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Heinrich Unverricht
Heinrich Unverricht (18 September 1853 – 22 April 1912) was a German internist who was a native of Breslau. Education and Medical career In 1877 he obtained his doctorate from the University of Breslau, where he was a student of Michael Anton Biermer (1827-1892). Later he became professor at Jena (1886) and Dorpat (1888), where he resigned in 1892 for political reasons, and became director of the city hospital at Magdeburg-Sudenburg, until his retirement in 1911. During this time he also served as president of the Magdeburg Medical Society, and as editor of the ''Zentralblatt für innere Medizin''. Unverricht published over fifty medical works, including ''Studien über die Lungenentzündung'', his prize-winning doctorate thesis on pneumonia. Research Heinrich Unverricht is most remembered for his research of epilepsy, especially his work with progressive myoclonus epilepsies (PME). In 1891 he described a form of PME that was later come to be known as " Unverricht-Lundbo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Progressive Myoclonus Epilepsies
Progressive Myoclonic Epilepsies (PME) are a rare group of inherited neurodegenerative diseases characterized by myoclonus, resistance to treatment, and neurological deterioration. The cause of PME depends largely on the type of PME. Most PMEs are caused by autosomal dominant or recessive and mitochondrial mutations. The location of the mutation also affects the inheritance and treatment of PME. Diagnosing PME is difficult due to their genetic heterogeneity and the lack of a genetic mutation identified in some patients. The prognosis depends largely on the worsening symptoms and failure to respond to treatment. There is no current cure for PME and treatment focuses on managing myoclonus and seizures through antiepileptic medication (AED). The age of onset depends on the specific PME but PME can affect people of all ages. In Unverricht-Lundborg disease (ULD) the age of onset is between 6–15 years, while in Adult Neuronal ceroid lipofuscinoses (Adult NCL) the age of onset can be a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1853 Births
Events January–March * January 6 – Florida Governor Thomas Brown signs legislation that provides public support for the new East Florida Seminary, leading to the establishment of the University of Florida. * January 8 – Taiping Rebellion: Zeng Guofan is ordered to assist the governor of Hunan in organising a militia force to search for local bandits. * January 12 – Taiping Rebellion: The Taiping army occupies Wuchang. * January 19 – Giuseppe Verdi's opera ''Il Trovatore'' premieres in performance at Teatro Apollo in Rome. * February 10 – Taiping Rebellion: Taiping forces assemble at Hanyang, Hankou, and Wuchang, for the march on Nanjing. * February 12 – The city of Puerto Montt is founded in the Reloncaví Sound, Chile. * February 22 – Washington University in St. Louis is founded as Eliot Seminary. * March – The clothing company Levi Strauss & Co. is founded in the United States. * March 4 – Inauguration of Franklin Pierce as 14th President of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nephritic Syndrome
Nephritic syndrome is a syndrome comprising signs of nephritis, which is kidney disease involving inflammation. It often occurs in the glomerulus, where it is called glomerulonephritis. Glomerulonephritis is characterized by inflammation and thinning of the glomerular basement membrane and the occurrence of small pores in the podocytes of the glomerulus. These pores become large enough to permit both proteins and red blood cells to pass into the urine (yielding proteinuria and hematuria, respectively). By contrast, nephrotic syndrome is characterized by proteinuria and a constellation of other symptoms that specifically do not include hematuria. Nephritic syndrome, like nephrotic syndrome, may involve low level of albumin in the blood due to the protein albumin moving from the blood to the urine. Signs and symptoms Historically, nephritic syndrome has been characterized by blood in the urine (hematuria), high blood pressure (hypertension), decreased urine output 3.5 g/day, lo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hemiparesis
Hemiparesis, or unilateral paresis, is weakness of one entire side of the body (''wikt:hemi-#Prefix, hemi-'' means "half"). Hemiplegia is, in its most severe form, complete paralysis of half of the body. Hemiparesis and hemiplegia can be caused by different medical conditions, including congenital causes, trauma, tumors, or stroke.Detailed article about hemiparesis at Disabled-World.com Signs and symptoms Depending on the type of hemiparesis diagnosed, different bodily functions can be affected. Some effects are expected (e.g., partial paralysis of a limb on the affected side). Other impairments, though, can at first seem completely non-related to the limb weakness but are, in fact, a direct result of the damage to the affected side of the brain. |
Dermatomyositis
Dermatomyositis (DM) is a long-term inflammatory disorder which affects skin and the muscles. Its symptoms are generally a skin rash and worsening muscle weakness over time. These may occur suddenly or develop over months. Other symptoms may include weight loss, fever, lung inflammation, or light sensitivity. Complications may include calcium deposits in muscles or skin. The cause is unknown. Theories include that it is an autoimmune disease or a result of a viral infection. Dermatomyositis may develop as a paraneoplastic syndrome associated with several forms of malignancy. It is a type of inflammatory myopathy. Diagnosis is typically based on some combination of symptoms, blood tests, electromyography, and muscle biopsies. While no cure for the condition is known, treatments generally improve symptoms. Treatments may include medication, physical therapy, exercise, heat therapy, orthotics and assistive devices, and rest. Medications in the corticosteroids family are typic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polymyositis
