Interleukin-22 Receptor

	Interleukin-22 Receptor Interleukin-22 receptor is a type II cytokine receptor. It binds to Interleukin-22. It is a heterodimer of α1 and IL-10Rβ2 subunits. References External links * Type II cytokine receptors {{membrane-protein-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	IL22RA1 Interleukin 22 receptor, alpha 1 is a protein that in humans is encoded by the IL22RA1 gene. Function The protein encoded by this gene belongs to the class II cytokine receptor Cytokine receptors are receptors that bind to cytokines. In recent years, the cytokine receptors have come to demand the attention of more investigators than cytokines themselves, partly because of their remarkable characteristics, and partly be ... family, and has been shown to be a receptor for interleukin 22 ( IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta ( IL10RB/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha ( IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. References Further reading * * * * * * * * * Type II cytokine receptors {{gene-1-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	IL22RA2 Interleukin-22 receptor subunit alpha-2 (IL-22RA2), also known as interleukin-22 binding protein (IL-22BP) is a naturally secreted monomeric protein acting as an interleukin-22 (IL-22) antagonist with inhibitory effects on IL-22 activity ''in vivo''. IL-22BP is in humans encoded by the ''IL22RA2'' gene located on chromosome 6, and in mice is encoded by the ''il22ra2'' gene located on chromosome 10. IL-22BP belongs to the class II cytokine receptor family and it is a soluble receptor homolog of IL-22R (aliases IL-22RA1/IL-22RA/IL-22R1). The main function of IL-22BP is the regulation of IL-22 biological activity through specific binding which blocks the interaction of IL-22 with its cell surface receptor IL-22R and thus prevents the downstream cellular signalling and response. IL-22 and IL-22BP interactions play an important role in health and disease and are involved in the regulation of steady-state homeostasis, inflammatory responses and cancer. Structure and interaction ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Type II Cytokine Receptor Type II cytokine receptors, also commonly known as class II cytokine receptors, are transmembrane proteins that are expressed on the surface of certain cells. They bind and respond to a select group of cytokines including interferon type I, interferon type II, interferon type III. and members of the interleukin-10 family These receptors are characterized by the lack of a WSXWS motif which differentiates them from type I cytokine receptors. Structure Typically type II cytokine receptors are heterodimers or multimers with a high and a low affinity component. These receptors are related predominantly by sequence similarities in their extracellular portions that are composed of tandem Ig-like domains. The structures for the extracellular domains of the receptors for interferon types, I, II, and III are all known. Type II cytokine receptors are tyrosine-kinase-linked receptors. The intracellular domain of type II cytokine receptors is typically associated with a tyrosine kinase ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Interleukin-22 Interleukin-22 (IL-22) is protein that in humans is encoded by the ''IL22'' gene. Structure IL-22 is an α-helical cytokine. IL-22 binds to a heterodimeric cell surface receptor composed of IL-10R2 and IL-22R1 subunits. IL-22R is expressed on tissue cells, and it is absent on immune cells. Crystallization is possible if the N-linked glycosylation sites are removed in mutants of IL-22 bound with high-affinity cell-surface receptor sIL-22R1. The crystallographic asymmetric unit contained two IL-22-sIL-22R1 complexes. Function IL-22 is produced by several populations of immune cells at a site of inflammation. Producers are αβ T cells classes Th1 cell, Th1, Th22 and T helper 17 cell, Th17 along with γδ T cells A T cell is a type of lymphocyte. T cells are one of the important white blood cells of the immune system and play a central role in the adaptive immune response. T cells can be distinguished from other lymphocytes by the presence of a T-cell re ..., NKT cell, N ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]