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ICIM Cugir
In statistical genetics, inclusive composite interval mapping (ICIM) has been proposed as an approach to QTL (quantitative trait locus) mapping for populations derived from bi-parental crosses. QTL mapping is based on genetic linkage map and phenotypic data and attempts to locate individual genetic factors on chromosomes and to estimate their genetic effects. Additive and dominance QTL mapping Two genetic assumptions used in ICIM are (1) the genotypic value of an individual is the summation of effects from all genes affecting the trait of interest; and (2) linked QTL are separated by at least one blank marker interval. Under the two assumptions, they proved that additive effect of the QTL located in a marker interval can be completely absorbed by the regression coefficients of the two flanking markers, while the QTL dominance effect causes marker dominance effects, as well as additive by additive and dominance by dominance interactions between the two flanking markers. By includin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Statistical Genetics
Statistical genetics is a scientific field concerned with the development and application of statistical methods for drawing inferences from genetic data. The term is most commonly used in the context of human genetics. Research in statistical genetics generally involves developing theory or methodology to support research in one of three related areas: *population genetics - Study of evolutionary processes affecting genetic variation between organisms *genetic epidemiology - Studying effects of genes on diseases *quantitative genetics - Studying the effects of genes on 'normal' phenotypes Statistical geneticists tend to collaborate closely with geneticists, molecular biologists, clinicians and bioinformaticians. Statistical genetics is a type of computational biology Computational biology refers to the use of data analysis, mathematical modeling and computational simulations to understand biological systems and relationships. An intersection of computer science, biology, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
QTL Mapping
A quantitative trait locus (QTL) is a locus (section of DNA) that correlates with variation of a quantitative trait in the phenotype of a population of organisms. QTLs are mapped by identifying which molecular markers (such as SNPs or AFLPs) correlate with an observed trait. This is often an early step in identifying the actual genes that cause the trait variation. Definition A quantitative trait locus (QTL) is a region of DNA which is associated with a particular phenotypic trait, which varies in degree and which can be attributed to polygenic effects, i.e., the product of two or more genes, and their environment. . These QTLs are often found on different chromosomes. The number of QTLs which explain variation in the phenotypic trait indicates the genetic architecture of a trait. It may indicate that plant height is controlled by many genes of small effect, or by a few genes of large effect. Typically, QTLs underlie continuous traits (those traits which vary continuously, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stepwise Regression
In statistics, stepwise regression is a method of fitting regression models in which the choice of predictive variables is carried out by an automatic procedure. In each step, a variable is considered for addition to or subtraction from the set of explanatory variables based on some prespecified criterion. Usually, this takes the form of a forward, backward, or combined sequence of ''F''-tests or ''t''-tests. The frequent practice of fitting the final selected model followed by reporting estimates and confidence intervals without adjusting them to take the model building process into account has led to calls to stop using stepwise model building altogetherFlom, P. L. and Cassell, D. L. (2007) "Stopping stepwise: Why stepwise and similar selection methods are bad, and what you should use," NESUG 2007. or to at least make sure model uncertainty is correctly reflected.Chatfield, C. (1995) "Model uncertainty, data mining and statistical inference," J. R. Statist. Soc. A 158, Part 3, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nested Association Mapping
Nested association mapping (NAM) is a technique designed by the labs of Edward BucklerJames Holland anfor identifying and dissecting the genetic architecture of complex traits in corn (''Zea mays''). It is important to note that nested association mapping (unlike association mapping) is a specific technique that cannot be performed outside of a specifically designed population such as the Maize NAM population, the details of which are described below. Theory behind NAM NAM was created as a means of combining the advantages and eliminating the disadvantages of two traditional methods for identifying quantitative trait loci: linkage analysis and association mapping. Linkage analysis depends upon recent genetic recombination between two different plant lines (as the result of a genetic cross) to identify general regions of interest, with the advantage of requiring few genetic markers to ensure genome wide coverage and high statistical power per allele. Linkage analysis, however, has ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Buckler Laboratory
A buckler (French ''bouclier'' 'shield', from Old French ''bocle, boucle'' 'boss') is a small shield, up to 45 cm (up to 18 in) in diameter, gripped in the fist with a central handle behind the boss. While being used in Europe since antiquity, it became more common as a companion weapon in hand-to-hand combat during the Medieval and Renaissance periods. Its size made it poor protection against missile weapons (e.g., arrows) but useful in deflecting the blow of an opponent's weapons, binding his arms, hindering his movements, or punching him. MS I.33, considered the earliest extant armed-combat manual, (around 1300) contains an early description of a system of combat with buckler and sword. Typology According to the typology of Schmidt, there are three main types of buckler regarding their shape: *Type I: round *Type II: rectangular or trapezoid *Type III: oval or teardrop-shaped These types are combined with the cross sections: *Type a: flat *Type b: concave *Type ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
