|
Herbert John Seddon
Sir Herbert John Seddon (13 July 1903 – 21 December 1977) was an English orthopaedic surgeon. He was Nuffield Professor of Orthopaedic Surgery at the University of Oxford, where his work and publications on peripheral nerve injuries gained him an international reputation. His classification of nerve injuries forms the basis of that in use into the 21st century. He went on to become director of the new Institute of Orthopaedics in London and subsequently the first Professor of Orthopaedics in the University of London. In this role he directed basic science research into orthopaedic conditions and developed postgraduate training in orthopaedic surgery. He was President of the British Orthopaedic Association, and was knighted in 1964 for services to orthopaedics. Early life and surgical training Herbert Seddon was born in Derby, the son of John Seddon, and his wife Ellen Seddon (née Thornton). He grew up in Manchester and went to school at William Hulme's Grammar School. He we ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Derby
Derby ( ) is a city and unitary authority area in Derbyshire, England. It lies on the banks of the River Derwent in the south of Derbyshire, which is in the East Midlands Region. It was traditionally the county town of Derbyshire. Derby gained city status in 1977, the population size has increased by 5.1%, from around 248,800 in 2011 to 261,400 in 2021. Derby was settled by Romans, who established the town of Derventio, later captured by the Anglo-Saxons, and later still by the Vikings, who made their town of one of the Five Boroughs of the Danelaw. Initially a market town, Derby grew rapidly in the industrial era. Home to Lombe's Mill, an early British factory, Derby has a claim to be one of the birthplaces of the Industrial Revolution. It contains the southern part of the Derwent Valley Mills World Heritage Site. With the arrival of the railways in the 19th century, Derby became a centre of the British rail industry. Derby is a centre for advanced transport manufactur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Malta (island)
Malta is the largest of the three major islands that constitute the Maltese archipelago. It is sometimes referred to as Valletta for statistical purposes to distinguish the main island from the Malta, entire country. Malta is in the middle of the Mediterranean Sea directly south of Italy and north of Libya. The island is long and wide, with a total area of . The capital is Valletta, while the largest locality is Rabat, Malta, Rabat. The island is made up of many small towns, which together form one Larger Urban Zones, larger urban zone with a population of 409,259. The landscape is characterised by low hills with terraced fields. History Humans have inhabited Malta since about 5200 BC, when stone age hunters or farmers arrived from Sicily. Early Neolithic settlements were discovered in open areas and also in caves, such as Għar Dalam. Around 3500 BC, a culture of megalithic temple builders then either supplanted or arose. They built some of the oldest existing, free-standing ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurotmesis
Neurotmesis (in Greek tmesis signifies "to cut") is part of Seddon's classification scheme used to classify nerve damage. It is the most serious nerve injury in the scheme. In this type of injury, both the nerve and the nerve sheath are disrupted. While partial recovery may occur, complete recovery is impossible. Symptoms Symptoms of neurotmesis include but are not limited to pain, dysesthesias (uncomfortable sensations), and complete loss of sensory and motor function of the affected nerve. Anatomy Neurotmesis occurs in the peripheral nervous system and most often in the upper-limb (arms), accounting for 73.5% of all peripheral nerve injury cases. Of these cases, the ulnar nerve was most often injured. Peripheral nerves are structured so that the axons are surrounded by most often a myelinated sheath and then an endoneurium. A perineurium surrounds that and the outermost layer is considered the epineurium. When injury occurs, "local vascular trauma leads to hemorrhage and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Axonotmesis
Axonotmesis is an injury to the peripheral nerve of one of the extremities of the body. The axons and their myelin sheath are damaged in this kind of injury, but the endoneurium, perineurium and epineurium remain intact. Motor and sensory functions distal to the point of injury are completely lost over time leading to Wallerian degeneration due to ischemia, or loss of blood supply. Axonotmesis is usually the result of a more severe crush or contusion than neurapraxia. Axonotmesis mainly follows a stretch injury. These stretch injuries can either dislocate joints or fracture a limb, due to which peripheral nerves are severed. If the sharp pain from the exposed axon of the nerve is not observed, one can identify a nerve injury from abnormal sensations in their limb. A doctor may ask for a nerve conduction velocity (NCV) test to completely diagnose the issue. If diagnosed as nerve injury, electromyography performed after 3 to 4 weeks shows signs of denervations and fibrillations, or ir ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurapraxia
Neurapraxia is a disorder of the peripheral nervous system in which there is a temporary loss of motor and sensory function due to blockage of nerve conduction, usually lasting an average of six to eight weeks before full recovery. Neurapraxia is derived from the word apraxia, meaning “loss or impairment of the ability to execute complex coordinated movements without muscular or sensory impairment”. This condition is typically caused by a blunt neural injury due to external blows or shock-like injuries to muscle fibers and skeletal nerve fibers, which leads to repeated or prolonged pressure buildup on the nerve. As a result of this pressure, ischemia occurs, a neural lesion results, and the human body naturally responds with edema extending in all directions from the source of the pressure. This lesion causes a complete or partial action potential conduction block over a segment of a nerve fiber and thus a reduction or loss of function in parts of the neural connection downst ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peripheral Nerve Injury Classification
