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Hypericum
''Hypericum'' is a genus of flowering plants in the family Hypericaceae (formerly considered a subfamily of Clusiaceae). The genus has a nearly worldwide distribution, missing only from tropical lowlands, deserts and polar regions. Many ''Hypericum'' species are regarded as invasive species and noxious weeds. All members of the genus may be referred to as St. John's wort, and some are known as goatweed. The white or pink flowered marsh St. John's worts of North America and eastern Asia are generally accepted as belonging to the separate genus '' Triadenum'' Raf. ''Hypericum'' is unusual for a genus of its size because a worldwide taxonomic monograph was produced for it by Norman Robson (working at the Natural History Museum, London). Robson recognizes 36 sections within ''Hypericum''. Description ''Hypericum'' species are quite variable in habit, occurring as trees, shrubs, annuals, and perennials. Trees in the sense of single stemmed woody plants are rare, as most woody s ...
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List Of Hypericum Species
The genus ''Hypericum'' contains approximately 500 species which are divided into 36 sections as described by botanist Norman Robson. This division into distinct sections is largely due to the fact that a genus-wide monograph was performed by Robson in 1977, which allowed for a comprehensive analysis of the genus's taxonomy. A phylogenetic study was more recently completed for the genus, which gave evidence to suggest that the genus '' Triadenum'' is a clade within ''Hypericum'' and that the genus '' Thornea'' is sister to ''Hypericum''. In addition, the study found that about 60% of the sections of ''Hypericum'' are monophyletic. Almost all species of ''Hypericum'' are either perennial herbs, shrubs, or small trees, but the genus also contains a small amount of subshrubs and annual herbs. Most of its species contain hypericin or hyperforin and some are used for their healing properties in folk medicine. The species' leaves are always placed opposite, and are normally d ...
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Hypericum Perforatum
''Hypericum perforatum'', known as St. John's wort, is a flowering plant in the family Hypericaceae and the type species of the genus '' Hypericum''. Possibly a hybrid between '' H. maculatum'' and '' H. attenuatum'', the species can be found across temperate areas of Eurasia and has been introduced as an invasive weed to much of North and South America, as well as South Africa and Australia. While the species is harmful to livestock and can interfere with prescription drugs, it has been used in folk medicine over centuries, and remains commercially cultivated in the 21st century. Hyperforin, a phytochemical constituent of the species, is under basic research for possible therapeutic properties. Description ''Hypericum perforatum'' is an herbaceous perennial plant with extensive, creeping rhizomes. Its reddish stems are erect and branched in the upper section, and can grow up to high. The stems are woody near their base and may appear jointed from leaf scars. The branche ...
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Hyperforin
Hyperforin is a phytochemical produced by some of the members of the plant genus '' Hypericum'', notably '' Hypericum perforatum'' (St John's wort). Hyperforin may be involved in the pharmacological effects of St. John's wort, specifically in its antidepressant effects. Occurrence Hyperforin has only been found in significant amounts in '' Hypericum perforatum'' with other related species such as ''Hypericum calycinum'' containing lower levels of the phytochemical. It accumulates in oil glands, pistils, and fruits, probably as a plant defensive compound. The first natural extractions were done with ethanol and afforded a 7:1 yield of crude extract to phytochemical however, this technique produced a mixture of hyperforin and adhyperforin. The extraction technique has since been modernized using lipophilic liquid CO2 extraction to afford a 3:1 crude to phytochemical extraction which is then further purified away from adhyperforin. This CO2 extraction is rather tricky still because ...
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Norman Robson (botanist)
Norman Keith Bonner Robson (1928 – 6 September 2021) was a Scientific Associate in the Plants Division, Department of Life Sciences at the Natural History Museum, London. He was a member of staff at the Museum from 1962–1988, retiring as Principal Scientific Officer with responsibility for General Herbarium Section I. Norman produced a worldwide taxonomic monograph of genus ''Hypericum'' between 1977 and 2012. Norman’s interest in ''Hypericum'' was stimulated by a final year project on the British species whilst at Aberdeen University. He continued work on the genus for his PhD at the University of Edinburgh (Robson, 1956) with a thesis entitled ‘Studies in the genus ''Hypericum'' L.’ that examined floral anatomy and evolution. At the Royal Botanic Gardens, Kew and subsequently at the Natural History Museum, Norman contributed accounts of Hypericum for Floras Flora is all the plant life present in a particular region or time, generally the naturally occurring ( ind ...
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Hypericin
Hypericin is a naphthodianthrone, an anthraquinone derivative which, together with hyperforin, is one of the principal active constituents of '' Hypericum'' ( Saint John's wort). Hypericin is believed to act as an antibiotic, antiviral and non-specific kinase inhibitor. Hypericin may inhibit the action of the enzyme dopamine β-hydroxylase, leading to increased dopamine levels, although thus possibly decreasing norepinephrine and epinephrine. It was initially believed that the anti-depressant pharmacological activity of hypericin was due to inhibition of monoamine oxidase enzyme. The crude extract of ''Hypericum'' is a weak inhibitor of MAO-A and MAO-B. Isolated hypericin does not display this activity, but does have some affinity for NMDA receptors. This points in the direction that other constituents are responsible for the MAOI effect. The current belief is that the mechanism of antidepressant activity is due to the inhibition of re-uptake of certain neurotransmitters. ...