Polymyositis (PM) is a type of chronic inflammation of the muscles (inflammatory myopathy) related to dermatomyositis and inclusion body myositis. Its name means "inflammation of many muscles" ('' poly-'' + '' myos-'' + ''-itis''). The inflammation of polymyositis is mainly found in the endomysial layer of skeletal muscle, whereas dermatomyositis is characterized primarily by inflammation of the perimysial layer of skeletal muscles. Signs and symptoms The hallmark of polymyositis is weakness and/or loss of muscle mass in the proximal musculature, as well as flexion of the neck and torso. These symptoms can be associated with marked pain in these areas as well. The hip extensors are often severely affected, leading to particular difficulty in climbing stairs and rising from a seated position. The skin involvement of dermatomyositis is absent in polymyositis. Dysphagia (difficulty swallowing) or other problems with esophageal motility occur in as many as 1/3 of patients. Low grad ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rudolf Virchow
Rudolf Ludwig Carl Virchow (; or ; 13 October 18215 September 1902) was a German physician, anthropologist, pathologist, prehistorian, biologist, writer, editor, and politician. He is known as "the father of modern pathology" and as the founder of social medicine, and to his colleagues, the "Pope of medicine". Virchow studied medicine at the Friedrich Wilhelm University under Johannes Peter Müller. While working at the Charité hospital, his investigation of the 1847–1848 typhus epidemic in Upper Silesia laid the foundation for public health in Germany, and paved his political and social careers. From it, he coined a well known aphorism: "Medicine is a social science, and politics is nothing else but medicine on a large scale". His participation in the Revolution of 1848 led to his expulsion from Charité the next year. He then published a newspaper ''Die Medizinische Reform'' (''The Medical Reform''). He took the first Chair of Pathological Anatomy at the University of Wü ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ernst Leberecht Wagner
Ernst Leberecht Wagner (12 March 1829 – 10 February 1888) was a German pathologist who was a native of Dehlitz, a town in the Burgenlandkreis district of Saxony-Anhalt. Education and Career He studied medicine in Leipzig under Karl August Wunderlich (1815–1877), in Prague under Josef Skoda (1805–1881) and in Vienna under Karl von Rokitansky (1804–1878). In 1855 he received his habilitation at the University of Leipzig, where in 1862 he became an associate professor. In 1869 Wagner became a "full professor" of general pathology and pathological anatomy at the University of Leipzig, and in 1871 founded the first institute of pathology at Leipzig. From 1877 until 1888 he was a professor of pathology and "special therapy" ( internal medicine) at Leipzig. Wagner was considered an excellent teacher, and two of his better known assistants were Adolf von Strümpell (1853–1925) and Paul Flechsig (1847–1929). His best written effort was a textbook ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epilepsy
Epilepsy is a group of non-communicable neurological disorders characterized by recurrent epileptic seizures. Epileptic seizures can vary from brief and nearly undetectable periods to long periods of vigorous shaking due to abnormal electrical activity in the brain. These episodes can result in physical injuries, either directly such as broken bones or through causing accidents. In epilepsy, seizures tend to recur and may have no immediate underlying cause. Isolated seizures that are provoked by a specific cause such as poisoning are not deemed to represent epilepsy. People with epilepsy may be treated differently in various areas of the world and experience varying degrees of social stigma due to the alarming nature of their symptoms. The underlying mechanism of epileptic seizures is excessive and abnormal neuronal activity in the cortex of the brain which can be observed in the electroencephalogram (EEG) of an individual. The reason this occurs in most cases of epilepsy is u ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kingdom Of Prussia
The Kingdom of Prussia (german: Königreich Preußen, ) was a German kingdom that constituted the state of Prussia between 1701 and 1918.Marriott, J. A. R., and Charles Grant Robertson. ''The Evolution of Prussia, the Making of an Empire''. Rev. ed. Oxford: Clarendon Press, 1946. It was the driving force behind the unification of Germany in 1871 and was the leading state of the German Empire until its dissolution in 1918. Although it took its name from the region called Prussia, it was based in the Margraviate of Brandenburg. Its capital was Berlin. The kings of Prussia were from the House of Hohenzollern. Brandenburg-Prussia, predecessor of the kingdom, became a military power under Frederick William, Elector of Brandenburg, known as "The Great Elector". As a kingdom, Prussia continued its rise to power, especially during the reign of Frederick II, more commonly known as Frederick the Great, who was the third son of Frederick William I.Horn, D. B. "The Youth of Frederick ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