Classification of peripheral nerve injury assists in prognosis and determination of treatment strategy. Classification of nerve injury was described by Seddon in 1943 and by Sunderland in 1951. The lowest degree of nerve injury in which the nerve remains intact but signaling ability is damaged is called neurapraxia. The second degree in which the axon is damaged but the surrounding connecting tissue remains intact is called axonotmesis. The last degree in which both the axon and connective tissue are damaged is called neurotmesis. Seddon's classification In 1943, Seddon described three basic types of peripheral nerve injury that include: Neurapraxia (Class I) It is a temporary interruption of conduction without loss of axonal continuity. In neurapraxia, there is a physiologic block of nerve conduction in the affected axons. Other characteristics: *It is the mildest type of peripheral nerve injury. *There are sensory-motor problems distal to the site of injury. *The endoneurium, p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nobel Prize
The Nobel Prizes ( ; sv, Nobelpriset ; no, Nobelprisen ) are five separate prizes that, according to Alfred Nobel's will of 1895, are awarded to "those who, during the preceding year, have conferred the greatest benefit to humankind." Alfred Nobel was a Swedish chemist, engineer, and industrialist most famously known for the invention of dynamite. He died in 1896. In his will, he bequeathed all of his "remaining realisable assets" to be used to establish five prizes which became known as "Nobel Prizes." Nobel Prizes were first awarded in 1901. Nobel Prizes are awarded in the fields of Physics, Chemistry, Physiology or Medicine, Literature, and Peace (Nobel characterized the Peace Prize as "to the person who has done the most or best to advance fellowship among nations, the abolition or reduction of standing armies, and the establishment and promotion of peace congresses"). In 1968, Sveriges Riksbank (Sweden's central bank) funded the establishment of the Prize in Economi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peter Medawar
Sir Peter Brian Medawar (; 28 February 1915 – 2 October 1987) was a Brazilian-British biologist and writer, whose works on graft rejection and the discovery of acquired immune tolerance have been fundamental to the medical practice of tissue and organ transplants. For his scientific works, he is regarded as the "father of transplantation". He is remembered for his wit both in person and in popular writings. Famous zoologists such as Richard Dawkins referred to him as "the wittiest of all scientific writers", and Stephen Jay Gould as "the cleverest man I have ever known". Medawar was the youngest child of a Lebanese father and a British mother, and was both a Brazilian and British citizen by birth. He studied at Marlborough College and Magdalen College, Oxford, and was professor of zoology at the University of Birmingham and University College London. Until he was partially disabled by a cerebral infarction, he was Director of the National Institute for Medical Research at M ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John Zachary Young
John Zachary Young FRS (18 March 1907 – 4 July 1997), generally known as "JZ" or "JZY", was an English zoologist and neurophysiologist, described as "one of the most influential biologists of the 20th century". Biography Young went to school at Marlborough College. In 1928, he received a first class honours degree in zoology from Magdalen College, Oxford. On Oct. 12, 1942, Young spoke at the Socratic Club in Oxford on the topic "Purpose and Design in Nature" as part of the series of talks and debates led by C. S. Lewis. He was elected a Fellow of the Royal Society in 1945 and served as Professor of Anatomy at University College London from then until 1974. The following year, he became a Professor Emeritus and proposed a degree programme in the Human Sciences. Young was elected to the American Academy of Arts and Sciences in 1957. Among his other honors are a Linnean Medal for zoology from the Linnean Society of London, awarded in 1973. He was elected to the American Philoso ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intervertebral Disc
An intervertebral disc (or intervertebral fibrocartilage) lies between adjacent vertebrae in the vertebral column. Each disc forms a fibrocartilaginous joint (a symphysis), to allow slight movement of the vertebrae, to act as a ligament to hold the vertebrae together, and to function as a shock absorber for the spine. Structure Intervertebral discs consist of an outer fibrous ring, the anulus fibrosus disci intervertebralis, which surrounds an inner gel-like center, the nucleus pulposus. The ''anulus fibrosus'' consists of several layers (laminae) of fibrocartilage made up of both type I and type II collagen. Type I is concentrated toward the edge of the ring, where it provides greater strength. The stiff laminae can withstand compressive forces. The fibrous intervertebral disc contains the ''nucleus pulposus'' and this helps to distribute pressure evenly across the disc. This prevents the development of stress concentrations which could cause damage to the underlying vertebrae ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kyphosis
Kyphosis is an abnormally excessive convex curvature of the spine as it occurs in the thoracic and sacral regions. Abnormal inward concave ''lordotic'' curving of the cervical and lumbar regions of the spine is called lordosis. It can result from degenerative disc disease; developmental abnormalities, most commonly Scheuermann's disease; Copenhagen disease, osteoporosis with compression fractures of the vertebra; multiple myeloma; or trauma. A normal thoracic spine extends from the 1st thoracic to the 12th thoracic vertebra and should have a slight kyphotic angle, ranging from 20° to 45°. When the "roundness" of the upper spine increases past 45° it is called kyphosis or "hyperkyphosis". Scheuermann's kyphosis is the most classic form of hyperkyphosis and is the result of wedged vertebrae that develop during adolescence. The cause is not currently known and the condition appears to be multifactorial and is seen more frequently in males than females. In the sense of a deformit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paraplegia
Paraplegia, or paraparesis, is an impairment in motor or sensory function of the lower extremities. The word comes from Ionic Greek () "half-stricken". It is usually caused by spinal cord injury or a congenital condition that affects the neural (brain) elements of the spinal canal. The area of the spinal canal that is affected in paraplegia is either the thoracic, lumbar, or sacral regions. If four limbs are affected by paralysis, tetraplegia or quadriplegia is the correct term. If only one limb is affected, the correct term is monoplegia. Spastic paraplegia is a form of paraplegia defined by spasticity of the affected muscles, rather than flaccid paralysis. The American Spinal Injury Association classifies spinal cord injury severity in the following manner. ASIA A is the complete loss of sensory function and motor skills below the injury. ASIA B is having some sensory function below the injury, but no motor function. In ASIA C, there is some motor function below the level of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