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Noxious Weed
A noxious weed, harmful weed or injurious weed is a weed that has been designated by an agricultural or other governing authority as a plant that is injurious to agricultural or horticultural crops, natural habitats or ecosystems, or humans or livestock. Most noxious weeds have been introduced into an ecosystem by ignorance, mismanagement, or accident. Some noxious weeds are native. Typically they are plants that grow aggressively, multiply quickly without natural controls (native herbivores, soil chemistry, etc.), and display adverse effects through contact or ingestion. Noxious weeds are a large problem in many parts of the world, greatly affecting areas of agriculture, forest management, nature reserves, parks and other open space. Many noxious weeds have come to new regions and countries through contaminated shipments of feed and crop seeds or were intentionally introduced as ornamental plants for horticultural use. Some "noxious weeds", such as ragwort, produce copious am ...
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Phloroglucinol
Phloroglucinol is an organic compound with the formula C6H3(OH)3. It is a colorless solid. It is used in the synthesis of pharmaceuticals and explosives. Phloroglucinol is one of three isomeric benzenetriols. The other two isomers are hydroxyquinol (1,2,4-benzenetriol) and pyrogallol (1,2,3-benzenetriol). Phloroglucinol, and its benzenetriol isomers, are still defined as "phenols" according to the IUPAC official nomenclature rules of chemical compounds. Many such monophenolics are often termed "polyphenols" by the cosmetic and parapharmaceutical industries, which does not match the scientifically accepted definition. Synthesis and occurrence In 1855, phloroglucinol was first prepared from phloretin by the Austrian chemist Heinrich Hlasiwetz (1825–1875). A modern synthesis of involves hydrolysis of benzene-1,3,5-triamine and its derivatives. Representative is the following route from trinitrobenzene. : The synthesis is noteworthy because ordinary aniline derivatives are un ...
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John And Paul
John and Paul (Latin: ''Ioannes, Paulus'') are saints who lived during the fourth century in the Roman Empire. They were martyred at Rome on 26 June. The year of their martyrdom is uncertain according to their ''Acts''; it occurred under Julian the Apostate (361–3). Hagiography In the second half of the fourth century, Byzantius, the Roman senator, and Saint Pammachius, his son, fashioned their house on the Cælian Hill into a Christian basilica. In the fifth century the ''presbyteri tituli Byzantii'' (priests of the church of Byzantius) are mentioned in an inscription and among the signatures of the Roman Council of 499. The church was also called the ''titulus Pammachii'' after Byzantius's son, the pious friend of St. Jerome.Kirsch, Johann Peter. "Sts. John and Paul." The Catholic Encyclope ...
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Paracelsus
Paracelsus (; ; 1493 – 24 September 1541), born Theophrastus von Hohenheim (full name Philippus Aureolus Theophrastus Bombastus von Hohenheim), was a Swiss physician, alchemist, lay theologian, and philosopher of the German Renaissance. He was a pioneer in several aspects of the " medical revolution" of the Renaissance, emphasizing the value of observation in combination with received wisdom. He is credited as the "father of toxicology". Paracelsus also had a substantial influence as a prophet or diviner, his "Prognostications" being studied by Rosicrucians in the 1600s. Paracelsianism is the early modern medical movement inspired by the study of his works. Biography Paracelsus was born in Egg an der Sihl, a village close to the Etzel Pass in Einsiedeln, Schwyz. He was born in a house right next to a bridge across the Sihl river (known as ''Teufelsbrücke''). The historical house, dated to the 14th century, was destroyed in 1814. The ''Restaurant Krone'' now stands in it ...
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Naphthodianthrone
''For the parent molecule 9,10-anthraquinone, see anthraquinone'' Anthraquinones (also known as anthraquinonoids) are a class of naturally occurring phenolic compounds based on the 9,10-anthraquinone skeleton. They are widely used industrially and occur naturally. Occurrence in plants : Natural pigments that are derivatives of anthraquinone are found, inter alia, in aloe latex, senna, rhubarb, and cascara buckthorn, fungi, lichens, and some insects. A type II polyketide synthase is responsible for anthraquinone biosynthesis in the bacterium '' Photorhabdus luminescens''. Chorismate, formed by isochorismate synthase in the shikimate pathway, is a precursor of anthraquinones in ''Morinda citrifolia''. Tests for anthraquinones in natural extracts have been established. *Senna glycosides from the senna. *Frangulin in Frangula alnus. * Aloe-emodin in aloe resin. * Carmine, a bright-red pigment derived from insects. *Hypericin and fagopyrin are naphthodianthrones, anthraquino ...
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