China and Mongolia, as well as more recently in parts of Europe and North America. It embraces the traditional Buddhist belief that all illness ultimately results from the three poisons: delusion, greed and aversion. Tibetan medicine follows the Buddha's Four Noble Truths which apply medical diagnostic logic to suffering. History As Indian culture flooded Ti ...
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Ophiocordyceps Sinensis
''Ophiocordyceps sinensis'' (formerly known as ''Cordyceps sinensis''), known colloquially as caterpillar fungus, is an entomopathogenic fungus (a fungus that grows on insects) in the family Ophiocordycipitaceae. It is mainly found in the meadows above on the Tibetan Plateau in Southwest China and the Himalayan regions of Bhutan and Nepal. It parasitizes larvae of ghost moths and produces a fruiting body which used to be valued as a herbal remedy and in traditional Chinese medicine. Caterpillar fungus contains the compound cordycepin, an adenosine derivative. However, the fruiting bodies harvested in nature usually contain high amounts of arsenic and other heavy metals so they are potentially toxic and sales have been strictly regulated by the CFDA (China Food and Drug Administration) since 2016. ''O. sinensis'' parasitizes the larvae of moths within the family Hepialidae, specifically genera found on the Tibetan Plateau and in the Himalayas, between elevations of . The fung ...
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